| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | OTS514 perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the OTS514_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.311564 |
| SLTM | SAFB-like, transcription modulator | 0.0669474 |
| EFNA5 | ephrin-A5 | 0.0599112 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0560294 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0545448 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0538644 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0538482 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0535789 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.050411 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0500559 |
| INTS6 | integrator complex subunit 6 | 0.0471942 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0463498 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0442154 |
| MYOF | myoferlin | 0.0427305 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0414323 |
| NABP1 | nucleic acid binding protein 1 | 0.0405802 |
| RNF213 | ring finger protein 213 | 0.0397702 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.038556 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0374188 |
| MYO1E | myosin IE | 0.0354585 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0353589 |
| HOMER1 | homer scaffolding protein 1 | 0.0327613 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0322666 |
| SP100 | SP100 nuclear antigen | 0.0317706 |
| SLC38A2 | solute carrier family 38, member 2 | 0.031443 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0312513 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.029124 |
| RAD51B | RAD51 paralog B | 0.0279526 |
| PM20D1 | peptidase M20 domain containing 1 | 0.027783 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0276565 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0269121 |
| BMP6 | bone morphogenetic protein 6 | 0.0268868 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0265944 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0259224 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0252063 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0249721 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0247006 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0239988 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0234566 |
| SMYD3 | SET and MYND domain containing 3 | 0.0233498 |
| AREG | amphiregulin | 0.0225293 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0220278 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0220019 |
| MAP7 | microtubule-associated protein 7 | 0.0218533 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0217636 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.021287 |
| CCNL1 | cyclin L1 | 0.0212811 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0211302 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0210348 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0208769 |
| VCL | vinculin | 0.0207285 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0205888 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0204549 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0202662 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0199225 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0196641 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.0192016 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0189927 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0189338 |
| NTN4 | netrin 4 | 0.0189069 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0186604 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0181185 |
| SVIL | supervillin | 0.018096 |
| IRS2 | insulin receptor substrate 2 | 0.0176941 |
| KIAA1217 | KIAA1217 | 0.0175982 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0175244 |
| EGR1 | early growth response 1 | 0.0164646 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0164414 |
| PRKCA | protein kinase C, alpha | 0.01641 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0157573 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0157324 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0156907 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0155722 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.0155692 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | 0.0152911 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0152761 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.015185 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.015099 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0150509 |
| HDAC4 | histone deacetylase 4 | 0.0149801 |
| TUFT1 | tuftelin 1 | 0.0146315 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0145534 |
| CCND1 | cyclin D1 | 0.014483 |
| KYNU | kynureninase | 0.0144632 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0140996 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0140777 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0140733 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.013976 |
| SMIM31 | small integral membrane protein 31 | 0.0139342 |
| CDR2 | cerebellar degeneration-related protein 2, 62kDa | 0.0137321 |
| SCEL | sciellin | 0.0137113 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0136984 |
| FHL2 | four and a half LIM domains 2 | 0.0136786 |
| CUX1 | cut-like homeobox 1 | 0.0136677 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0136287 |
| CMIP | c-Maf inducing protein | 0.0135581 |
| TJP1 | tight junction protein 1 | 0.0135263 |
| TLE4 | transducin-like enhancer of split 4 | 0.0134832 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0133436 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.013321 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.174129 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.161723 |
| UBC | ubiquitin C | -0.0825341 |
| TMSB10 | thymosin beta 10 | -0.0815239 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0804072 |
| NDRG1 | N-myc downstream regulated 1 | -0.0718263 |
| PTMA | prothymosin, alpha | -0.0624185 |
| FAM13A | family with sequence similarity 13, member A | -0.0617692 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0614495 |
| FTL | ferritin, light polypeptide | -0.0574106 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0550844 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0538301 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0531287 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0464101 |
| NGLY1 | N-glycanase 1 | -0.0439665 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0418452 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0413125 |
| ENO1 | enolase 1, (alpha) | -0.0403802 |
| HDLBP | high density lipoprotein binding protein | -0.0381461 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0379831 |
| MKI67 | marker of proliferation Ki-67 | -0.037551 |
| TMEM165 | transmembrane protein 165 | -0.0370995 |
| MT2A | metallothionein 2A | -0.0370465 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0362249 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0356994 |
| CANX | calnexin | -0.0355034 |
| TPD52 | tumor protein D52 | -0.0351112 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0346651 |
| RPS3 | ribosomal protein S3 | -0.0342917 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0330055 |
| PCBP2 | poly(rC) binding protein 2 | -0.0313045 |
| OGA | O-GlcNAcase | -0.0303633 |
| H1-0 | H1.0 linker histone | -0.0299372 |
| ARRDC3 | arrestin domain containing 3 | -0.0294057 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0293704 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0290999 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0281495 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0275682 |
| CES1 | carboxylesterase 1 | -0.0275332 |
| WDR45B | WD repeat domain 45B | -0.0265602 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0264046 |
| RPS27A | ribosomal protein S27a | -0.0257032 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0256931 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0256181 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0256067 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0254628 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0253332 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0251181 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.025112 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0245779 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0244502 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0244481 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0244456 |
| CDCP1 | CUB domain containing protein 1 | -0.0244018 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0242022 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0232691 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0232088 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0229008 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0227996 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0227891 |
| ZNF292 | zinc finger protein 292 | -0.0227547 |
| TOP1 | topoisomerase (DNA) I | -0.0225651 |
| GOLGB1 | golgin B1 | -0.0224332 |
| LAMC2 | laminin, gamma 2 | -0.0221617 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0221257 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0218823 |
| RNMT | RNA (guanine-7-) methyltransferase | -0.021868 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0217835 |
| SEC61G | Sec61 gamma subunit | -0.0217033 |
| SUCO | SUN domain containing ossification factor | -0.0216939 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0210225 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0207702 |
| AHNAK | AHNAK nucleoprotein | -0.0207181 |
| SEPTIN2 | septin 2 | -0.0203403 |
| BBX | bobby sox homolog (Drosophila) | -0.0203161 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0202322 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0201016 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0200877 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0200277 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0197879 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0197821 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.019754 |
| CCNI | cyclin I | -0.019574 |
| USP3 | ubiquitin specific peptidase 3 | -0.0193844 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0191994 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0191341 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0190948 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0189356 |
| TPM3 | tropomyosin 3 | -0.0186579 |
| HYOU1 | hypoxia up-regulated 1 | -0.0185828 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0184677 |
| PERP | PERP, TP53 apoptosis effector | -0.0183174 |
| PKM | pyruvate kinase, muscle | -0.0182459 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0181845 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0180632 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | -0.0179564 |
| MATR3 | matrin 3 | -0.0178016 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0177156 |
| SBF2 | SET binding factor 2 | -0.0176813 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0176661 |
