Olanzapine_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Olanzapine perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Olanzapine_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.134634
MCL1 myeloid cell leukemia 1 0.128204
PDE4D phosphodiesterase 4D, cAMP-specific 0.107181
THSD4 thrombospondin, type I, domain containing 4 0.0959529
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0946863
IGF1R insulin-like growth factor 1 receptor 0.0858221
ZSWIM6 zinc finger, SWIM-type containing 6 0.074725
HOMER1 homer scaffolding protein 1 0.0713355
ELL2 elongation factor, RNA polymerase II, 2 0.0708338
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0692079
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0662584
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0633339
OSMR oncostatin M receptor 0.0630543
WWOX WW domain containing oxidoreductase 0.0623765
GRAMD1B GRAM domain containing 1B 0.060561
RAB7A RAB7A, member RAS oncogene family 0.0602136
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0562105
VCL vinculin 0.0552097
TRIP12 thyroid hormone receptor interactor 12 0.0544155
RIMS2 regulating synaptic membrane exocytosis 2 0.0533314
INTS6 integrator complex subunit 6 0.0532039
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0498157
PDLIM5 PDZ and LIM domain 5 0.0491788
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0485527
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0463864
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0457078
PDE10A phosphodiesterase 10A 0.0456386
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0448337
TXNRD1 thioredoxin reductase 1 0.0444862
JMJD1C jumonji domain containing 1C 0.0442666
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0436363
FMNL2 formin-like 2 0.0435663
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0429124
WWTR1 WW domain containing transcription regulator 1 0.0416129
PRKCE protein kinase C, epsilon 0.041393
YBX3 Y box binding protein 3 0.0413604
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0394857
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0394316
PMEPA1 prostate transmembrane protein, androgen induced 1 0.039062
STC1 stanniocalcin 1 0.0383383
BICD1 bicaudal D homolog 1 (Drosophila) 0.038331
RRM2 ribonucleotide reductase M2 0.0382587
GSK3B glycogen synthase kinase 3 beta 0.0377857
DOCK5 dedicator of cytokinesis 5 0.0373143
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0355776
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0355601
NFE2L2 nuclear factor, erythroid 2-like 2 0.0354199
SLC38A2 solute carrier family 38, member 2 0.0348172
WNT2B wingless-type MMTV integration site family, member 2B 0.0347407
ADIPOR2 adiponectin receptor 2 0.0345747
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0340846
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0324329
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0322902
SNAP25 synaptosomal-associated protein, 25kDa 0.0319613
LOC102724023 ES1 protein homolog, mitochondrial 0.0314673
HELZ2 helicase with zinc finger 2, transcriptional coactivator 0.0313739
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0312982
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0312577
FUS FUS RNA binding protein 0.0308901
SVIL supervillin 0.0306016
CMIP c-Maf inducing protein 0.0304409
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0297217
YAP1 Yes-associated protein 1 0.0295729
TRIM59 tripartite motif containing 59 0.029122
SFPQ splicing factor proline/glutamine-rich 0.029034
NEK10 NIMA-related kinase 10 0.0288754
AGO2 argonaute RISC catalytic component 2 0.0288498
RCOR1 REST corepressor 1 0.0287639
ZNFX1 zinc finger, NFX1-type containing 1 0.0285841
TRIO trio Rho guanine nucleotide exchange factor 0.0285477
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0282139
DUSP16 dual specificity phosphatase 16 0.0279047
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0279046
AEBP2 AE binding protein 2 0.0278135
RABGAP1L RAB GTPase activating protein 1-like 0.027784
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0276128
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0274951
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0273714
CFAP44 cilia and flagella associated protein 44 0.0273694
DNAH14 dynein, axonemal, heavy chain 14 0.0271636
ACTN1 actinin, alpha 1 0.027093
ZFAND3 zinc finger, AN1-type domain 3 0.0268054
PDE8A phosphodiesterase 8A 0.0267145
SMAD3 SMAD family member 3 0.0266153
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0264106
TRA2A transformer 2 alpha homolog (Drosophila) 0.0263415
IFI6 interferon, alpha-inducible protein 6 0.0261773
ATP13A3 ATPase type 13A3 0.0258993
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0257385
MRTFA myocardin related transcription factor A 0.0257086
PUM1 pumilio RNA-binding family member 1 0.0254991
EIF3B eukaryotic translation initiation factor 3, subunit B 0.025154
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0250198
RBM19 RNA binding motif protein 19 0.025015
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0247362
ITSN1 intersectin 1 (SH3 domain protein) 0.0246244
