| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/135398516 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in OSI-027 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 2.32 |
| MYO3A | myosin IIIA | 1.93 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 1.69 |
| TMEM59 | transmembrane protein 59 | 1.6 |
| COQ8A | coenzyme Q8A | 1.58 |
| DUSP4 | dual specificity phosphatase 4 | 1.36 |
| TSPAN3 | tetraspanin 3 | 1.33 |
| NDFIP1 | Nedd4 family interacting protein 1 | 1.25 |
| APOB | apolipoprotein B | 1.24 |
| RNF167 | ring finger protein 167 | 1.23 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 1.2 |
| IRS2 | insulin receptor substrate 2 | 1.19 |
| LTBP3 | latent transforming growth factor beta binding protein 3 | 1.15 |
| H1-0 | H1.0 linker histone | 1.11 |
| ITM2B | integral membrane protein 2B | 1.09 |
| PCMTD2 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 | 1.08 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 1.08 |
| MT2A | metallothionein 2A | 1.08 |
| GAS6 | growth arrest-specific 6 | 1.05 |
| POF1B | premature ovarian failure, 1B | 1.04 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F | 1.03 |
| IGF1R | insulin-like growth factor 1 receptor | 1.03 |
| FHIT | fragile histidine triad | 1.01 |
| PIP | prolactin-induced protein | 1.01 |
| ZC3H6 | zinc finger CCCH-type containing 6 | 1.01 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.98 |
| ELK3 | ELK3, ETS-domain protein (SRF accessory protein 2) | 0.98 |
| KLHL36 | kelch-like family member 36 | 0.98 |
| H1FX | H1 histone family, member X | 0.98 |
| DUSP6 | dual specificity phosphatase 6 | 0.97 |
| NDRG1 | N-myc downstream regulated 1 | 0.96 |
| EGR1 | early growth response 1 | 0.94 |
| MPZL2 | myelin protein zero-like 2 | 0.93 |
| ITM2C | integral membrane protein 2C | 0.93 |
| MFSD6 | major facilitator superfamily domain containing 6 | 0.91 |
| RNF13 | ring finger protein 13 | 0.89 |
| JUN | jun proto-oncogene | 0.88 |
| LAMC2 | laminin, gamma 2 | 0.88 |
| HAL | histidine ammonia-lyase | 0.88 |
| ATE1 | arginyltransferase 1 | 0.87 |
| PPL | periplakin | 0.85 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.84 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.84 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | 0.83 |
| FOSL1 | FOS-like antigen 1 | 0.83 |
| DAP | death-associated protein | 0.83 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.83 |
| KMT5C | lysine methyltransferase 5C | 0.83 |
| UNG | uracil-DNA glycosylase | 0.83 |
| SLC6A17 | solute carrier family 6 (neutral amino acid transporter), member 17 | 0.83 |
| TMEM200A | transmembrane protein 200A | 0.82 |
| SLC44A2 | solute carrier family 44 (choline transporter), member 2 | 0.82 |
| FAM122B | family with sequence similarity 122B | 0.81 |
| PBXIP1 | pre-B-cell leukemia homeobox interacting protein 1 | 0.81 |
| TRIM2 | tripartite motif containing 2 | 0.81 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 0.81 |
| AXL | AXL receptor tyrosine kinase | 0.81 |
| SLC2A4RG | SLC2A4 regulator | 0.81 |
| ZNF805 | zinc finger protein 805 | 0.79 |
| NDFIP2 | Nedd4 family interacting protein 2 | 0.79 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.79 |
| TSPAN5 | tetraspanin 5 | 0.78 |
| TRIML2 | tripartite motif family-like 2 | 0.78 |
| ESAM | endothelial cell adhesion molecule | 0.78 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | 0.77 |
| ACVR1B | activin A receptor, type IB | 0.77 |
| SDHAF4 | succinate dehydrogenase complex assembly factor 4 | 0.76 |
