Olanzapine_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Olanzapine perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Olanzapine_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PM20D1 peptidase M20 domain containing 1 0.142325
PDE10A phosphodiesterase 10A 0.106636
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.102896
KYNU kynureninase 0.0967467
DST dystonin 0.0945492
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0869063
RGS2 regulator of G-protein signaling 2 0.0851452
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0775756
COL8A1 collagen, type VIII, alpha 1 0.0773725
VIM vimentin 0.0765377
PDE4D phosphodiesterase 4D, cAMP-specific 0.0714182
RPS4X ribosomal protein S4, X-linked 0.0701355
RPS12 ribosomal protein S12 0.0669866
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0655134
CTIF CBP80/20-dependent translation initiation factor 0.063459
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0607258
TRIO trio Rho guanine nucleotide exchange factor 0.0597132
SMOC1 SPARC related modular calcium binding 1 0.0588501
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0582963
ZSWIM6 zinc finger, SWIM-type containing 6 0.0565912
COL5A2 collagen, type V, alpha 2 0.0560301
ASPH aspartate beta-hydroxylase 0.0533723
DOCK4 dedicator of cytokinesis 4 0.0532208
PDLIM5 PDZ and LIM domain 5 0.0530855
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0521589
PRKN parkin RBR E3 ubiquitin protein ligase 0.0518896
VCL vinculin 0.0500751
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0481812
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0477395
GRAMD1B GRAM domain containing 1B 0.047395
FLNA filamin A, alpha 0.0456386
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0451182
FMNL2 formin-like 2 0.0450812
TGFBR1 transforming growth factor, beta receptor 1 0.0450381
RAB3B RAB3B, member RAS oncogene family 0.0434274
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0407641
EFNA5 ephrin-A5 0.0405619
BASP1 brain abundant, membrane attached signal protein 1 0.0405476
MYH9 myosin, heavy chain 9, non-muscle 0.040199
RPS3 ribosomal protein S3 0.0391492
DOCK5 dedicator of cytokinesis 5 0.0378219
MT2A metallothionein 2A 0.0370622
MAML3 mastermind-like 3 (Drosophila) 0.0362236
ANTXR1 anthrax toxin receptor 1 0.0361213
SH3KBP1 SH3-domain kinase binding protein 1 0.0356158
ADARB1 adenosine deaminase, RNA-specific, B1 0.034804
P3H2 prolyl 3-hydroxylase 2 0.0346255
FNDC3B fibronectin type III domain containing 3B 0.0342216
FLNB filamin B, beta 0.0340645
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0323308
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.032032
RAD51B RAD51 paralog B 0.0319312
BDNF brain-derived neurotrophic factor 0.03191
ATXN1 ataxin 1 0.0314417
APLP2 amyloid beta (A4) precursor-like protein 2 0.0309755
ACTN4 actinin, alpha 4 0.0305638
MSN moesin 0.0301983
NEK7 NIMA-related kinase 7 0.0301304
RPL23 ribosomal protein L23 0.0298878
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.029741
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0291254
BCAR3 breast cancer anti-estrogen resistance 3 0.0289809
ITPK1 inositol-tetrakisphosphate 1-kinase 0.0283572
RPL9 ribosomal protein L9 0.027879
IRS2 insulin receptor substrate 2 0.0275513
RPS17 ribosomal protein S17 0.0268264
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0267812
NHSL1 NHS-like 1 0.0259394
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0257933
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.0256308
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.024877
TNRC18 trinucleotide repeat containing 18 0.0248231
SFPQ splicing factor proline/glutamine-rich 0.0246561
BMP6 bone morphogenetic protein 6 0.0241225
TPM3 tropomyosin 3 0.0234321
RPL7 ribosomal protein L7 0.0234266
INTS6 integrator complex subunit 6 0.0232266
RPL13A ribosomal protein L13a 0.0229464
GLCE glucuronic acid epimerase 0.0229047
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0225852
NCAPG2 non-SMC condensin II complex, subunit G2 0.0225824
PKM pyruvate kinase, muscle 0.0224924
HSPA8 heat shock 70kDa protein 8 0.022463
PDE7B phosphodiesterase 7B 0.0224024
BACE2 beta-site APP-cleaving enzyme 2 0.022118
LDHA lactate dehydrogenase A 0.0218675
NCOR2 nuclear receptor corepressor 2 0.0217946
KRT19 keratin 19, type I 0.021667
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0216619
CHD1 chromodomain helicase DNA binding protein 1 0.0215432
PTEN phosphatase and tensin homolog 0.0212065
PRELID2 PRELI domain containing 2 0.0211439
WWTR1 WW domain containing transcription regulator 1 0.02096
MYO10 myosin X 0.0208808
PCBP2 poly(rC) binding protein 2 0.0208056
PTPRM protein tyrosine phosphatase, receptor type, M 0.0207723
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0205572
SEPTIN9 septin 9 0.0203644
FLRT2 fibronectin leucine rich transmembrane protein 2 0.0203315
NFE2L1 nuclear factor, erythroid 2-like 1 0.0201

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.302398
