| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A pentacyclic triterpenoid that is olean-12-en-28-oic acid substituted by a beta-hydroxy group at position 3. (Chemical Entities of Biological Interest Ontology, CHEBI_37659) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/10494 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Oleanolic Acid relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KMT2B | lysine (K)-specific methyltransferase 2B | 1.34 |
| MYO15B | myosin XVB | 1.11 |
| TEN1 | TEN1 CST complex subunit | 1.09 |
| HECW2 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 | 1.06 |
| FMNL3 | formin-like 3 | 0.84 |
| ALPK3 | alpha-kinase 3 | 0.84 |
| CFAP54 | cilia and flagella associated 54 | 0.72 |
| PRELID1 | PRELI domain containing 1 | 0.71 |
| NLGN2 | neuroligin 2 | 0.69 |
| AASDH | aminoadipate-semialdehyde dehydrogenase | 0.68 |
| TSPAN3 | tetraspanin 3 | 0.67 |
| DHRS4L1 | dehydrogenase/reductase (SDR family) member 4 like 1 | 0.65 |
| H3C1 | H3 clustered histone 1 | 0.63 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | 0.61 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | 0.6 |
| TRMO | tRNA methyltransferase O | 0.6 |
| STC2 | stanniocalcin 2 | 0.59 |
| E2F8 | E2F transcription factor 8 | 0.58 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 0.57 |
| CHCHD2P9 | coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 9 | 0.56 |
| TRIB3 | tribbles pseudokinase 3 | 0.55 |
| ATXN7L2 | ataxin 7-like 2 | 0.52 |
| PRELID3B | PRELI domain containing 3B | 0.5 |
| TIMM10B | translocase of inner mitochondrial membrane 10 homolog B (yeast) | 0.47 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 0.45 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.44 |
| ZER1 | zyg-11 related, cell cycle regulator | 0.43 |
| ZSCAN26 | zinc finger and SCAN domain containing 26 | 0.43 |
| ASB3 | ankyrin repeat and SOCS box containing 3 | 0.42 |
| MCOLN2 | mucolipin 2 | 0.42 |
| C12ORF60 | chromosome 12 open reading frame 60 | 0.42 |
| PPARGC1B | peroxisome proliferator-activated receptor gamma, coactivator 1 beta | 0.4 |
| ZSCAN25 | zinc finger and SCAN domain containing 25 | 0.4 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.39 |
| ABCD4 | ATP-binding cassette, sub-family D (ALD), member 4 | 0.39 |
| CD63 | CD63 molecule | 0.39 |
| ZNF77 | zinc finger protein 77 | 0.39 |
| ZNF174 | zinc finger protein 174 | 0.39 |
| MCL1 | myeloid cell leukemia 1 | 0.38 |
| UPP1 | uridine phosphorylase 1 | 0.38 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | 0.38 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.38 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.38 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | 0.37 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.37 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.37 |
| KAT6B | K(lysine) acetyltransferase 6B | 0.37 |
| ZNF410 | zinc finger protein 410 | 0.36 |
| BHLHA15 | basic helix-loop-helix family, member a15 | 0.36 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | 0.35 |
| OSGIN2 | oxidative stress induced growth inhibitor family member 2 | 0.35 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | 0.35 |
| SARDH | sarcosine dehydrogenase | 0.35 |
| CNTLN | centlein, centrosomal protein | 0.34 |
| BOLA1 | bolA family member 1 | 0.34 |
| MCM9 | minichromosome maintenance complex component 9 | 0.33 |
| TRIM9 | tripartite motif containing 9 | 0.33 |
| FBXO46 | F-box protein 46 | 0.33 |
| STAB1 | stabilin 1 | 0.33 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.33 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.32 |
| RPGR | retinitis pigmentosa GTPase regulator | 0.32 |
