Oleic acid_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MEST mesoderm specific transcript 0.156722
EEF2 eukaryotic translation elongation factor 2 0.141984
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.118969
VEGFA vascular endothelial growth factor A 0.108115
DSCAM Down syndrome cell adhesion molecule 0.0732713
SFTPA2 surfactant protein A2 0.0582131
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0521465
OGA O-GlcNAcase 0.0519605
KDM6A lysine (K)-specific demethylase 6A 0.0514257
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0502852
FTH1 ferritin, heavy polypeptide 1 0.0495504
SQSTM1 sequestosome 1 0.0478967
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0474797
SIK3 SIK family kinase 3 0.0469395
ZNF608 zinc finger protein 608 0.0450595
KDM2A lysine (K)-specific demethylase 2A 0.0442446
QKI QKI, KH domain containing, RNA binding 0.0441079
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0419807
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0417728
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.0414496
ERBIN erbb2 interacting protein 0.0403395
SPPL3 signal peptide peptidase like 3 0.040099
FN1 fibronectin 1 0.039923
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0397514
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0396697
ZNF292 zinc finger protein 292 0.0388582
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0378174
LOC112694756 uncharaterized LOC112694756 0.0376261
WNK1 WNK lysine deficient protein kinase 1 0.0357845
ELF2 E74-like factor 2 (ets domain transcription factor) 0.03528
APP amyloid beta (A4) precursor protein 0.0344339
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0342397
DDIT4 DNA-damage-inducible transcript 4 0.0331148
MED13 mediator complex subunit 13 0.0328083
KMT2E lysine (K)-specific methyltransferase 2E 0.032361
PRPF8 pre-mRNA processing factor 8 0.032109
CAMTA1 calmodulin binding transcription activator 1 0.0314762
MED13L mediator complex subunit 13-like 0.0314694
HOXA3 homeobox A3 0.0311996
ZNF516 zinc finger protein 516 0.0305746
ADM adrenomedullin 0.0302307
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0300345
SKIL SKI-like proto-oncogene 0.0299906
TRIP12 thyroid hormone receptor interactor 12 0.0297877
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0297445
APLP2 amyloid beta (A4) precursor-like protein 2 0.0294817
DBN1 drebrin 1 0.0288682
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0286778
WAC WW domain containing adaptor with coiled-coil 0.0282387
ITGAV integrin, alpha V 0.0281017
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.0280771
ARRDC3 arrestin domain containing 3 0.028069
ELOVL5 ELOVL fatty acid elongase 5 0.0276465
PDS5B PDS5 cohesin associated factor B 0.0275312
PCBP2 poly(rC) binding protein 2 0.027378
ANKRD12 ankyrin repeat domain 12 0.0273167
ZFAND3 zinc finger, AN1-type domain 3 0.0272027
VMP1 vacuole membrane protein 1 0.0270959
EIF5 eukaryotic translation initiation factor 5 0.0268762
SMAD3 SMAD family member 3 0.0268469
NCOR1 nuclear receptor corepressor 1 0.0268002
PTEN phosphatase and tensin homolog 0.0267182
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0265725
RPS18 ribosomal protein S18 0.0263488
FLNA filamin A, alpha 0.0262645
SCAF11 SR-related CTD-associated factor 11 0.0261976
GSK3B glycogen synthase kinase 3 beta 0.0261852
SFPQ splicing factor proline/glutamine-rich 0.0261596
ITSN2 intersectin 2 0.0258362
YAP1 Yes-associated protein 1 0.0258117
LCOR ligand dependent nuclear receptor corepressor 0.0257717
SRRM2 serine/arginine repetitive matrix 2 0.0256851
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains 0.0255207
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0254872
FBXL20 F-box and leucine-rich repeat protein 20 0.0254265
GOLGB1 golgin B1 0.0252634
SMAP1 small ArfGAP 1 0.0252565
TBC1D5 TBC1 domain family, member 5 0.0252494
AGO3 argonaute RISC catalytic component 3 0.0251782
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0251387
KMT2C lysine (K)-specific methyltransferase 2C 0.0250636
KMT2A lysine (K)-specific methyltransferase 2A 0.0249318
RHEB Ras homolog enriched in brain 0.0249303
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0248732
DST dystonin 0.0247924
PKM pyruvate kinase, muscle 0.0247155
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0247101
NFYA nuclear transcription factor Y, alpha 0.0246757
KIDINS220 kinase D-interacting substrate, 220kDa 0.0245638
IRF1 interferon regulatory factor 1 0.0244422
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0244237
SPAG9 sperm associated antigen 9 0.0243993
PPP4R2 protein phosphatase 4, regulatory subunit 2 0.0242348
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0242274
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0242014
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0239345
