OVE-208 Gene Set

Dataset LINCS L1000 CMAP Chemical Perturbation Consensus Signatures
Category transcriptomics
Type small molecule perturbation
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Genes

44 genes differentially expressed following the OVE-208 small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 6.77628
CD40 CD40 molecule, TNF receptor superfamily member 5 5.40571
SKIC8 SKI8 subunit of superkiller complex 4.92563
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1 4.7343
AURKB aurora kinase B 4.47514
NIPBL Nipped-B homolog (Drosophila) 3.80529
CLTA clathrin, light chain A 3.68646
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 3.58645
NVL nuclear VCP-like 3.53721
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.48641
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1 3.46881
MIR600HG MIR600 host gene 3.45843
CASP10 caspase 10, apoptosis-related cysteine peptidase 3.39971
N4BP3 NEDD4 binding protein 3 3.38534
IREB2 iron-responsive element binding protein 2 3.37886
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 3.32604
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 3.27755
SAA3P serum amyloid A3 pseudogene 3.24901
MMP2 matrix metallopeptidase 2 3.16784
NCR3 natural cytotoxicity triggering receptor 3 3.1628
ZNF750 zinc finger protein 750 3.15565
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 3.14852
KIF11 kinesin family member 11 3.12536
FOCAD focadhesin 3.11281
IFNAR1 interferon (alpha, beta and omega) receptor 1 3.10753
USP18 ubiquitin specific peptidase 18 3.09758
SDHAP1 succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 1 3.065
NIT1 nitrilase 1 3.06413
DCAF10 DDB1 and CUL4 associated factor 10 3.0629
ZNF117 zinc finger protein 117 3.00118

decreased expression

Symbol Name Standardized Value
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 -3.89948
FGF1 fibroblast growth factor 1 (acidic) -3.85229
SACS sacsin molecular chaperone -3.70912
TFF1 trefoil factor 1 -3.56705
KDSR 3-ketodihydrosphingosine reductase -3.43149
ASPA aspartoacylase -3.39651
NPAS3 neuronal PAS domain protein 3 -3.34019
TLL2 tolloid-like 2 -3.26197
C3ORF52 chromosome 3 open reading frame 52 -3.15553
BRD2 bromodomain containing 2 -3.09508
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14 -3.08973
LYN LYN proto-oncogene, Src family tyrosine kinase -3.06757
LHX6 LIM homeobox 6 -3.06137
CEP170 centrosomal protein 170kDa -3.02691