OTS514_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description OTS514 perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the OTS514_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SAMD4A sterile alpha motif domain containing 4A 0.0855004
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0838297
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0829989
PDE4D phosphodiesterase 4D, cAMP-specific 0.07702
TRIO trio Rho guanine nucleotide exchange factor 0.0726355
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0698066
WAC WW domain containing adaptor with coiled-coil 0.0698009
ZFAND3 zinc finger, AN1-type domain 3 0.0682106
FMNL2 formin-like 2 0.067734
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0665753
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0660223
RBM39 RNA binding motif protein 39 0.0616746
FNDC3B fibronectin type III domain containing 3B 0.0596783
PUM2 pumilio RNA-binding family member 2 0.0535207
ELL2 elongation factor, RNA polymerase II, 2 0.05277
DSCAM Down syndrome cell adhesion molecule 0.0524621
UBASH3B ubiquitin associated and SH3 domain containing B 0.0484268
ANKRD11 ankyrin repeat domain 11 0.0477188
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0461834
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.04563
SMOC1 SPARC related modular calcium binding 1 0.0444731
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0437829
BIRC6 baculoviral IAP repeat containing 6 0.0435555
FLNB filamin B, beta 0.0431804
EEF1G eukaryotic translation elongation factor 1 gamma 0.0428316
ZNF207 zinc finger protein 207 0.042068
DOCK5 dedicator of cytokinesis 5 0.0418106
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0417051
RICTOR RPTOR independent companion of MTOR, complex 2 0.0414463
COPA coatomer protein complex, subunit alpha 0.0404315
CCNL1 cyclin L1 0.0395799
PARD3 par-3 family cell polarity regulator 0.0395422
CCL5 chemokine (C-C motif) ligand 5 0.0391959
EGFR epidermal growth factor receptor 0.0387643
ITCH itchy E3 ubiquitin protein ligase 0.0381728
MACF1 microtubule-actin crosslinking factor 1 0.0373954
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.03705
CFLAR CASP8 and FADD-like apoptosis regulator 0.0370419
APP amyloid beta (A4) precursor protein 0.0368211
LPP LIM domain containing preferred translocation partner in lipoma 0.0367555
THSD4 thrombospondin, type I, domain containing 4 0.0365844
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.036003
USP36 ubiquitin specific peptidase 36 0.0358722
FAM107B family with sequence similarity 107, member B 0.0355097
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0351468
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0347338
MT1X metallothionein 1X 0.0345184
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0341997
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0341752
MYOF myoferlin 0.033598
AKAP13 A kinase (PRKA) anchor protein 13 0.033439
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0326981
USP34 ubiquitin specific peptidase 34 0.0325659
STRN3 striatin, calmodulin binding protein 3 0.0318933
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0318391
ZSWIM6 zinc finger, SWIM-type containing 6 0.0315116
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0314703
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0313578
ZFR zinc finger RNA binding protein 0.0312434
IGFBP3 insulin-like growth factor binding protein 3 0.0311342
GLG1 golgi glycoprotein 1 0.0307581
ARHGAP26 Rho GTPase activating protein 26 0.0306295
NUP98 nucleoporin 98kDa 0.0303819
MED13 mediator complex subunit 13 0.0302991
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0300379
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0295623
DOCK4 dedicator of cytokinesis 4 0.029523
PTK2 protein tyrosine kinase 2 0.0293573
RCOR1 REST corepressor 1 0.0292516
CSNK1A1 casein kinase 1, alpha 1 0.0287356
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0286213
BASP1 brain abundant, membrane attached signal protein 1 0.028398
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0283319
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0279372
CMIP c-Maf inducing protein 0.0278323
RAB1A RAB1A, member RAS oncogene family 0.027431
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0273474
CUL3 cullin 3 0.0271169
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0270773
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0269749
FBXO11 F-box protein 11 0.0269013
NDRG1 N-myc downstream regulated 1 0.0268286
CTBP2 C-terminal binding protein 2 0.0268106
KCMF1 potassium channel modulatory factor 1 0.0266499
EXT1 exostosin glycosyltransferase 1 0.0264694
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0262462
FUS FUS RNA binding protein 0.026132
ITGB5 integrin, beta 5 0.0259469
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0258094
PPP4R3A protein phosphatase 4 regulatory subunit 3A 0.0257461
ACTG1 actin gamma 1 0.0257059
RBM6 RNA binding motif protein 6 0.0256925
