OTS514_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description OTS514 perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the OTS514_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.225531
FN1 fibronectin 1 0.223771
TGFBI transforming growth factor, beta-induced, 68kDa 0.204392
CDH13 cadherin 13 0.108491
CADM1 cell adhesion molecule 1 0.10402
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.100727
TRIO trio Rho guanine nucleotide exchange factor 0.0998943
COL6A3 collagen, type VI, alpha 3 0.0995926
FNDC3B fibronectin type III domain containing 3B 0.0988359
LOXL2 lysyl oxidase-like 2 0.0978548
EEF1G eukaryotic translation elongation factor 1 gamma 0.0930237
JARID2 jumonji, AT rich interactive domain 2 0.0888489
EEF2 eukaryotic translation elongation factor 2 0.0709342
P4HB prolyl 4-hydroxylase, beta polypeptide 0.064988
MYH9 myosin, heavy chain 9, non-muscle 0.0631811
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.060985
VEGFA vascular endothelial growth factor A 0.0567408
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0532388
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0524084
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.051686
EGFR epidermal growth factor receptor 0.0515698
PTK2 protein tyrosine kinase 2 0.0515608
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 0.0511977
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0494527
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0480135
COL5A1 collagen, type V, alpha 1 0.0474304
SOD2 superoxide dismutase 2, mitochondrial 0.045614
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0441113
PDIA3 protein disulfide isomerase family A, member 3 0.0430662
CALR calreticulin 0.0404782
NAV2 neuron navigator 2 0.0404515
DOCK5 dedicator of cytokinesis 5 0.0388706
FLNA filamin A, alpha 0.0375958
CMIP c-Maf inducing protein 0.0368518
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.036612
MTSS1 metastasis suppressor 1 0.0362529
ACTG1 actin gamma 1 0.0353149
ADM adrenomedullin 0.034181
ZSWIM6 zinc finger, SWIM-type containing 6 0.0341246
CCNL1 cyclin L1 0.0330505
TTC3 tetratricopeptide repeat domain 3 0.0324285
COL6A2 collagen, type VI, alpha 2 0.0323197
PLEC plectin 0.0312844
ANKRD17 ankyrin repeat domain 17 0.0309118
ATXN1 ataxin 1 0.0305123
GANAB glucosidase, alpha; neutral AB 0.0301678
TM4SF1 transmembrane 4 L six family member 1 0.0301473
RUNX1 runt-related transcription factor 1 0.0300275
CAMTA1 calmodulin binding transcription activator 1 0.0298735
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0296998
LDHA lactate dehydrogenase A 0.0296861
TRAM1 translocation associated membrane protein 1 0.0295056
ANKRD11 ankyrin repeat domain 11 0.0293648
PDIA5 protein disulfide isomerase family A, member 5 0.0293188
FNIP1 folliculin interacting protein 1 0.0291536
FTH1 ferritin, heavy polypeptide 1 0.0290349
COL6A1 collagen, type VI, alpha 1 0.0286482
PICALM phosphatidylinositol binding clathrin assembly protein 0.0286163
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0285432
ARRDC3 arrestin domain containing 3 0.0285024
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0280375
DPYSL2 dihydropyrimidinase-like 2 0.0279471
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0272332
FMNL2 formin-like 2 0.0270276
CLTC clathrin, heavy chain (Hc) 0.0266148
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0265532
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0258984
COG5 component of oligomeric golgi complex 5 0.0257949
IL6 interleukin 6 0.0254378
LPP LIM domain containing preferred translocation partner in lipoma 0.0253223
RYK receptor-like tyrosine kinase 0.0253124
CLMP CXADR-like membrane protein 0.0252721
PGK1 phosphoglycerate kinase 1 0.0250491
RAB6A RAB6A, member RAS oncogene family 0.0249724
MRTFA myocardin related transcription factor A 0.0249508
SLC38A2 solute carrier family 38, member 2 0.0248786
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme 0.0248142
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0246099
ANKHD1 ankyrin repeat and KH domain containing 1 0.0244792
CDK13 cyclin-dependent kinase 13 0.0239324
MYO10 myosin X 0.0237106
YARS1 tyrosyl-tRNA synthetase 1 0.0235644
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0234948
TENT4A terminal nucleotidyltransferase 4A 0.0234537
ESYT2 extended synaptotagmin-like protein 2 0.0233786
PTPRM protein tyrosine phosphatase, receptor type, M 0.0233584
NAV1 neuron navigator 1 0.0231189
USP34 ubiquitin specific peptidase 34 0.022927
NFE2L1 nuclear factor, erythroid 2-like 1 0.0227911
CCNY cyclin Y 0.0227692
ITCH itchy E3 ubiquitin protein ligase 0.0227604
EXT1 exostosin glycosyltransferase 1 0.0223612
RAB1A RAB1A, member RAS oncogene family 0.0223061
NAMPT nicotinamide phosphoribosyltransferase 0.0222974
ZNF207 zinc finger protein 207 0.0219909
FLNB filamin B, beta 0.0219151
EFNA5 ephrin-A5 0.0219075
NOTCH2 notch 2 0.0219021
FAT1 FAT atypical cadherin 1 0.0216159
PDE10A phosphodiesterase 10A 0.0214929

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.180716
