Olanzapine_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Olanzapine perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Olanzapine_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.213135
MYH9 myosin, heavy chain 9, non-muscle 0.122239
KYNU kynureninase 0.107064
TRIO trio Rho guanine nucleotide exchange factor 0.0602409
ZSWIM6 zinc finger, SWIM-type containing 6 0.0599699
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0597612
FLNA filamin A, alpha 0.0553202
EXT1 exostosin glycosyltransferase 1 0.0502409
FNDC3B fibronectin type III domain containing 3B 0.0498165
FN1 fibronectin 1 0.048996
COL5A1 collagen, type V, alpha 1 0.0482188
MACF1 microtubule-actin crosslinking factor 1 0.046487
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0462982
NRXN3 neurexin 3 0.0447391
PRELID2 PRELI domain containing 2 0.0438328
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0437511
SOD2 superoxide dismutase 2, mitochondrial 0.0436715
ATXN1 ataxin 1 0.0432288
HIP1 huntingtin interacting protein 1 0.0417901
COL6A1 collagen, type VI, alpha 1 0.0413828
EGFR epidermal growth factor receptor 0.0392074
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0388239
TNS3 tensin 3 0.0387813
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.038283
GSE1 Gse1 coiled-coil protein 0.0379616
INTS6 integrator complex subunit 6 0.0366704
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0362283
CD44 CD44 molecule (Indian blood group) 0.0349584
PDLIM5 PDZ and LIM domain 5 0.0347929
RUNX1 runt-related transcription factor 1 0.0337971
SSBP2 single-stranded DNA binding protein 2 0.0332167
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0326476
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0325929
DNAH11 dynein, axonemal, heavy chain 11 0.0321193
PSD3 pleckstrin and Sec7 domain containing 3 0.0313269
FBXL7 F-box and leucine-rich repeat protein 7 0.0309756
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0301223
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0300644
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0298974
CLIP2 CAP-GLY domain containing linker protein 2 0.0298856
RIGI RNA sensor RIG-I 0.0294801
MAML2 mastermind-like 2 (Drosophila) 0.0290296
GLIS3 GLIS family zinc finger 3 0.0285103
NCOR2 nuclear receptor corepressor 2 0.027522
SMAD3 SMAD family member 3 0.0273405
VEGFC vascular endothelial growth factor C 0.0267123
PLEC plectin 0.0265844
BBS9 Bardet-Biedl syndrome 9 0.0261886
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0261023
MPRIP myosin phosphatase Rho interacting protein 0.0258814
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0253925
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.025283
SAMD4A sterile alpha motif domain containing 4A 0.0250938
MYOF myoferlin 0.0243743
HIPK2 homeodomain interacting protein kinase 2 0.0243428
CUX1 cut-like homeobox 1 0.0243059
AUTS2 autism susceptibility candidate 2 0.0240465
ITGAV integrin, alpha V 0.0238676
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0238446
FAT1 FAT atypical cadherin 1 0.0237137
PRICKLE2 prickle homolog 2 (Drosophila) 0.0236895
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0236538
CCDC102B coiled-coil domain containing 102B 0.0229377
NAV1 neuron navigator 1 0.0229133
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0227976
CTBP2 C-terminal binding protein 2 0.0227778
SMYD3 SET and MYND domain containing 3 0.0226318
RAD51B RAD51 paralog B 0.0224045
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0222288
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0215452
FAM20C family with sequence similarity 20, member C 0.0214917
LPP LIM domain containing preferred translocation partner in lipoma 0.0214849
CANX calnexin 0.0214378
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0212148
SPIDR scaffolding protein involved in DNA repair 0.0211801
ZMIZ1 zinc finger, MIZ-type containing 1 0.0210891
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0208793
ANO6 anoctamin 6 0.0207544
COL7A1 collagen, type VII, alpha 1 0.0205246
WWOX WW domain containing oxidoreductase 0.0205186
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0203419
NAV2 neuron navigator 2 0.0200716
SON SON DNA binding protein 0.0199632
TNRC18 trinucleotide repeat containing 18 0.0199196
GRB10 growth factor receptor-bound protein 10 0.0197973
EXOC4 exocyst complex component 4 0.0197218
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0196841
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0196268
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0195515
ASPH aspartate beta-hydroxylase 0.0195449
EPAS1 endothelial PAS domain protein 1 0.0194009
PTK2 protein tyrosine kinase 2 0.0193767
SEPTIN9 septin 9 0.0193767
PTPRM protein tyrosine phosphatase, receptor type, M 0.0187795
HSPA8 heat shock 70kDa protein 8 0.0187735
NCAPG2 non-SMC condensin II complex, subunit G2 0.0187595
