Olanzapine_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Olanzapine perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Olanzapine_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0792058
QKI QKI, KH domain containing, RNA binding 0.0622173
ZNF292 zinc finger protein 292 0.0564443
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0556648
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.05548
KMT2E lysine (K)-specific methyltransferase 2E 0.0532149
WAC WW domain containing adaptor with coiled-coil 0.0527686
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0523828
NAMPT nicotinamide phosphoribosyltransferase 0.0518262
SSBP2 single-stranded DNA binding protein 2 0.0516954
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0461758
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0442555
KDM3A lysine (K)-specific demethylase 3A 0.0430758
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0426251
HELZ helicase with zinc finger 0.0396263
TFG TRK-fused gene 0.0392853
GOLGA4 golgin A4 0.0390552
CCNL1 cyclin L1 0.0386992
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0385116
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0376934
ELOVL5 ELOVL fatty acid elongase 5 0.0367813
RNF145 ring finger protein 145 0.036279
TXNIP thioredoxin interacting protein 0.0344076
CDC73 cell division cycle 73 0.0329866
RPL3 ribosomal protein L3 0.032559
COPA coatomer protein complex, subunit alpha 0.0321424
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0320254
EML4 echinoderm microtubule associated protein like 4 0.0314219
FXR1 fragile X mental retardation, autosomal homolog 1 0.031358
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0312833
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0311216
MATR3 matrin 3 0.0302538
SETD5 SET domain containing 5 0.0298262
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0293267
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0293237
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0290159
NUP58 nucleoporin 58 0.0288208
ADAM9 ADAM metallopeptidase domain 9 0.0286326
TMSB4X thymosin beta 4, X-linked 0.0284392
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.028226
NBAS neuroblastoma amplified sequence 0.0282207
XPO1 exportin 1 0.0277078
PTBP2 polypyrimidine tract binding protein 2 0.0277057
SEC23A Sec23 homolog A (S. cerevisiae) 0.026855
PCBP2 poly(rC) binding protein 2 0.0268089
CORO1C coronin, actin binding protein, 1C 0.0256941
USP3 ubiquitin specific peptidase 3 0.025477
EIF4B eukaryotic translation initiation factor 4B 0.0252266
COG6 component of oligomeric golgi complex 6 0.0252237
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0251473
FAM13A family with sequence similarity 13, member A 0.0251023
RLF rearranged L-myc fusion 0.0249519
FBXO11 F-box protein 11 0.024812
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0247377
ARID4B AT rich interactive domain 4B (RBP1-like) 0.024329
RAB18 RAB18, member RAS oncogene family 0.0242091
CHD1 chromodomain helicase DNA binding protein 1 0.0241088
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0238362
ECT2 epithelial cell transforming 2 0.0236773
CRY1 cryptochrome circadian clock 1 0.0234455
UBA6 ubiquitin-like modifier activating enzyme 6 0.0232614
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0231287
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0227641
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0227101
FAM168A family with sequence similarity 168, member A 0.022527
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.022338
TAC4 tachykinin 4 (hemokinin) 0.0223288
RYBP RING1 and YY1 binding protein 0.0219814
PICALM phosphatidylinositol binding clathrin assembly protein 0.0218579
TOP2B topoisomerase (DNA) II beta 180kDa 0.0217994
EEF2 eukaryotic translation elongation factor 2 0.0217553
PDIA3 protein disulfide isomerase family A, member 3 0.021649
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0216143
SPAG9 sperm associated antigen 9 0.0214656
COPB1 coatomer protein complex, subunit beta 1 0.0212246
FBLN2 fibulin 2 0.0210295
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0209305
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0206321
RHOA ras homolog family member A 0.0206047
TRERF1 transcriptional regulating factor 1 0.0205943
MSI2 musashi RNA-binding protein 2 0.0205435
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0204526
CSNK1A1 casein kinase 1, alpha 1 0.0201385
GPBP1 GC-rich promoter binding protein 1 0.0201372
RHEB Ras homolog enriched in brain 0.0200553
NCOR1 nuclear receptor corepressor 1 0.0200359
RNASE3 ribonuclease, RNase A family, 3 0.0200331
CSF1 colony stimulating factor 1 (macrophage) 0.0199774
RAB6A RAB6A, member RAS oncogene family 0.0196194
NOP58 NOP58 ribonucleoprotein 0.0194797
CASC3 cancer susceptibility candidate 3 0.0194562
PLK2 polo-like kinase 2 0.0192426
YTHDC1 YTH domain containing 1 0.0190747
