Olanzapine_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Olanzapine perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Olanzapine_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.231277
EXT1 exostosin glycosyltransferase 1 0.14094
ASPH aspartate beta-hydroxylase 0.107576
NRG1 neuregulin 1 0.0889481
HIPK2 homeodomain interacting protein kinase 2 0.0759268
HMGA2 high mobility group AT-hook 2 0.0753754
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0633179
VCL vinculin 0.0620967
NTN4 netrin 4 0.0593919
SMAD3 SMAD family member 3 0.0566181
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0560817
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0543269
FLNA filamin A, alpha 0.0518521
SEPTIN9 septin 9 0.0510064
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.04977
ZSWIM6 zinc finger, SWIM-type containing 6 0.0494361
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.04873
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0486689
NRP1 neuropilin 1 0.0468318
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0467536
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.04668
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0463188
INTS6 integrator complex subunit 6 0.0458295
DST dystonin 0.045635
AEBP2 AE binding protein 2 0.0446421
NPAS2 neuronal PAS domain protein 2 0.0439946
FNDC3B fibronectin type III domain containing 3B 0.0438322
AHR aryl hydrocarbon receptor 0.0436228
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0426095
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0423816
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.041673
FNDC3A fibronectin type III domain containing 3A 0.0414482
PALLD palladin, cytoskeletal associated protein 0.0413295
MYH9 myosin, heavy chain 9, non-muscle 0.0403461
ANKRD28 ankyrin repeat domain 28 0.039797
RNF213 ring finger protein 213 0.0381253
LTBP1 latent transforming growth factor beta binding protein 1 0.036737
PTK2 protein tyrosine kinase 2 0.0362866
LOXL2 lysyl oxidase-like 2 0.0356573
PDLIM5 PDZ and LIM domain 5 0.0351292
SMYD3 SET and MYND domain containing 3 0.0349781
GLIS3 GLIS family zinc finger 3 0.0346304
PDE4D phosphodiesterase 4D, cAMP-specific 0.0346268
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.034209
NXN nucleoredoxin 0.0341617
ZC3H12C zinc finger CCCH-type containing 12C 0.0337825
NRIP1 nuclear receptor interacting protein 1 0.0337112
IL6ST interleukin 6 signal transducer 0.0322152
ATF6 activating transcription factor 6 0.0322073
RPH3AL rabphilin 3A-like (without C2 domains) 0.0320529
RAB31 RAB31, member RAS oncogene family 0.0317104
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0305953
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0302974
LRMDA leucine rich melanocyte differentiation associated 0.0301787
BICD1 bicaudal D homolog 1 (Drosophila) 0.0299781
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0297869
PRELID2 PRELI domain containing 2 0.029707
EPS8 epidermal growth factor receptor pathway substrate 8 0.0296292
TGFB2 transforming growth factor, beta 2 0.0294517
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0292411
DUSP16 dual specificity phosphatase 16 0.0289177
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0288706
RAB10 RAB10, member RAS oncogene family 0.0288624
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0285174
CLIP2 CAP-GLY domain containing linker protein 2 0.0284171
TMEM156 transmembrane protein 156 0.0283546
AHNAK AHNAK nucleoprotein 0.0281775
ARHGAP35 Rho GTPase activating protein 35 0.0279804
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0272762
MLPH melanophilin 0.0270615
SFTPA2 surfactant protein A2 0.0270473
FHIT fragile histidine triad 0.026969
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0266713
EXOC4 exocyst complex component 4 0.0266333
FBN1 fibrillin 1 0.026503
SVIL supervillin 0.0264958
ATXN1 ataxin 1 0.0263043
RASAL2 RAS protein activator like 2 0.0260476
MBNL1 muscleblind-like splicing regulator 1 0.0259359
AHNAK2 AHNAK nucleoprotein 2 0.0256524
VEGFC vascular endothelial growth factor C 0.0254737
DOCK5 dedicator of cytokinesis 5 0.0252338
UBASH3B ubiquitin associated and SH3 domain containing B 0.0252108
KSR1 kinase suppressor of ras 1 0.0250148
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0247926
SHB Src homology 2 domain containing adaptor protein B 0.0246865
PRKCA protein kinase C, alpha 0.0244698
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.024468
TTC28 tetratricopeptide repeat domain 28 0.02423
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0239454
FOXP1 forkhead box P1 0.0238496
PLEC plectin 0.0234916
LIMCH1 LIM and calponin homology domains 1 0.0234831
LPP LIM domain containing preferred translocation partner in lipoma 0.0228729
ENAH enabled homolog (Drosophila) 0.0227517
FHL2 four and a half LIM domains 2 0.0225696
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0223105
