Oleic acid_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.103734
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0797775
MMP12 matrix metallopeptidase 12 0.0771686
YAP1 Yes-associated protein 1 0.0765337
EEF2 eukaryotic translation elongation factor 2 0.0611775
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0609918
HMGA2 high mobility group AT-hook 2 0.05995
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0594675
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0448409
RRM2 ribonucleotide reductase M2 0.0413044
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0405659
BIRC3 baculoviral IAP repeat containing 3 0.0391818
AHNAK AHNAK nucleoprotein 0.0378333
ANXA1 annexin A1 0.0356015
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0355954
LOC112694756 uncharaterized LOC112694756 0.0355181
ADIPOR2 adiponectin receptor 2 0.0353295
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0338384
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0333601
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0315279
TXNRD1 thioredoxin reductase 1 0.0300052
CLTC clathrin, heavy chain (Hc) 0.0297226
EHBP1 EH domain binding protein 1 0.0289665
IPO7 importin 7 0.0286365
H1-0 H1.0 linker histone 0.0284422
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0282809
ERRFI1 ERBB receptor feedback inhibitor 1 0.0274007
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0272801
CALR calreticulin 0.0268755
ASPH aspartate beta-hydroxylase 0.0263171
VMP1 vacuole membrane protein 1 0.0260296
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0253426
TAS2R14 taste receptor, type 2, member 14 0.0251446
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0249939
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0247358
TPM3 tropomyosin 3 0.024671
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0246708
DPYD dihydropyrimidine dehydrogenase 0.0246605
ZSWIM6 zinc finger, SWIM-type containing 6 0.0243187
JMJD1C jumonji domain containing 1C 0.0242028
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0237895
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0237151
PDGFC platelet derived growth factor C 0.0237023
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.0236702
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0233312
NLGN1 neuroligin 1 0.0232949
HSPA8 heat shock 70kDa protein 8 0.0232532
WNK1 WNK lysine deficient protein kinase 1 0.0228378
TENM3 teneurin transmembrane protein 3 0.0226163
PDIA4 protein disulfide isomerase family A, member 4 0.0224493
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0222833
WWOX WW domain containing oxidoreductase 0.0216606
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0216429
LPP LIM domain containing preferred translocation partner in lipoma 0.0216033
STIP1 stress-induced phosphoprotein 1 0.0209435
CANX calnexin 0.020882
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.020877
HDLBP high density lipoprotein binding protein 0.0204188
USP34 ubiquitin specific peptidase 34 0.0200423
PCDH7 protocadherin 7 0.0198796
FLNA filamin A, alpha 0.0198137
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0197478
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.019417
SPATS2 spermatogenesis associated, serine-rich 2 0.0190415
EIF4A2 eukaryotic translation initiation factor 4A2 0.0188314
NCAPD2 non-SMC condensin I complex, subunit D2 0.018765
PDE4D phosphodiesterase 4D, cAMP-specific 0.0186774
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0185607
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0184404
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0184078
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0181019
DST dystonin 0.0180555
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0180024
HDAC9 histone deacetylase 9 0.0177632
INTS6 integrator complex subunit 6 0.0176294
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0174591
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0174487
GOLGB1 golgin B1 0.0174349
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.017266
DENND5A DENN/MADD domain containing 5A 0.0172298
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0169766
FNIP1 folliculin interacting protein 1 0.016933
FXR1 fragile X mental retardation, autosomal homolog 1 0.016817
AFF4 AF4/FMR2 family, member 4 0.0163752
ASXL2 additional sex combs like transcriptional regulator 2 0.0163406
TBC1D5 TBC1 domain family, member 5 0.0162364
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0160834
HSPA4 heat shock 70kDa protein 4 0.0157749
ZBTB20 zinc finger and BTB domain containing 20 0.0157039
APLP2 amyloid beta (A4) precursor-like protein 2 0.0156495
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0156116
ZNF638 zinc finger protein 638 0.0155902
CLDN1 claudin 1 0.015527
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0154641
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0153799