| MMADHC | methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria | 0.32 |
| FBXO34 | F-box protein 34 | 0.32 |
| CCDC28A | coiled-coil domain containing 28A | 0.32 |
| LIME1 | Lck interacting transmembrane adaptor 1 | 0.32 |
| TOP1MT | topoisomerase (DNA) I, mitochondrial | 0.32 |
| ZNF263 | zinc finger protein 263 | 0.32 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.32 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.31 |
| C11ORF49 | chromosome 11 open reading frame 49 | 0.31 |
| RASSF3 | Ras association (RalGDS/AF-6) domain family member 3 | 0.31 |
| ULBP1 | UL16 binding protein 1 | 0.31 |
| ZKSCAN8 | zinc finger with KRAB and SCAN domains 8 | 0.3 |
| C1ORF122 | chromosome 1 open reading frame 122 | 0.3 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.3 |
| ZFHX4 | zinc finger homeobox 4 | 0.3 |
| SLC25A25 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 | 0.3 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | 0.3 |
| CRCP | CGRP receptor component | 0.29 |
| ZNF142 | zinc finger protein 142 | 0.29 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | 0.29 |
| ZDHHC8 | zinc finger, DHHC-type containing 8 | 0.29 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.28 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 0.28 |
| ZC3H10 | zinc finger CCCH-type containing 10 | 0.28 |
| DENND5A | DENN/MADD domain containing 5A | 0.28 |
| RASSF1 | Ras association (RalGDS/AF-6) domain family member 1 | 0.28 |
| ZNF320 | zinc finger protein 320 | 0.28 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | 0.27 |
| RPUSD1 | RNA pseudouridylate synthase domain containing 1 | 0.27 |
| SDC1 | syndecan 1 | 0.27 |
| SESN1 | sestrin 1 | 0.27 |
| FAN1 | FANCD2/FANCI-associated nuclease 1 | 0.27 |
| SMAD1 | SMAD family member 1 | 0.27 |
| TECPR1 | tectonin beta-propeller repeat containing 1 | 0.27 |
| SLC19A1 | solute carrier family 19 (folate transporter), member 1 | 0.27 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 0.27 |
| SMARCD3 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 | 0.27 |
| MPHOSPH9 | M-phase phosphoprotein 9 | 0.27 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SGSH | N-sulfoglucosamine sulfohydrolase | -1.66 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -1.38 |
| ESPN | espin | -0.86 |
| KLHL23 | kelch-like family member 23 | -0.84 |
| COQ10B | coenzyme Q10 homolog B (S. cerevisiae) | -0.82 |
| COL11A1 | collagen, type XI, alpha 1 | -0.7 |
| PLIN2 | perilipin 2 | -0.66 |
| TICAM1 | toll-like receptor adaptor molecule 1 | -0.6 |
| CMTM6 | CKLF-like MARVEL transmembrane domain containing 6 | -0.58 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.57 |
| SLC30A3 | solute carrier family 30 (zinc transporter), member 3 | -0.56 |
| PTPMT1 | protein tyrosine phosphatase, mitochondrial 1 | -0.54 |
| ITGA7 | integrin, alpha 7 | -0.53 |
| NAA38 | N(alpha)-acetyltransferase 38, NatC auxiliary subunit | -0.52 |
| SYTL2 | synaptotagmin-like 2 | -0.51 |
| KIAA1324L | KIAA1324-like | -0.5 |
| PPTC7 | PTC7 protein phosphatase homolog (S. cerevisiae) | -0.5 |
| KIF27 | kinesin family member 27 | -0.49 |
| SYN1 | synapsin I | -0.48 |
| ZNF513 | zinc finger protein 513 | -0.48 |
| ZNF776 | zinc finger protein 776 | -0.47 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.46 |
| SQLE | squalene epoxidase | -0.45 |
| JAK2 | Janus kinase 2 | -0.45 |
| ZNF276 | zinc finger protein 276 | -0.45 |
| BCL6 | B-cell CLL/lymphoma 6 | -0.43 |
| ABHD5 | abhydrolase domain containing 5 | -0.43 |
| STK19 | serine/threonine kinase 19 | -0.42 |
| ANO8 | anoctamin 8 | -0.41 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | -0.4 |
| HSPA12B | heat shock 70kD protein 12B | -0.4 |
