Obesity Gene Set

Dataset DISEASES Experimental Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description An eating-related disorder in which excess body fat has accumulated to such an extent that health may be negatively affected. It is commonly defined as a body mass index (weight divided by height squared) of 30 kg/m2 or higher.|A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY). (Experimental Factor Ontology, EFO_0001073)
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Genes

54 genes associated with the disease Obesity in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
FTO fat mass and obesity associated 2.031
RPGRIP1L RPGRIP1-like 2.031
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 1.783
LIN7C lin-7 homolog C (C. elegans) 1.783
MC4R melanocortin 4 receptor 1.675
NEGR1 neuronal growth regulator 1 1.591
BDNF brain-derived neurotrophic factor 1.537
TFAP2D transcription factor AP-2 delta (activating enhancer binding protein 2 delta) 1.502
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 1.502
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 1.376
PRKCH protein kinase C, eta 1.346
GAL3ST3 galactose-3-O-sulfotransferase 3 1.247
LEPR leptin receptor 1.247
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 1.247
KLC2 kinesin light chain 2 1.247
LEPROT leptin receptor overlapping transcript 1.247
PACS1 phosphofurin acidic cluster sorting protein 1 1.247
SF3B2 splicing factor 3b, subunit 2, 145kDa 1.247
HOXB1 homeobox B1 1.224
HOXB8 homeobox B8 1.224
HOXB9 homeobox B9 1.224
HOXB2 homeobox B2 1.224
HOXB3 homeobox B3 1.224
HOXB5 homeobox B5 1.224
HOXB4 homeobox B4 1.224
HOXB7 homeobox B7 1.224
HOXB6 homeobox B6 1.224
CD19 CD19 molecule 1.202
LAT linker for activation of T cells 1.202
TUFM Tu translation elongation factor, mitochondrial 1.202
SH2B1 SH2B adaptor protein 1 1.202
RABEP2 rabaptin, RAB GTPase binding effector protein 2 1.202
CCR3 chemokine (C-C motif) receptor 3 1.202
ATXN2L ataxin 2-like 1.202
SPNS1 spinster homolog 1 (Drosophila) 1.202
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 1.202
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein 1.202
CCR1 chemokine (C-C motif) receptor 1 1.202
ADCY3 adenylate cyclase 3 1.19
CENPO centromere protein O 1.19
NCOA1 nuclear receptor coactivator 1 1.19
DNAJC27 DnaJ (Hsp40) homolog, subfamily C, member 27 1.19
PTRHD1 peptidyl-tRNA hydrolase domain containing 1 1.19
TTC39B tetratricopeptide repeat domain 39B 1.173
MMS22L MMS22-like, DNA repair protein 1.059
KLHL32 kelch-like family member 32 1.059
MTMR9 myotubularin related protein 9 0.95
FAM167A family with sequence similarity 167, member A 0.95
SLC35G5 solute carrier family 35, member G5 0.95
TMEM18 transmembrane protein 18 0.795
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 0.674
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.572
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.563
LYPLAL1 lysophospholipase-like 1 0.561