Olanzapine_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Olanzapine perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Olanzapine_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SMAD3 SMAD family member 3 0.0836323
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0688349
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0611125
MYH9 myosin, heavy chain 9, non-muscle 0.0584244
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0536004
FLNA filamin A, alpha 0.0418037
PLEC plectin 0.0356356
TGM2 transglutaminase 2 0.0344852
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0331887
CEP250 centrosomal protein 250kDa 0.0327108
AKAP12 A kinase (PRKA) anchor protein 12 0.0302685
NUMA1 nuclear mitotic apparatus protein 1 0.0300266
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.0283076
DGKD diacylglycerol kinase, delta 130kDa 0.0273218
AHNAK2 AHNAK nucleoprotein 2 0.0262302
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0257167
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0254594
BCAR3 breast cancer anti-estrogen resistance 3 0.0249887
CPNE1 copine I 0.0246069
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0242729
MKI67 marker of proliferation Ki-67 0.0239677
PDE4D phosphodiesterase 4D, cAMP-specific 0.0232199
ANLN anillin, actin binding protein 0.0229233
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0223931
KMT2D lysine (K)-specific methyltransferase 2D 0.0222515
AREG amphiregulin 0.0220924
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0220146
RAD23B RAD23 homolog B (S. cerevisiae) 0.0215524
TM9SF4 transmembrane 9 superfamily protein member 4 0.0210106
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0208816
KIAA0232 KIAA0232 0.0205914
SRCAP Snf2-related CREBBP activator protein 0.0203255
SGO2 shugoshin 2 0.0202395
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa 0.0201578
ACTN4 actinin, alpha 4 0.0198986
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0198265
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.0195655
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma 0.0194024
CENPE centromere protein E, 312kDa 0.0193389
TTI1 TELO2 interacting protein 1 0.0192284
HSPA8 heat shock 70kDa protein 8 0.0191357
PYGB phosphorylase, glycogen; brain 0.0191137
KIAA1549L KIAA1549-like 0.019056
UBAC2 UBA domain containing 2 0.0187548
SEPTIN9 septin 9 0.0187236
TXNRD1 thioredoxin reductase 1 0.0186794
CENPF centromere protein F, 350/400kDa 0.0186692
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0185931
YAP1 Yes-associated protein 1 0.018343
CCNB1 cyclin B1 0.0183071
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0182707
RARS1 arginyl-tRNA synthetase 1 0.0180809
BCL9L B-cell CLL/lymphoma 9-like 0.018005
CNOT12 CCR4-NOT transcription complex subunit 12 0.0179256
NCOR2 nuclear receptor corepressor 2 0.0177839
FAM193B family with sequence similarity 193, member B 0.0177283
CORO1C coronin, actin binding protein, 1C 0.0176481
LHFPL6 LHFPL tetraspan subfamily member 6 0.0175719
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.017405
SAMD12 sterile alpha motif domain containing 12 0.0173301
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0173108
UBE2G1 ubiquitin-conjugating enzyme E2G 1 0.0172749
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0172646
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0172377
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0170523
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0170499
ZMYND11 zinc finger, MYND-type containing 11 0.0170239
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0169971
ZBTB44 zinc finger and BTB domain containing 44 0.0169003
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.0168258
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0164587
NFE2L1 nuclear factor, erythroid 2-like 1 0.0162674
CSNK1D casein kinase 1, delta 0.0162498
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0161692
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0160025
HMMR hyaluronan-mediated motility receptor (RHAMM) 0.015869
ZC3H18 zinc finger CCCH-type containing 18 0.0157848
EEF2 eukaryotic translation elongation factor 2 0.0157018
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0156069
CKAP5 cytoskeleton associated protein 5 0.0155705
RANBP9 RAN binding protein 9 0.015553
EHD4 EH-domain containing 4 0.0155454
ANKZF1 ankyrin repeat and zinc finger domain containing 1 0.0155218
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0154919
FMNL2 formin-like 2 0.0152683
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0151867
SPAG5 sperm associated antigen 5 0.0151791
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.0151311
TJP1 tight junction protein 1 0.0151234
COQ10B coenzyme Q10 homolog B (S. cerevisiae) 0.0150309
PER1 period circadian clock 1 0.0150017
TTC21B tetratricopeptide repeat domain 21B 0.0149965
TMX1 thioredoxin-related transmembrane protein 1 0.0149345
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0148837
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0148774
CKAP2L cytoskeleton associated protein 2-like 0.0148254
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0147848