NEGR1 neuronal growth regulator 1 0.0153311
NRXN3 neurexin 3 0.0152717
SFTPA2 surfactant protein A2 0.0151704
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.015139
LRMDA leucine rich melanocyte differentiation associated 0.0148896

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.115554
AREG amphiregulin -0.113157
PTMA prothymosin, alpha -0.0460747
RPL35A ribosomal protein L35a -0.0347498
RPS12 ribosomal protein S12 -0.0341096
FTL ferritin, light polypeptide -0.0318625
RPS29 ribosomal protein S29 -0.0304552
RPLP2 ribosomal protein, large, P2 -0.0285063
RPS3 ribosomal protein S3 -0.0277836
MYL12B myosin, light chain 12B, regulatory -0.0276303
RPL37A ribosomal protein L37a -0.0269978
RPS21 ribosomal protein S21 -0.024792
RPS19 ribosomal protein S19 -0.0243313
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0234285
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0223716
ATP5F1B ATP synthase F1 subunit beta -0.0221992
RPS23 ribosomal protein S23 -0.0221137
RPL23 ribosomal protein L23 -0.021653
RPS24 ribosomal protein S24 -0.0206871
RPL36 ribosomal protein L36 -0.0204062
PFN1 profilin 1 -0.0203281
NAP1L1 nucleosome assembly protein 1-like 1 -0.0194782
RPL37 ribosomal protein L37 -0.0186975
CNRIP1 cannabinoid receptor interacting protein 1 -0.0179183
RPS13 ribosomal protein S13 -0.0176756
RPL26 ribosomal protein L26 -0.0174012
RPS16 ribosomal protein S16 -0.0172814
RPL36A ribosomal protein L36a -0.0171932
RPL9 ribosomal protein L9 -0.0171041
RPS14 ribosomal protein S14 -0.0166695
TPT1 tumor protein, translationally-controlled 1 -0.0160688
RPL31 ribosomal protein L31 -0.0152652
RPL34 ribosomal protein L34 -0.0150699
VDAC1 voltage-dependent anion channel 1 -0.0150671
RPS8 ribosomal protein S8 -0.0150634
RPS27A ribosomal protein S27a -0.0150322
HSPB1 heat shock 27kDa protein 1 -0.0145292
RPL28 ribosomal protein L28 -0.0144741
RBM25 RNA binding motif protein 25 -0.0142906
RPLP1 ribosomal protein, large, P1 -0.0142774
RPL38 ribosomal protein L38 -0.0140252
RPS25 ribosomal protein S25 -0.0138138
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0137068
EIF1 eukaryotic translation initiation factor 1 -0.013623
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0131542
SLC38A1 solute carrier family 38, member 1 -0.013113
MGAT4C MGAT4 family, member C -0.013088
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0130451
RPL32 ribosomal protein L32 -0.0130061
RPS20 ribosomal protein S20 -0.0128477
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0127751
RPS6 ribosomal protein S6 -0.012728
HMGA1 high mobility group AT-hook 1 -0.0126263
RBMX RNA binding motif protein, X-linked -0.0124097
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0122019
IFIH1 interferon induced with helicase C domain 1 -0.0120753
RPL8 ribosomal protein L8 -0.012032
PCBP2 poly(rC) binding protein 2 -0.0119432
RPL27 ribosomal protein L27 -0.0118864
RPL19 ribosomal protein L19 -0.0116782
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0116575
ZNF804A zinc finger protein 804A -0.0116157
RPS27 ribosomal protein S27 -0.0111824
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0111592
S100A10 S100 calcium binding protein A10 -0.0110439
RPS15 ribosomal protein S15 -0.0109287
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0108801
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0101748
BTG3 BTG family, member 3 -0.0101656
S100A6 S100 calcium binding protein A6 -0.0101237
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0100624
RPLP0 ribosomal protein, large, P0 -0.0100172
YBX3 Y box binding protein 3 -0.0099742
RPL7A ribosomal protein L7a -0.00992993
UQCRB ubiquinol-cytochrome c reductase binding protein -0.00980868
EIF5B eukaryotic translation initiation factor 5B -0.00975825
RASAL2 RAS protein activator like 2 -0.00974463
GARS1 glycyl-tRNA synthetase 1 -0.00971195
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.00960941
WDR43 WD repeat domain 43 -0.00934435
RPL11 ribosomal protein L11 -0.0092696
S100A11 S100 calcium binding protein A11 -0.00926012
THOC2 THO complex 2 -0.0092332
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.00922592
DTNA dystrobrevin, alpha -0.00920262
RPL27A ribosomal protein L27a -0.00910851
RPL5 ribosomal protein L5 -0.00899496
RBM39 RNA binding motif protein 39 -0.00884808
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.00860181
RPL12 ribosomal protein L12 -0.00849305
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.00848771
WSB1 WD repeat and SOCS box containing 1 -0.00848507
RPS11 ribosomal protein S11 -0.00848026
KPNB1 karyopherin (importin) beta 1 -0.00838457
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.00836529
MRPL51 mitochondrial ribosomal protein L51 -0.00832887
RPS10 ribosomal protein S10 -0.0082412
PDCD5 programmed cell death 5 -0.00819832
VIM vimentin -0.00808268
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.00804692