| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A benzodiazepine that has formula C17H20N4S. (Chemical Entities of Biological Interest Ontology, CHEBI_7735) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/135398745 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Olanzapine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TSPAN3 | tetraspanin 3 | 1.0 |
| TMC4 | transmembrane channel-like 4 | 0.86 |
| DCLK2 | doublecortin-like kinase 2 | 0.69 |
| CD63 | CD63 molecule | 0.57 |
| ZNRD1 | zinc ribbon domain containing 1 | 0.52 |
| RASSF3 | Ras association (RalGDS/AF-6) domain family member 3 | 0.51 |
| MTSS2 | MTSS I-BAR domain containing 2 | 0.5 |
| SASH1 | SAM and SH3 domain containing 1 | 0.49 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | 0.46 |
| DAPK2 | death-associated protein kinase 2 | 0.45 |
| CCDC14 | coiled-coil domain containing 14 | 0.43 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.43 |
| FRMPD3 | FERM and PDZ domain containing 3 | 0.42 |
| DOCK11 | dedicator of cytokinesis 11 | 0.42 |
| MT-ND5 | NADH dehydrogenase, subunit 5 (complex I) | 0.42 |
| TRIB3 | tribbles pseudokinase 3 | 0.4 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 0.39 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.39 |
| ZNF696 | zinc finger protein 696 | 0.38 |
| ANAPC11 | anaphase promoting complex subunit 11 | 0.38 |
| SYN2 | synapsin II | 0.37 |
| CABLES2 | Cdk5 and Abl enzyme substrate 2 | 0.35 |
| ZNF777 | zinc finger protein 777 | 0.35 |
| DERPC | DERPC proline and glycine rich nuclear protein | 0.35 |
| SLC25A14 | solute carrier family 25 (mitochondrial carrier, brain), member 14 | 0.34 |
| B4GALT2 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 | 0.34 |
| PKHD1L1 | polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 | 0.34 |
| TMEM9 | transmembrane protein 9 | 0.34 |
| MYRF | myelin regulatory factor | 0.33 |
| ELK3 | ELK3, ETS-domain protein (SRF accessory protein 2) | 0.33 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | 0.33 |
| CNTRL | centriolin | 0.33 |
| C2ORF42 | chromosome 2 open reading frame 42 | 0.32 |
| ZNF324 | zinc finger protein 324 | 0.32 |
| TTC38 | tetratricopeptide repeat domain 38 | 0.32 |
| ALDH3B1 | aldehyde dehydrogenase 3 family, member B1 | 0.31 |
| TRAF5 | TNF receptor-associated factor 5 | 0.31 |
| OTULIN | OTU deubiquitinase with linear linkage specificity | 0.31 |
| HLA-F | major histocompatibility complex, class I, F | 0.3 |
| COMMD6 | COMM domain containing 6 | 0.3 |
| CHCHD2P9 | coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 9 | 0.3 |
| FAM122A | family with sequence similarity 122A | 0.3 |
| DUSP5 | dual specificity phosphatase 5 | 0.3 |
| PAFAH1B2 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) | 0.3 |
| ZNHIT1 | zinc finger, HIT-type containing 1 | 0.3 |
| FMNL3 | formin-like 3 | 0.3 |
| ZMYND19 | zinc finger, MYND-type containing 19 | 0.3 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | 0.29 |
| ENOX2 | ecto-NOX disulfide-thiol exchanger 2 | 0.29 |
| PLPP3 | phospholipid phosphatase 3 | 0.28 |
| VIM | vimentin | 0.28 |
| ADM | adrenomedullin | 0.28 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.28 |
| MLF1 | myeloid leukemia factor 1 | 0.28 |
| MPV17L2 | MPV17 mitochondrial membrane protein-like 2 | 0.28 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.28 |
| SYTL3 | synaptotagmin-like 3 | 0.28 |
| ZNF335 | zinc finger protein 335 | 0.28 |
| EGR1 | early growth response 1 | 0.28 |
| TAF1A | TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa | 0.28 |
| COQ10B | coenzyme Q10 homolog B (S. cerevisiae) | 0.27 |
| FBRSL1 | fibrosin-like 1 | 0.27 |
| AGRN | agrin | 0.27 |
| HEXIM2 | hexamethylene bis-acetamide inducible 2 | 0.27 |