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.253144
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.215251
FN1 fibronectin 1 -0.148246
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.102749
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0985936
TM4SF1 transmembrane 4 L six family member 1 -0.0825091
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0806573
NAMPT nicotinamide phosphoribosyltransferase -0.0749417
RPL35A ribosomal protein L35a -0.0732655
FNDC3A fibronectin type III domain containing 3A -0.0659884
IGFBP3 insulin-like growth factor binding protein 3 -0.0648936
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0580205
S100A6 S100 calcium binding protein A6 -0.055769
S100A10 S100 calcium binding protein A10 -0.0555438
SPAG9 sperm associated antigen 9 -0.0554387
PDIA3 protein disulfide isomerase family A, member 3 -0.0518404
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0479014
HLA-B major histocompatibility complex, class I, B -0.0469955
STC1 stanniocalcin 1 -0.0466944
IFIH1 interferon induced with helicase C domain 1 -0.0457082
TFPI2 tissue factor pathway inhibitor 2 -0.0451317
RPS21 ribosomal protein S21 -0.0449017
RPL34 ribosomal protein L34 -0.0445615
WARS1 tryptophanyl-tRNA synthetase 1 -0.0433032
RPLP1 ribosomal protein, large, P1 -0.0418569
ACTG1 actin gamma 1 -0.0407924
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0399179
UBC ubiquitin C -0.0396698
SMYD3 SET and MYND domain containing 3 -0.039596
CDH13 cadherin 13 -0.0393292
ELL2 elongation factor, RNA polymerase II, 2 -0.0381102
RPS13 ribosomal protein S13 -0.038029
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0372055
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.03671
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0359551
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0358245
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0350061
BMERB1 bMERB domain containing 1 -0.034933
CANX calnexin -0.0343986
RPS6 ribosomal protein S6 -0.0342991
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0336003
TMSB4X thymosin beta 4, X-linked -0.0334262
RPS23 ribosomal protein S23 -0.0327102
SCN3A sodium channel, voltage gated, type III alpha subunit -0.0324953
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0320625
TENM3 teneurin transmembrane protein 3 -0.0319154
RPL38 ribosomal protein L38 -0.0319145
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0312878
GNAS GNAS complex locus -0.030742
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.030566
LMAN1 lectin, mannose-binding, 1 -0.0302936
BCAS3 breast carcinoma amplified sequence 3 -0.0298422
NCKAP5 NCK-associated protein 5 -0.0291583
ABLIM1 actin binding LIM protein 1 -0.0291556
SOX4 SRY (sex determining region Y)-box 4 -0.0290178
PTMA prothymosin, alpha -0.0282492
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0282325
CTSL cathepsin L -0.0281846
FOXC1 forkhead box C1 -0.0281598
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.027762
SLC16A6 solute carrier family 16, member 6 -0.0277467
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0277458
RPS8 ribosomal protein S8 -0.0276471
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0274275
RPL39 ribosomal protein L39 -0.027388
ZMYND8 zinc finger, MYND-type containing 8 -0.0268466
AKR1C1 aldo-keto reductase family 1, member C1 -0.0267921
RYR2 ryanodine receptor 2 (cardiac) -0.0267114
CLIP1 CAP-GLY domain containing linker protein 1 -0.026305
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -0.0262656
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0257193
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0255592
RPLP0 ribosomal protein, large, P0 -0.0255483
TMX4 thioredoxin-related transmembrane protein 4 -0.0254026
NBEAL1 neurobeachin-like 1 -0.0251705
UNC5D unc-5 homolog D (C. elegans) -0.0245957
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0245158
RAB1A RAB1A, member RAS oncogene family -0.0244532
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0242613
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0240633
KPNB1 karyopherin (importin) beta 1 -0.0239297
CD99 CD99 molecule -0.0238901
TPM4 tropomyosin 4 -0.0237142
RPS27A ribosomal protein S27a -0.0236495
CALU calumenin -0.0234482
RPL8 ribosomal protein L8 -0.0234214
EIF1 eukaryotic translation initiation factor 1 -0.0230747
ENO1 enolase 1, (alpha) -0.0229409
CD44 CD44 molecule (Indian blood group) -0.0228495
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0228288
IFI16 interferon, gamma-inducible protein 16 -0.0225415
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0225374
CREB5 cAMP responsive element binding protein 5 -0.0223902
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0220584
SRPK2 SRSF protein kinase 2 -0.0217436
RPS15 ribosomal protein S15 -0.0216499
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0215646
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.021557
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0213641