OTS514_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description OTS514 perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

103 genes differentially expressed following the OTS514_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGR1 early growth response 1 0.245132
PDE4D phosphodiesterase 4D, cAMP-specific 0.182499
FNDC3B fibronectin type III domain containing 3B 0.180083
TRIO trio Rho guanine nucleotide exchange factor 0.150294
NKD1 naked cuticle homolog 1 (Drosophila) 0.136494
PSD3 pleckstrin and Sec7 domain containing 3 0.115429
PDIA3 protein disulfide isomerase family A, member 3 0.108579
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.104639
ATXN1 ataxin 1 0.104033
COL5A2 collagen, type V, alpha 2 0.0975486
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0848746
DST dystonin 0.0760782
GOLGA4 golgin A4 0.0660803
MYO1E myosin IE 0.0647295
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0595829
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0558813
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0495417
FAT1 FAT atypical cadherin 1 0.0487052
EFNA5 ephrin-A5 0.0468561
EHBP1 EH domain binding protein 1 0.0426729
PTEN phosphatase and tensin homolog 0.0407151
MED13 mediator complex subunit 13 0.03685
EEF1G eukaryotic translation elongation factor 1 gamma 0.0347341
NDRG1 N-myc downstream regulated 1 0.0305726
GCC2 GRIP and coiled-coil domain containing 2 0.0292636
HMGA1 high mobility group AT-hook 1 0.0250251
H3-3B H3.3 histone B 0.0249666
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0223479
ZBTB20 zinc finger and BTB domain containing 20 0.0204938
RPS25 ribosomal protein S25 0.0173916
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0168669
ACTG1 actin gamma 1 0.0117043
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0111812
TTC3 tetratricopeptide repeat domain 3 0.0109075
RPS8 ribosomal protein S8 0.0102583
MSI2 musashi RNA-binding protein 2 0.0101773
RPL35A ribosomal protein L35a 0.00786844
ARB2A ARB2 cotranscriptional regulator A 0.00760243
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.00701012
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.00667318
JMJD1C jumonji domain containing 1C 0.00144843
TPM4 tropomyosin 4 3.91841E-4

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.189714
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.158338
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.155724
ZNF292 zinc finger protein 292 -0.145395
TPT1 tumor protein, translationally-controlled 1 -0.143117
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.130266
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.115599
RTN4 reticulon 4 -0.0906861
PTMA prothymosin, alpha -0.0863999
RPS3 ribosomal protein S3 -0.064411
RPL23 ribosomal protein L23 -0.0633714
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0618965
FN1 fibronectin 1 -0.0617043
ADAM10 ADAM metallopeptidase domain 10 -0.0584139
PARD3 par-3 family cell polarity regulator -0.057174
SLC38A2 solute carrier family 38, member 2 -0.0556737
CCNI cyclin I -0.0545885
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0489258
PGK1 phosphoglycerate kinase 1 -0.0479327
HDLBP high density lipoprotein binding protein -0.039603
RPS27A ribosomal protein S27a -0.0376327
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0373077
TENM3 teneurin transmembrane protein 3 -0.0363878
NUP58 nucleoporin 58 -0.0359956
UBC ubiquitin C -0.0353304
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0332823
LMNA lamin A/C -0.030961
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0299227
EXT1 exostosin glycosyltransferase 1 -0.0296725
VMP1 vacuole membrane protein 1 -0.0293533
RPL9 ribosomal protein L9 -0.0259808
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0251755
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0249591
RPS19 ribosomal protein S19 -0.0247456
VCL vinculin -0.0235776
RLF rearranged L-myc fusion -0.0233201
LDHA lactate dehydrogenase A -0.0228952
ANXA2 annexin A2 -0.0217198
TMSB10 thymosin beta 10 -0.0206339
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0204542
GLG1 golgi glycoprotein 1 -0.0202957
GPC6 glypican 6 -0.0189889
PKM pyruvate kinase, muscle -0.0186961
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0181764
POTEF POTE ankyrin domain family, member F -0.0177576
AKAP12 A kinase (PRKA) anchor protein 12 -0.0175888
ACTN4 actinin, alpha 4 -0.0166219
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0165647
EEF2 eukaryotic translation elongation factor 2 -0.0155606
MTDH metadherin -0.0134292
DSCAM Down syndrome cell adhesion molecule -0.0121413
ENO1 enolase 1, (alpha) -0.0120891
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0113136
RPS29 ribosomal protein S29 -0.00964031
NAMPT nicotinamide phosphoribosyltransferase -0.00940395
FTL ferritin, light polypeptide -0.0050174
BIRC6 baculoviral IAP repeat containing 6 -0.00354998
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.00157451
BPTF bromodomain PHD finger transcription factor -0.00131237
WAC WW domain containing adaptor with coiled-coil -2.03105E-4
ARHGAP32 Rho GTPase activating protein 32 -1.99764E-5