Obesity Gene Set

Dataset DISEASES Curated Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description An eating-related disorder in which excess body fat has accumulated to such an extent that health may be negatively affected. It is commonly defined as a body mass index (weight divided by height squared) of 30 kg/m2 or higher.|A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY). (Experimental Factor Ontology, EFO_0001073)
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Genes

65 genes involed in the disease Obesity from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.

Symbol Name Standardized Value
TRIM32 tripartite motif containing 32 4.0
LIPE lipase, hormone-sensitive 4.0
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 4.0
BBIP1 BBSome interacting protein 1 4.0
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 4.0
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 4.0
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B 4.0
PPARG peroxisome proliferator-activated receptor gamma 4.0
MC4R melanocortin 4 receptor 4.0
ADIPOQ adiponectin, C1Q and collagen domain containing 4.0
IFT74 intraflagellar transport 74 4.0
FTO fat mass and obesity associated 4.0
CEP290 centrosomal protein 290kDa 4.0
LEPR leptin receptor 4.0
IFT172 intraflagellar transport 172 4.0
POMC proopiomelanocortin 4.0
IFT27 intraflagellar transport 27 4.0
ADRB3 adrenoceptor beta 3 4.0
MRAP2 melanocortin 2 receptor accessory protein 2 4.0
PNPLA3 patatin-like phospholipase domain containing 3 4.0
CELA2A chymotrypsin-like elastase family, member 2A 4.0
NR0B2 nuclear receptor subfamily 0, group B, member 2 4.0
WDPCP WD repeat containing planar cell polarity effector 4.0
BBS12 Bardet-Biedl syndrome 12 4.0
BBS10 Bardet-Biedl syndrome 10 4.0
BBS7 Bardet-Biedl syndrome 7 4.0
BBS4 Bardet-Biedl syndrome 4 4.0
BBS5 Bardet-Biedl syndrome 5 4.0
BBS2 Bardet-Biedl syndrome 2 4.0
BBS1 Bardet-Biedl syndrome 1 4.0
BBS9 Bardet-Biedl syndrome 9 4.0
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 4.0
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 4.0
CARTPT CART prepropeptide 4.0
KIF7 kinesin family member 7 4.0
TMEM67 transmembrane protein 67 4.0
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 4.0
ALMS1 Alstrom syndrome protein 1 4.0
TTC21B tetratricopeptide repeat domain 21B 4.0
ARL6 ADP-ribosylation factor-like 6 4.0
RETN resistin 4.0
AFF4 AF4/FMR2 family, member 4 4.0
SDCCAG8 serologically defined colon cancer antigen 8 4.0
MAGEL2 melanoma antigen family L2 4.0
ADCY3 adenylate cyclase 3 4.0
PCSK1 proprotein convertase subtilisin/kexin type 1 4.0
CNR1 cannabinoid receptor 1 (brain) 4.0
KIDINS220 kinase D-interacting substrate, 220kDa 4.0
HDAC8 histone deacetylase 8 4.0
CPE carboxypeptidase E 4.0
LZTFL1 leucine zipper transcription factor-like 1 4.0
CEP19 centrosomal protein 19kDa 4.0
TUB tubby bipartite transcription factor 4.0
GNAS GNAS complex locus 4.0
TTC8 tetratricopeptide repeat domain 8 4.0
LEP leptin 4.0
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 4.0
MKS1 Meckel syndrome, type 1 4.0
LAS1L LAS1-like (S. cerevisiae) 4.0
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa 4.0
MKKS McKusick-Kaufman syndrome 4.0
CCDC28B coiled-coil domain containing 28B 4.0
ASIP agouti signaling protein 4.0
AGRP agouti related neuropeptide 4.0
VPS13B vacuolar protein sorting 13 homolog B (yeast) 4.0