| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | OTS514 perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the OTS514_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.105853 |
| EGFR | epidermal growth factor receptor | 0.0681455 |
| HDAC9 | histone deacetylase 9 | 0.0636935 |
| PKM | pyruvate kinase, muscle | 0.0615308 |
| PDGFC | platelet derived growth factor C | 0.0555831 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0513381 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0479828 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0450226 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0443967 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0406745 |
| CCNL1 | cyclin L1 | 0.0397739 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0366156 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0363941 |
| TACC2 | transforming, acidic coiled-coil containing protein 2 | 0.034457 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0306004 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0300428 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0299599 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0293053 |
| TMEM65 | transmembrane protein 65 | 0.0283475 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0282617 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0279888 |
| NCKAP1 | NCK-associated protein 1 | 0.0273661 |
| RPL23 | ribosomal protein L23 | 0.0256948 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0243496 |
| ZNF644 | zinc finger protein 644 | 0.0243016 |
| CDC73 | cell division cycle 73 | 0.0241969 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0237826 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0237244 |
| POTEF | POTE ankyrin domain family, member F | 0.0235709 |
| JMJD1C | jumonji domain containing 1C | 0.0234695 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0233434 |
| ZZZ3 | zinc finger, ZZ-type containing 3 | 0.0232722 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0231638 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0227735 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0224883 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | 0.0211758 |
| RPL9 | ribosomal protein L9 | 0.0211097 |
| EPC2 | enhancer of polycomb homolog 2 (Drosophila) | 0.0207839 |
| MAST2 | microtubule associated serine/threonine kinase 2 | 0.0202614 |
| SLC39A9 | solute carrier family 39, member 9 | 0.0196812 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0196777 |
| CREBBP | CREB binding protein | 0.0193625 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0186374 |
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | 0.0186019 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0185959 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0185378 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.018494 |
| IGF2 | insulin-like growth factor 2 | 0.0183653 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0183237 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0182882 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0181837 |
| TIAM2 | T-cell lymphoma invasion and metastasis 2 | 0.0181296 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0180353 |
| SON | SON DNA binding protein | 0.0179982 |
| FAT1 | FAT atypical cadherin 1 | 0.0179748 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0177845 |
| CLTC | clathrin, heavy chain (Hc) | 0.0177396 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0176877 |
| UBAP2 | ubiquitin associated protein 2 | 0.0176552 |
| BRD2 | bromodomain containing 2 | 0.0176208 |
| ZNF207 | zinc finger protein 207 | 0.0176129 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0174693 |
| FAM193A | family with sequence similarity 193, member A | 0.0173493 |
| INO80 | INO80 complex subunit | 0.0173424 |
| LENG8 | leukocyte receptor cluster (LRC) member 8 | 0.0172424 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0172012 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0171494 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0169351 |
| VMP1 | vacuole membrane protein 1 | 0.0167543 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0167002 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0164362 |
| MLIP | muscular LMNA-interacting protein | 0.0163911 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0163194 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0161073 |
| PFN1 | profilin 1 | 0.0160998 |
| ATP6V1H | ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H | 0.0160988 |
| UQCC1 | ubiquinol-cytochrome c reductase complex assembly factor 1 | 0.0158863 |
| ZMYM4 | zinc finger, MYM-type 4 | 0.0158845 |
| ARFGEF1 | ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) | 0.0157732 |
| RBM33 | RNA binding motif protein 33 | 0.0157356 |
| RNASE12 | ribonuclease, RNase A family, 12 (non-active) | 0.0156786 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0156065 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.015519 |
| FNIP1 | folliculin interacting protein 1 | 0.0154931 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0154829 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0154521 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.0153209 |
| PTGES2 | prostaglandin E synthase 2 | 0.0152846 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0152461 |
| LYST | lysosomal trafficking regulator | 0.0152147 |
| FARS2 | phenylalanyl-tRNA synthetase 2, mitochondrial | 0.0151991 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0151893 |
| SGMS2 | sphingomyelin synthase 2 | 0.0151013 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0150754 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0149318 |
| EGR1 | early growth response 1 | 0.0148943 |
