| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Olanzapine perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Olanzapine_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.118893 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.116196 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.110695 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.106069 |
| HMGA2 | high mobility group AT-hook 2 | 0.100497 |
| YAP1 | Yes-associated protein 1 | 0.0791965 |
| RRM2 | ribonucleotide reductase M2 | 0.076944 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0732248 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0706517 |
| VIM | vimentin | 0.0695108 |
| INTS6 | integrator complex subunit 6 | 0.0650061 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0626678 |
| DENND5A | DENN/MADD domain containing 5A | 0.0587543 |
| ADIPOR2 | adiponectin receptor 2 | 0.057932 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0533243 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0532407 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0497289 |
| TMSB10 | thymosin beta 10 | 0.0470057 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.046979 |
| FLNA | filamin A, alpha | 0.0454761 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0445804 |
| WWOX | WW domain containing oxidoreductase | 0.0436385 |
| TPI1 | triosephosphate isomerase 1 | 0.0414969 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0408673 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0395954 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0388163 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0381678 |
| RCOR1 | REST corepressor 1 | 0.0369735 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0366218 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0356581 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0343779 |
| HOMER1 | homer scaffolding protein 1 | 0.0340715 |
| YBX3 | Y box binding protein 3 | 0.0340166 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0337568 |
| RBM19 | RNA binding motif protein 19 | 0.0337337 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0336803 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0326705 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0321842 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.031199 |
| BRD2 | bromodomain containing 2 | 0.0310811 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.030889 |
| AHRR | aryl-hydrocarbon receptor repressor | 0.03077 |
| FADS2 | fatty acid desaturase 2 | 0.0307194 |
| TNRC18 | trinucleotide repeat containing 18 | 0.0305964 |
| STIP1 | stress-induced phosphoprotein 1 | 0.0299943 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0299165 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0295708 |
| RTN4 | reticulon 4 | 0.0290443 |
| GSK3B | glycogen synthase kinase 3 beta | 0.028679 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0285412 |
| DIAPH1 | diaphanous-related formin 1 | 0.0281691 |
| NRXN3 | neurexin 3 | 0.0276556 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0276307 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0271398 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0271021 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0270871 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0270663 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0266739 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0259075 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0258625 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0257467 |
| HDAC9 | histone deacetylase 9 | 0.025303 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0252693 |
| ASXL2 | additional sex combs like transcriptional regulator 2 | 0.025135 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0250243 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | 0.0249486 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0246769 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.0246237 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0244756 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0244719 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0243214 |
| AUTS2 | autism susceptibility candidate 2 | 0.0241604 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0240353 |
| RPS4X | ribosomal protein S4, X-linked | 0.0239254 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0238762 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0237959 |
| CMIP | c-Maf inducing protein | 0.0236377 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0235591 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0235406 |
| RSU1 | Ras suppressor protein 1 | 0.0234574 |
| RPS9 | ribosomal protein S9 | 0.0233203 |
| ZNF638 | zinc finger protein 638 | 0.0232309 |
| POLA1 | polymerase (DNA directed), alpha 1, catalytic subunit | 0.0230507 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0228022 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0227658 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0226242 |
| CPNE1 | copine I | 0.0224013 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0222989 |
| MCF2L | MCF.2 cell line derived transforming sequence-like | 0.0222039 |
| DCAF8 | DDB1 and CUL4 associated factor 8 | 0.0220573 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0219946 |
| RPS12 | ribosomal protein S12 | 0.0219925 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | 0.0219285 |
| SKI | SKI proto-oncogene | 0.0215859 |
| H1-5 | H1.5 linker histone, cluster member | 0.0215588 |
| SERTAD2 | SERTA domain containing 2 | 0.0215479 |
| GSE1 | Gse1 coiled-coil protein | 0.0213707 |
