Obesity Gene Set

Dataset dbGAP Gene-Trait Associations
Category disease or phenotype associations
Type trait
Description An eating-related disorder in which excess body fat has accumulated to such an extent that health may be negatively affected. It is commonly defined as a body mass index (weight divided by height squared) of 30 kg/m2 or higher.|A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY). (Experimental Factor Ontology, EFO_0001073)
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Genes

25 genes associated with the trait Obesity in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.

Symbol Name Standardized Value
FTO fat mass and obesity associated 1.65663
BDNF-AS BDNF antisense RNA 1.28701
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.907793
HOXB5 homeobox B5 0.807263
PAX5 paired box 5 0.769036
NCAM2 neural cell adhesion molecule 2 0.696869
NPC1 Niemann-Pick disease, type C1 0.585749
SOX6 SRY (sex determining region Y)-box 6 0.567219
LHFPL3 lipoma HMGIC fusion partner-like 3 0.527821
PCDH9 protocadherin 9 0.527821
TTC28 tetratricopeptide repeat domain 28 0.527821
WWOX WW domain containing oxidoreductase 0.518003
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.50084
ALPK1 alpha-kinase 1 0.50084
EML6 echinoderm microtubule associated protein like 6 0.50084
TIAM1 T-cell lymphoma invasion and metastasis 1 0.406869
ANO3 anoctamin 3 0.378873
TJP2 tight junction protein 2 0.378873
FBN2 fibrillin 2 0.378873
RARB retinoic acid receptor, beta 0.378873
RFTN1 raftlin, lipid raft linker 1 0.356676
RGS6 regulator of G-protein signaling 6 0.356676
MACROD2 MACRO domain containing 2 0.356676
GPC6 glypican 6 0.33862
MLN motilin 0.33862