Oleic acid_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.199486
PLEC plectin 0.159506
FLNB filamin B, beta 0.155855
IGFBP3 insulin-like growth factor binding protein 3 0.137654
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.134301
TXNRD1 thioredoxin reductase 1 0.129675
EGFR epidermal growth factor receptor 0.117366
PSD3 pleckstrin and Sec7 domain containing 3 0.0979661
EFNA5 ephrin-A5 0.0933496
TGM2 transglutaminase 2 0.092165
DOCK5 dedicator of cytokinesis 5 0.0920618
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0879779
FTH1 ferritin, heavy polypeptide 1 0.0843275
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0811347
SMAD3 SMAD family member 3 0.0800985
NDRG1 N-myc downstream regulated 1 0.0785968
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0778442
APLP2 amyloid beta (A4) precursor-like protein 2 0.0765532
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0716505
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.069752
DSPP dentin sialophosphoprotein 0.0662512
EXT1 exostosin glycosyltransferase 1 0.0655949
EEF2 eukaryotic translation elongation factor 2 0.0644873
SGMS2 sphingomyelin synthase 2 0.0639954
TRRAP transformation/transcription domain-associated protein 0.0635428
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0635368
ITPRID2 ITPR interacting domain containing 2 0.0630773
GREB1L growth regulation by estrogen in breast cancer-like 0.0627512
MBNL1 muscleblind-like splicing regulator 1 0.0622415
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0610455
AKAP13 A kinase (PRKA) anchor protein 13 0.0606017
AHNAK AHNAK nucleoprotein 0.0603473
MPRIP myosin phosphatase Rho interacting protein 0.0595898
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0588949
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.057477
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0567773
MYH9 myosin, heavy chain 9, non-muscle 0.0554747
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0553564
ARHGAP42 Rho GTPase activating protein 42 0.0544337
MSN moesin 0.0538739
LOC112694756 uncharaterized LOC112694756 0.0533354
MUC17 mucin 17, cell surface associated 0.0524148
SEPTIN9 septin 9 0.0522157
BAIAP2L1 BAI1-associated protein 2-like 1 0.0519378
TPM3 tropomyosin 3 0.0518951
EZR ezrin 0.0517025
GDA guanine deaminase 0.0506016
PPARD peroxisome proliferator-activated receptor delta 0.0500365
ASPH aspartate beta-hydroxylase 0.0498282
FMNL2 formin-like 2 0.0496866
ZSWIM6 zinc finger, SWIM-type containing 6 0.0480673
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0473085
DSG2 desmoglein 2 0.0471835
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0469436
SRRM2 serine/arginine repetitive matrix 2 0.0464653
UBA6 ubiquitin-like modifier activating enzyme 6 0.0463767
HMGA2 high mobility group AT-hook 2 0.0458497
DIAPH1 diaphanous-related formin 1 0.0456205
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0455709
UBE2H ubiquitin-conjugating enzyme E2H 0.0454913
ABTB3 ankyrin repeat and BTB domain containing 3 0.0454529
POTEF POTE ankyrin domain family, member F 0.0450695
TRIO trio Rho guanine nucleotide exchange factor 0.044988
THSD4 thrombospondin, type I, domain containing 4 0.0446635
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0437277
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0435259
CD44 CD44 molecule (Indian blood group) 0.0432194
MCL1 myeloid cell leukemia 1 0.0425751
UBE2R2 ubiquitin-conjugating enzyme E2R 2 0.0425239
FNDC3B fibronectin type III domain containing 3B 0.0421006
ITGA6 integrin, alpha 6 0.0420536
RASAL2 RAS protein activator like 2 0.0415987
JMJD1C jumonji domain containing 1C 0.0415825
KMT2E lysine (K)-specific methyltransferase 2E 0.0411163
CLMP CXADR-like membrane protein 0.0409521
LPP LIM domain containing preferred translocation partner in lipoma 0.0407926
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0405799
ERBIN erbb2 interacting protein 0.0398474
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0396833
NCOR2 nuclear receptor corepressor 2 0.0394001
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0389787
RICTOR RPTOR independent companion of MTOR, complex 2 0.038657
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0382696
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.0378323
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0370972
LMTK2 lemur tyrosine kinase 2 0.0368188
RUNX1 runt-related transcription factor 1 0.0368152
CDCP1 CUB domain containing protein 1 0.036723
MYO1E myosin IE 0.0365904
FOSL1 FOS-like antigen 1 0.0364581
SVIL supervillin 0.035929
H1-0 H1.0 linker histone 0.035923
HIPK2 homeodomain interacting protein kinase 2 0.034836
MED13L mediator complex subunit 13-like 0.0348241
FLNA filamin A, alpha 0.034646
MYOF myoferlin 0.0343814
KDM2A lysine (K)-specific demethylase 2A 0.0341203
BMP6 bone morphogenetic protein 6 0.0338851
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0338606
