| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | OTS514 perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the OTS514_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SPAG9 | sperm associated antigen 9 | 0.0533648 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0483148 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0375286 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0340229 |
| FN1 | fibronectin 1 | 0.0284658 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0279854 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0271635 |
| BRD2 | bromodomain containing 2 | 0.0268513 |
| IGF2 | insulin-like growth factor 2 | 0.0262441 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0251769 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.023542 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0234176 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | 0.022853 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0224739 |
| UBAP2 | ubiquitin associated protein 2 | 0.0219145 |
| USP25 | ubiquitin specific peptidase 25 | 0.0209785 |
| SRPK2 | SRSF protein kinase 2 | 0.0205666 |
| PLEKHG1 | pleckstrin homology domain containing, family G (with RhoGef domain) member 1 | 0.0196988 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0196838 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0195653 |
| JMJD1C | jumonji domain containing 1C | 0.0191082 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0189872 |
| ADNP | activity-dependent neuroprotector homeobox | 0.0183267 |
| RCOR1 | REST corepressor 1 | 0.0182037 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0181031 |
| CDK13 | cyclin-dependent kinase 13 | 0.0180001 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0179874 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | 0.0179087 |
| CDC73 | cell division cycle 73 | 0.0177872 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0175322 |
| SFTPA2 | surfactant protein A2 | 0.0173711 |
| CDK19 | cyclin-dependent kinase 19 | 0.0173656 |
| ZFHX3 | zinc finger homeobox 3 | 0.0172559 |
| TMEM135 | transmembrane protein 135 | 0.0171878 |
| MEF2C | myocyte enhancer factor 2C | 0.0169966 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0169256 |
| INTS6 | integrator complex subunit 6 | 0.0166271 |
| PSPC1 | paraspeckle component 1 | 0.0164453 |
| CCNL1 | cyclin L1 | 0.0164224 |
| WDR26 | WD repeat domain 26 | 0.0163762 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | 0.0163056 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 0.0161863 |
| TBCA | tubulin folding cofactor A | 0.0159849 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.0159752 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0159345 |
| MED13L | mediator complex subunit 13-like | 0.0157323 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0156738 |
| PRKD1 | protein kinase D1 | 0.0156178 |
| RPL9 | ribosomal protein L9 | 0.0153382 |
| TRIM2 | tripartite motif containing 2 | 0.0152564 |
| PCNX4 | pecanex 4 | 0.0151988 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0151747 |
| KLHDC10 | kelch domain containing 10 | 0.015172 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0151513 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0150898 |
| GARRE1 | granule associated Rac and RHOG effector 1 | 0.0150752 |
| TOX | thymocyte selection-associated high mobility group box | 0.0150316 |
| PLD3 | phospholipase D family, member 3 | 0.0149568 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0148094 |
| TTLL10 | tubulin tyrosine ligase-like family member 10 | 0.0147682 |
| PDS5A | PDS5 cohesin associated factor A | 0.0146343 |
| FAM193A | family with sequence similarity 193, member A | 0.0145823 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0145074 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0144797 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | 0.0144608 |
| NXN | nucleoredoxin | 0.0144248 |
| PPL | periplakin | 0.0143424 |
| OPHN1 | oligophrenin 1 | 0.0143364 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0143255 |
| FLNB | filamin B, beta | 0.0141872 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | 0.0141235 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | 0.0140078 |
| NCOA6 | nuclear receptor coactivator 6 | 0.0138432 |
| SIK2 | salt-inducible kinase 2 | 0.0138407 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0138119 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0138026 |
| DMTF1 | cyclin D binding myb-like transcription factor 1 | 0.0138014 |
| RNASEH2A | ribonuclease H2, subunit A | 0.0135411 |
| MCF2L2 | MCF.2 cell line derived transforming sequence-like 2 | 0.0135277 |
| AHCTF1 | AT hook containing transcription factor 1 | 0.0134492 |
| DENND4C | DENN/MADD domain containing 4C | 0.0133409 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | 0.0132513 |
| PHF14 | PHD finger protein 14 | 0.0131984 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0131442 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | 0.0130844 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0130456 |
| HIP1 | huntingtin interacting protein 1 | 0.0129929 |
| TMEM87A | transmembrane protein 87A | 0.0129358 |
| CCDC138 | coiled-coil domain containing 138 | 0.0128808 |
| ACAP2 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 | 0.0128409 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | 0.0128207 |
| ATF7IP | activating transcription factor 7 interacting protein | 0.0128153 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0128062 |
| RASAL2 | RAS protein activator like 2 | 0.012724 |
| SEC62 | SEC62 homolog (S. cerevisiae) | 0.0127236 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0127004 |
