Olanzapine_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Olanzapine perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Olanzapine_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VCL vinculin 0.184007
EXT1 exostosin glycosyltransferase 1 0.125962
VIM vimentin 0.122953
AKAP12 A kinase (PRKA) anchor protein 12 0.116595
PLAT plasminogen activator, tissue 0.0922631
MYH9 myosin, heavy chain 9, non-muscle 0.0818735
TLE4 transducin-like enhancer of split 4 0.0811466
ZSWIM6 zinc finger, SWIM-type containing 6 0.0734707
TPM1 tropomyosin 1 (alpha) 0.0695048
THSD4 thrombospondin, type I, domain containing 4 0.0687495
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0655122
NPAS2 neuronal PAS domain protein 2 0.0627382
SLIT2 slit homolog 2 (Drosophila) 0.0592002
MACF1 microtubule-actin crosslinking factor 1 0.0576089
SEPTIN9 septin 9 0.0550844
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0536229
MCL1 myeloid cell leukemia 1 0.0532791
TIMP3 TIMP metallopeptidase inhibitor 3 0.0518695
LPP LIM domain containing preferred translocation partner in lipoma 0.0495095
ANTXR1 anthrax toxin receptor 1 0.0483354
CEMIP cell migration inducing protein, hyaluronan binding 0.0468132
RPS3 ribosomal protein S3 0.0463618
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.046333
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0439276
RAD51B RAD51 paralog B 0.0419955
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0419086
MYO1E myosin IE 0.0419049
FN1 fibronectin 1 0.0406795
RPS12 ribosomal protein S12 0.0397432
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0383649
PDLIM5 PDZ and LIM domain 5 0.0380386
BICD1 bicaudal D homolog 1 (Drosophila) 0.0379904
FLNB filamin B, beta 0.0379009
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0378577
CRH corticotropin releasing hormone 0.0374041
CALD1 caldesmon 1 0.0370015
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0356928
FAM107B family with sequence similarity 107, member B 0.0354788
TPM4 tropomyosin 4 0.0353894
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.035095
VMP1 vacuole membrane protein 1 0.034613
ACTN1 actinin, alpha 1 0.0343637
RNF213 ring finger protein 213 0.0337305
FNDC3B fibronectin type III domain containing 3B 0.0336562
ASPH aspartate beta-hydroxylase 0.033616
SIK2 salt-inducible kinase 2 0.0335775
PACS1 phosphofurin acidic cluster sorting protein 1 0.0331567
CTNND1 catenin (cadherin-associated protein), delta 1 0.0330821
FERMT2 fermitin family member 2 0.0330104
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0328244
HOMER1 homer scaffolding protein 1 0.0321564
RPL19 ribosomal protein L19 0.0320519
AMOTL1 angiomotin like 1 0.0313415
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0313013
NRG1 neuregulin 1 0.0312259
TIMP2 TIMP metallopeptidase inhibitor 2 0.031154
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0310866
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0310401
MSI2 musashi RNA-binding protein 2 0.0309627
NFE2L1 nuclear factor, erythroid 2-like 1 0.0307918
PRKCA protein kinase C, alpha 0.03066
SMAD3 SMAD family member 3 0.0305924
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0302546
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0300753
PTPRM protein tyrosine phosphatase, receptor type, M 0.0299062
PDE10A phosphodiesterase 10A 0.0297453
DNM3 dynamin 3 0.0292067
PTPRE protein tyrosine phosphatase, receptor type, E 0.0290565
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0283129
NES nestin 0.0281913
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0279346
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0276092
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0275249
EPAS1 endothelial PAS domain protein 1 0.0273072
EGR1 early growth response 1 0.0272669
RCOR1 REST corepressor 1 0.0270203
ANKRD11 ankyrin repeat domain 11 0.026978
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0269728
B2M beta-2-microglobulin 0.0269415
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.026838
RAB7A RAB7A, member RAS oncogene family 0.0267343
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.0267329
IGFBP5 insulin-like growth factor binding protein 5 0.0264464
RPL23 ribosomal protein L23 0.02633
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.026153
BPTF bromodomain PHD finger transcription factor 0.0259433
CADM1 cell adhesion molecule 1 0.025665
CDH13 cadherin 13 0.0253613
SP100 SP100 nuclear antigen 0.0253239
VEGFA vascular endothelial growth factor A 0.0252382
STK38L serine/threonine kinase 38 like 0.0252093
SETBP1 SET binding protein 1 0.0251628
FLT1 fms-related tyrosine kinase 1 0.0250811
FRMD5 FERM domain containing 5 0.0248124
PDE4D phosphodiesterase 4D, cAMP-specific 0.024381
HILPDA hypoxia inducible lipid droplet-associated 0.0242401
LSAMP limbic system-associated membrane protein 0.0241273
SMG6 SMG6 nonsense mediated mRNA decay factor 0.0240059