ZFAND3 zinc finger, AN1-type domain 3 0.0222742
AOPEP aminopeptidase O (putative) 0.0219818
BPTF bromodomain PHD finger transcription factor 0.0219538

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.0803446
PTMA prothymosin, alpha -0.0739462
MT2A metallothionein 2A -0.0692405
FTL ferritin, light polypeptide -0.0641776
TMSB10 thymosin beta 10 -0.0640505
VIM vimentin -0.0554672
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0545864
MRPS6 mitochondrial ribosomal protein S6 -0.0489004
TPT1 tumor protein, translationally-controlled 1 -0.0399634
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0384568
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.03745
TMEM165 transmembrane protein 165 -0.0371183
RPS12 ribosomal protein S12 -0.0361352
RPL9 ribosomal protein L9 -0.0332502
RPL37A ribosomal protein L37a -0.0322201
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0309451
ACBD3 acyl-CoA binding domain containing 3 -0.0304909
RPL31 ribosomal protein L31 -0.0301738
B2M beta-2-microglobulin -0.0299854
SOX4 SRY (sex determining region Y)-box 4 -0.0291771
ENO2 enolase 2 (gamma, neuronal) -0.0273682
RPL26 ribosomal protein L26 -0.0272856
DUSP6 dual specificity phosphatase 6 -0.0266792
RPS6 ribosomal protein S6 -0.0261507
RACK1 receptor for activated C kinase 1 -0.0247538
RPS27 ribosomal protein S27 -0.0238749
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0238539
SUCO SUN domain containing ossification factor -0.0237386
NAP1L1 nucleosome assembly protein 1-like 1 -0.0237213
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0236427
S100A6 S100 calcium binding protein A6 -0.023012
LOC102724023 ES1 protein homolog, mitochondrial -0.0225318
RBM25 RNA binding motif protein 25 -0.0219205
RPLP1 ribosomal protein, large, P1 -0.0216493
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0214171
GOLGA4 golgin A4 -0.0213506
ARF4 ADP-ribosylation factor 4 -0.0213039
RPS3 ribosomal protein S3 -0.0212836
CALR calreticulin -0.0209975
HMGA1 high mobility group AT-hook 1 -0.020571
CADM1 cell adhesion molecule 1 -0.0205663
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0204863
RPL11 ribosomal protein L11 -0.0198346
RPL35A ribosomal protein L35a -0.0197628
EIF5B eukaryotic translation initiation factor 5B -0.0195025
RTN4 reticulon 4 -0.0193404
RPL37 ribosomal protein L37 -0.0186469
IGFBP3 insulin-like growth factor binding protein 3 -0.0186431
HILPDA hypoxia inducible lipid droplet-associated -0.0184028
CANX calnexin -0.0182596
RPS19 ribosomal protein S19 -0.0182076
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0179068
EGR1 early growth response 1 -0.0178078
CALU calumenin -0.0177284
POTEF POTE ankyrin domain family, member F -0.0176596
BIRC6 baculoviral IAP repeat containing 6 -0.0176594
RPS24 ribosomal protein S24 -0.0175208
FAM13A family with sequence similarity 13, member A -0.0173309
RPL36 ribosomal protein L36 -0.0171466
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0166063
CTSD cathepsin D -0.0159226
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0159224
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0156609
FTH1 ferritin, heavy polypeptide 1 -0.0153964
RPL12 ribosomal protein L12 -0.0153774
UBXN4 UBX domain protein 4 -0.0152755
IFI27 interferon, alpha-inducible protein 27 -0.0152293
ADAM8 ADAM metallopeptidase domain 8 -0.0150579
RPL13A ribosomal protein L13a -0.0149727
CCNL1 cyclin L1 -0.0149579
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0148798
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0147628
ZNF292 zinc finger protein 292 -0.0147196
RPL36A ribosomal protein L36a -0.0147087
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0145834
PIM3 Pim-3 proto-oncogene, serine/threonine kinase -0.0144912
GARS1 glycyl-tRNA synthetase 1 -0.0144499
FLNB filamin B, beta -0.014405
RAB1A RAB1A, member RAS oncogene family -0.0143768
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0143568
NACA nascent polypeptide-associated complex alpha subunit -0.0142174
RGS2 regulator of G-protein signaling 2 -0.0141434
RPS17 ribosomal protein S17 -0.0141097
RPL18 ribosomal protein L18 -0.0139763
RPL34 ribosomal protein L34 -0.0138761
RPS8 ribosomal protein S8 -0.013645
LAMB3 laminin, beta 3 -0.0136084
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0135416
NKTR natural killer cell triggering receptor -0.013465
NUCB2 nucleobindin 2 -0.0132827
RPL23 ribosomal protein L23 -0.0131592
TMEM87A transmembrane protein 87A -0.0129567
TMSB4X thymosin beta 4, X-linked -0.0128962
RPLP2 ribosomal protein, large, P2 -0.0127937
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0126075
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa -0.0125933
RPS25 ribosomal protein S25 -0.0125899
SEC31A SEC31 homolog A (S. cerevisiae) -0.0125253
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0124639
AKAP9 A kinase (PRKA) anchor protein 9 -0.012354