ORC5 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description origin recognition complex, subunit 5|The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Oct 2010] (NCBI Entrez Gene Database, 5001)
External Link http://www.ncbi.nlm.nih.gov/gene/5001
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Genes

48 interacting proteins for ORC5 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ATR ATR serine/threonine kinase
ATRIP ATR interacting protein
CALCOCO2 calcium binding and coiled-coil domain 2
CCNA1 cyclin A1
CCNA2 cyclin A2
CDC45 cell division cycle 45
CDC5L cell division cycle 5-like
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
DBF4 DBF4 zinc finger
DGKA diacylglycerol kinase, alpha 80kDa
DMRTA1 DMRT-like family A1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
KRT18 keratin 18, type I
LAMB2 laminin, beta 2 (laminin S)
LRWD1 leucine-rich repeats and WD repeat domain containing 1
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
NONO non-POU domain containing, octamer-binding
ORC1 origin recognition complex, subunit 1
ORC2 origin recognition complex, subunit 2
ORC3 origin recognition complex, subunit 3
ORC4 origin recognition complex, subunit 4
ORC6 origin recognition complex, subunit 6
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRIM2 primase, DNA, polypeptide 2 (58kDa)
RB1 retinoblastoma 1
RPA2 replication protein A2, 32kDa
SIPA1L2 signal-induced proliferation-associated 1 like 2
STAB1 stabilin 1
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TXNDC11 thioredoxin domain containing 11
UBC ubiquitin C
UBD ubiquitin D
UBQLN4 ubiquilin 4