| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | OTS514 perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the OTS514_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.50143 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0394134 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0363456 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0277118 |
| CCNL1 | cyclin L1 | 0.0271455 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0239667 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0219426 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0202378 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0196689 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0189944 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0189396 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0185497 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0184936 |
| AAK1 | AP2 associated kinase 1 | 0.0177471 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0171883 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0171554 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0170615 |
| MYO1B | myosin IB | 0.0169645 |
| DTNA | dystrobrevin, alpha | 0.0167724 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0167465 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.016299 |
| SERTAD2 | SERTA domain containing 2 | 0.0155808 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0153749 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0152917 |
| CCNY | cyclin Y | 0.0152303 |
| SIK3 | SIK family kinase 3 | 0.0150353 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | 0.0148286 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0144167 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0143816 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 0.014343 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0134802 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0134511 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0134461 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0131209 |
| MXD1 | MAX dimerization protein 1 | 0.0130848 |
| JAK1 | Janus kinase 1 | 0.0129519 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0128945 |
| ABHD5 | abhydrolase domain containing 5 | 0.0128621 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.012739 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0123725 |
| INTS6 | integrator complex subunit 6 | 0.0121259 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | 0.0120869 |
| MED13L | mediator complex subunit 13-like | 0.0119877 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0119584 |
| USP6NL | USP6 N-terminal like | 0.011781 |
| RPL4 | ribosomal protein L4 | 0.0115617 |
| ZNF207 | zinc finger protein 207 | 0.0112464 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0111412 |
| NCKAP1 | NCK-associated protein 1 | 0.0109294 |
| RBM33 | RNA binding motif protein 33 | 0.0108463 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0106767 |
| FUS | FUS RNA binding protein | 0.0106159 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0106008 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0104972 |
| CLIC4 | chloride intracellular channel 4 | 0.0104944 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0104006 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | 0.010379 |
| HSPA1B | heat shock 70kDa protein 1B | 0.0103546 |
| TENT4A | terminal nucleotidyltransferase 4A | 0.0103247 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0103181 |
| ATXN2L | ataxin 2-like | 0.0102784 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.010253 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0102143 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0101574 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0101525 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0101066 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0100757 |
| FLNA | filamin A, alpha | 0.0100755 |
| SPAG9 | sperm associated antigen 9 | 0.0100634 |
| FBXO42 | F-box protein 42 | 0.010028 |
| OLA1 | Obg-like ATPase 1 | 0.0100186 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.00998415 |
| NUP153 | nucleoporin 153kDa | 0.00990893 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.00977785 |
| QKI | QKI, KH domain containing, RNA binding | 0.00973361 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.00956627 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0095456 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.00939278 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.00938199 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.00937321 |
| USP47 | ubiquitin specific peptidase 47 | 0.00926409 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.00925949 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.00924791 |
| TSC22D2 | TSC22 domain family, member 2 | 0.00920627 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.00917 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.00909043 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.00908235 |
| TLE4 | transducin-like enhancer of split 4 | 0.00907249 |
| PDZD8 | PDZ domain containing 8 | 0.00904789 |
| ZNF451 | zinc finger protein 451 | 0.00898516 |
| RAPGEF1 | Rap guanine nucleotide exchange factor (GEF) 1 | 0.00897644 |
| CNNM4 | cyclin and CBS domain divalent metal cation transport mediator 4 | 0.00884163 |
| LCN2 | lipocalin 2 | 0.00881485 |
| SCFD1 | sec1 family domain containing 1 | 0.00880214 |
| FOXO1 | forkhead box O1 | 0.00878011 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.00871563 |
