| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | OTS514 perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the OTS514_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.169388 |
| LAMA4 | laminin, alpha 4 | 0.133242 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.119841 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.106441 |
| GPC6 | glypican 6 | 0.0945679 |
| TJP1 | tight junction protein 1 | 0.0797349 |
| SPAG9 | sperm associated antigen 9 | 0.0790096 |
| SRPK2 | SRSF protein kinase 2 | 0.0759143 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0758567 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0747692 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0720295 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0689472 |
| CUL1 | cullin 1 | 0.0670281 |
| PLS3 | plastin 3 | 0.0664679 |
| LMO7 | LIM domain 7 | 0.0657802 |
| FRMD6 | FERM domain containing 6 | 0.0644381 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0621363 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0615531 |
| LAMB3 | laminin, beta 3 | 0.0611038 |
| SNX13 | sorting nexin 13 | 0.0605148 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0604326 |
| MYO10 | myosin X | 0.0590724 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0568671 |
| CUX1 | cut-like homeobox 1 | 0.0568039 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0556524 |
| POTEF | POTE ankyrin domain family, member F | 0.0547263 |
| HELZ | helicase with zinc finger | 0.0546233 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0539754 |
| PDS5A | PDS5 cohesin associated factor A | 0.0537991 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0525849 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0513703 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0504489 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0490733 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.046961 |
| LAMC2 | laminin, gamma 2 | 0.0457774 |
| SMYD3 | SET and MYND domain containing 3 | 0.045571 |
| FMNL2 | formin-like 2 | 0.0455238 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0453496 |
| PKN2 | protein kinase N2 | 0.0447967 |
| RAD51B | RAD51 paralog B | 0.0446438 |
| GPATCH2L | G patch domain containing 2-like | 0.0445446 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0442124 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0435647 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0433597 |
| EHBP1 | EH domain binding protein 1 | 0.0430428 |
| CCNL1 | cyclin L1 | 0.0429024 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0424105 |
| FAM13A | family with sequence similarity 13, member A | 0.0422401 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0413538 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0401886 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0401282 |
| THOC2 | THO complex 2 | 0.0397914 |
| ANXA2 | annexin A2 | 0.0397894 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0392841 |
| DST | dystonin | 0.0389472 |
| COG5 | component of oligomeric golgi complex 5 | 0.0385 |
| ZFHX3 | zinc finger homeobox 3 | 0.0378868 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0375867 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0375558 |
| SBF2 | SET binding factor 2 | 0.0369812 |
| TCF12 | transcription factor 12 | 0.0369208 |
| ANKRD28 | ankyrin repeat domain 28 | 0.036899 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0362688 |
| TMEM165 | transmembrane protein 165 | 0.035903 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0357128 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0356311 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0356275 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0354282 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0353986 |
| NDRG1 | N-myc downstream regulated 1 | 0.0353114 |
| MYO6 | myosin VI | 0.0351548 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0349527 |
| FOXO3 | forkhead box O3 | 0.0334447 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0332667 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0330928 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0318962 |
| RPL38 | ribosomal protein L38 | 0.0315275 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0311606 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0308838 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0307163 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0306727 |
| FHIT | fragile histidine triad | 0.0306723 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0305812 |
| SMAD3 | SMAD family member 3 | 0.0303879 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | 0.0303504 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.029838 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.029793 |
| ATP11A | ATPase, class VI, type 11A | 0.0297824 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0297078 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.029096 |
| MED13 | mediator complex subunit 13 | 0.0289143 |
| H1-0 | H1.0 linker histone | 0.0285162 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0284173 |
| FCHO2 | FCH domain only 2 | 0.0282819 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0282652 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0280477 |
| SLMAP | sarcolemma associated protein | 0.0279071 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.0277987 |
| RCOR1 | REST corepressor 1 | 0.0273717 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | 0.0272721 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.170049 |
| S100A9 | S100 calcium binding protein A9 | -0.102868 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0982193 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0956284 |
| PTMA | prothymosin, alpha | -0.0952335 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0877846 |
| TMSB10 | thymosin beta 10 | -0.085274 |
| FN1 | fibronectin 1 | -0.0779394 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0725893 |
| FTL | ferritin, light polypeptide | -0.0720845 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0711399 |
| THBS1 | thrombospondin 1 | -0.070035 |
| EZR | ezrin | -0.0695299 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0688795 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0677383 |
| JMJD1C | jumonji domain containing 1C | -0.0671401 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0654239 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.064369 |
| ENO1 | enolase 1, (alpha) | -0.0638849 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0624013 |
| CCNI | cyclin I | -0.0600801 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0578139 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0568102 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0563291 |
| TRIM33 | tripartite motif containing 33 | -0.0557393 |
| RPLP1 | ribosomal protein, large, P1 | -0.0548201 |
| RAI14 | retinoic acid induced 14 | -0.0547538 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0531634 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0530218 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0519421 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0513756 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.049961 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0495299 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0493751 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.049176 |
| RPS19 | ribosomal protein S19 | -0.0484583 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0480679 |
| GOLGB1 | golgin B1 | -0.0476042 |
| VCL | vinculin | -0.0467695 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0462526 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.046168 |
| SNX14 | sorting nexin 14 | -0.0455536 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0446393 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0446184 |
| EFNA5 | ephrin-A5 | -0.0443736 |
| RPS14 | ribosomal protein S14 | -0.0443353 |
| RRBP1 | ribosome binding protein 1 | -0.0430936 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0424724 |
| ABHD17C | abhydrolase domain containing 17C | -0.0423347 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | -0.0421702 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0421198 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.041943 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0415945 |
| UBC | ubiquitin C | -0.0412322 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.040918 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0406723 |
| ZNF638 | zinc finger protein 638 | -0.039724 |
| DIDO1 | death inducer-obliterator 1 | -0.039558 |
| PARD3 | par-3 family cell polarity regulator | -0.0392639 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0389895 |
| RPS8 | ribosomal protein S8 | -0.0383078 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0371606 |
| IGF2 | insulin-like growth factor 2 | -0.0370727 |
| ZNF292 | zinc finger protein 292 | -0.0365979 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | -0.0364087 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0363677 |
| RPS12 | ribosomal protein S12 | -0.0359479 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0351669 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0346785 |
| BPTF | bromodomain PHD finger transcription factor | -0.0341254 |
| RPS27A | ribosomal protein S27a | -0.0341151 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0340129 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0331695 |
| PGK1 | phosphoglycerate kinase 1 | -0.0330099 |
| RAB10 | RAB10, member RAS oncogene family | -0.0326101 |
| DSPP | dentin sialophosphoprotein | -0.0322058 |
| CDK13 | cyclin-dependent kinase 13 | -0.0313583 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0312683 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0310417 |
| KDM1A | lysine (K)-specific demethylase 1A | -0.0309346 |
| TBL1X | transducin (beta)-like 1X-linked | -0.0309064 |
| RNF145 | ring finger protein 145 | -0.0307337 |
| MATR3 | matrin 3 | -0.0304772 |
| MED13L | mediator complex subunit 13-like | -0.0303218 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0301193 |
| RNF213 | ring finger protein 213 | -0.0301179 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0298503 |
| CDC27 | cell division cycle 27 | -0.0294932 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0293232 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0292627 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0291406 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0290079 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0287786 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0287257 |
| TPM4 | tropomyosin 4 | -0.0284152 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0283833 |
| RASA2 | RAS p21 protein activator 2 | -0.0280714 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0279245 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0278329 |
| FLNB | filamin B, beta | -0.0277852 |