DPYD dihydropyrimidine dehydrogenase 0.0187138
APLP2 amyloid beta (A4) precursor-like protein 2 0.01871
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0185589
ECE1 endothelin converting enzyme 1 0.0185154

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.196035
TMSB10 thymosin beta 10 -0.196001
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.172207
VIM vimentin -0.145388
HLA-B major histocompatibility complex, class I, B -0.138643
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0880765
FTL ferritin, light polypeptide -0.0849569
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0811001
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0786371
B2M beta-2-microglobulin -0.0782146
MT1X metallothionein 1X -0.0592669
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0503947
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0464881
NDRG1 N-myc downstream regulated 1 -0.0460079
F3 coagulation factor III (thromboplastin, tissue factor) -0.0458545
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0424726
TPT1 tumor protein, translationally-controlled 1 -0.042189
PTMA prothymosin, alpha -0.0417318
RPL34 ribosomal protein L34 -0.0411165
STC1 stanniocalcin 1 -0.0392406
HLA-C major histocompatibility complex, class I, C -0.0391583
S100A6 S100 calcium binding protein A6 -0.0372312
S100A9 S100 calcium binding protein A9 -0.0333968
POTEF POTE ankyrin domain family, member F -0.0332542
WSB1 WD repeat and SOCS box containing 1 -0.0331435
RPS6 ribosomal protein S6 -0.0329013
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0315787
EIF1 eukaryotic translation initiation factor 1 -0.0312879
GOLGA4 golgin A4 -0.0312357
ACTG1 actin gamma 1 -0.0309888
PDIA3 protein disulfide isomerase family A, member 3 -0.0302845
COL1A2 collagen, type I, alpha 2 -0.0301859
RPL35A ribosomal protein L35a -0.0295158
KMT2E lysine (K)-specific methyltransferase 2E -0.0288961
RRBP1 ribosome binding protein 1 -0.0286684
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.028609
GARS1 glycyl-tRNA synthetase 1 -0.0271213
H3-3B H3.3 histone B -0.0268247
LOC112694756 uncharaterized LOC112694756 -0.0262228
HLA-A major histocompatibility complex, class I, A -0.0262189
RPS8 ribosomal protein S8 -0.0258649
NAMPT nicotinamide phosphoribosyltransferase -0.0255588
IL6 interleukin 6 -0.0254475
RPL11 ribosomal protein L11 -0.0246586
ADM adrenomedullin -0.023824
RPLP0 ribosomal protein, large, P0 -0.023801
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0234702
ZMYND8 zinc finger, MYND-type containing 8 -0.0226982
PTN pleiotrophin -0.0225372
TPM4 tropomyosin 4 -0.0224987
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0222321
TM4SF1 transmembrane 4 L six family member 1 -0.0222309
RPL37 ribosomal protein L37 -0.0219461
RPS21 ribosomal protein S21 -0.0217248
TMEM165 transmembrane protein 165 -0.0216231
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0214521
COL1A1 collagen, type I, alpha 1 -0.0211794
IGFBP3 insulin-like growth factor binding protein 3 -0.0209853
SERF2 small EDRK-rich factor 2 -0.0209097
CALR calreticulin -0.0207853
S100A10 S100 calcium binding protein A10 -0.020405
RPLP1 ribosomal protein, large, P1 -0.0202928
RBM39 RNA binding motif protein 39 -0.0201905
RBM25 RNA binding motif protein 25 -0.0201608
TNNC1 troponin C type 1 (slow) -0.0199586
ENO1 enolase 1, (alpha) -0.019926
RPL37A ribosomal protein L37a -0.0196419
RPS19 ribosomal protein S19 -0.0195657
LMAN1 lectin, mannose-binding, 1 -0.0191623
RLF rearranged L-myc fusion -0.0191555
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0188884
KDM5B lysine (K)-specific demethylase 5B -0.0187801
TENT5A terminal nucleotidyltransferase 5A -0.0187068
RTN4 reticulon 4 -0.018494
ARRDC3 arrestin domain containing 3 -0.0184092
RPS14 ribosomal protein S14 -0.0183646
RPS24 ribosomal protein S24 -0.0183265
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0182785
RPL31 ribosomal protein L31 -0.0181577
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0180368
PTPRF protein tyrosine phosphatase, receptor type, F -0.0179891
RPL26 ribosomal protein L26 -0.017986
RPS23 ribosomal protein S23 -0.0179169
HILPDA hypoxia inducible lipid droplet-associated -0.0179001
LOX lysyl oxidase -0.017731
LAMB3 laminin, beta 3 -0.0175576
RPS3 ribosomal protein S3 -0.0174081
RPL36A ribosomal protein L36a -0.0173908
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0173518
SEPTIN7 septin 7 -0.0172311
MXI1 MAX interactor 1, dimerization protein -0.0171199
RPLP2 ribosomal protein, large, P2 -0.0170754
RPS27 ribosomal protein S27 -0.0169751
RPL36 ribosomal protein L36 -0.0168493
GNAS GNAS complex locus -0.0167314
UBC ubiquitin C -0.0167222
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.016682
MYADM myeloid-associated differentiation marker -0.0166114
CCNI cyclin I -0.0164268
CBX3 chromobox homolog 3 -0.0163652