KDM6A lysine (K)-specific demethylase 6A 0.018945
SCAF11 SR-related CTD-associated factor 11 0.0188146
SEC24A SEC24 family member A 0.0185384
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0184829
ADAM17 ADAM metallopeptidase domain 17 0.0183902
SPRED2 sprouty-related, EVH1 domain containing 2 0.0183789
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.018358

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.340313
PTMA prothymosin, alpha -0.204686
TPT1 tumor protein, translationally-controlled 1 -0.16454
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.121841
RPL35A ribosomal protein L35a -0.115419
ACTG1 actin gamma 1 -0.10819
RPS6 ribosomal protein S6 -0.0959298
PDE4D phosphodiesterase 4D, cAMP-specific -0.0930996
PDE4B phosphodiesterase 4B, cAMP-specific -0.0911198
RPS8 ribosomal protein S8 -0.0874061
RPL34 ribosomal protein L34 -0.0786334
RPLP2 ribosomal protein, large, P2 -0.0784937
RPS19 ribosomal protein S19 -0.0750365
RPL37A ribosomal protein L37a -0.0735017
RPL12 ribosomal protein L12 -0.0733671
RPS3 ribosomal protein S3 -0.0721349
RPL9 ribosomal protein L9 -0.0712535
RPL31 ribosomal protein L31 -0.0707307
RPLP1 ribosomal protein, large, P1 -0.0703968
RPL11 ribosomal protein L11 -0.0696547
RPS13 ribosomal protein S13 -0.0684474
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0683806
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0683165
EGFR epidermal growth factor receptor -0.0660539
RPL26 ribosomal protein L26 -0.0647028
RPS23 ribosomal protein S23 -0.0637815
EIF1 eukaryotic translation initiation factor 1 -0.063571
FOXP1 forkhead box P1 -0.0625103
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0620713
S100A6 S100 calcium binding protein A6 -0.0602066
RPS25 ribosomal protein S25 -0.0557174
TMSB10 thymosin beta 10 -0.0542817
RPL23 ribosomal protein L23 -0.0536126
RPS12 ribosomal protein S12 -0.0534824
RPL32 ribosomal protein L32 -0.0525636
ARL4C ADP-ribosylation factor-like 4C -0.0524736
CCND1 cyclin D1 -0.0522793
NBEA neurobeachin -0.0520951
RPS29 ribosomal protein S29 -0.0520904
RPL7A ribosomal protein L7a -0.0485433
RPL19 ribosomal protein L19 -0.0483512
RPS27A ribosomal protein S27a -0.0479763
RPL36 ribosomal protein L36 -0.0479139
GLI3 GLI family zinc finger 3 -0.0466369
RPS24 ribosomal protein S24 -0.0460337
RPLP0 ribosomal protein, large, P0 -0.0444182
RPS21 ribosomal protein S21 -0.0434589
RPL37 ribosomal protein L37 -0.0429321
S100A9 S100 calcium binding protein A9 -0.0406644
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0400078
TAS2R14 taste receptor, type 2, member 14 -0.0399517
RPS15 ribosomal protein S15 -0.0399284
RPS16 ribosomal protein S16 -0.0398966
MYL12B myosin, light chain 12B, regulatory -0.0397033
SMYD3 SET and MYND domain containing 3 -0.0377278
VCL vinculin -0.0374912
RPL13A ribosomal protein L13a -0.036793
RPL27 ribosomal protein L27 -0.036308
RPS17 ribosomal protein S17 -0.036297
RPS11 ribosomal protein S11 -0.0359212
TTC28 tetratricopeptide repeat domain 28 -0.0355434
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0354231
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0352095
EFNA5 ephrin-A5 -0.0349117
SLC38A2 solute carrier family 38, member 2 -0.0348017
S100A10 S100 calcium binding protein A10 -0.0340736
RPL18 ribosomal protein L18 -0.0331002
RPL36A ribosomal protein L36a -0.0324654
RPL30 ribosomal protein L30 -0.0320977
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0317098
IFI16 interferon, gamma-inducible protein 16 -0.0310746
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0303757
RPL35 ribosomal protein L35 -0.0303172
TXNRD1 thioredoxin reductase 1 -0.0300412
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0296742
RACK1 receptor for activated C kinase 1 -0.0296707
RPS14 ribosomal protein S14 -0.0296648
MT2A metallothionein 2A -0.02875
PFN1 profilin 1 -0.0286195
RPL7 ribosomal protein L7 -0.0285121
PRELID2 PRELI domain containing 2 -0.0284144
RPL5 ribosomal protein L5 -0.0281253
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0279547
LPP LIM domain containing preferred translocation partner in lipoma -0.027765
FAF1 Fas (TNFRSF6) associated factor 1 -0.0269626
RPL38 ribosomal protein L38 -0.0269398
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0265566
RPL28 ribosomal protein L28 -0.0265351
PRDX2 peroxiredoxin 2 -0.0256112
SMC4 structural maintenance of chromosomes 4 -0.0255972
DIAPH2 diaphanous-related formin 2 -0.0254359
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0253299
NPAS2 neuronal PAS domain protein 2 -0.0253206
CRPPA CDP-L-ribitol pyrophosphorylase A -0.0252961
ENO2 enolase 2 (gamma, neuronal) -0.0251498
GPHN gephyrin -0.0250479
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0250178
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0250036
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0246701
RPL10A ribosomal protein L10a -0.0246506