| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | OTS514 perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the OTS514_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EEF2 | eukaryotic translation elongation factor 2 | 0.0539818 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0487901 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.036299 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0358254 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0272323 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0267043 |
| CCNL1 | cyclin L1 | 0.0264059 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0256542 |
| INTS6 | integrator complex subunit 6 | 0.0245795 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.024105 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0237818 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0232407 |
| GPHN | gephyrin | 0.021195 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0200665 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0197984 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0192832 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0188424 |
| COPA | coatomer protein complex, subunit alpha | 0.0184785 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0182931 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | 0.0171255 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0171137 |
| PHF3 | PHD finger protein 3 | 0.0170798 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0170394 |
| ATF6 | activating transcription factor 6 | 0.0170078 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0168209 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0165968 |
| CLTC | clathrin, heavy chain (Hc) | 0.0165716 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0165442 |
| TMEM41B | transmembrane protein 41B | 0.016535 |
| CUL3 | cullin 3 | 0.0164669 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0161026 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | 0.0156492 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0155964 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0155535 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0154415 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0153518 |
| YARS1 | tyrosyl-tRNA synthetase 1 | 0.0147709 |
| CAPRIN2 | caprin family member 2 | 0.0146899 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0144034 |
| SRSF6 | serine/arginine-rich splicing factor 6 | 0.014377 |
| ATP11A | ATPase, class VI, type 11A | 0.0142846 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0142655 |
| MEF2D | myocyte enhancer factor 2D | 0.0142316 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0141815 |
| USP22 | ubiquitin specific peptidase 22 | 0.0140553 |
| PREPL | prolyl endopeptidase-like | 0.0140427 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.0139716 |
| WDR26 | WD repeat domain 26 | 0.0137901 |
| HOMER1 | homer scaffolding protein 1 | 0.0136748 |
| AEBP2 | AE binding protein 2 | 0.0136416 |
| PER1 | period circadian clock 1 | 0.0134268 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0133585 |
| RYK | receptor-like tyrosine kinase | 0.0133238 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0131198 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0129464 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0129419 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0127137 |
| STIP1 | stress-induced phosphoprotein 1 | 0.0126711 |
| USP15 | ubiquitin specific peptidase 15 | 0.0125524 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0125456 |
| RBM33 | RNA binding motif protein 33 | 0.0122697 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0122321 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | 0.0121913 |
| BRD2 | bromodomain containing 2 | 0.0121878 |
| SPAG9 | sperm associated antigen 9 | 0.0121547 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0118913 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0118113 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0117648 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.0116886 |
| GOLGA8A | golgin A8 family, member A | 0.0116602 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0113915 |
| SLC39A9 | solute carrier family 39, member 9 | 0.0113323 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.011185 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0111516 |
| FUS | FUS RNA binding protein | 0.0110922 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0110242 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.010954 |
| RAB7A | RAB7A, member RAS oncogene family | 0.01091 |
| SESN2 | sestrin 2 | 0.0108597 |
| WNT2B | wingless-type MMTV integration site family, member 2B | 0.0108394 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0107105 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0106256 |
| UBQLN1 | ubiquilin 1 | 0.0106209 |
| CALU | calumenin | 0.0104892 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0104269 |
| ATXN2L | ataxin 2-like | 0.0103695 |
| ANO6 | anoctamin 6 | 0.0103221 |
| PGK1 | phosphoglycerate kinase 1 | 0.0102495 |
| ZNF800 | zinc finger protein 800 | 0.0101775 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0101619 |
| MAT2A | methionine adenosyltransferase II, alpha | 0.0100826 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.0100609 |
| ZNF638 | zinc finger protein 638 | 0.0100071 |
| MYO6 | myosin VI | 0.00998446 |
| FNIP1 | folliculin interacting protein 1 | 0.00991422 |
| PLEC | plectin | 0.00990652 |