TRA2A transformer 2 alpha homolog (Drosophila) 0.0256766
FOXO3 forkhead box O3 0.025647
PTPRM protein tyrosine phosphatase, receptor type, M 0.0253574
EEF2 eukaryotic translation elongation factor 2 0.0249645
SVIL supervillin 0.0249296
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0248786
NEMF nuclear export mediator factor 0.0248451
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0248079

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.121548
TMSB10 thymosin beta 10 -0.120536
TXNRD1 thioredoxin reductase 1 -0.0809518
TFPI2 tissue factor pathway inhibitor 2 -0.0633028
VIM vimentin -0.0630406
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0539453
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0487781
EGR1 early growth response 1 -0.0401817
RPL19 ribosomal protein L19 -0.0390148
PTMA prothymosin, alpha -0.0366925
FGB fibrinogen beta chain -0.0355246
MT2A metallothionein 2A -0.0303786
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0291038
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0279512
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0255324
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0243205
AKAP12 A kinase (PRKA) anchor protein 12 -0.0242485
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0240339
RPS19 ribosomal protein S19 -0.0228832
RPLP1 ribosomal protein, large, P1 -0.0228141
YBX1 Y box binding protein 1 -0.0217532
RPS29 ribosomal protein S29 -0.020624
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0203821
RPS27A ribosomal protein S27a -0.0202315
PFN1 profilin 1 -0.0202045
C15ORF48 chromosome 15 open reading frame 48 -0.0199323
BIRC3 baculoviral IAP repeat containing 3 -0.0198097
FTH1 ferritin, heavy polypeptide 1 -0.0194663
RPS21 ribosomal protein S21 -0.0194318
RPL31 ribosomal protein L31 -0.0192447
S100A11 S100 calcium binding protein A11 -0.0185893
RPL7 ribosomal protein L7 -0.0183579
ATP5F1E ATP synthase F1 subunit epsilon -0.0183146
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0182628
RPS12 ribosomal protein S12 -0.0174026
CENPF centromere protein F, 350/400kDa -0.0170368
ENO1 enolase 1, (alpha) -0.0168392
NNMT nicotinamide N-methyltransferase -0.016778
POTEF POTE ankyrin domain family, member F -0.01666
RPL23 ribosomal protein L23 -0.0165925
RPS15 ribosomal protein S15 -0.0164369
IER3 immediate early response 3 -0.0160806
RPS5 ribosomal protein S5 -0.0155027
RPS8 ribosomal protein S8 -0.0148866
S100A9 S100 calcium binding protein A9 -0.0146427
RPL36 ribosomal protein L36 -0.014585
HMGB1 high mobility group box 1 -0.0144379
RPL12 ribosomal protein L12 -0.0143903
RPS16 ribosomal protein S16 -0.0143675
RPL8 ribosomal protein L8 -0.0143109
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0140426
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0139196
RPL32 ribosomal protein L32 -0.0134519
SERF2 small EDRK-rich factor 2 -0.0133798
PRDX1 peroxiredoxin 1 -0.0132562
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0131926
S100A6 S100 calcium binding protein A6 -0.0129463
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -0.0129268
AREG amphiregulin -0.0129247
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0127453
RPS3 ribosomal protein S3 -0.0123053
NSUN6 NOP2/Sun domain family, member 6 -0.0122642
RACK1 receptor for activated C kinase 1 -0.012062
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0119817
CNRIP1 cannabinoid receptor interacting protein 1 -0.0118924
ASPH aspartate beta-hydroxylase -0.0118333
RPL18 ribosomal protein L18 -0.0118216
HDAC9 histone deacetylase 9 -0.01162
RPS17 ribosomal protein S17 -0.0115827
RPS27 ribosomal protein S27 -0.0114195
CBX3 chromobox homolog 3 -0.011256
MKI67 marker of proliferation Ki-67 -0.0112326
KLF6 Kruppel-like factor 6 -0.0112046
RPS23 ribosomal protein S23 -0.0111474
GSTP1 glutathione S-transferase pi 1 -0.0111259
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -0.0111126
NCOA7 nuclear receptor coactivator 7 -0.0111062
RPL35A ribosomal protein L35a -0.0110087
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0109133
S100A10 S100 calcium binding protein A10 -0.0108916
RPLP2 ribosomal protein, large, P2 -0.0106435
TBC1D5 TBC1 domain family, member 5 -0.0105952
STMN1 stathmin 1 -0.0103967
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.010276
RPS25 ribosomal protein S25 -0.0102722
ATP5F1B ATP synthase F1 subunit beta -0.0102531
TUBA1B tubulin, alpha 1b -0.0101794
PARK7 parkinson protein 7 -0.0101033
EPGN epithelial mitogen -0.00995827
LDHB lactate dehydrogenase B -0.00989062
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.00968823
GRAMD1B GRAM domain containing 1B -0.00965455
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.00961703
RPS14 ribosomal protein S14 -0.00960836
TPM4 tropomyosin 4 -0.00956822
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.00956008
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.0094816
RPS10 ribosomal protein S10 -0.00945834
RPL37A ribosomal protein L37a -0.00934685
TAGLN2 transgelin 2 -0.00931304