| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | OTS514 perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the OTS514_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.138221 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.123604 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.113402 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.112906 |
| CD44 | CD44 molecule (Indian blood group) | 0.110427 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.104317 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.103652 |
| NAV2 | neuron navigator 2 | 0.0869462 |
| PGK1 | phosphoglycerate kinase 1 | 0.0816182 |
| NDRG1 | N-myc downstream regulated 1 | 0.0734261 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | 0.0707355 |
| SFTPA2 | surfactant protein A2 | 0.0689239 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0687991 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0670174 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0668726 |
| MT2A | metallothionein 2A | 0.064264 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0630028 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.062749 |
| FLNB | filamin B, beta | 0.0566999 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0564722 |
| CCNL1 | cyclin L1 | 0.0563035 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0542645 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0537363 |
| ADM | adrenomedullin | 0.0515019 |
| LDHA | lactate dehydrogenase A | 0.0496786 |
| HDAC9 | histone deacetylase 9 | 0.0490801 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0480087 |
| CDH13 | cadherin 13 | 0.0478234 |
| FNIP1 | folliculin interacting protein 1 | 0.0453536 |
| LOXL2 | lysyl oxidase-like 2 | 0.0441948 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0436012 |
| COL5A1 | collagen, type V, alpha 1 | 0.0432962 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0427456 |
| KYNU | kynureninase | 0.0418778 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0410157 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0405005 |
| MYOF | myoferlin | 0.0398444 |
| FLNA | filamin A, alpha | 0.0397119 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0395759 |
| STC1 | stanniocalcin 1 | 0.0394823 |
| ARRDC3 | arrestin domain containing 3 | 0.0378741 |
| EGFR | epidermal growth factor receptor | 0.0378514 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0377367 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0369705 |
| FMNL2 | formin-like 2 | 0.0369681 |
| PRELID2 | PRELI domain containing 2 | 0.0365582 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0356387 |
| TMEM132D | transmembrane protein 132D | 0.0355038 |
| RND3 | Rho family GTPase 3 | 0.035427 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0351518 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0350522 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0350216 |
| CALR | calreticulin | 0.0348979 |
| HMGA2 | high mobility group AT-hook 2 | 0.0336424 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0327264 |
| YEATS2 | YEATS domain containing 2 | 0.0324993 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.031841 |
| TRIM25 | tripartite motif containing 25 | 0.0317764 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0316874 |
| MMP12 | matrix metallopeptidase 12 | 0.0313066 |
| SEPTIN9 | septin 9 | 0.0310188 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.030944 |
| SNX9 | sorting nexin 9 | 0.0305112 |
| MT1X | metallothionein 1X | 0.0304905 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.029597 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0290112 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0284481 |
| VAC14 | Vac14 homolog (S. cerevisiae) | 0.0280797 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0279945 |
| UBAP2 | ubiquitin associated protein 2 | 0.0278761 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.027847 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0276954 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0276537 |
| FOXO3 | forkhead box O3 | 0.027398 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.0272172 |
| GDF15 | growth differentiation factor 15 | 0.0270497 |
| CADM1 | cell adhesion molecule 1 | 0.0267702 |
| RUNX1 | runt-related transcription factor 1 | 0.0267355 |
| TNS3 | tensin 3 | 0.0267325 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.026696 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0266163 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.0265877 |
| CDK19 | cyclin-dependent kinase 19 | 0.0263927 |
| STC2 | stanniocalcin 2 | 0.0261163 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0261086 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.026023 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0254693 |
| ZNF638 | zinc finger protein 638 | 0.0253937 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0252051 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0251612 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.0251355 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0250662 |
| NONO | non-POU domain containing, octamer-binding | 0.025063 |
| AFF3 | AF4/FMR2 family, member 3 | 0.024709 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0246633 |