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.174277
TMSB10 thymosin beta 10 -0.113795
IGFBP3 insulin-like growth factor binding protein 3 -0.0894578
COL1A1 collagen, type I, alpha 1 -0.0873851
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0656363
FTL ferritin, light polypeptide -0.0613941
PTMA prothymosin, alpha -0.056127
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.044832
TPM4 tropomyosin 4 -0.0423886
IER3 immediate early response 3 -0.0381083
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0362961
TMSB4X thymosin beta 4, X-linked -0.0360477
MAP1B microtubule-associated protein 1B -0.0347277
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0342609
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0332655
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.031648
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0306113
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0304771
HMGA2 high mobility group AT-hook 2 -0.0304124
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0289101
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0287204
AHNAK AHNAK nucleoprotein -0.0286749
YBX1 Y box binding protein 1 -0.0285005
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.028397
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0283399
EGR1 early growth response 1 -0.0270234
CALD1 caldesmon 1 -0.0256838
RAD21 RAD21 homolog (S. pombe) -0.0252392
RRBP1 ribosome binding protein 1 -0.024885
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0247762
CNTN5 contactin 5 -0.0246782
ANXA2 annexin A2 -0.0244062
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0237621
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0230457
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.023027
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0224673
DPYD dihydropyrimidine dehydrogenase -0.0223878
PALLD palladin, cytoskeletal associated protein -0.0219203
TPM1 tropomyosin 1 (alpha) -0.0196201
VCL vinculin -0.0194662
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -0.0194036
CANX calnexin -0.0191104
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.019044
F3 coagulation factor III (thromboplastin, tissue factor) -0.0189659
VCAN versican -0.0188942
ASPH aspartate beta-hydroxylase -0.0188222
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0186925
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0180673
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0178871
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0178059
KLF7 Kruppel-like factor 7 (ubiquitous) -0.017756
KLF6 Kruppel-like factor 6 -0.0176941
ENO1 enolase 1, (alpha) -0.0176489
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0176026
RPL32 ribosomal protein L32 -0.0175684
RPL19 ribosomal protein L19 -0.0163494
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0163173
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0162087
CALM3 calmodulin 3 (phosphorylase kinase, delta) -0.0161538
GLIS3 GLIS family zinc finger 3 -0.0158645
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0157789
PSD3 pleckstrin and Sec7 domain containing 3 -0.0157009
CST3 cystatin C -0.015654
SQLE squalene epoxidase -0.0154707
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0154323
TUBA1B tubulin, alpha 1b -0.0153681
S100A9 S100 calcium binding protein A9 -0.0152379
LTBP1 latent transforming growth factor beta binding protein 1 -0.0152072
NREP neuronal regeneration related protein -0.0149295
PIEZO2 piezo-type mechanosensitive ion channel component 2 -0.0148017
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0146835
S100A10 S100 calcium binding protein A10 -0.0146078
TXNRD1 thioredoxin reductase 1 -0.0145119
RSRC1 arginine/serine-rich coiled-coil 1 -0.0144696
CAVIN1 caveolae associated protein 1 -0.0144393
KPNB1 karyopherin (importin) beta 1 -0.0142309
RIPK2 receptor-interacting serine-threonine kinase 2 -0.0141003
KDM3A lysine (K)-specific demethylase 3A -0.0140698
SAMD9 sterile alpha motif domain containing 9 -0.0139543
BZW1 basic leucine zipper and W2 domains 1 -0.0139236
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0139096
HMGB1 high mobility group box 1 -0.0136171
ZBTB38 zinc finger and BTB domain containing 38 -0.0134359
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -0.0133333
TKT transketolase -0.0132355
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0131239
RPS5 ribosomal protein S5 -0.0131044
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0130244
AFAP1 actin filament associated protein 1 -0.0130042
FSTL1 follistatin-like 1 -0.0127373
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0126822
LOC112694756 uncharaterized LOC112694756 -0.0126792
IL6ST interleukin 6 signal transducer -0.0126718
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.0125792
PDE4D phosphodiesterase 4D, cAMP-specific -0.0123703
RPL14 ribosomal protein L14 -0.0121354
IFIH1 interferon induced with helicase C domain 1 -0.0121276
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0120847
THY1 Thy-1 cell surface antigen -0.0119173