| LMBRD1 | LMBR1 domain containing 1 | 0.76 |
| SOCS2 | suppressor of cytokine signaling 2 | 0.76 |
| ZNF362 | zinc finger protein 362 | 0.76 |
| CTHRC1 | collagen triple helix repeat containing 1 | 0.76 |
| HECA | headcase homolog (Drosophila) | 0.76 |
| CDT1 | chromatin licensing and DNA replication factor 1 | 0.75 |
| CCN2 | cellular communication network factor 2 | 0.75 |
| TRIB1 | tribbles pseudokinase 1 | 0.74 |
| C1QTNF3 | C1q and tumor necrosis factor related protein 3 | 0.74 |
| H6PD | hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) | 0.73 |
| HEXD | hexosaminidase D | 0.73 |
| TCEAL4 | transcription elongation factor A (SII)-like 4 | 0.73 |
| RNASE4 | ribonuclease, RNase A family, 4 | 0.73 |
| TM7SF3 | transmembrane 7 superfamily member 3 | 0.73 |
| PAM | peptidylglycine alpha-amidating monooxygenase | 0.73 |
| RTN2 | reticulon 2 | 0.72 |
| ELF4 | E74-like factor 4 (ets domain transcription factor) | 0.72 |
| CYHR1 | cysteine/histidine-rich 1 | 0.72 |
| APOBEC3G | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | 0.71 |
| MT-CO1 | cytochrome c oxidase subunit I | 0.71 |
| HSD17B8 | hydroxysteroid (17-beta) dehydrogenase 8 | 0.7 |
| CRBN | cereblon | 0.7 |
| MSRB2 | methionine sulfoxide reductase B2 | 0.7 |
| NBR1 | neighbor of BRCA1 gene 1 | 0.69 |
| GSTA1 | glutathione S-transferase alpha 1 | 0.69 |
| PNPLA2 | patatin-like phospholipase domain containing 2 | 0.69 |
| CD63 | CD63 molecule | 0.68 |
| ANKRD2 | ankyrin repeat domain 2 (stretch responsive muscle) | 0.68 |
| PPTC7 | PTC7 protein phosphatase homolog (S. cerevisiae) | 0.68 |
| ACAD10 | acyl-CoA dehydrogenase family, member 10 | 0.68 |
| MT1L | metallothionein 1L (gene/pseudogene) | 0.68 |
| ACY1 | aminoacylase 1 | 0.68 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PPP1R26 | protein phosphatase 1, regulatory subunit 26 | -4.58 |
| AAGAB | alpha- and gamma-adaptin binding protein | -1.52 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -1.46 |
| PRELID3B | PRELI domain containing 3B | -1.45 |
| PRELID1 | PRELI domain containing 1 | -1.37 |
| DUSP7 | dual specificity phosphatase 7 | -1.33 |
| PDP2 | pyruvate dehyrogenase phosphatase catalytic subunit 2 | -1.32 |
| XIRP1 | xin actin binding repeat containing 1 | -1.3 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -1.23 |
| TRIB3 | tribbles pseudokinase 3 | -1.23 |
| SESN2 | sestrin 2 | -1.22 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -1.21 |
| AXIN2 | axin 2 | -1.18 |
| NEU1 | sialidase 1 (lysosomal sialidase) | -1.17 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -1.16 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | -1.16 |
| NAGS | N-acetylglutamate synthase | -1.16 |
| PSAT1 | phosphoserine aminotransferase 1 | -1.15 |
| ZRANB1 | zinc finger, RAN-binding domain containing 1 | -1.1 |
| PLK1 | polo-like kinase 1 | -1.07 |
| VDR | vitamin D (1,25- dihydroxyvitamin D3) receptor | -1.07 |
| ABCF2 | ATP-binding cassette, sub-family F (GCN20), member 2 | -1.07 |
| RUNDC1 | RUN domain containing 1 | -1.05 |
| RAB43 | RAB43, member RAS oncogene family | -1.03 |
| RNF115 | ring finger protein 115 | -1.03 |
| MICA | MHC class I polypeptide-related sequence A | -1.02 |
| DNAJB5 | DnaJ (Hsp40) homolog, subfamily B, member 5 | -1.0 |
| SLC1A4 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | -1.0 |
| ZNF277 | zinc finger protein 277 | -1.0 |
| GABARAPL2 | GABA(A) receptor-associated protein-like 2 | -1.0 |
| ZMYND19 | zinc finger, MYND-type containing 19 | -0.99 |
