Oleic acid_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.116106
MYH9 myosin, heavy chain 9, non-muscle 0.109144
SPTBN1 spectrin, beta, non-erythrocytic 1 0.101332
SOD2 superoxide dismutase 2, mitochondrial 0.0851841
EXT1 exostosin glycosyltransferase 1 0.0709033
ASPH aspartate beta-hydroxylase 0.0694238
EEF2 eukaryotic translation elongation factor 2 0.0610743
PLEC plectin 0.0581751
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0551451
PDLIM5 PDZ and LIM domain 5 0.0524263
FNDC3B fibronectin type III domain containing 3B 0.051087
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0493722
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0474796
VCAM1 vascular cell adhesion molecule 1 0.0453494
ICAM1 intercellular adhesion molecule 1 0.0404989
SMAD3 SMAD family member 3 0.0401591
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0386834
APP amyloid beta (A4) precursor protein 0.0374926
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0358504
FLNA filamin A, alpha 0.0353623
SEPTIN9 septin 9 0.0352552
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0343259
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.033653
KYNU kynureninase 0.0334641
JAK1 Janus kinase 1 0.0334129
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0329865
NRIP1 nuclear receptor interacting protein 1 0.0328085
ZSWIM6 zinc finger, SWIM-type containing 6 0.0315257
SUCO SUN domain containing ossification factor 0.0314497
PDIA4 protein disulfide isomerase family A, member 4 0.0307412
CXCL8 chemokine (C-X-C motif) ligand 8 0.0307394
FAT1 FAT atypical cadherin 1 0.0305582
SHB Src homology 2 domain containing adaptor protein B 0.0286169
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0284322
NAV2 neuron navigator 2 0.0272305
AHNAK AHNAK nucleoprotein 0.0271994
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0271698
TLE4 transducin-like enhancer of split 4 0.0258962
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0254837
TNIP1 TNFAIP3 interacting protein 1 0.0254292
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.0253391
DOCK5 dedicator of cytokinesis 5 0.0251211
NRP2 neuropilin 2 0.0250606
NFE2L2 nuclear factor, erythroid 2-like 2 0.0250312
MYOF myoferlin 0.0241008
INTS6 integrator complex subunit 6 0.0234552
MBNL2 muscleblind-like splicing regulator 2 0.0224169
COG5 component of oligomeric golgi complex 5 0.0223264
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0221564
MACF1 microtubule-actin crosslinking factor 1 0.021647
ANKRD33B ankyrin repeat domain 33B 0.0215708
CTBP2 C-terminal binding protein 2 0.0212362
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0212107
SPAG9 sperm associated antigen 9 0.0208169
CRY1 cryptochrome circadian clock 1 0.0206164
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0203467
NAMPT nicotinamide phosphoribosyltransferase 0.0203401
BZW1 basic leucine zipper and W2 domains 1 0.0202628
CLTC clathrin, heavy chain (Hc) 0.0200951
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.020094
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0200422
TGM2 transglutaminase 2 0.0199272
COPA coatomer protein complex, subunit alpha 0.0197857
RAD23B RAD23 homolog B (S. cerevisiae) 0.0197374
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0197157
TMED2 transmembrane emp24 domain trafficking protein 2 0.019402
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0189233
SAMD4A sterile alpha motif domain containing 4A 0.0188076
PALLD palladin, cytoskeletal associated protein 0.018677
CREB5 cAMP responsive element binding protein 5 0.0184187
RLIM ring finger protein, LIM domain interacting 0.0183212
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0182952
AFF1 AF4/FMR2 family, member 1 0.0181691
TUT7 terminal uridylyl transferase 7 0.018106
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0180127
MBNL1 muscleblind-like splicing regulator 1 0.0179014
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.017779
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.017757
GDI2 GDP dissociation inhibitor 2 0.0175826
TUFT1 tuftelin 1 0.0174146
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.017225
COPB1 coatomer protein complex, subunit beta 1 0.0171348
COL4A2 collagen, type IV, alpha 2 0.0170234
UBQLN1 ubiquilin 1 0.0169822
CHD1 chromodomain helicase DNA binding protein 1 0.0168545
ANXA2 annexin A2 0.0167231
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0165267
DSCAM Down syndrome cell adhesion molecule 0.016497
SEC24D SEC24 family member D 0.0164943
ATF3 activating transcription factor 3 0.0163344
FHL2 four and a half LIM domains 2 0.0163142
PTPRJ protein tyrosine phosphatase, receptor type, J 0.016121
EIF4A2 eukaryotic translation initiation factor 4A2 0.0160804
HDLBP high density lipoprotein binding protein 0.0160518
MSN moesin 0.0159543