| SPATA2L | spermatogenesis associated 2-like | 0.27 |
| LIFR | leukemia inhibitory factor receptor alpha | 0.27 |
| TMEM106C | transmembrane protein 106C | 0.27 |
| MYNN | myoneurin | 0.27 |
| FAT4 | FAT atypical cadherin 4 | 0.27 |
| FOSL1 | FOS-like antigen 1 | 0.27 |
| PXMP4 | peroxisomal membrane protein 4, 24kDa | 0.27 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | 0.26 |
| LAMA3 | laminin, alpha 3 | 0.26 |
| RHBDF1 | rhomboid 5 homolog 1 (Drosophila) | 0.26 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.26 |
| CNTLN | centlein, centrosomal protein | 0.26 |
| PDE3B | phosphodiesterase 3B, cGMP-inhibited | 0.26 |
| MLPH | melanophilin | 0.26 |
| HSP90AA4P | heat shock protein 90kDa alpha (cytosolic), class A member 4, pseudogene | 0.26 |
| R3HCC1L | R3H domain and coiled-coil containing 1-like | 0.26 |
| ZWINT | ZW10 interacting kinetochore protein | 0.26 |
| DNAJC22 | DnaJ (Hsp40) homolog, subfamily C, member 22 | 0.26 |
| ZRANB1 | zinc finger, RAN-binding domain containing 1 | 0.26 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.25 |
| UBE2A | ubiquitin-conjugating enzyme E2A | 0.25 |
| UBTD1 | ubiquitin domain containing 1 | 0.25 |
| LTBR | lymphotoxin beta receptor (TNFR superfamily, member 3) | 0.25 |
| ZNF276 | zinc finger protein 276 | 0.25 |
| CCN3 | cellular communication network factor 3 | 0.25 |
| PAH | phenylalanine hydroxylase | 0.25 |
| AEN | apoptosis enhancing nuclease | 0.24 |
| DNLZ | DNL-type zinc finger | 0.24 |
| SH3RF2 | SH3 domain containing ring finger 2 | 0.24 |
| BAIAP2 | BAI1-associated protein 2 | 0.24 |
| COX16 | COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) | 0.24 |
| PPP1R11 | protein phosphatase 1, regulatory (inhibitor) subunit 11 | 0.24 |
| MTUS2 | microtubule associated tumor suppressor candidate 2 | 0.24 |
| ITGA7 | integrin, alpha 7 | 0.24 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.24 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH13 | myosin, heavy chain 13, skeletal muscle | -1.21 |
| HIST2H2AA3 | histone cluster 2, H2aa3 | -0.69 |
| C15ORF61 | chromosome 15 open reading frame 61 | -0.65 |
| NAAA | N-acylethanolamine acid amidase | -0.59 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.55 |
| PEG10 | paternally expressed 10 | -0.51 |
| CLIC3 | chloride intracellular channel 3 | -0.49 |
| PLA2G4B | phospholipase A2, group IVB (cytosolic) | -0.49 |
| SNX15 | sorting nexin 15 | -0.47 |
| KIF27 | kinesin family member 27 | -0.47 |
| SNRPF | small nuclear ribonucleoprotein polypeptide F | -0.47 |
| ABCA12 | ATP-binding cassette, sub-family A (ABC1), member 12 | -0.42 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.42 |
| GAS8 | growth arrest-specific 8 | -0.41 |
| ABHD3 | abhydrolase domain containing 3 | -0.4 |
| UBAP1 | ubiquitin associated protein 1 | -0.4 |
| AMACR | alpha-methylacyl-CoA racemase | -0.38 |
| SIRT3 | sirtuin 3 | -0.38 |
| FAM124A | family with sequence similarity 124A | -0.38 |
| REEP1 | receptor accessory protein 1 | -0.37 |
| ECHS1 | enoyl CoA hydratase, short chain, 1, mitochondrial | -0.37 |
| IER3IP1 | immediate early response 3 interacting protein 1 | -0.36 |
| PIP | prolactin-induced protein | -0.36 |
| VGF | VGF nerve growth factor inducible | -0.35 |
| CYP27B1 | cytochrome P450, family 27, subfamily B, polypeptide 1 | -0.35 |
| TYSND1 | trypsin domain containing 1 | -0.35 |
| TM7SF3 | transmembrane 7 superfamily member 3 | -0.35 |
| MFHAS1 | malignant fibrous histiocytoma amplified sequence 1 | -0.34 |
| CCNDBP1 | cyclin D-type binding-protein 1 | -0.34 |
| CRY1 | cryptochrome circadian clock 1 | -0.34 |
| YPEL5 | yippee-like 5 (Drosophila) | -0.34 |
| STX2 | syntaxin 2 | -0.34 |
| NDOR1 | NADPH dependent diflavin oxidoreductase 1 | -0.33 |
