| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | OTS514 perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the OTS514_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0898696 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0859222 |
| CCNL1 | cyclin L1 | 0.0588796 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0481878 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0469449 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0409693 |
| JMJD1C | jumonji domain containing 1C | 0.0389734 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0387984 |
| YAP1 | Yes-associated protein 1 | 0.036268 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0358386 |
| TMEM41B | transmembrane protein 41B | 0.0353702 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0351377 |
| RTN4 | reticulon 4 | 0.0293949 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0291128 |
| PDGFC | platelet derived growth factor C | 0.02877 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0269934 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0266072 |
| EGR1 | early growth response 1 | 0.0258532 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0255338 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0253269 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.0252852 |
| VMP1 | vacuole membrane protein 1 | 0.0248635 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | 0.0248427 |
| EDARADD | EDAR-associated death domain | 0.0246951 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0238669 |
| EPHA5 | EPH receptor A5 | 0.0238257 |
| PCBP2 | poly(rC) binding protein 2 | 0.0230987 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0230404 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0225868 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0222344 |
| RCOR1 | REST corepressor 1 | 0.0213713 |
| CDK17 | cyclin-dependent kinase 17 | 0.0206559 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0201894 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0199178 |
| SESN2 | sestrin 2 | 0.0197307 |
| POTEF | POTE ankyrin domain family, member F | 0.0197088 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0196135 |
| MED13L | mediator complex subunit 13-like | 0.0190709 |
| NUP58 | nucleoporin 58 | 0.0189092 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0189039 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0187982 |
| CCN2 | cellular communication network factor 2 | 0.0185249 |
| BRD2 | bromodomain containing 2 | 0.018008 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0172184 |
| EXOC6B | exocyst complex component 6B | 0.016575 |
| FAT1 | FAT atypical cadherin 1 | 0.0164667 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0160974 |
| PRKCE | protein kinase C, epsilon | 0.0160591 |
| DENND5A | DENN/MADD domain containing 5A | 0.0155575 |
| INTS6 | integrator complex subunit 6 | 0.0154786 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.0152407 |
| NABP1 | nucleic acid binding protein 1 | 0.0152337 |
| LRP6 | low density lipoprotein receptor-related protein 6 | 0.0151341 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.015045 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0148638 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0148298 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0148298 |
| TBK1 | TANK-binding kinase 1 | 0.0147593 |
| GANAB | glucosidase, alpha; neutral AB | 0.014594 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0145018 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.0144674 |
| HMGA2 | high mobility group AT-hook 2 | 0.0144514 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.014422 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0144092 |
| TJP1 | tight junction protein 1 | 0.0142313 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0141352 |
| RPS26 | ribosomal protein S26 | 0.0138135 |
| ZNF207 | zinc finger protein 207 | 0.0137799 |
| TNRC6C | trinucleotide repeat containing 6C | 0.0137792 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0137125 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0135961 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0135661 |
| FLNA | filamin A, alpha | 0.0135477 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0134202 |
| KDM6B | lysine (K)-specific demethylase 6B | 0.013404 |
| MEF2D | myocyte enhancer factor 2D | 0.0132375 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0131477 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0131312 |
| FOSL1 | FOS-like antigen 1 | 0.0131248 |
| PER1 | period circadian clock 1 | 0.013036 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0130083 |
| TM9SF4 | transmembrane 9 superfamily protein member 4 | 0.0126331 |
| MGAT4C | MGAT4 family, member C | 0.0125882 |
| TENT4A | terminal nucleotidyltransferase 4A | 0.0124424 |
| ATP11A | ATPase, class VI, type 11A | 0.0123831 |
| SF1 | splicing factor 1 | 0.0123551 |
| MEMO1 | mediator of cell motility 1 | 0.0122925 |
| GSE1 | Gse1 coiled-coil protein | 0.0120963 |
| FAM193A | family with sequence similarity 193, member A | 0.0118964 |
| YARS1 | tyrosyl-tRNA synthetase 1 | 0.0118526 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | 0.0118418 |
| NUP98 | nucleoporin 98kDa | 0.0117779 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.011758 |
| DCAF6 | DDB1 and CUL4 associated factor 6 | 0.0117345 |
| NCOR2 | nuclear receptor corepressor 2 | 0.011693 |
| SERTAD2 | SERTA domain containing 2 | 0.0116422 |
| RNF13 | ring finger protein 13 | 0.0115959 |
| PGK1 | phosphoglycerate kinase 1 | 0.0115447 |
