Olanzapine_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Olanzapine perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Olanzapine_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FLNA filamin A, alpha 0.152984
MYH9 myosin, heavy chain 9, non-muscle 0.09163
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0914932
FNDC3B fibronectin type III domain containing 3B 0.0693563
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0658784
HDAC9 histone deacetylase 9 0.0650184
DST dystonin 0.0648461
COL5A1 collagen, type V, alpha 1 0.0642632
VIM vimentin 0.0628451
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.061144
SEPTIN9 septin 9 0.0591698
LDHA lactate dehydrogenase A 0.057985
MAP1B microtubule-associated protein 1B 0.0577728
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0577209
PLEC plectin 0.0569082
FLNB filamin B, beta 0.056776
AKAP12 A kinase (PRKA) anchor protein 12 0.0566879
NFE2L1 nuclear factor, erythroid 2-like 1 0.0548209
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0542133
CD44 CD44 molecule (Indian blood group) 0.0530322
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0525914
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0524537
MPRIP myosin phosphatase Rho interacting protein 0.0521039
SMAD3 SMAD family member 3 0.0519211
NCOR2 nuclear receptor corepressor 2 0.0510342
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0503545
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0490471
TPM3 tropomyosin 3 0.0486651
VCL vinculin 0.0477275
RNF213 ring finger protein 213 0.0473555
DOCK5 dedicator of cytokinesis 5 0.0455205
NAV1 neuron navigator 1 0.0455069
L1CAM L1 cell adhesion molecule 0.0454926
APP amyloid beta (A4) precursor protein 0.0448657
ACTN4 actinin, alpha 4 0.0447753
MSN moesin 0.0441145
EXT1 exostosin glycosyltransferase 1 0.0439131
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0431423
SQSTM1 sequestosome 1 0.0427771
PKM pyruvate kinase, muscle 0.0424786
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0418757
SP100 SP100 nuclear antigen 0.0416313
RUNX1 runt-related transcription factor 1 0.041582
TIMP2 TIMP metallopeptidase inhibitor 2 0.0414871
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.0414196
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0414011
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0403153
RHOBTB3 Rho-related BTB domain containing 3 0.0399665
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0394998
MBNL1 muscleblind-like splicing regulator 1 0.0394959
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0391746
ASPH aspartate beta-hydroxylase 0.0382545
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0374883
PRELID2 PRELI domain containing 2 0.037398
NAV2 neuron navigator 2 0.0370485
NEK7 NIMA-related kinase 7 0.0369145
PLAT plasminogen activator, tissue 0.0364247
EEF2 eukaryotic translation elongation factor 2 0.0363473
WWTR1 WW domain containing transcription regulator 1 0.0362321
IQGAP1 IQ motif containing GTPase activating protein 1 0.0359928
SRRM2 serine/arginine repetitive matrix 2 0.0358833
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0358414
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0358335
TLE4 transducin-like enhancer of split 4 0.0354256
MB21D2 Mab-21 domain containing 2 0.0348587
SON SON DNA binding protein 0.0348287
MACF1 microtubule-actin crosslinking factor 1 0.0345462
GLIS3 GLIS family zinc finger 3 0.0334015
VEGFC vascular endothelial growth factor C 0.0333167
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0328832
PLXNA2 plexin A2 0.0328712
BCL2L1 BCL2-like 1 0.0324581
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0311149
TRIO trio Rho guanine nucleotide exchange factor 0.0303938
LAMB1 laminin, beta 1 0.0299649
SVIL supervillin 0.0298655
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0297966
RRM2 ribonucleotide reductase M2 0.029701
DSPP dentin sialophosphoprotein 0.0296554
SHB Src homology 2 domain containing adaptor protein B 0.0296356
JMJD1C jumonji domain containing 1C 0.0295399
ADAR adenosine deaminase, RNA-specific 0.0294639
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0290414
ATXN1 ataxin 1 0.0287722
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0287301
TRABD2B TraB domain containing 2B 0.0287047
GSE1 Gse1 coiled-coil protein 0.0282755
ADAM19 ADAM metallopeptidase domain 19 0.0281922
BRD2 bromodomain containing 2 0.028163
PDLIM5 PDZ and LIM domain 5 0.0280558
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.028047
DNMBP dynamin binding protein 0.0279775
MCL1 myeloid cell leukemia 1 0.0275769
RNF144A ring finger protein 144A 0.0274046
CANX calnexin 0.0270096
ADAM9 ADAM metallopeptidase domain 9 0.0267183
ZSWIM6 zinc finger, SWIM-type containing 6 0.0264893
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0259841
ITPRID2 ITPR interacting domain containing 2 0.0259723
LHFPL6 LHFPL tetraspan subfamily member 6 0.0259713

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.312872
