Olanzapine_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Olanzapine perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Olanzapine_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.141706
VIM vimentin 0.11752
FN1 fibronectin 1 0.115813
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.100286
EGFR epidermal growth factor receptor 0.0959763
SMAD3 SMAD family member 3 0.0949857
AHNAK AHNAK nucleoprotein 0.0864523
EFNA5 ephrin-A5 0.0856013
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0834935
PSD3 pleckstrin and Sec7 domain containing 3 0.0781713
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0744811
FLNB filamin B, beta 0.072439
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0713552
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0688815
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0685666
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0682428
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0679443
TPT1 tumor protein, translationally-controlled 1 0.067136
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0668672
LIMCH1 LIM and calponin homology domains 1 0.0664737
NALF1 NALCN channel auxiliary factor 1 0.063744
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0626642
MYOF myoferlin 0.0607005
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0596548
SMAD2 SMAD family member 2 0.0576682
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.057327
GPC6 glypican 6 0.0565976
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0561655
BMAL2 basic helix-loop-helix ARNT like 2 0.0530452
TXNRD1 thioredoxin reductase 1 0.0495129
BACE2 beta-site APP-cleaving enzyme 2 0.0493479
PTPRM protein tyrosine phosphatase, receptor type, M 0.0492325
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0492323
ASPH aspartate beta-hydroxylase 0.0489931
CTBP2 C-terminal binding protein 2 0.0477295
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0462018
NPAS2 neuronal PAS domain protein 2 0.0459572
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0456459
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0450436
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.044239
LIMS1 LIM and senescent cell antigen-like domains 1 0.0434014
TENM3 teneurin transmembrane protein 3 0.0423121
USP53 ubiquitin specific peptidase 53 0.0422501
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0420511
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0419932
HMGA2 high mobility group AT-hook 2 0.0418508
ZEB1 zinc finger E-box binding homeobox 1 0.0417526
VCL vinculin 0.0413351
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0404823
LAMC2 laminin, gamma 2 0.0402751
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0395796
SEPTIN9 septin 9 0.0391205
DSCAM Down syndrome cell adhesion molecule 0.0391189
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0387321
BBX bobby sox homolog (Drosophila) 0.0386259
CDH13 cadherin 13 0.0384092
FER fer (fps/fes related) tyrosine kinase 0.0384018
CTSB cathepsin B 0.0382315
NFE2L2 nuclear factor, erythroid 2-like 2 0.0379916
DOCK5 dedicator of cytokinesis 5 0.0379443
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0375381
AK1 adenylate kinase 1 0.0369419
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0369263
ANKRD28 ankyrin repeat domain 28 0.0367332
CAPN2 calpain 2, (m/II) large subunit 0.0364166
CTNND1 catenin (cadherin-associated protein), delta 1 0.0363466
FAT1 FAT atypical cadherin 1 0.0362457
ATF4 activating transcription factor 4 0.0361341
IGFBP3 insulin-like growth factor binding protein 3 0.0359351
MYH9 myosin, heavy chain 9, non-muscle 0.0359123
RBM6 RNA binding motif protein 6 0.0357305
ZBTB20 zinc finger and BTB domain containing 20 0.0357035
NT5E 5'-nucleotidase, ecto (CD73) 0.0349083
ACIN1 apoptotic chromatin condensation inducer 1 0.0348408
EPS8 epidermal growth factor receptor pathway substrate 8 0.0347877
CUL3 cullin 3 0.0346908
FRMD5 FERM domain containing 5 0.0346226
OXR1 oxidation resistance 1 0.0345791
PRRC2B proline-rich coiled-coil 2B 0.0344006
CSNK2A2 casein kinase 2, alpha prime polypeptide 0.0342564
LMO7 LIM domain 7 0.0341276
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0339211
NCOA3 nuclear receptor coactivator 3 0.0336968
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0336477
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0335591
THSD4 thrombospondin, type I, domain containing 4 0.0335474
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.0328882
TRIO trio Rho guanine nucleotide exchange factor 0.0326359
BABAM2 BRISC and BRCA1 A complex member 2 0.0325907
LCOR ligand dependent nuclear receptor corepressor 0.0324535
CNKSR3 CNKSR family member 3 0.031955
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0317423
GLIS3 GLIS family zinc finger 3 0.03166
PRELID2 PRELI domain containing 2 0.031622
FRMD4A FERM domain containing 4A 0.0314409
SDCCAG8 serologically defined colon cancer antigen 8 0.031263
JAK1 Janus kinase 1 0.0311386
MYO9B myosin IXB 0.0311189
RNF130 ring finger protein 130 0.0310753
CDK13 cyclin-dependent kinase 13 0.0305182

decreased expression

Symbol Name Standardized Value
GRB10 growth factor receptor-bound protein 10 -0.174669