LPP LIM domain containing preferred translocation partner in lipoma 0.0245989
DOCK1 dedicator of cytokinesis 1 0.0243447
CDK17 cyclin-dependent kinase 17 0.0241119
BRD2 bromodomain containing 2 0.0238926

decreased expression

Symbol Name Standardized Value
TFPI2 tissue factor pathway inhibitor 2 -0.117708
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0887211
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0680075
PTMA prothymosin, alpha -0.0638561
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0625852
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.05544
GOLGA4 golgin A4 -0.0533179
RAD51B RAD51 paralog B -0.0516198
TMEM165 transmembrane protein 165 -0.0493443
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0471786
RPS3 ribosomal protein S3 -0.0470578
ZNF292 zinc finger protein 292 -0.0443927
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0437536
PHIP pleckstrin homology domain interacting protein -0.0427861
ANKRD12 ankyrin repeat domain 12 -0.0425938
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0412458
COPA coatomer protein complex, subunit alpha -0.038713
YBX1 Y box binding protein 1 -0.037719
PDIA6 protein disulfide isomerase family A, member 6 -0.036356
RSF1 remodeling and spacing factor 1 -0.0363524
RPL37A ribosomal protein L37a -0.0360836
TPI1 triosephosphate isomerase 1 -0.0357654
RPL37 ribosomal protein L37 -0.0353702
MKI67 marker of proliferation Ki-67 -0.035159
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0351074
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0349206
CSDE1 cold shock domain containing E1, RNA-binding -0.0346958
CENPF centromere protein F, 350/400kDa -0.0346929
RPL26 ribosomal protein L26 -0.0346243
RPS2 ribosomal protein S2 -0.0334756
RPLP1 ribosomal protein, large, P1 -0.0333964
RPL12 ribosomal protein L12 -0.0330986
RTN4 reticulon 4 -0.0329691
RPS8 ribosomal protein S8 -0.032938
TLK1 tousled-like kinase 1 -0.0305148
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0301802
GOLGB1 golgin B1 -0.0295894
RPL3 ribosomal protein L3 -0.029215
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0286979
XPO1 exportin 1 -0.028555
CANX calnexin -0.0278347
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0276502
RPS27 ribosomal protein S27 -0.0275402
ZFR zinc finger RNA binding protein -0.0271305
PCLO piccolo presynaptic cytomatrix protein -0.0270457
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -0.0270349
RBM25 RNA binding motif protein 25 -0.0267308
ATXN2 ataxin 2 -0.0266013
BRWD3 bromodomain and WD repeat domain containing 3 -0.026527
POTEF POTE ankyrin domain family, member F -0.0265076
TPD52 tumor protein D52 -0.0264967
AKAP9 A kinase (PRKA) anchor protein 9 -0.0264637
SRPK1 SRSF protein kinase 1 -0.0262491
KIF5B kinesin family member 5B -0.0261635
WDPCP WD repeat containing planar cell polarity effector -0.0261146
RPS19 ribosomal protein S19 -0.0259656
PDIA3 protein disulfide isomerase family A, member 3 -0.0256345
BBX bobby sox homolog (Drosophila) -0.0253918
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0253577
RB1CC1 RB1-inducible coiled-coil 1 -0.0252748
HELZ helicase with zinc finger -0.0252589
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0252265
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0249734
H1-0 H1.0 linker histone -0.0249333
SBF2 SET binding factor 2 -0.0248796
CAMKMT calmodulin-lysine N-methyltransferase -0.0248028
USP34 ubiquitin specific peptidase 34 -0.0244187
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0241594
KDM3A lysine (K)-specific demethylase 3A -0.0240312
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0238669
MT2A metallothionein 2A -0.023762
SMC4 structural maintenance of chromosomes 4 -0.0236452
CHD1L chromodomain helicase DNA binding protein 1-like -0.0231899
EGR1 early growth response 1 -0.0231265
CFDP1 craniofacial development protein 1 -0.0227664
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.022505
CCND2 cyclin D2 -0.0222815
NAMPT nicotinamide phosphoribosyltransferase -0.0222357
MYO6 myosin VI -0.0221283
SRP54 signal recognition particle 54kDa -0.022122
CBX3 chromobox homolog 3 -0.0219643
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0218802
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0218681
RAB6A RAB6A, member RAS oncogene family -0.0218615
DYM dymeclin -0.0217898
SCAF11 SR-related CTD-associated factor 11 -0.0217229
ZMYND8 zinc finger, MYND-type containing 8 -0.0216856
SRSF11 serine/arginine-rich splicing factor 11 -0.0215117
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0214749
ZBTB20 zinc finger and BTB domain containing 20 -0.0212026
MON2 MON2 homolog (S. cerevisiae) -0.0211584
TBC1D23 TBC1 domain family, member 23 -0.0210106
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0209103
CAVIN1 caveolae associated protein 1 -0.0208975
RPS6 ribosomal protein S6 -0.020891
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0207519
ENO1 enolase 1, (alpha) -0.0207335
CPNE8 copine VIII -0.0206859
MACF1 microtubule-actin crosslinking factor 1 -0.0204556
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0204545