MYO1E myosin IE 0.0159538
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.015903
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0158724
ZFAND3 zinc finger, AN1-type domain 3 0.0158708
ARRDC3 arrestin domain containing 3 0.01587

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.239973
TMSB10 thymosin beta 10 -0.184427
VIM vimentin -0.177461
FRMD4A FERM domain containing 4A -0.154985
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.148574
FTL ferritin, light polypeptide -0.128782
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0930732
B2M beta-2-microglobulin -0.0904579
HLA-B major histocompatibility complex, class I, B -0.0902617
CP ceruloplasmin (ferroxidase) -0.079291
RPS6 ribosomal protein S6 -0.0773044
RPL35A ribosomal protein L35a -0.0729967
MT2A metallothionein 2A -0.0665584
NDRG1 N-myc downstream regulated 1 -0.0559404
RPL23 ribosomal protein L23 -0.0554091
PTMA prothymosin, alpha -0.0552142
HSPB1 heat shock 27kDa protein 1 -0.05503
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0511066
RPS19 ribosomal protein S19 -0.0486018
PFN1 profilin 1 -0.0476259
CTSD cathepsin D -0.0452859
RPS8 ribosomal protein S8 -0.0439816
RPL34 ribosomal protein L34 -0.0427933
TPT1 tumor protein, translationally-controlled 1 -0.0408868
RPL31 ribosomal protein L31 -0.0402957
EIF1 eukaryotic translation initiation factor 1 -0.0394484
RPLP2 ribosomal protein, large, P2 -0.0392428
RPL28 ribosomal protein L28 -0.0389179
RPS21 ribosomal protein S21 -0.0373315
TPM1 tropomyosin 1 (alpha) -0.0369542
RPLP1 ribosomal protein, large, P1 -0.0367655
ARL4C ADP-ribosylation factor-like 4C -0.0362469
S100A11 S100 calcium binding protein A11 -0.0357423
PLIN2 perilipin 2 -0.0348293
ZMYND8 zinc finger, MYND-type containing 8 -0.0343556
RPL37A ribosomal protein L37a -0.034166
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0338042
IFI27 interferon, alpha-inducible protein 27 -0.0336731
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0331445
RPS13 ribosomal protein S13 -0.0316822
MGST1 microsomal glutathione S-transferase 1 -0.03162
RPS24 ribosomal protein S24 -0.031301
S100A6 S100 calcium binding protein A6 -0.0299522
MRPS6 mitochondrial ribosomal protein S6 -0.0296288
IFITM3 interferon induced transmembrane protein 3 -0.0293211
RPS14 ribosomal protein S14 -0.0291968
APOL1 apolipoprotein L, 1 -0.0287062
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0285853
IFI6 interferon, alpha-inducible protein 6 -0.0285598
POTEF POTE ankyrin domain family, member F -0.028291
RTN4 reticulon 4 -0.0282225
SERF2 small EDRK-rich factor 2 -0.0278569
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0277564
MTDH metadherin -0.0277016
HLA-A major histocompatibility complex, class I, A -0.0273675
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0273116
CBX3 chromobox homolog 3 -0.0272499
ANXA4 annexin A4 -0.0267087
RPL36 ribosomal protein L36 -0.0266158
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0264479
RPL36A ribosomal protein L36a -0.0264194
OXR1 oxidation resistance 1 -0.026389
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0263656
LY6E lymphocyte antigen 6 complex, locus E -0.0253733
TSHZ2 teashirt zinc finger homeobox 2 -0.0250003
CKAP4 cytoskeleton-associated protein 4 -0.0248003
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0247656
RPS27 ribosomal protein S27 -0.0246384
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0246376
BNC2 basonuclin 2 -0.0243388
RPL8 ribosomal protein L8 -0.0243144
EIF5B eukaryotic translation initiation factor 5B -0.0243094
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0242077
UGCG UDP-glucose ceramide glucosyltransferase -0.0239103
RPS27A ribosomal protein S27a -0.0239031
CYBA cytochrome b-245, alpha polypeptide -0.0238665
RPL26 ribosomal protein L26 -0.0237763
IFITM1 interferon induced transmembrane protein 1 -0.0237695
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0236167
KPNB1 karyopherin (importin) beta 1 -0.0235901
CXXC1 CXXC finger protein 1 -0.0235493
RPL35 ribosomal protein L35 -0.0234691
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0230995
ACTG1 actin gamma 1 -0.0230012
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0228512
RPS11 ribosomal protein S11 -0.0227145
CD63 CD63 molecule -0.0224634
RPS23 ribosomal protein S23 -0.0221413
RPS29 ribosomal protein S29 -0.0220339
PDIA3 protein disulfide isomerase family A, member 3 -0.0220294
RPL9 ribosomal protein L9 -0.0219896
MYADM myeloid-associated differentiation marker -0.0218598
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0218273
CCL2 chemokine (C-C motif) ligand 2 -0.0217154
RPL37 ribosomal protein L37 -0.0215435
TPM4 tropomyosin 4 -0.0215384
PKM pyruvate kinase, muscle -0.0211506
RPL27 ribosomal protein L27 -0.0211475
CA12 carbonic anhydrase XII -0.0211229
CD82 CD82 molecule -0.0209944