NDRG1 N-myc downstream regulated 1 -0.143516
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.131516
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.11098
ATOSA atos homolog A -0.105352
MXD1 MAX dimerization protein 1 -0.103751
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.100233
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.086166
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0715853
ELL2 elongation factor, RNA polymerase II, 2 -0.0700047
FTH1 ferritin, heavy polypeptide 1 -0.0651366
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0650449
PDE4D phosphodiesterase 4D, cAMP-specific -0.0638839
IGF2 insulin-like growth factor 2 -0.0636059
FTL ferritin, light polypeptide -0.0618831
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0618702
SPAG9 sperm associated antigen 9 -0.0608114
GLCCI1 glucocorticoid induced 1 -0.0603031
RIGI RNA sensor RIG-I -0.0595362
RNF149 ring finger protein 149 -0.0579091
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0577903
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0569702
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0561883
WSB1 WD repeat and SOCS box containing 1 -0.0546321
PLAUR plasminogen activator, urokinase receptor -0.0543413
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0539587
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0534474
EGR1 early growth response 1 -0.052768
FMN1 formin 1 -0.0521895
NEMF nuclear export mediator factor -0.0500043
TMOD3 tropomodulin 3 (ubiquitous) -0.04879
LSAMP limbic system-associated membrane protein -0.0486814
MCTP2 multiple C2 domains, transmembrane 2 -0.047938
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0479262
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0472802
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0469823
ZMYND8 zinc finger, MYND-type containing 8 -0.0468323
PTEN phosphatase and tensin homolog -0.0467722
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0465525
ISG20 interferon stimulated exonuclease gene 20kDa -0.0455208
POTEF POTE ankyrin domain family, member F -0.0450472
GLS2 glutaminase 2 (liver, mitochondrial) -0.0449922
SACK1A scaffolding CK1 anchoring protein A -0.0448276
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0444323
RPL35A ribosomal protein L35a -0.0443694
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.043663
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0436618
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0435344
MYO1E myosin IE -0.0429798
TENT5A terminal nucleotidyltransferase 5A -0.0424178
C6ORF132 chromosome 6 open reading frame 132 -0.0423169
NAP1L4 nucleosome assembly protein 1-like 4 -0.0422773
USP3 ubiquitin specific peptidase 3 -0.0416503
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0415859
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0415418
TLK1 tousled-like kinase 1 -0.0415271
NPTN neuroplastin -0.0409586
MBD5 methyl-CpG binding domain protein 5 -0.0404042
NKD1 naked cuticle homolog 1 (Drosophila) -0.0401077
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0397993
UBE2H ubiquitin-conjugating enzyme E2H -0.0397874
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0390012
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0387148
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0383178
DOCK4 dedicator of cytokinesis 4 -0.0381096
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0378474
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.037755
ZFAND3 zinc finger, AN1-type domain 3 -0.0377326
ZNF638 zinc finger protein 638 -0.0376531
NAP1L1 nucleosome assembly protein 1-like 1 -0.0371999
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0371583
MAML2 mastermind-like 2 (Drosophila) -0.0366509
HLA-B major histocompatibility complex, class I, B -0.0366326
IL6ST interleukin 6 signal transducer -0.0365541
REPS1 RALBP1 associated Eps domain containing 1 -0.0358788
TUT4 terminal uridylyl transferase 4 -0.0357768
GCC2 GRIP and coiled-coil domain containing 2 -0.0357297
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0356856
KYNU kynureninase -0.0354087
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0353784
PICALM phosphatidylinositol binding clathrin assembly protein -0.0353096
KHDC4 KH domain containing 4, pre-mRNA splicing factor -0.0351523
CDK6 cyclin-dependent kinase 6 -0.0351262
KPNB1 karyopherin (importin) beta 1 -0.0349574
NIPBL Nipped-B homolog (Drosophila) -0.0345769
SDC4 syndecan 4 -0.0344639
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -0.0343551
CSNK1A1 casein kinase 1, alpha 1 -0.0340216
NAMPT nicotinamide phosphoribosyltransferase -0.0336784
HELZ helicase with zinc finger -0.0331489
CD2AP CD2-associated protein -0.0322136
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 -0.0320583
PDIA3 protein disulfide isomerase family A, member 3 -0.0320345
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.031833
B2M beta-2-microglobulin -0.0317402
RPL23 ribosomal protein L23 -0.0316486
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0315127
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0313209
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0310175
MXI1 MAX interactor 1, dimerization protein -0.0308277