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0335935

decreased expression

Symbol Name Standardized Value
LAMB3 laminin, beta 3 -0.202547
TMSB10 thymosin beta 10 -0.202004
TPT1 tumor protein, translationally-controlled 1 -0.192708
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0650145
RPL37A ribosomal protein L37a -0.063075
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0579835
LMO7 LIM domain 7 -0.0576237
WSB1 WD repeat and SOCS box containing 1 -0.0557096
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0535705
PLAUR plasminogen activator, urokinase receptor -0.0487174
RPS24 ribosomal protein S24 -0.0473865
RPLP2 ribosomal protein, large, P2 -0.0473358
RPS25 ribosomal protein S25 -0.0470701
RPS3 ribosomal protein S3 -0.0427197
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0423583
RPL34 ribosomal protein L34 -0.0410942
RPL26 ribosomal protein L26 -0.0399983
PTMA prothymosin, alpha -0.0394796
EIF1 eukaryotic translation initiation factor 1 -0.0363302
F3 coagulation factor III (thromboplastin, tissue factor) -0.0359446
RPS29 ribosomal protein S29 -0.0359209
RPL31 ribosomal protein L31 -0.0354807
RPS8 ribosomal protein S8 -0.0351029
RPL35A ribosomal protein L35a -0.0348811
RPS21 ribosomal protein S21 -0.0334531
RPL30 ribosomal protein L30 -0.032467
GNAS GNAS complex locus -0.0320046
RPS27A ribosomal protein S27a -0.0314908
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0313069
RPL36A ribosomal protein L36a -0.0311835
RPL36 ribosomal protein L36 -0.0308319
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.030699
UBE2B ubiquitin-conjugating enzyme E2B -0.030343
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0296479
RPLP1 ribosomal protein, large, P1 -0.0291505
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0291245
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0278821
RPS12 ribosomal protein S12 -0.0276699
RBM39 RNA binding motif protein 39 -0.0264683
RPL28 ribosomal protein L28 -0.0259176
RPS13 ribosomal protein S13 -0.0258327
IER3 immediate early response 3 -0.0256485
MORF4L2 mortality factor 4 like 2 -0.0251756
PGK1 phosphoglycerate kinase 1 -0.0250268
RPL11 ribosomal protein L11 -0.0249967
S100A4 S100 calcium binding protein A4 -0.0246344
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0244006
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.0234698
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0232013
VEZT vezatin, adherens junctions transmembrane protein -0.0228666
RPS11 ribosomal protein S11 -0.0228016
RPL38 ribosomal protein L38 -0.0224704
GCC2 GRIP and coiled-coil domain containing 2 -0.0222686
ACTG1 actin gamma 1 -0.0220934
RPS23 ribosomal protein S23 -0.0218052
IFI6 interferon, alpha-inducible protein 6 -0.0217632
RPL37 ribosomal protein L37 -0.0215866
UPP1 uridine phosphorylase 1 -0.0214235
RPL12 ribosomal protein L12 -0.0213868
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0211647
RPL23 ribosomal protein L23 -0.0211234
RPS20 ribosomal protein S20 -0.0210399
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0208753
NT5C2 5'-nucleotidase, cytosolic II -0.0207751
FTL ferritin, light polypeptide -0.0204176
RPL9 ribosomal protein L9 -0.020285
KDM3A lysine (K)-specific demethylase 3A -0.0202481
RPS16 ribosomal protein S16 -0.0202225
SEM1 SEM1 26S proteasome subunit -0.0200922
S100A11 S100 calcium binding protein A11 -0.019873
RPS15 ribosomal protein S15 -0.0196859
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0195908
MARCHF6 membrane associated ring-CH-type finger 6 -0.0191113
RPL27A ribosomal protein L27a -0.0189431
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0188136
RAD21 RAD21 homolog (S. pombe) -0.0185869
CD63 CD63 molecule -0.0185271
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 -0.0184998
RPLP0 ribosomal protein, large, P0 -0.0184018
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0183513
EPCAM epithelial cell adhesion molecule -0.0183061
MYL12B myosin, light chain 12B, regulatory -0.0179379
SDCBP syndecan binding protein (syntenin) -0.0176167
ZC3H3 zinc finger CCCH-type containing 3 -0.0174171
TPM4 tropomyosin 4 -0.0171774
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.01709
S100A10 S100 calcium binding protein A10 -0.0168108
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0167914
RPL32 ribosomal protein L32 -0.016472
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0164146
RPS27 ribosomal protein S27 -0.0161188
ISG15 ISG15 ubiquitin-like modifier -0.0161
EDF1 endothelial differentiation-related factor 1 -0.0159218
CD164 CD164 molecule, sialomucin -0.0157652
NABP1 nucleic acid binding protein 1 -0.0156856
UBC ubiquitin C -0.0155284
NACA nascent polypeptide-associated complex alpha subunit -0.0154283
MYSM1 Myb-like, SWIRM and MPN domains 1 -0.0153824
DUSP12 dual specificity phosphatase 12 -0.0152876
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.0149544