| FLNA | filamin A, alpha | 0.00983659 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.00981517 |
| CEP95 | centrosomal protein 95kDa | 0.00980379 |
| TMEM39A | transmembrane protein 39A | 0.00979722 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.357523 |
| TMSB10 | thymosin beta 10 | -0.167689 |
| PTMA | prothymosin, alpha | -0.117906 |
| VIM | vimentin | -0.0993853 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0958097 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0894596 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0719861 |
| YBX3 | Y box binding protein 3 | -0.0504372 |
| RPS3 | ribosomal protein S3 | -0.049297 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0487274 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0475802 |
| POTEF | POTE ankyrin domain family, member F | -0.0455502 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0435146 |
| RPS8 | ribosomal protein S8 | -0.0430278 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0414451 |
| GRAMD1B | GRAM domain containing 1B | -0.0408104 |
| TPI1 | triosephosphate isomerase 1 | -0.0394154 |
| TPM3 | tropomyosin 3 | -0.0393716 |
| TPM4 | tropomyosin 4 | -0.0381926 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0358608 |
| FTL | ferritin, light polypeptide | -0.0357893 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0351439 |
| HLA-B | major histocompatibility complex, class I, B | -0.0331704 |
| RPS12 | ribosomal protein S12 | -0.0330239 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0315163 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0313274 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0312894 |
| RPLP1 | ribosomal protein, large, P1 | -0.0312306 |
| RPS21 | ribosomal protein S21 | -0.0309602 |
| PTMS | parathymosin | -0.0301918 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0301567 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0299395 |
| PFN1 | profilin 1 | -0.029798 |
| YBX1 | Y box binding protein 1 | -0.0288316 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0287423 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0284394 |
| MT2A | metallothionein 2A | -0.0282759 |
| RYR3 | ryanodine receptor 3 | -0.0282216 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0277715 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0271735 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0268933 |
| RPS19 | ribosomal protein S19 | -0.0268505 |
| RPL26 | ribosomal protein L26 | -0.0267557 |
| RPL31 | ribosomal protein L31 | -0.0267071 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0266492 |
| CENPF | centromere protein F, 350/400kDa | -0.0261988 |
| RPL32 | ribosomal protein L32 | -0.0261012 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0258856 |
| ITSN1 | intersectin 1 (SH3 domain protein) | -0.0257685 |
| HDGF | hepatoma-derived growth factor | -0.0255012 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0254723 |
| RPS6 | ribosomal protein S6 | -0.0250533 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0249599 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0249566 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0245247 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0244806 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0243027 |
| RPL37 | ribosomal protein L37 | -0.0239324 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0238429 |
| SSH2 | slingshot protein phosphatase 2 | -0.0237903 |
| RPL19 | ribosomal protein L19 | -0.0236785 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | -0.0234673 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0232296 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0230961 |
| RPS27 | ribosomal protein S27 | -0.0229224 |
| RPS17 | ribosomal protein S17 | -0.022815 |
| RPL12 | ribosomal protein L12 | -0.0226199 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0225965 |
| SET | SET nuclear proto-oncogene | -0.0222756 |
| CBX3 | chromobox homolog 3 | -0.0222221 |
| RPL8 | ribosomal protein L8 | -0.0222063 |
| ENO1 | enolase 1, (alpha) | -0.0220866 |
| RPL37A | ribosomal protein L37a | -0.0220793 |
| PTK2 | protein tyrosine kinase 2 | -0.0220709 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0217417 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0216799 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0214164 |
| RPL35A | ribosomal protein L35a | -0.021316 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0211988 |
| OSMR | oncostatin M receptor | -0.0210979 |
| LATS2 | large tumor suppressor kinase 2 | -0.0209392 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.02091 |
| RBM25 | RNA binding motif protein 25 | -0.0207895 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0207584 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0205908 |
| TPM2 | tropomyosin 2 (beta) | -0.0205574 |
| BSG | basigin (Ok blood group) | -0.0204847 |
| CUX1 | cut-like homeobox 1 | -0.0204535 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0204348 |
| MCL1 | myeloid cell leukemia 1 | -0.0204076 |
| AHNAK | AHNAK nucleoprotein | -0.0202686 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0200812 |
| BBX | bobby sox homolog (Drosophila) | -0.0199874 |
| HMGA2 | high mobility group AT-hook 2 | -0.019933 |
| EGR1 | early growth response 1 | -0.0197355 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0195246 |
| S100A10 | S100 calcium binding protein A10 | -0.0194032 |
| MAP4 | microtubule-associated protein 4 | -0.0192348 |
| RPS4X | ribosomal protein S4, X-linked | -0.018882 |
| S100A11 | S100 calcium binding protein A11 | -0.018807 |