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0238653
CTBP2 C-terminal binding protein 2 0.0237392
SUCO SUN domain containing ossification factor 0.0235597
MAP2K4 mitogen-activated protein kinase kinase 4 0.0234357

decreased expression

Symbol Name Standardized Value
CADM2 cell adhesion molecule 2 -0.213318
PRKG1 protein kinase, cGMP-dependent, type I -0.181514
PEG10 paternally expressed 10 -0.178023
VIM vimentin -0.154094
MGP matrix Gla protein -0.143658
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.106019
COL1A2 collagen, type I, alpha 2 -0.0806438
RPS8 ribosomal protein S8 -0.0792748
TPT1 tumor protein, translationally-controlled 1 -0.078876
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0771493
TPK1 thiamin pyrophosphokinase 1 -0.0763326
TMSB10 thymosin beta 10 -0.0754134
RPLP1 ribosomal protein, large, P1 -0.0737186
RPS6 ribosomal protein S6 -0.0633336
RPL35A ribosomal protein L35a -0.0623968
RPS24 ribosomal protein S24 -0.060474
HMGA2 high mobility group AT-hook 2 -0.0602615
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0583647
WSB1 WD repeat and SOCS box containing 1 -0.0569543
RPLP2 ribosomal protein, large, P2 -0.05421
PTMA prothymosin, alpha -0.0503713
RPL31 ribosomal protein L31 -0.0501291
ACTG1 actin gamma 1 -0.0464245
RPL34 ribosomal protein L34 -0.0460769
RPL23 ribosomal protein L23 -0.0451854
NBEA neurobeachin -0.0444802
TSHZ2 teashirt zinc finger homeobox 2 -0.0441652
RPL37A ribosomal protein L37a -0.0423498
MT2A metallothionein 2A -0.0419481
RPS25 ribosomal protein S25 -0.0419083
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0409845
MSRB3 methionine sulfoxide reductase B3 -0.0408105
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0396852
RPL26 ribosomal protein L26 -0.0391353
RANBP17 RAN binding protein 17 -0.0390167
RPL30 ribosomal protein L30 -0.0388438
KPNB1 karyopherin (importin) beta 1 -0.0385979
RPS14 ribosomal protein S14 -0.038411
RPL5 ribosomal protein L5 -0.0383919
RPL37 ribosomal protein L37 -0.0383727
RPL38 ribosomal protein L38 -0.0382605
RPL19 ribosomal protein L19 -0.0363241
RPS12 ribosomal protein S12 -0.0360389
RBM25 RNA binding motif protein 25 -0.0349075
RPS23 ribosomal protein S23 -0.0343853
RSU1 Ras suppressor protein 1 -0.033976
TPM4 tropomyosin 4 -0.0337699
RPS11 ribosomal protein S11 -0.0335043
RPLP0 ribosomal protein, large, P0 -0.0333898
RHOBTB3 Rho-related BTB domain containing 3 -0.0329533
RACK1 receptor for activated C kinase 1 -0.0328679
RPL12 ribosomal protein L12 -0.0323337
RPS27A ribosomal protein S27a -0.0322029
RPS29 ribosomal protein S29 -0.0319501
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0311898
MTDH metadherin -0.0311042
DEK DEK proto-oncogene -0.0279642
VCL vinculin -0.0278327
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0278208
REEP3 receptor accessory protein 3 -0.0275747
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0275284
RPS21 ribosomal protein S21 -0.0272819
RPL36 ribosomal protein L36 -0.0271804
RPL28 ribosomal protein L28 -0.0266747
FGFR1 fibroblast growth factor receptor 1 -0.0265296
EIF5B eukaryotic translation initiation factor 5B -0.0262105
RPS5 ribosomal protein S5 -0.0261757
DLG1 discs, large homolog 1 (Drosophila) -0.0259685
RPS13 ribosomal protein S13 -0.0258735
CLMP CXADR-like membrane protein -0.0258316
TRIO trio Rho guanine nucleotide exchange factor -0.0257509
ATP11A ATPase, class VI, type 11A -0.0254108
TRIM9 tripartite motif containing 9 -0.0252047
RPL11 ribosomal protein L11 -0.0251113
RPS19 ribosomal protein S19 -0.0248983
RPL27A ribosomal protein L27a -0.0248086
RPL9 ribosomal protein L9 -0.0246809
SEPTIN11 septin 11 -0.0244731
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0241952
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0241731
SOBP sine oculis binding protein homolog (Drosophila) -0.0239055
MARCHF6 membrane associated ring-CH-type finger 6 -0.023518
TBCA tubulin folding cofactor A -0.0235026
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0232197
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0231438
SERBP1 SERPINE1 mRNA binding protein 1 -0.0229599
MMP16 matrix metallopeptidase 16 (membrane-inserted) -0.0227096
RPS10 ribosomal protein S10 -0.0226653
S100A9 S100 calcium binding protein A9 -0.0226293
RPS16 ribosomal protein S16 -0.022534
SLC38A2 solute carrier family 38, member 2 -0.0222249
DENND1A DENN/MADD domain containing 1A -0.0219754
RSL1D1 ribosomal L1 domain containing 1 -0.0219436
KAZN kazrin, periplakin interacting protein -0.0215962
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0215744
ZMYND8 zinc finger, MYND-type containing 8 -0.0210931
KIF26B kinesin family member 26B -0.0206913
E2F3 E2F transcription factor 3 -0.0206209
NACA nascent polypeptide-associated complex alpha subunit -0.0205873
RPL7A ribosomal protein L7a -0.0205394