Oleic acid_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0908405
TRIO trio Rho guanine nucleotide exchange factor 0.0889622
CDH13 cadherin 13 0.0776767
AHNAK AHNAK nucleoprotein 0.0772609
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0770101
FLNA filamin A, alpha 0.0663046
PODXL podocalyxin-like 0.0633403
FLNB filamin B, beta 0.0630785
MYH9 myosin, heavy chain 9, non-muscle 0.0492788
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0486961
AKAP12 A kinase (PRKA) anchor protein 12 0.048436
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0484339
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0479326
CD44 CD44 molecule (Indian blood group) 0.0478012
COL5A1 collagen, type V, alpha 1 0.0466754
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0464281
PBX3 pre-B-cell leukemia homeobox 3 0.0458363
ASPH aspartate beta-hydroxylase 0.0456665
MAP1B microtubule-associated protein 1B 0.0454521
FSTL1 follistatin-like 1 0.0453685
SEPTIN9 septin 9 0.044346
HDAC9 histone deacetylase 9 0.0428949
TPM3 tropomyosin 3 0.0416505
CENPF centromere protein F, 350/400kDa 0.0412427
NAV1 neuron navigator 1 0.0409251
LOC112694756 uncharaterized LOC112694756 0.0409182
FNDC3B fibronectin type III domain containing 3B 0.0407914
EEF2 eukaryotic translation elongation factor 2 0.0404944
EGFR epidermal growth factor receptor 0.0400838
PLEC plectin 0.0398657
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0398639
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0387178
ANXA2 annexin A2 0.0385798
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0363546
MSN moesin 0.0349772
MACF1 microtubule-actin crosslinking factor 1 0.0336746
SLC39A11 solute carrier family 39, member 11 0.0331459
EFNA5 ephrin-A5 0.0326728
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.031978
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0303892
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0301392
ANKRD11 ankyrin repeat domain 11 0.0295317
BHLHE40 basic helix-loop-helix family, member e40 0.029195
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0282361
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0282246
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0281091
POTEF POTE ankyrin domain family, member F 0.0279277
MYOF myoferlin 0.0279156
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0275632
DSPP dentin sialophosphoprotein 0.0272218
ERBIN erbb2 interacting protein 0.0263283
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0263139
ELL2 elongation factor, RNA polymerase II, 2 0.02593
RUNX1 runt-related transcription factor 1 0.0255339
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0248405
COPA coatomer protein complex, subunit alpha 0.0247208
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0247139
RHOBTB3 Rho-related BTB domain containing 3 0.0246624
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0241545
LNPEP leucyl/cystinyl aminopeptidase 0.0240619
APP amyloid beta (A4) precursor protein 0.0237274
MB21D2 Mab-21 domain containing 2 0.0233722
ERRFI1 ERBB receptor feedback inhibitor 1 0.0231088
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0230663
IQGAP1 IQ motif containing GTPase activating protein 1 0.0230444
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0227717
NDRG1 N-myc downstream regulated 1 0.0225246
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0225039
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0217767
AHNAK2 AHNAK nucleoprotein 2 0.0214472
DLG1 discs, large homolog 1 (Drosophila) 0.0212334
DOCK5 dedicator of cytokinesis 5 0.0208655
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0204189
L1CAM L1 cell adhesion molecule 0.0203109
ANO6 anoctamin 6 0.0202617
SHB Src homology 2 domain containing adaptor protein B 0.0200059
ADAM9 ADAM metallopeptidase domain 9 0.0199298
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0196706
MKI67 marker of proliferation Ki-67 0.0196442
DCLK2 doublecortin-like kinase 2 0.0194726
BCL2L1 BCL2-like 1 0.0194127
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0187198
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0185879
DNMBP dynamin binding protein 0.0185403
PFKP phosphofructokinase, platelet 0.0185022
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0183793
DGKG diacylglycerol kinase, gamma 90kDa 0.0180702
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0179865
VCL vinculin 0.0179243
ZSWIM6 zinc finger, SWIM-type containing 6 0.0179188
LDHA lactate dehydrogenase A 0.0175349
ACER3 alkaline ceramidase 3 0.01723
SEPTIN7 septin 7 0.0171473
NOTCH2 notch 2 0.0171185
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0170294
KIAA1549L KIAA1549-like 0.0169982
ZMIZ1 zinc finger, MIZ-type containing 1 0.0168663
NCOR2 nuclear receptor corepressor 2 0.0168595
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0168462
DPYSL2 dihydropyrimidinase-like 2 0.0168431

