| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | OTS514 perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the OTS514_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GDA | guanine deaminase | 0.0895091 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0761896 |
| COL5A2 | collagen, type V, alpha 2 | 0.0673834 |
| PDE10A | phosphodiesterase 10A | 0.0667581 |
| DST | dystonin | 0.0658848 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0620542 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0593811 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.058494 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.05366 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0420661 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0410944 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0405838 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0394064 |
| COL4A5 | collagen, type IV, alpha 5 | 0.0369556 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0343269 |
| GRAMD1B | GRAM domain containing 1B | 0.0320795 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0318129 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0313785 |
| PCBP3 | poly(rC) binding protein 3 | 0.0305805 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0289962 |
| KYNU | kynureninase | 0.0289531 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0288497 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0283775 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0268296 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.0265043 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0250859 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0249796 |
| CD109 | CD109 molecule | 0.02389 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0234188 |
| COL4A6 | collagen, type IV, alpha 6 | 0.0234178 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0231694 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0230694 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0206237 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0204248 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | 0.0201381 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0199133 |
| RPL9 | ribosomal protein L9 | 0.0198937 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0197072 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0195882 |
| NRCAM | neuronal cell adhesion molecule | 0.019426 |
| NTN4 | netrin 4 | 0.0192867 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0192412 |
| GPRIN3 | GPRIN family member 3 | 0.0187584 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0187474 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0185344 |
| DOCK4 | dedicator of cytokinesis 4 | 0.018025 |
| FLNA | filamin A, alpha | 0.0178047 |
| PTEN | phosphatase and tensin homolog | 0.0177701 |
| GLCCI1 | glucocorticoid induced 1 | 0.0171751 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0169368 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0163085 |
| DISP1 | dispatched homolog 1 (Drosophila) | 0.0162803 |
| FMNL2 | formin-like 2 | 0.016245 |
| NEK7 | NIMA-related kinase 7 | 0.0159702 |
| ATXN1 | ataxin 1 | 0.0158827 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.015846 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0151529 |
| MAP7 | microtubule-associated protein 7 | 0.015076 |
| TMEM144 | transmembrane protein 144 | 0.0148955 |
| AOPEP | aminopeptidase O (putative) | 0.0146644 |
| OSMR | oncostatin M receptor | 0.014611 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.014433 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0142991 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0142642 |
| PRKAA2 | protein kinase, AMP-activated, alpha 2 catalytic subunit | 0.0140935 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0139741 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0139365 |
| CHL1 | cell adhesion molecule L1-like | 0.0138923 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0137413 |
| RTN1 | reticulon 1 | 0.0136982 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0136801 |
| LAMA5 | laminin, alpha 5 | 0.0136074 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.013567 |
| ENAH | enabled homolog (Drosophila) | 0.0135228 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0133816 |
| SMYD3 | SET and MYND domain containing 3 | 0.0130049 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0126909 |
| MFF | mitochondrial fission factor | 0.0126484 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0125203 |
| RPH3AL | rabphilin 3A-like (without C2 domains) | 0.0122961 |
| SVIL | supervillin | 0.0122947 |
| ALPK2 | alpha-kinase 2 | 0.0120549 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0117559 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0116386 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0114765 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0112994 |
| RAB3B | RAB3B, member RAS oncogene family | 0.0112833 |
| BMP6 | bone morphogenetic protein 6 | 0.0111841 |
| RAD51B | RAD51 paralog B | 0.0111797 |
| NRG1 | neuregulin 1 | 0.011165 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0111509 |
| ITGB8 | integrin, beta 8 | 0.0109997 |
| INTS6 | integrator complex subunit 6 | 0.0109069 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0108611 |
| UTY | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked | 0.0108141 |
| VCL | vinculin | 0.0107806 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | 0.0107028 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0107023 |
| KRT19 | keratin 19, type I | 0.0106083 |
| MSN | moesin | 0.0106012 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.223031 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.204421 |
| TMSB10 | thymosin beta 10 | -0.126848 |
| VIM | vimentin | -0.122135 |
| PTMA | prothymosin, alpha | -0.114182 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.10944 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.108632 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.105954 |
| FTL | ferritin, light polypeptide | -0.0836441 |
| CANX | calnexin | -0.0778054 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0719322 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0659897 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0627163 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0607445 |
| SPAG9 | sperm associated antigen 9 | -0.0563735 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.050477 |
| RPLP1 | ribosomal protein, large, P1 | -0.0468707 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0444179 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.041944 |
| RPS24 | ribosomal protein S24 | -0.041938 |
| RPS12 | ribosomal protein S12 | -0.0404573 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0403213 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0397972 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0388646 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0381522 |
| RPL26 | ribosomal protein L26 | -0.0376354 |
| B2M | beta-2-microglobulin | -0.0372757 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.036976 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.036561 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0361966 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0356889 |
| RPS8 | ribosomal protein S8 | -0.0352991 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0350963 |
| PDGFA | platelet-derived growth factor alpha polypeptide | -0.0350049 |
| RPL12 | ribosomal protein L12 | -0.0348997 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0348812 |
| RPL31 | ribosomal protein L31 | -0.0347765 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0347248 |
| RGS2 | regulator of G-protein signaling 2 | -0.0345434 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0337954 |
| GOLGA4 | golgin A4 | -0.033759 |
| SRGN | serglycin | -0.0329048 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0322113 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.031539 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0311273 |
| S100A10 | S100 calcium binding protein A10 | -0.030782 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0307596 |
| OGA | O-GlcNAcase | -0.0300575 |
| IER3 | immediate early response 3 | -0.0298537 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0296097 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0295891 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0294948 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0294806 |
| STC1 | stanniocalcin 1 | -0.0292949 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0287686 |
| UBC | ubiquitin C | -0.0284827 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0283903 |
| EZR | ezrin | -0.027405 |
| WDR45B | WD repeat domain 45B | -0.0273917 |
| MATR3 | matrin 3 | -0.0272251 |
| S100A6 | S100 calcium binding protein A6 | -0.0268807 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0266178 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0265938 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0263791 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0263181 |
| MORF4L2 | mortality factor 4 like 2 | -0.0262019 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0261399 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.0259092 |
| TMSB4X | thymosin beta 4, X-linked | -0.0257881 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0253589 |
| RPS27A | ribosomal protein S27a | -0.0250611 |
| GNAS | GNAS complex locus | -0.0248039 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0247846 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0247338 |
| RPS3 | ribosomal protein S3 | -0.0245639 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0245513 |
| ENO1 | enolase 1, (alpha) | -0.0241703 |
| RPL19 | ribosomal protein L19 | -0.0241531 |
| YBX1 | Y box binding protein 1 | -0.024095 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0239822 |
| NDRG1 | N-myc downstream regulated 1 | -0.0237821 |
| ANXA1 | annexin A1 | -0.0237361 |
| SEPTIN7 | septin 7 | -0.0236534 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.023449 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0229729 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0219656 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0219314 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0218908 |
| RPS6 | ribosomal protein S6 | -0.0218123 |
| FAM13A | family with sequence similarity 13, member A | -0.0217745 |
| TPD52 | tumor protein D52 | -0.0215945 |
| LMNA | lamin A/C | -0.0213451 |
| CALR | calreticulin | -0.0210935 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.020867 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.0206926 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0205041 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0204641 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0204202 |
| CENPF | centromere protein F, 350/400kDa | -0.0204009 |
| RPL34 | ribosomal protein L34 | -0.0199855 |