| BMPR1A | bone morphogenetic protein receptor, type IA | 0.0147036 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0146816 |
| AGO3 | argonaute RISC catalytic component 3 | 0.0146602 |
| USP24 | ubiquitin specific peptidase 24 | 0.0145691 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.397004 |
| TMSB4X | thymosin beta 4, X-linked | -0.205544 |
| AHNAK | AHNAK nucleoprotein | -0.143462 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0963282 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0928553 |
| VCL | vinculin | -0.0907272 |
| BMP10 | bone morphogenetic protein 10 | -0.0867459 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0799033 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0765241 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0711307 |
| EZR | ezrin | -0.065906 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0644944 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | -0.0642098 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0611637 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0594438 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0578868 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0564146 |
| RPS8 | ribosomal protein S8 | -0.0546881 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0535589 |
| TXNRD1 | thioredoxin reductase 1 | -0.0531228 |
| FLNB | filamin B, beta | -0.0529676 |
| S100A6 | S100 calcium binding protein A6 | -0.0526376 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0495511 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0495275 |
| TNFRSF11B | tumor necrosis factor receptor superfamily, member 11b | -0.0480677 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0470589 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0462733 |
| CCND1 | cyclin D1 | -0.0460271 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0459527 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0435274 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0433021 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0427692 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0417514 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0413319 |
| TPM4 | tropomyosin 4 | -0.0412482 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0412398 |
| SQSTM1 | sequestosome 1 | -0.0412243 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0400568 |
| SET | SET nuclear proto-oncogene | -0.0392388 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.039045 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0387886 |
| RPL37A | ribosomal protein L37a | -0.0384107 |
| NFIA | nuclear factor I/A | -0.0381582 |
| MKI67 | marker of proliferation Ki-67 | -0.0377651 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0374087 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0369591 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0365747 |
| MATR3 | matrin 3 | -0.0364102 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | -0.0361623 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0358802 |
| SMC3 | structural maintenance of chromosomes 3 | -0.0356165 |
| RPL12 | ribosomal protein L12 | -0.034927 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.03482 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0345032 |
| RPS12 | ribosomal protein S12 | -0.0343561 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0342923 |
| RRBP1 | ribosome binding protein 1 | -0.0339688 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.033869 |
| RPS24 | ribosomal protein S24 | -0.0338502 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0331463 |
| MAP4 | microtubule-associated protein 4 | -0.0331394 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0330613 |
| RPLP1 | ribosomal protein, large, P1 | -0.0327172 |
| EFNA5 | ephrin-A5 | -0.0323989 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.0323454 |
| S100A10 | S100 calcium binding protein A10 | -0.0321778 |
| RPL31 | ribosomal protein L31 | -0.0321542 |
| RPL34 | ribosomal protein L34 | -0.0318365 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0317388 |
| PYGB | phosphorylase, glycogen; brain | -0.0316239 |
| CANX | calnexin | -0.0315545 |
| NBEA | neurobeachin | -0.0312204 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0305381 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0303297 |
| GNAS | GNAS complex locus | -0.0302008 |
| RPL26 | ribosomal protein L26 | -0.0301128 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.030101 |
| RPLP0 | ribosomal protein, large, P0 | -0.0299177 |
| RPS3 | ribosomal protein S3 | -0.0299151 |
| FOXP1 | forkhead box P1 | -0.0298765 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0298617 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0295785 |
| DUSP6 | dual specificity phosphatase 6 | -0.0291454 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0286622 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0284964 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0283721 |
| ENO1 | enolase 1, (alpha) | -0.0280101 |
| HDLBP | high density lipoprotein binding protein | -0.027993 |
| ENOX1 | ecto-NOX disulfide-thiol exchanger 1 | -0.0279517 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0279492 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0276647 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0274695 |
| DUSP4 | dual specificity phosphatase 4 | -0.0274042 |
| MYO5C | myosin VC | -0.0273168 |
| EBNA1BP2 | EBNA1 binding protein 2 | -0.0270669 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0270047 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0269544 |
| TAOK1 | TAO kinase 1 | -0.0267081 |
| CENPF | centromere protein F, 350/400kDa | -0.0265678 |
| NEBL | nebulette | -0.0265344 |