| HDAC5 | histone deacetylase 5 | 0.0126278 |
| AGO3 | argonaute RISC catalytic component 3 | 0.0124423 |
| MCL1 | myeloid cell leukemia 1 | 0.0123705 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.012364 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.204541 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.181056 |
| TMSB10 | thymosin beta 10 | -0.147286 |
| COL11A1 | collagen, type XI, alpha 1 | -0.134154 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.125855 |
| COL5A2 | collagen, type V, alpha 2 | -0.110132 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0936395 |
| PTMA | prothymosin, alpha | -0.0895035 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0808197 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0804785 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0729771 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0696525 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0639702 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0611317 |
| ITGAV | integrin, alpha V | -0.0604173 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0602875 |
| TMSB4X | thymosin beta 4, X-linked | -0.0595005 |
| COL3A1 | collagen, type III, alpha 1 | -0.058872 |
| YBX1 | Y box binding protein 1 | -0.0585306 |
| RPS12 | ribosomal protein S12 | -0.0566801 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0539602 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0537374 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0520725 |
| AHNAK | AHNAK nucleoprotein | -0.0502489 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.050029 |
| SET | SET nuclear proto-oncogene | -0.0493453 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0478607 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0473012 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0468268 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0460818 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0447847 |
| DST | dystonin | -0.0446606 |
| POTEF | POTE ankyrin domain family, member F | -0.0445529 |
| ENO1 | enolase 1, (alpha) | -0.0441015 |
| RPS27A | ribosomal protein S27a | -0.0440879 |
| RPLP1 | ribosomal protein, large, P1 | -0.0431161 |
| RPL5 | ribosomal protein L5 | -0.0422084 |
| THBS1 | thrombospondin 1 | -0.0416745 |
| NTM | neurotrimin | -0.0411915 |
| CENPF | centromere protein F, 350/400kDa | -0.0399291 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0397879 |
| TENM3 | teneurin transmembrane protein 3 | -0.0392059 |
| UBC | ubiquitin C | -0.038571 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | -0.0385671 |
| HMGB1 | high mobility group box 1 | -0.037143 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0369903 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -0.0365101 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | -0.036018 |
| ACTG1 | actin gamma 1 | -0.0359687 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.0359205 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.034699 |
| RPS16 | ribosomal protein S16 | -0.0345462 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0345353 |
| MKI67 | marker of proliferation Ki-67 | -0.0342097 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.033878 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.033076 |
| CANX | calnexin | -0.0329734 |
| EMP1 | epithelial membrane protein 1 | -0.0328471 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.032414 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | -0.0323876 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0323272 |
| MATR3 | matrin 3 | -0.0323069 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0321417 |
| S100A10 | S100 calcium binding protein A10 | -0.0318279 |
| RAI1 | retinoic acid induced 1 | -0.0318271 |
| TPX2 | TPX2, microtubule-associated | -0.0315109 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0311626 |
| CDK6 | cyclin-dependent kinase 6 | -0.0302979 |
| PCDH9 | protocadherin 9 | -0.0297832 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0293112 |
| RPS24 | ribosomal protein S24 | -0.0286993 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -0.0285443 |
| CADM2 | cell adhesion molecule 2 | -0.028242 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0277329 |
| HMGB2 | high mobility group box 2 | -0.027486 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0274655 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0274251 |
| ANXA1 | annexin A1 | -0.0273294 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0271501 |
| CALR | calreticulin | -0.0267779 |
| TPM3 | tropomyosin 3 | -0.0265256 |
| SFRP4 | secreted frizzled-related protein 4 | -0.0265156 |
| RPS8 | ribosomal protein S8 | -0.0264252 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0259094 |
| NRG1 | neuregulin 1 | -0.0249846 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0249498 |
| PFN1 | profilin 1 | -0.024824 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.0246141 |
| SRP72 | signal recognition particle 72kDa | -0.0245374 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0240723 |
| GNAS | GNAS complex locus | -0.0240534 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0240502 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | -0.0240364 |
| RPL7 | ribosomal protein L7 | -0.0240223 |
| RPL23 | ribosomal protein L23 | -0.0240044 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0239111 |
| OLA1 | Obg-like ATPase 1 | -0.0236683 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.023612 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0234312 |
| XPO1 | exportin 1 | -0.0232422 |
