Olanzapine_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Olanzapine perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Olanzapine_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CEMIP cell migration inducing protein, hyaluronan binding 0.0731367
VCL vinculin 0.0713505
LAMA4 laminin, alpha 4 0.0571269
EXT1 exostosin glycosyltransferase 1 0.0512373
AREG amphiregulin 0.0483368
MYH9 myosin, heavy chain 9, non-muscle 0.0476638
MACF1 microtubule-actin crosslinking factor 1 0.0469112
FAT1 FAT atypical cadherin 1 0.0460384
MYO1E myosin IE 0.0443162
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0404034
ITPRID2 ITPR interacting domain containing 2 0.0384293
PDLIM5 PDZ and LIM domain 5 0.0373486
ACTN4 actinin, alpha 4 0.0326006
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0318676
KRT18 keratin 18, type I 0.0309845
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0306948
NDRG1 N-myc downstream regulated 1 0.029736
CTNND1 catenin (cadherin-associated protein), delta 1 0.0295313
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0294339
KLF5 Kruppel-like factor 5 (intestinal) 0.0289423
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0281822
AKAP13 A kinase (PRKA) anchor protein 13 0.0277185
TUFT1 tuftelin 1 0.0276592
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0273787
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0268118
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0261408
KLF6 Kruppel-like factor 6 0.0248244
LOC102724023 ES1 protein homolog, mitochondrial 0.0240884
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0240595
SHB Src homology 2 domain containing adaptor protein B 0.0237596
SOX9 SRY (sex determining region Y)-box 9 0.0237079
NCEH1 neutral cholesterol ester hydrolase 1 0.0235091
FLNA filamin A, alpha 0.0231529
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0229887
EGFR epidermal growth factor receptor 0.022784
MUC13 mucin 13, cell surface associated 0.0225167
SMAD3 SMAD family member 3 0.0224146
MYO5B myosin VB 0.0222965
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0219311
PLEC plectin 0.0218727
CLDN4 claudin 4 0.0217855
MCL1 myeloid cell leukemia 1 0.0217356
MBNL1 muscleblind-like splicing regulator 1 0.0215367
GADD45A growth arrest and DNA-damage-inducible, alpha 0.0213582
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0212248
JARID2 jumonji, AT rich interactive domain 2 0.021028
MARCHF3 membrane associated ring-CH-type finger 3 0.0207601
LMO7 LIM domain 7 0.0206707
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.0206499
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0204668
LURAP1L leucine rich adaptor protein 1-like 0.0202463
ARHGAP42 Rho GTPase activating protein 42 0.0201628
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0198311
PDE10A phosphodiesterase 10A 0.0196575
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0196572
ASPH aspartate beta-hydroxylase 0.0195067
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0193062
MPRIP myosin phosphatase Rho interacting protein 0.0191377
ADARB1 adenosine deaminase, RNA-specific, B1 0.0191092
SEPTIN9 septin 9 0.0189931
CEMIP2 cell migration inducing hyaluronidase 2 0.0188249
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0187736
EPS8 epidermal growth factor receptor pathway substrate 8 0.0187615
ARHGAP26 Rho GTPase activating protein 26 0.0180575
DUSP16 dual specificity phosphatase 16 0.0175081
INTS6 integrator complex subunit 6 0.0174514
ERRFI1 ERBB receptor feedback inhibitor 1 0.0168847
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0168527
PLAUR plasminogen activator, urokinase receptor 0.0166782
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0166253
ADGRV1 adhesion G protein-coupled receptor V1 0.016491
MYH14 myosin, heavy chain 14, non-muscle 0.016459
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0164285
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0161196
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0160017
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0156986
CAPRIN2 caprin family member 2 0.0156023
WWOX WW domain containing oxidoreductase 0.0155587
HBEGF heparin-binding EGF-like growth factor 0.015503
TOM1L2 target of myb1-like 2 (chicken) 0.0154981
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.0152372
ARGLU1 arginine and glutamate rich 1 0.0149295
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.0148983
SMAD2 SMAD family member 2 0.0148807
WDR1 WD repeat domain 1 0.0148348
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0147201
CDPF1 cysteine-rich, DPF motif domain containing 1 0.0146611
TRIM2 tripartite motif containing 2 0.0145623
IER2 immediate early response 2 0.014439
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0144255
TRA2B transformer 2 beta homolog (Drosophila) 0.0142341
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0141291
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0139623
APLP2 amyloid beta (A4) precursor-like protein 2 0.0139249