| LARP4B | La ribonucleoprotein domain family, member 4B | 0.0213253 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.0212543 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0212091 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.142883 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.125061 |
| MMP12 | matrix metallopeptidase 12 | -0.103045 |
| EHBP1 | EH domain binding protein 1 | -0.0877661 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0754315 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.0648388 |
| SYT1 | synaptotagmin I | -0.0633001 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0632574 |
| ANXA1 | annexin A1 | -0.0611791 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0607255 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0591265 |
| ZNF804A | zinc finger protein 804A | -0.0585801 |
| TMEM41B | transmembrane protein 41B | -0.0578495 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0576165 |
| RASAL2 | RAS protein activator like 2 | -0.0572595 |
| TMEM123 | transmembrane protein 123 | -0.0501514 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0490002 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0485199 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0480222 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0476629 |
| CLDN1 | claudin 1 | -0.046931 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0417877 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0408931 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0390928 |
| NLGN1 | neuroligin 1 | -0.0390712 |
| KIF5B | kinesin family member 5B | -0.0388588 |
| BCHE | butyrylcholinesterase | -0.0381817 |
| PRR11 | proline rich 11 | -0.037536 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0373662 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0372972 |
| NF1 | neurofibromin 1 | -0.0371935 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0364393 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0363247 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0353452 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0350193 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0347759 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0346567 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0342183 |
| MGAT4C | MGAT4 family, member C | -0.034198 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0334638 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0334188 |
| S100A6 | S100 calcium binding protein A6 | -0.0333824 |
| AHNAK | AHNAK nucleoprotein | -0.0333646 |
| VMP1 | vacuole membrane protein 1 | -0.0330086 |
| KIF18B | kinesin family member 18B | -0.0326555 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.031982 |
| WDR43 | WD repeat domain 43 | -0.0319744 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0314358 |
| SBF2 | SET binding factor 2 | -0.0312969 |
| CENPF | centromere protein F, 350/400kDa | -0.031149 |
| RAP1GDS1 | RAP1, GTP-GDP dissociation stimulator 1 | -0.0305679 |
| ECT2 | epithelial cell transforming 2 | -0.0303454 |
| PARD3 | par-3 family cell polarity regulator | -0.0301547 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0290794 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0290242 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0289297 |
| THOC2 | THO complex 2 | -0.0283971 |
| AREG | amphiregulin | -0.028222 |
| CDK17 | cyclin-dependent kinase 17 | -0.0280397 |
| MKI67 | marker of proliferation Ki-67 | -0.0278143 |
| NAV3 | neuron navigator 3 | -0.0271525 |
| CENPE | centromere protein E, 312kDa | -0.027063 |
| TSPAN5 | tetraspanin 5 | -0.0270585 |
| MAP4 | microtubule-associated protein 4 | -0.0269461 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -0.0267935 |
| WDR45B | WD repeat domain 45B | -0.0267647 |
| ZNF292 | zinc finger protein 292 | -0.0266578 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0264704 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.0264677 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.025881 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0258686 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.025547 |
| RPL36A | ribosomal protein L36a | -0.0254533 |
| BPTF | bromodomain PHD finger transcription factor | -0.0253492 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0252003 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0249928 |
| LARP1 | La ribonucleoprotein domain family, member 1 | -0.0247331 |
| H1-0 | H1.0 linker histone | -0.02467 |
| ZFP64 | ZFP64 zinc finger protein | -0.0243302 |
| PRR16 | proline rich 16 | -0.0243244 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0242902 |
| FSTL5 | follistatin-like 5 | -0.0241772 |
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | -0.0241157 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0240714 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | -0.0240541 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0239555 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0239161 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0238997 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0238697 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0238569 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.023768 |
| TWSG1 | twisted gastrulation BMP signaling modulator 1 | -0.0235772 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | -0.0235668 |
| RPS6 | ribosomal protein S6 | -0.0234509 |
| NHSL1 | NHS-like 1 | -0.0231342 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0230847 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0230681 |
| HLTF | helicase-like transcription factor | -0.0226606 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0226251 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | -0.0223858 |