| TTC39A | tetratricopeptide repeat domain 39A | -0.33 |
| PDP2 | pyruvate dehyrogenase phosphatase catalytic subunit 2 | -0.32 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.32 |
| PITX1 | paired-like homeodomain 1 | -0.32 |
| PPT1 | palmitoyl-protein thioesterase 1 | -0.32 |
| BRD7 | bromodomain containing 7 | -0.31 |
| FAM160A1 | family with sequence similarity 160, member A1 | -0.31 |
| HECA | headcase homolog (Drosophila) | -0.31 |
| TESC | tescalcin | -0.31 |
| ADCK5 | aarF domain containing kinase 5 | -0.3 |
| EPM2AIP1 | EPM2A (laforin) interacting protein 1 | -0.3 |
| ERO1B | endoplasmic reticulum oxidoreductase 1 beta | -0.3 |
| ZNF524 | zinc finger protein 524 | -0.3 |
| CYB5A | cytochrome b5 type A (microsomal) | -0.3 |
| UQCRH | ubiquinol-cytochrome c reductase hinge protein | -0.3 |
| SYTL1 | synaptotagmin-like 1 | -0.29 |
| RNASET2 | ribonuclease T2 | -0.29 |
| RAB27B | RAB27B, member RAS oncogene family | -0.29 |
| PEX13 | peroxisomal biogenesis factor 13 | -0.28 |
| ZSCAN31 | zinc finger and SCAN domain containing 31 | -0.28 |
| LAMA2 | laminin, alpha 2 | -0.28 |
| TAF10 | TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa | -0.28 |
| ZBTB17 | zinc finger and BTB domain containing 17 | -0.28 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -0.28 |
| COL6A3 | collagen, type VI, alpha 3 | -0.27 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.27 |
| EAF1 | ELL associated factor 1 | -0.27 |
| SPIRE2 | spire-type actin nucleation factor 2 | -0.27 |
| ATP6V1F | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F | -0.27 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | -0.27 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.27 |
| USF1 | upstream transcription factor 1 | -0.27 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | -0.27 |
| DUSP7 | dual specificity phosphatase 7 | -0.27 |
| PPTC7 | PTC7 protein phosphatase homolog (S. cerevisiae) | -0.27 |
| MIDN | midnolin | -0.27 |
| ORMDL1 | ORMDL sphingolipid biosynthesis regulator 1 | -0.26 |
| GADD45GIP1 | growth arrest and DNA-damage-inducible, gamma interacting protein 1 | -0.26 |
| DNAL4 | dynein, axonemal, light chain 4 | -0.26 |
| MITD1 | MIT, microtubule interacting and transport, domain containing 1 | -0.26 |
| GPR108 | G protein-coupled receptor 108 | -0.26 |
| ENPP5 | ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) | -0.26 |
| GSTM5 | glutathione S-transferase mu 5 | -0.26 |
| C1ORF109 | chromosome 1 open reading frame 109 | -0.26 |
| AHI1 | Abelson helper integration site 1 | -0.25 |
| MRPS14 | mitochondrial ribosomal protein S14 | -0.25 |
| PRMT6 | protein arginine methyltransferase 6 | -0.25 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.25 |
| GPR179 | G protein-coupled receptor 179 | -0.25 |
| LRP6 | low density lipoprotein receptor-related protein 6 | -0.25 |
| WDR19 | WD repeat domain 19 | -0.25 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | -0.25 |
| OGG1 | 8-oxoguanine DNA glycosylase | -0.25 |
| IL17RA | interleukin 17 receptor A | -0.25 |
| SP140 | SP140 nuclear body protein | -0.25 |
| ZNF451 | zinc finger protein 451 | -0.25 |
| VHL | von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase | -0.24 |
| S100A14 | S100 calcium binding protein A14 | -0.24 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.24 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.24 |
| PARD6G | par-6 family cell polarity regulator gamma | -0.24 |
| ETV6 | ets variant 6 | -0.24 |
| NOP10 | NOP10 ribonucleoprotein | -0.24 |
| EPN3 | epsin 3 | -0.24 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.24 |
| WARS2 | tryptophanyl tRNA synthetase 2, mitochondrial | -0.24 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | -0.24 |