| ANKRD52 | ankyrin repeat domain 52 | -0.99 |
| SORT1 | sortilin 1 | -0.98 |
| AURKA | aurora kinase A | -0.98 |
| KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | -0.97 |
| CDC20 | cell division cycle 20 | -0.96 |
| DNAL4 | dynein, axonemal, light chain 4 | -0.96 |
| SYAP1 | synapse associated protein 1 | -0.96 |
| CEP72 | centrosomal protein 72kDa | -0.96 |
| UBXN2B | UBX domain protein 2B | -0.95 |
| SHCBP1 | SHC SH2-domain binding protein 1 | -0.95 |
| STC2 | stanniocalcin 2 | -0.94 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.94 |
| AMD1 | adenosylmethionine decarboxylase 1 | -0.94 |
| NES | nestin | -0.93 |
| ODC1 | ornithine decarboxylase 1 | -0.93 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.93 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.93 |
| UCK1 | uridine-cytidine kinase 1 | -0.93 |
| ZUP1 | zinc finger containing ubiquitin peptidase 1 | -0.92 |
| KBTBD8 | kelch repeat and BTB (POZ) domain containing 8 | -0.91 |
| FUT1 | fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) | -0.91 |
| EIF1AD | eukaryotic translation initiation factor 1A domain containing | -0.91 |
| CDC6 | cell division cycle 6 | -0.91 |
| DONSON | downstream neighbor of SON | -0.9 |
| CCNB1 | cyclin B1 | -0.9 |
| TPGS1 | tubulin polyglutamylase complex subunit 1 | -0.9 |
| IPPK | inositol 1,3,4,5,6-pentakisphosphate 2-kinase | -0.89 |
| AEN | apoptosis enhancing nuclease | -0.89 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.89 |
| CHKA | choline kinase alpha | -0.89 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.88 |
| UBE2S | ubiquitin-conjugating enzyme E2S | -0.88 |
| CCDC138 | coiled-coil domain containing 138 | -0.88 |
| MTMR4 | myotubularin related protein 4 | -0.88 |
| TYMS | thymidylate synthetase | -0.88 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -0.88 |
| SPATA2 | spermatogenesis associated 2 | -0.87 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.86 |
| CDC34 | cell division cycle 34 | -0.86 |
| RBIS | ribosomal biogenesis factor | -0.86 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | -0.86 |
| AP1S2 | adaptor-related protein complex 1, sigma 2 subunit | -0.86 |
| TUBE1 | tubulin, epsilon 1 | -0.85 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | -0.85 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | -0.85 |
| LSM10 | LSM10, U7 small nuclear RNA associated | -0.85 |
| HMOX1 | heme oxygenase 1 | -0.85 |
| LRRC58 | leucine rich repeat containing 58 | -0.84 |
| LTV1 | LTV1 ribosome biogenesis factor | -0.84 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | -0.84 |
| CCND3 | cyclin D3 | -0.84 |
| C5ORF34 | chromosome 5 open reading frame 34 | -0.84 |
| GRB10 | growth factor receptor-bound protein 10 | -0.84 |
| BCL9 | B-cell CLL/lymphoma 9 | -0.83 |
| ZCCHC2 | zinc finger, CCHC domain containing 2 | -0.82 |
| DEPDC7 | DEP domain containing 7 | -0.82 |
| UCK2 | uridine-cytidine kinase 2 | -0.82 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.82 |
| RNF6 | ring finger protein (C3H2C3 type) 6 | -0.82 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | -0.81 |
| MAP7D1 | MAP7 domain containing 1 | -0.81 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -0.81 |
| CENPE | centromere protein E, 312kDa | -0.81 |
| KDM4A | lysine (K)-specific demethylase 4A | -0.81 |
| CDC123 | cell division cycle 123 | -0.81 |
| ACBD6 | acyl-CoA binding domain containing 6 | -0.81 |
| RAB18 | RAB18, member RAS oncogene family | -0.8 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.8 |