| SNTA1 | syntrophin, alpha 1 | -0.39 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.38 |
| FAM135A | family with sequence similarity 135, member A | -0.36 |
| ZNF275 | zinc finger protein 275 | -0.36 |
| GRHL1 | grainyhead-like 1 (Drosophila) | -0.35 |
| NCBP2AS2 | NCBP2 antisense 2 (head to head) | -0.35 |
| COL6A3 | collagen, type VI, alpha 3 | -0.34 |
| UQCRQ | ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa | -0.34 |
| PTGES | prostaglandin E synthase | -0.34 |
| CCAR2 | cell cycle and apoptosis regulator 2 | -0.34 |
| TMEM143 | transmembrane protein 143 | -0.34 |
| ARSK | arylsulfatase family, member K | -0.33 |
| CLTA | clathrin, light chain A | -0.33 |
| SPAG17 | sperm associated antigen 17 | -0.33 |
| NIPSNAP3A | nipsnap homolog 3A (C. elegans) | -0.33 |
| ABHD2 | abhydrolase domain containing 2 | -0.33 |
| DNAJC19 | DnaJ (Hsp40) homolog, subfamily C, member 19 | -0.32 |
| NOTCH3 | notch 3 | -0.32 |
| TOB1 | transducer of ERBB2, 1 | -0.32 |
| GALT | galactose-1-phosphate uridylyltransferase | -0.32 |
| NUS1 | nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) | -0.32 |
| ZNF205 | zinc finger protein 205 | -0.31 |
| GPRC5C | G protein-coupled receptor, class C, group 5, member C | -0.31 |
| MAGEA2 | melanoma antigen family A2 | -0.31 |
| ZNF503 | zinc finger protein 503 | -0.31 |
| NGFR | nerve growth factor receptor | -0.3 |
| OGFRL1 | opioid growth factor receptor-like 1 | -0.3 |
| ACTN4 | actinin, alpha 4 | -0.3 |
| NAGS | N-acetylglutamate synthase | -0.3 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.3 |
| FBXW2 | F-box and WD repeat domain containing 2 | -0.3 |
| CDC25B | cell division cycle 25B | -0.29 |
| PON3 | paraoxonase 3 | -0.29 |
| SMARCC2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 | -0.29 |
| CASZ1 | castor zinc finger 1 | -0.29 |
| C12ORF66 | chromosome 12 open reading frame 66 | -0.29 |
| FAR2 | fatty acyl CoA reductase 2 | -0.29 |
| NDUFAB1 | NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa | -0.28 |
| BCO2 | beta-carotene oxygenase 2 | -0.28 |
| IGF1R | insulin-like growth factor 1 receptor | -0.28 |
| LAMTOR4 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 | -0.28 |
| ZNF296 | zinc finger protein 296 | -0.28 |
| EGR1 | early growth response 1 | -0.28 |
| SLC35C1 | solute carrier family 35 (GDP-fucose transporter), member C1 | -0.28 |
| DHDDS | dehydrodolichyl diphosphate synthase | -0.28 |
| RECK | reversion-inducing-cysteine-rich protein with kazal motifs | -0.28 |
| BDNF | brain-derived neurotrophic factor | -0.28 |
| PRG4 | proteoglycan 4 | -0.27 |
| PRDM15 | PR domain containing 15 | -0.27 |
| TMEM199 | transmembrane protein 199 | -0.27 |
| GMCL2 | germ cell-less 2, spermatogenesis associated | -0.27 |
| ZNF700 | zinc finger protein 700 | -0.27 |
| REEP3 | receptor accessory protein 3 | -0.27 |
| ALG12 | ALG12, alpha-1,6-mannosyltransferase | -0.27 |
| ZIC5 | Zic family member 5 | -0.27 |
| SHFL | shiftless antiviral inhibitor of ribosomal frameshifting | -0.27 |
| ATP5IF1 | ATP synthase inhibitory factor subunit 1 | -0.26 |
| ART5 | ADP-ribosyltransferase 5 | -0.26 |
| BLOC1S2 | biogenesis of lysosomal organelles complex-1, subunit 2 | -0.26 |
| JCAD | junctional cadherin 5 associated | -0.26 |
| APOBEC3F | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F | -0.26 |
| COX18 | COX18 cytochrome c oxidase assembly factor | -0.26 |
| LTO1 | LTO1 maturation factor of ABCE1 | -0.26 |
| ZNF354A | zinc finger protein 354A | -0.26 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.26 |
| SLC35A5 | solute carrier family 35, member A5 | -0.26 |
| EMB | embigin | -0.25 |
| DDHD2 | DDHD domain containing 2 | -0.25 |