| LOX | lysyl oxidase | 0.024663 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0246512 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0245027 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0244636 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0243794 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.222215 |
| FRMD4A | FERM domain containing 4A | -0.14077 |
| FTL | ferritin, light polypeptide | -0.114302 |
| TMSB10 | thymosin beta 10 | -0.111855 |
| VCL | vinculin | -0.10774 |
| FN1 | fibronectin 1 | -0.0944103 |
| EGR1 | early growth response 1 | -0.0935895 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0725579 |
| IER3 | immediate early response 3 | -0.063865 |
| PTMA | prothymosin, alpha | -0.0581804 |
| BICC1 | BicC family RNA binding protein 1 | -0.0571329 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0553882 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0549811 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0535842 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0472582 |
| CENPF | centromere protein F, 350/400kDa | -0.0454086 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0438048 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0420534 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0393422 |
| TXNRD1 | thioredoxin reductase 1 | -0.0384687 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0382193 |
| VCAN | versican | -0.0379551 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0379203 |
| AHNAK | AHNAK nucleoprotein | -0.03786 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0372701 |
| TMSB4X | thymosin beta 4, X-linked | -0.0369193 |
| MKI67 | marker of proliferation Ki-67 | -0.036586 |
| TPM4 | tropomyosin 4 | -0.03646 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0338982 |
| PALLD | palladin, cytoskeletal associated protein | -0.0331544 |
| ANLN | anillin, actin binding protein | -0.0328306 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0327036 |
| HLA-B | major histocompatibility complex, class I, B | -0.0320273 |
| GLIS3 | GLIS family zinc finger 3 | -0.031788 |
| CALD1 | caldesmon 1 | -0.0312784 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0309694 |
| RPS8 | ribosomal protein S8 | -0.0307206 |
| YBX1 | Y box binding protein 1 | -0.030478 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0302259 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0302251 |
| RAI14 | retinoic acid induced 14 | -0.0302124 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0291725 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0291691 |
| TPM1 | tropomyosin 1 (alpha) | -0.0288704 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0276324 |
| KRT19 | keratin 19, type I | -0.0271847 |
| QKI | QKI, KH domain containing, RNA binding | -0.0271087 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0270164 |
| DIAPH2 | diaphanous-related formin 2 | -0.0269073 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0268854 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0264399 |
| ANXA2 | annexin A2 | -0.0263492 |
| S100A9 | S100 calcium binding protein A9 | -0.0263085 |
| RPS27A | ribosomal protein S27a | -0.0262158 |
| KIF4A | kinesin family member 4A | -0.0256714 |
| B2M | beta-2-microglobulin | -0.0253962 |
| RPL32 | ribosomal protein L32 | -0.0253781 |
| RPS24 | ribosomal protein S24 | -0.0252929 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0252555 |
| RPL19 | ribosomal protein L19 | -0.0251938 |
| NAV1 | neuron navigator 1 | -0.0251439 |
| ENO1 | enolase 1, (alpha) | -0.0250626 |
| FRMD5 | FERM domain containing 5 | -0.024837 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0245226 |
| SFRP1 | secreted frizzled-related protein 1 | -0.0242677 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0241955 |
| THBS1 | thrombospondin 1 | -0.0239322 |
| SBF2 | SET binding factor 2 | -0.0239015 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0238391 |
| EZR | ezrin | -0.0235147 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0234883 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0229905 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0229103 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0221817 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0221794 |
| CTSD | cathepsin D | -0.0221242 |
| RRBP1 | ribosome binding protein 1 | -0.021914 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0215606 |
| DIAPH3 | diaphanous-related formin 3 | -0.0213677 |
| PLIN2 | perilipin 2 | -0.0213066 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0212475 |
| RIGI | RNA sensor RIG-I | -0.0209828 |
| PRR11 | proline rich 11 | -0.0207 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0204414 |
| IER2 | immediate early response 2 | -0.0203945 |
| RPL31 | ribosomal protein L31 | -0.0202195 |
| RPL36A | ribosomal protein L36a | -0.0198567 |
| TNNC1 | troponin C type 1 (slow) | -0.019725 |
| COL1A2 | collagen, type I, alpha 2 | -0.019462 |
| RPLP2 | ribosomal protein, large, P2 | -0.0193996 |
| RPS12 | ribosomal protein S12 | -0.019286 |
| RPLP1 | ribosomal protein, large, P1 | -0.019222 |
| GOLGB1 | golgin B1 | -0.0192097 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0191729 |
| RPS19 | ribosomal protein S19 | -0.019118 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -0.0191178 |
| DST | dystonin | -0.0190713 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0189694 |
| COL1A1 | collagen, type I, alpha 1 | -0.0189304 |
| RPL26 | ribosomal protein L26 | -0.0189153 |