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.20534
DLG1 discs, large homolog 1 (Drosophila) -0.137293
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.127728
ABI3BP ABI family, member 3 (NESH) binding protein -0.100647
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.093479
LOX lysyl oxidase -0.0921914
SUCNR1 succinate receptor 1 -0.0803317
THBS2 thrombospondin 2 -0.0780613
TMSB10 thymosin beta 10 -0.0651901
S100A6 S100 calcium binding protein A6 -0.0625144
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0571819
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0566695
ELL2 elongation factor, RNA polymerase II, 2 -0.0559954
COL8A1 collagen, type VIII, alpha 1 -0.0531967
AHNAK AHNAK nucleoprotein -0.0529064
HLA-B major histocompatibility complex, class I, B -0.0515592
SLC38A1 solute carrier family 38, member 1 -0.0510701
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0508402
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0501655
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0483563
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.047356
S100A10 S100 calcium binding protein A10 -0.0463496
AUTS2 autism susceptibility candidate 2 -0.0460431
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0457132
CCND1 cyclin D1 -0.0445632
MSI2 musashi RNA-binding protein 2 -0.0434839
COL1A2 collagen, type I, alpha 2 -0.042037
NDRG1 N-myc downstream regulated 1 -0.0414994
MT2A metallothionein 2A -0.0394921
CSTB cystatin B (stefin B) -0.0389252
ZEB1 zinc finger E-box binding homeobox 1 -0.0386463
SLC39A11 solute carrier family 39, member 11 -0.0369161
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.035023
FRMD4A FERM domain containing 4A -0.0345649
MEIS2 Meis homeobox 2 -0.03439
FBN1 fibrillin 1 -0.0341952
TM4SF1 transmembrane 4 L six family member 1 -0.0337678
TPT1 tumor protein, translationally-controlled 1 -0.0337533
PDIA3 protein disulfide isomerase family A, member 3 -0.0335079
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0323655
MRPS6 mitochondrial ribosomal protein S6 -0.0317188
FLT1 fms-related tyrosine kinase 1 -0.0306678
ANKRD10 ankyrin repeat domain 10 -0.0305805
RPL35A ribosomal protein L35a -0.0303975
CD99 CD99 molecule -0.0303929
PTMA prothymosin, alpha -0.0288975
PBX3 pre-B-cell leukemia homeobox 3 -0.0266098
INSIG1 insulin induced gene 1 -0.026574
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0264461
ZNF217 zinc finger protein 217 -0.0263872
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0254792
SOD2 superoxide dismutase 2, mitochondrial -0.0254572
PLAUR plasminogen activator, urokinase receptor -0.025234
ZNF292 zinc finger protein 292 -0.024448
COL3A1 collagen, type III, alpha 1 -0.0242275
KRT81 keratin 81, type II -0.0241934
RPS24 ribosomal protein S24 -0.0239417
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0238648
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0237688
HLA-C major histocompatibility complex, class I, C -0.0236778
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0231585
CAVIN1 caveolae associated protein 1 -0.0227144
GNAS GNAS complex locus -0.0213185
ZMYND8 zinc finger, MYND-type containing 8 -0.020513
SH3BP5 SH3-domain binding protein 5 (BTK-associated) -0.0202466
RPL37A ribosomal protein L37a -0.0201808
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0201207
MAML2 mastermind-like 2 (Drosophila) -0.0201056
MT1X metallothionein 1X -0.0200129
CD109 CD109 molecule -0.0194416
SPDL1 spindle apparatus coiled-coil protein 1 -0.0192613
MBD5 methyl-CpG binding domain protein 5 -0.0189172
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -0.0182231
EHBP1 EH domain binding protein 1 -0.0178416
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0176718
DYNLT1 dynein, light chain, Tctex-type 1 -0.0174777
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -0.0168655
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0168088
ULK1 unc-51 like autophagy activating kinase 1 -0.0165961
WTAP Wilms tumor 1 associated protein -0.0165904
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0163004
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0162891
MMP12 matrix metallopeptidase 12 -0.0161735
H3-3B H3.3 histone B -0.0159667
NT5C2 5'-nucleotidase, cytosolic II -0.0159573
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0157348
RNF169 ring finger protein 169 -0.0156934
SNX14 sorting nexin 14 -0.0156099
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0154113
UGCG UDP-glucose ceramide glucosyltransferase -0.0152369
COL1A1 collagen, type I, alpha 1 -0.0151801
FNBP1 formin binding protein 1 -0.0151191
CD47 CD47 molecule -0.0149735
DGKG diacylglycerol kinase, gamma 90kDa -0.0148982
TTC3 tetratricopeptide repeat domain 3 -0.0148938
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0147989
USP3 ubiquitin specific peptidase 3 -0.0147364
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 -0.0147161
BTG1 B-cell translocation gene 1, anti-proliferative -0.014638