| YTHDC1 | YTH domain containing 1 | 0.00870974 |
| MYO6 | myosin VI | 0.00868066 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.00863895 |
| INSIG2 | insulin induced gene 2 | 0.00863511 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.277304 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.197983 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.177664 |
| MT2A | metallothionein 2A | -0.141935 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.135813 |
| ENO1 | enolase 1, (alpha) | -0.12546 |
| EHBP1 | EH domain binding protein 1 | -0.125191 |
| APOA2 | apolipoprotein A-II | -0.116726 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0978189 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0975776 |
| DSPP | dentin sialophosphoprotein | -0.0866351 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0857835 |
| GPC6 | glypican 6 | -0.0846666 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0826609 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0781252 |
| APOB | apolipoprotein B | -0.0774303 |
| FN1 | fibronectin 1 | -0.0765373 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0736059 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0660605 |
| C3 | complement component 3 | -0.0659399 |
| FRMD5 | FERM domain containing 5 | -0.0655181 |
| DST | dystonin | -0.0652336 |
| PEG3 | paternally expressed 3 | -0.0651007 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0618648 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0609203 |
| TMSB10 | thymosin beta 10 | -0.060406 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.060402 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0602073 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0587898 |
| GPC3 | glypican 3 | -0.0572832 |
| TPM4 | tropomyosin 4 | -0.0544966 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0521178 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0482507 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0481093 |
| VCL | vinculin | -0.0474888 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0471859 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0440841 |
| CP | ceruloplasmin (ferroxidase) | -0.0434696 |
| RPS8 | ribosomal protein S8 | -0.0432187 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0428628 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0427612 |
| RNF213 | ring finger protein 213 | -0.0423577 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0410873 |
| RPS19 | ribosomal protein S19 | -0.039951 |
| RPS24 | ribosomal protein S24 | -0.0381962 |
| FTL | ferritin, light polypeptide | -0.0380409 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0369619 |
| ASPH | aspartate beta-hydroxylase | -0.0364236 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0356189 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0356123 |
| EGR1 | early growth response 1 | -0.0348861 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0342669 |
| PTCHD4 | patched domain containing 4 | -0.0342064 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0340865 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0339857 |
| APOE | apolipoprotein E | -0.0339646 |
| PLIN2 | perilipin 2 | -0.0330869 |
| ITGA1 | integrin, alpha 1 | -0.0322194 |
| RRBP1 | ribosome binding protein 1 | -0.0315365 |
| RPS27A | ribosomal protein S27a | -0.0312625 |
| RPS6 | ribosomal protein S6 | -0.0311039 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0309889 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | -0.0306947 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0302528 |
| B2M | beta-2-microglobulin | -0.0299555 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0299538 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0299025 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0297356 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.0293925 |
| KRT18 | keratin 18, type I | -0.0286787 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0283286 |
| RPL31 | ribosomal protein L31 | -0.0281173 |
| ATP10A | ATPase, class V, type 10A | -0.0281133 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0277955 |
| AHNAK | AHNAK nucleoprotein | -0.0272664 |
| TMEM123 | transmembrane protein 123 | -0.0270692 |
| RPL11 | ribosomal protein L11 | -0.0270533 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0269836 |
| RPS29 | ribosomal protein S29 | -0.0265976 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0265732 |
| RPL37A | ribosomal protein L37a | -0.0265184 |
| TRIM26 | tripartite motif containing 26 | -0.0264203 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.026283 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.0260595 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0260085 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.025954 |
| RPLP1 | ribosomal protein, large, P1 | -0.0258407 |
| RPLP2 | ribosomal protein, large, P2 | -0.0257786 |
| RPS14 | ribosomal protein S14 | -0.0256326 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0255655 |
| PERP | PERP, TP53 apoptosis effector | -0.0254535 |
| RPL12 | ribosomal protein L12 | -0.0254148 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.0248612 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0246548 |
| FERMT1 | fermitin family member 1 | -0.0244269 |
| RPS21 | ribosomal protein S21 | -0.0243471 |
| RIGI | RNA sensor RIG-I | -0.0242888 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0242507 |
| ITGAV | integrin, alpha V | -0.0240412 |
| S100A9 | S100 calcium binding protein A9 | -0.0239396 |