NKD1 naked cuticle homolog 1 (Drosophila) 0.0147368
PTGES2 prostaglandin E synthase 2 0.0147095
WDR1 WD repeat domain 1 0.0146714

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.329791
PTMA prothymosin, alpha -0.111035
IGFBP3 insulin-like growth factor binding protein 3 -0.110116
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.10451
TPT1 tumor protein, translationally-controlled 1 -0.0964605
FNDC3B fibronectin type III domain containing 3B -0.0953292
TMSB10 thymosin beta 10 -0.0923972
ZBTB20 zinc finger and BTB domain containing 20 -0.0877853
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0870142
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0790458
VIM vimentin -0.0769036
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0740758
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0738105
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0735198
GPC6 glypican 6 -0.068386
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.060007
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.059949
EGR1 early growth response 1 -0.0592624
GOLGA4 golgin A4 -0.0568162
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0568082
RPLP1 ribosomal protein, large, P1 -0.0559327
GNAS GNAS complex locus -0.0553462
FTH1 ferritin, heavy polypeptide 1 -0.0543814
RAD51B RAD51 paralog B -0.0541611
ZNF609 zinc finger protein 609 -0.0525983
SMYD3 SET and MYND domain containing 3 -0.0519649
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0519371
IER3 immediate early response 3 -0.0502139
PKM pyruvate kinase, muscle -0.0501275
SDC4 syndecan 4 -0.050058
LDHA lactate dehydrogenase A -0.0497604
DST dystonin -0.0495006
RAI14 retinoic acid induced 14 -0.049436
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0492636
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.049171
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0490753
ZNF638 zinc finger protein 638 -0.0488051
ATM ATM serine/threonine kinase -0.0486273
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0479988
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0477319
IGF2 insulin-like growth factor 2 -0.0476284
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0471542
ATG7 autophagy related 7 -0.0462601
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0449995
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0446615
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0443543
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0442611
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0439041
BPTF bromodomain PHD finger transcription factor -0.0437701
PRSS23 protease, serine, 23 -0.0431456
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0423836
HILPDA hypoxia inducible lipid droplet-associated -0.0421519
PNISR PNN-interacting serine/arginine-rich protein -0.0411421
DPYD dihydropyrimidine dehydrogenase -0.0408201
RPL35A ribosomal protein L35a -0.0407569
HMGA2 high mobility group AT-hook 2 -0.040272
SPAG9 sperm associated antigen 9 -0.0399664
NT5E 5'-nucleotidase, ecto (CD73) -0.0399002
MCTP1 multiple C2 domains, transmembrane 1 -0.0394951
PRKCA protein kinase C, alpha -0.0391956
VMP1 vacuole membrane protein 1 -0.0390495
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0384497
NCOR1 nuclear receptor corepressor 1 -0.038245
ENO2 enolase 2 (gamma, neuronal) -0.0380238
AFF4 AF4/FMR2 family, member 4 -0.0375756
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0375399
NDRG1 N-myc downstream regulated 1 -0.0374644
RSF1 remodeling and spacing factor 1 -0.037404
NGLY1 N-glycanase 1 -0.0372175
SQSTM1 sequestosome 1 -0.0370527
TAS2R14 taste receptor, type 2, member 14 -0.0362055
BASP1 brain abundant, membrane attached signal protein 1 -0.0361739
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0361653
OSMR oncostatin M receptor -0.0357742
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0355249
SCAPER S-phase cyclin A-associated protein in the ER -0.0353013
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0351178
IL1RAP interleukin 1 receptor accessory protein -0.0350955
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0350351
USP34 ubiquitin specific peptidase 34 -0.0349993
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0348286
RPS13 ribosomal protein S13 -0.0344699
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0340862
SRPK2 SRSF protein kinase 2 -0.0338744
OASL 2'-5'-oligoadenylate synthetase-like -0.0336969
LRRC49 leucine rich repeat containing 49 -0.0332807
SMAP1 small ArfGAP 1 -0.0329819
CANX calnexin -0.0328308
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0326864
ZMYND8 zinc finger, MYND-type containing 8 -0.0325249
SH3KBP1 SH3-domain kinase binding protein 1 -0.0325101
GPHN gephyrin -0.0323301
CHD9 chromodomain helicase DNA binding protein 9 -0.0322334
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0322099
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0319773
EIF1 eukaryotic translation initiation factor 1 -0.0318398
CD44 CD44 molecule (Indian blood group) -0.0317817
ANKRD12 ankyrin repeat domain 12 -0.0317384
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0314921
PARD3 par-3 family cell polarity regulator -0.0313643