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.187031
VIM vimentin -0.120231
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.100124
FBN1 fibrillin 1 -0.0892958
MT2A metallothionein 2A -0.0806822
HLA-B major histocompatibility complex, class I, B -0.0756484
COL8A1 collagen, type VIII, alpha 1 -0.0739997
COL1A2 collagen, type I, alpha 2 -0.0661275
PLAT plasminogen activator, tissue -0.0525273
ZBTB20 zinc finger and BTB domain containing 20 -0.0523289
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0516412
SOD2 superoxide dismutase 2, mitochondrial -0.0509794
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0508946
PTMA prothymosin, alpha -0.0427608
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0412555
MEIS2 Meis homeobox 2 -0.039364
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0386253
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0369428
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0354646
TPT1 tumor protein, translationally-controlled 1 -0.035158
MX2 MX dynamin-like GTPase 2 -0.031936
LOX lysyl oxidase -0.0313893
IFITM1 interferon induced transmembrane protein 1 -0.0309954
FRMD5 FERM domain containing 5 -0.0309783
PRSS23 protease, serine, 23 -0.0303344
COL5A2 collagen, type V, alpha 2 -0.0293381
IFIH1 interferon induced with helicase C domain 1 -0.0292931
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0290842
THBS2 thrombospondin 2 -0.0290574
B2M beta-2-microglobulin -0.0284445
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0280704
IGFBP3 insulin-like growth factor binding protein 3 -0.0267462
ARL15 ADP-ribosylation factor-like 15 -0.0263619
LMNA lamin A/C -0.0253315
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0249924
GPC6 glypican 6 -0.0245934
WARS1 tryptophanyl-tRNA synthetase 1 -0.0244728
AUTS2 autism susceptibility candidate 2 -0.0241841
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0237967
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0234374
LOXL2 lysyl oxidase-like 2 -0.0231282
IFITM3 interferon induced transmembrane protein 3 -0.0229873
IFI6 interferon, alpha-inducible protein 6 -0.0228565
RPS3 ribosomal protein S3 -0.0227669
RPL37A ribosomal protein L37a -0.0227473
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0226203
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0226165
WSB1 WD repeat and SOCS box containing 1 -0.0225142
IFI16 interferon, gamma-inducible protein 16 -0.0223525
ARL4C ADP-ribosylation factor-like 4C -0.0223398
CAVIN1 caveolae associated protein 1 -0.0222995
FTL ferritin, light polypeptide -0.0222839
JAZF1 JAZF zinc finger 1 -0.0220638
NAP1L1 nucleosome assembly protein 1-like 1 -0.0219195
PRRX1 paired related homeobox 1 -0.0214167
S100A11 S100 calcium binding protein A11 -0.0212921
SUCNR1 succinate receptor 1 -0.0211649
RPS8 ribosomal protein S8 -0.0209728
PSD3 pleckstrin and Sec7 domain containing 3 -0.0205499
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0204473
MRPS6 mitochondrial ribosomal protein S6 -0.0199767
RPLP2 ribosomal protein, large, P2 -0.0196404
CCL5 chemokine (C-C motif) ligand 5 -0.0194564
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0191212
HLA-E major histocompatibility complex, class I, E -0.0189109
ABI3BP ABI family, member 3 (NESH) binding protein -0.01875
RPL36 ribosomal protein L36 -0.018439
RPL35A ribosomal protein L35a -0.018188
COL3A1 collagen, type III, alpha 1 -0.0180735
ISG15 ISG15 ubiquitin-like modifier -0.0177604
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0175568
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0175348
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0171739
RPL28 ribosomal protein L28 -0.0168986
HLA-C major histocompatibility complex, class I, C -0.0165337
GARS1 glycyl-tRNA synthetase 1 -0.0163127
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0161617
RPL31 ribosomal protein L31 -0.0161483
ANKRD10 ankyrin repeat domain 10 -0.0158054
EHBP1 EH domain binding protein 1 -0.0155108
FBXL7 F-box and leucine-rich repeat protein 7 -0.0152191
COL1A1 collagen, type I, alpha 1 -0.0151614
PLAUR plasminogen activator, urokinase receptor -0.0151139
UBC ubiquitin C -0.014909
EIF1 eukaryotic translation initiation factor 1 -0.0148275
SYT1 synaptotagmin I -0.0147818
TPM1 tropomyosin 1 (alpha) -0.0147085
CD63 CD63 molecule -0.0143484
CSTB cystatin B (stefin B) -0.0143172
HSPB1 heat shock 27kDa protein 1 -0.0142892
GOLGA2 golgin A2 -0.0142387
FGF13 fibroblast growth factor 13 -0.0142307
RPS13 ribosomal protein S13 -0.0140398
SLC38A1 solute carrier family 38, member 1 -0.0140271
RPS24 ribosomal protein S24 -0.0139668
PDE4D phosphodiesterase 4D, cAMP-specific -0.0138971
RPS27A ribosomal protein S27a -0.0138838
VDAC1 voltage-dependent anion channel 1 -0.0136924
RPS19 ribosomal protein S19 -0.0136391
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0136269