| CLDND1 | claudin domain containing 1 | 0.0115356 |
| CNOT3 | CCR4-NOT transcription complex, subunit 3 | 0.0113886 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.345154 |
| TMSB10 | thymosin beta 10 | -0.219448 |
| PTMA | prothymosin, alpha | -0.132629 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.102228 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0984967 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.09128 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0863378 |
| ANXA1 | annexin A1 | -0.0819249 |
| AHNAK | AHNAK nucleoprotein | -0.0816429 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0812562 |
| FTL | ferritin, light polypeptide | -0.0792369 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0782892 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0712809 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0673949 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0667985 |
| CLDN1 | claudin 1 | -0.061937 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0604314 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0573454 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.056501 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0558112 |
| CANX | calnexin | -0.0546839 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.054116 |
| RPLP1 | ribosomal protein, large, P1 | -0.0515921 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0504944 |
| RPS27A | ribosomal protein S27a | -0.0496206 |
| RPS3 | ribosomal protein S3 | -0.0474198 |
| RPS8 | ribosomal protein S8 | -0.0470788 |
| EHBP1 | EH domain binding protein 1 | -0.0455219 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0454259 |
| ENO1 | enolase 1, (alpha) | -0.0452631 |
| H1-0 | H1.0 linker histone | -0.0449103 |
| TMEM123 | transmembrane protein 123 | -0.0444666 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0442562 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0426373 |
| RPS24 | ribosomal protein S24 | -0.0423451 |
| RPL19 | ribosomal protein L19 | -0.0405219 |
| RPL12 | ribosomal protein L12 | -0.0402814 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -0.0402064 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0401135 |
| RPS6 | ribosomal protein S6 | -0.0395183 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0394526 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0390514 |
| YBX1 | Y box binding protein 1 | -0.0388745 |
| RPL26 | ribosomal protein L26 | -0.0383707 |
| DST | dystonin | -0.0377445 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.037555 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0375254 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0373421 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0372067 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0370352 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.035723 |
| LMO7 | LIM domain 7 | -0.0355664 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0354808 |
| HDLBP | high density lipoprotein binding protein | -0.0335466 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0324229 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0315977 |
| GCG | glucagon | -0.0315178 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0313322 |
| MKI67 | marker of proliferation Ki-67 | -0.0310776 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0305556 |
| RPS12 | ribosomal protein S12 | -0.0305432 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.030147 |
| RPL34 | ribosomal protein L34 | -0.0300348 |
| S100A10 | S100 calcium binding protein A10 | -0.0296037 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0294317 |
| ACTG1 | actin gamma 1 | -0.0292935 |
| RPL32 | ribosomal protein L32 | -0.0291639 |
| CENPF | centromere protein F, 350/400kDa | -0.0290189 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0284517 |
| ASPH | aspartate beta-hydroxylase | -0.0283284 |
| MMP12 | matrix metallopeptidase 12 | -0.0282796 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0278941 |
| TPM4 | tropomyosin 4 | -0.0278725 |
| SRP72 | signal recognition particle 72kDa | -0.0274884 |
| EZR | ezrin | -0.0270985 |
| CCDC47 | coiled-coil domain containing 47 | -0.0270146 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0268373 |
| RPL11 | ribosomal protein L11 | -0.0267613 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | -0.0266983 |
| RPS5 | ribosomal protein S5 | -0.0263237 |
| PA2G4 | proliferation-associated 2G4, 38kDa | -0.026279 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0259862 |
| PARK7 | parkinson protein 7 | -0.0258048 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0255908 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0255261 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0255027 |
| RAI14 | retinoic acid induced 14 | -0.0254271 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0251171 |
| ILF3 | interleukin enhancer binding factor 3, 90kDa | -0.0250635 |
| RPL31 | ribosomal protein L31 | -0.0250286 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.0250118 |
| RACK1 | receptor for activated C kinase 1 | -0.024894 |
| HNRNPAB | heterogeneous nuclear ribonucleoprotein A/B | -0.0246956 |
| SYT1 | synaptotagmin I | -0.0245725 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0245305 |
| GNAS | GNAS complex locus | -0.024468 |
| RPLP2 | ribosomal protein, large, P2 | -0.0242873 |
| BRCA1 | breast cancer 1, early onset | -0.0242486 |
| GNL3 | guanine nucleotide binding protein-like 3 (nucleolar) | -0.0242105 |
| DPYD | dihydropyrimidine dehydrogenase | -0.023707 |
