| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | OTS514 perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the OTS514_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.202824 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.150038 |
| FN1 | fibronectin 1 | 0.115476 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.092343 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0819031 |
| CCNL1 | cyclin L1 | 0.0686795 |
| NDRG1 | N-myc downstream regulated 1 | 0.0640615 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0638127 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0562336 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0541032 |
| POTEF | POTE ankyrin domain family, member F | 0.043756 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0421165 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0408743 |
| HMGA1 | high mobility group AT-hook 1 | 0.0353292 |
| PKM | pyruvate kinase, muscle | 0.035111 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0341378 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0340015 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0336257 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0330459 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.032171 |
| FAM13A | family with sequence similarity 13, member A | 0.0318775 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0308387 |
| MSN | moesin | 0.0304751 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0296396 |
| ZNF207 | zinc finger protein 207 | 0.0290978 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0289638 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0285838 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0274815 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0268803 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.026652 |
| RNF145 | ring finger protein 145 | 0.0265984 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0265705 |
| PCBP2 | poly(rC) binding protein 2 | 0.0262124 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0253804 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0250712 |
| CALR | calreticulin | 0.0250072 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0249676 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.024952 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0248296 |
| SPAG9 | sperm associated antigen 9 | 0.0243208 |
| PAPOLA | poly(A) polymerase alpha | 0.0242425 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0241978 |
| NUP58 | nucleoporin 58 | 0.0235191 |
| ARRDC3 | arrestin domain containing 3 | 0.0232554 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0231104 |
| RBM25 | RNA binding motif protein 25 | 0.0230228 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0228891 |
| CDC73 | cell division cycle 73 | 0.0224016 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0222643 |
| NPTN | neuroplastin | 0.0219566 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0218391 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0217486 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0212962 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0212844 |
| HELZ | helicase with zinc finger | 0.0211558 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0210999 |
| MATR3 | matrin 3 | 0.0208633 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0206217 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0204804 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0204281 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0203888 |
| WAC | WW domain containing adaptor with coiled-coil | 0.020301 |
| ZNF292 | zinc finger protein 292 | 0.0200803 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0200693 |
| NCKAP1 | NCK-associated protein 1 | 0.0200629 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0199196 |
| PEG10 | paternally expressed 10 | 0.0196692 |
| LDHB | lactate dehydrogenase B | 0.0194719 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0193661 |
| USP3 | ubiquitin specific peptidase 3 | 0.0192986 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0192803 |
| WDR43 | WD repeat domain 43 | 0.0192741 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0192297 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0192263 |
| SNX9 | sorting nexin 9 | 0.0190699 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0189635 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0189099 |
| TPD52 | tumor protein D52 | 0.0184825 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0183481 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0183232 |
| ANXA5 | annexin A5 | 0.0183199 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0182737 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0179821 |
| RPL9 | ribosomal protein L9 | 0.0179656 |
| SFTPA2 | surfactant protein A2 | 0.0178776 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | 0.0175424 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0175314 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.017486 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0174533 |
| BRD2 | bromodomain containing 2 | 0.0174475 |
| RNASE3 | ribonuclease, RNase A family, 3 | 0.0170713 |
| TFG | TRK-fused gene | 0.0170371 |
| PLS3 | plastin 3 | 0.0168621 |
| MXD1 | MAX dimerization protein 1 | 0.0168294 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0167716 |
| FOSL1 | FOS-like antigen 1 | 0.0166971 |
| TMED10 | transmembrane emp24-like trafficking protein 10 (yeast) | 0.0166568 |
| IL6ST | interleukin 6 signal transducer | 0.0166134 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0164672 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0164329 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.159152 |
| TMSB10 | thymosin beta 10 | -0.106567 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.100455 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0927281 |
| LMO7 | LIM domain 7 | -0.0842216 |
| PTMA | prothymosin, alpha | -0.0802163 |
| EFNA5 | ephrin-A5 | -0.0778288 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0727782 |
| FTL | ferritin, light polypeptide | -0.0724174 |
| TMSB4X | thymosin beta 4, X-linked | -0.069677 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0599081 |
| AHNAK | AHNAK nucleoprotein | -0.0589923 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0565826 |
| LAMC2 | laminin, gamma 2 | -0.0522863 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.049779 |
| FBXO32 | F-box protein 32 | -0.0464897 |
| CSTB | cystatin B (stefin B) | -0.0463572 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0460816 |
| VCL | vinculin | -0.0458292 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0448666 |
| S100A10 | S100 calcium binding protein A10 | -0.0446121 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0442741 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0435714 |
| CD2AP | CD2-associated protein | -0.0412512 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0406436 |
| EPCAM | epithelial cell adhesion molecule | -0.0396963 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0396866 |
| LAMB3 | laminin, beta 3 | -0.0393658 |
| NAV2 | neuron navigator 2 | -0.0382251 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0377666 |
| ENO1 | enolase 1, (alpha) | -0.0361164 |
| RAI14 | retinoic acid induced 14 | -0.0358528 |
| TPM4 | tropomyosin 4 | -0.0356736 |
| MYO6 | myosin VI | -0.0355758 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0348598 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0347648 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0342161 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.033557 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0330362 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0324478 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.031842 |
| MAP4 | microtubule-associated protein 4 | -0.0318407 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0310512 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0298815 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0293092 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0288342 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0281212 |
| MX2 | MX dynamin-like GTPase 2 | -0.02773 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0274724 |
| HDLBP | high density lipoprotein binding protein | -0.0274295 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0273942 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0273242 |
| CCND1 | cyclin D1 | -0.0269609 |
| ACTG1 | actin gamma 1 | -0.026745 |
| RNF213 | ring finger protein 213 | -0.0262029 |
| RIGI | RNA sensor RIG-I | -0.0259721 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | -0.0259596 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0258031 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0255051 |
| HLA-E | major histocompatibility complex, class I, E | -0.0254199 |
| HLA-B | major histocompatibility complex, class I, B | -0.0252003 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0251907 |
| RRBP1 | ribosome binding protein 1 | -0.0247706 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0247398 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0246972 |
| SACK1A | scaffolding CK1 anchoring protein A | -0.0246672 |
| ATP11A | ATPase, class VI, type 11A | -0.0245707 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0245127 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0244724 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0243471 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0241143 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0240659 |
| ZNF217 | zinc finger protein 217 | -0.0240127 |
| ASPH | aspartate beta-hydroxylase | -0.0239264 |
| MYO1E | myosin IE | -0.0236667 |
| MAP1B | microtubule-associated protein 1B | -0.0230852 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0229659 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | -0.0229184 |
| FRMD5 | FERM domain containing 5 | -0.0226194 |
| PLSCR1 | phospholipid scramblase 1 | -0.0224191 |
| CAVIN1 | caveolae associated protein 1 | -0.0223959 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | -0.0223207 |
| GOLGB1 | golgin B1 | -0.0222114 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0221873 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | -0.0221045 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.022045 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0220365 |
| ARHGAP20 | Rho GTPase activating protein 20 | -0.0220126 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0219629 |
| NF1 | neurofibromin 1 | -0.0217323 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0217203 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0213418 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0212996 |
| ATXN1 | ataxin 1 | -0.0211849 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.021108 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0210651 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0210325 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0208643 |
| GOLGA3 | golgin A3 | -0.0206475 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0206142 |