STK38L serine/threonine kinase 38 like 0.0137927
DUSP4 dual specificity phosphatase 4 0.0137273
NRXN3 neurexin 3 0.0136294
CATSPERB catsper channel auxiliary subunit beta 0.0135525
GAK cyclin G associated kinase 0.0134739
LIPH lipase, member H 0.0134405

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.220343
NPSR1 neuropeptide S receptor 1 -0.217915
PTMA prothymosin, alpha -0.188246
MUC6 mucin 6, oligomeric mucus/gel-forming -0.125334
TMSB10 thymosin beta 10 -0.121657
RPS6 ribosomal protein S6 -0.118074
NALF1 NALCN channel auxiliary factor 1 -0.111802
ANXA2 annexin A2 -0.102816
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0958404
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0890604
RPL35A ribosomal protein L35a -0.0866342
ALCAM activated leukocyte cell adhesion molecule -0.0816334
S100A6 S100 calcium binding protein A6 -0.0768223
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0747594
ACTG1 actin gamma 1 -0.0743043
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0731759
ITGA6 integrin, alpha 6 -0.0716647
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0692865
GREB1L growth regulation by estrogen in breast cancer-like -0.0688573
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0669757
AHNAK AHNAK nucleoprotein -0.0661986
CALB1 calbindin 1, 28kDa -0.0642927
RPS8 ribosomal protein S8 -0.0624152
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0615743
POTEF POTE ankyrin domain family, member F -0.057351
RPL34 ribosomal protein L34 -0.0533822
GPHN gephyrin -0.0502431
RPS23 ribosomal protein S23 -0.0470132
RPLP0 ribosomal protein, large, P0 -0.0459523
RPLP1 ribosomal protein, large, P1 -0.0456381
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0453435
SBF2 SET binding factor 2 -0.0443669
KIF5B kinesin family member 5B -0.0437244
ESYT2 extended synaptotagmin-like protein 2 -0.0422504
RPS21 ribosomal protein S21 -0.0397327
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0397262
ENO1 enolase 1, (alpha) -0.0396475
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0393594
PATJ PATJ crumbs cell polarity complex component -0.0388989
RNF217 ring finger protein 217 -0.0388108
EPCAM epithelial cell adhesion molecule -0.0387574
GCC2 GRIP and coiled-coil domain containing 2 -0.0386855
DEK DEK proto-oncogene -0.038228
LOC112694756 uncharaterized LOC112694756 -0.0378401
RPL8 ribosomal protein L8 -0.0377532
PDIA3 protein disulfide isomerase family A, member 3 -0.0376984
NFIA nuclear factor I/A -0.0376331
MAP4 microtubule-associated protein 4 -0.0376119
ANTXR2 anthrax toxin receptor 2 -0.0375567
RPS13 ribosomal protein S13 -0.0374389
RPS27A ribosomal protein S27a -0.037419
GOLGA4 golgin A4 -0.036942
FLNB filamin B, beta -0.0367767
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0367569
EHBP1 EH domain binding protein 1 -0.0363861
LDHA lactate dehydrogenase A -0.0353381
PKM pyruvate kinase, muscle -0.0351744
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0349298
PPARG peroxisome proliferator-activated receptor gamma -0.0344538
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0342211
CENPF centromere protein F, 350/400kDa -0.0339438
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0338441
RPL32 ribosomal protein L32 -0.0337992
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0334671
AKAP9 A kinase (PRKA) anchor protein 9 -0.0333747
HMGB1 high mobility group box 1 -0.0332883
RPS25 ribosomal protein S25 -0.0331548
AGR2 anterior gradient 2 -0.0329838
ATP5F1B ATP synthase F1 subunit beta -0.0327028
S100A10 S100 calcium binding protein A10 -0.0326586
KRT8 keratin 8, type II -0.0325716
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0323076
SERBP1 SERPINE1 mRNA binding protein 1 -0.0317045
MLEC malectin -0.0310843
BACE2 beta-site APP-cleaving enzyme 2 -0.0309238
TPM4 tropomyosin 4 -0.0307759
PNISR PNN-interacting serine/arginine-rich protein -0.0306175
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0302424
WDR45B WD repeat domain 45B -0.0301722
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0298386
LMNA lamin A/C -0.0298241
PTPRR protein tyrosine phosphatase, receptor type, R -0.0298024
FAF1 Fas (TNFRSF6) associated factor 1 -0.0295637
SLC35F3 solute carrier family 35, member F3 -0.0294411
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0292494
DLG1 discs, large homolog 1 (Drosophila) -0.0291907
ARFGEF3 ARFGEF family member 3 -0.0289893
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0286132
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0286113
RTN4 reticulon 4 -0.0285766
PTK2 protein tyrosine kinase 2 -0.0285194
KTN1 kinectin 1 (kinesin receptor) -0.0283566
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0281957
TFF1 trefoil factor 1 -0.0281559
FNBP1L formin binding protein 1-like -0.0280801
RPL5 ribosomal protein L5 -0.028071
SRPK1 SRSF protein kinase 1 -0.028048
MTDH metadherin -0.0279998
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0279783
EZR ezrin -0.0279245