GREM2 gremlin 2, DAN family BMP antagonist 0.0239332
GLI2 GLI family zinc finger 2 0.0238772

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.290881
IGF2 insulin-like growth factor 2 -0.277647
LPIN1 lipin 1 -0.0902243
MEIS2 Meis homeobox 2 -0.0816955
SOS1 son of sevenless homolog 1 (Drosophila) -0.0744332
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0719605
COL1A1 collagen, type I, alpha 1 -0.069872
NCAM2 neural cell adhesion molecule 2 -0.0689242
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0687429
SYT1 synaptotagmin I -0.0671081
NPEPPS aminopeptidase puromycin sensitive -0.0496448
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0485056
MAP1B microtubule-associated protein 1B -0.0467315
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0418654
ZNF292 zinc finger protein 292 -0.0407289
NAMPT nicotinamide phosphoribosyltransferase -0.0401973
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0391416
GOLGA4 golgin A4 -0.0382909
HAND2 heart and neural crest derivatives expressed 2 -0.0375803
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0360951
ZMYM2 zinc finger, MYM-type 2 -0.0359463
DPH6 diphthamine biosynthesis 6 -0.0353258
FBXL20 F-box and leucine-rich repeat protein 20 -0.0347153
HELZ helicase with zinc finger -0.0330969
USP3 ubiquitin specific peptidase 3 -0.033087
GPC5 glypican 5 -0.0324653
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0322515
WDR45B WD repeat domain 45B -0.0315087
OGA O-GlcNAcase -0.0314691
ANGPT1 angiopoietin 1 -0.0312904
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0311992
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0300714
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0294607
DLC1 DLC1 Rho GTPase activating protein -0.0276956
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.027309
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0270716
AOPEP aminopeptidase O (putative) -0.0262856
MATR3 matrin 3 -0.0259455
CADM2 cell adhesion molecule 2 -0.0253854
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.025108
MBD5 methyl-CpG binding domain protein 5 -0.0249235
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.024477
GNA13 guanine nucleotide binding protein (G protein), alpha 13 -0.0241111
CDC27 cell division cycle 27 -0.0238891
ZNF654 zinc finger protein 654 -0.0233248
TNPO1 transportin 1 -0.0232288
CD36 CD36 molecule (thrombospondin receptor) -0.0232168
AUTS2 autism susceptibility candidate 2 -0.0229671
SCAF11 SR-related CTD-associated factor 11 -0.0227884
FRMD4A FERM domain containing 4A -0.0225065
PUM2 pumilio RNA-binding family member 2 -0.0219862
TENT5A terminal nucleotidyltransferase 5A -0.0213642
NRIP1 nuclear receptor interacting protein 1 -0.0213169
GNAS GNAS complex locus -0.0212095
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0208718
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0208668
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.020812
PHOX2B paired-like homeobox 2b -0.0205514
DSCAM Down syndrome cell adhesion molecule -0.0205177
PRKD1 protein kinase D1 -0.0203335
MARCHF6 membrane associated ring-CH-type finger 6 -0.0202533
RFC3 replication factor C (activator 1) 3, 38kDa -0.0202382
USP9Y ubiquitin specific peptidase 9, Y-linked -0.0201849
H3-3B H3.3 histone B -0.020142
ADGRG6 adhesion G protein-coupled receptor G6 -0.0201409
GPHN gephyrin -0.0201256
PNISR PNN-interacting serine/arginine-rich protein -0.019834
NREP neuronal regeneration related protein -0.0197754
TULP4 tubby like protein 4 -0.0195626
NUP58 nucleoporin 58 -0.0195384
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0193549
HAS2 hyaluronan synthase 2 -0.0192348
FNBP1 formin binding protein 1 -0.0191997
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0191416
PRTG protogenin -0.0191156
TCERG1 transcription elongation regulator 1 -0.0188379
PHF3 PHD finger protein 3 -0.01874
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.018644
RPL38 ribosomal protein L38 -0.0185454
LMAN1 lectin, mannose-binding, 1 -0.018477
CLTC clathrin, heavy chain (Hc) -0.0183413
ANAPC5 anaphase promoting complex subunit 5 -0.0182777
WDR36 WD repeat domain 36 -0.0179938
ZNF804A zinc finger protein 804A -0.017953
SBNO1 strawberry notch homolog 1 (Drosophila) -0.0179343
ZFC3H1 zinc finger, C3H1-type containing -0.0178787
SEPTIN2 septin 2 -0.0177222
TNRC6A trinucleotide repeat containing 6A -0.0176955
CSDE1 cold shock domain containing E1, RNA-binding -0.0176574
ANKRD10 ankyrin repeat domain 10 -0.0175204
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0171646
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.0170733
RTN4 reticulon 4 -0.0170579
OLA1 Obg-like ATPase 1 -0.016884
ZFAND6 zinc finger, AN1-type domain 6 -0.01671
ATXN10 ataxin 10 -0.016645
RALYL RALY RNA binding protein-like -0.0165216
ACTG1 actin gamma 1 -0.0163262
INTS2 integrator complex subunit 2 -0.0163106
CCT8 chaperonin containing TCP1, subunit 8 (theta) -0.0162972