Oleic acid_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NCOA3 nuclear receptor coactivator 3 0.0632517
CLTC clathrin, heavy chain (Hc) 0.0550778
CEP250 centrosomal protein 250kDa 0.049208
CATSPERB catsper channel auxiliary subunit beta 0.0479762
LPP LIM domain containing preferred translocation partner in lipoma 0.0419517
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0392201
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0385507
CDK12 cyclin-dependent kinase 12 0.0374293
INTS6 integrator complex subunit 6 0.037081
ITCH itchy E3 ubiquitin protein ligase 0.036589
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0358312
SP100 SP100 nuclear antigen 0.0352331
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0350255
PTK2 protein tyrosine kinase 2 0.0336527
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0328086
THSD4 thrombospondin, type I, domain containing 4 0.0296264
FNDC3A fibronectin type III domain containing 3A 0.0289755
FTH1 ferritin, heavy polypeptide 1 0.0288725
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0286905
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0281038
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0252962
KRT18 keratin 18, type I 0.0244272
VCP valosin containing protein 0.0241725
PTPRK protein tyrosine phosphatase, receptor type, K 0.0241617
FBXL20 F-box and leucine-rich repeat protein 20 0.023777
PRRC2B proline-rich coiled-coil 2B 0.0236028
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.023347
LARP4B La ribonucleoprotein domain family, member 4B 0.0232573
LIMCH1 LIM and calponin homology domains 1 0.0231265
STIP1 stress-induced phosphoprotein 1 0.0230225
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0223467
STAU1 staufen double-stranded RNA binding protein 1 0.0219529
PLEC plectin 0.0219257
BZW1 basic leucine zipper and W2 domains 1 0.0216566
TRIO trio Rho guanine nucleotide exchange factor 0.0209859
ZSWIM6 zinc finger, SWIM-type containing 6 0.0207489
ADAR adenosine deaminase, RNA-specific 0.020599
HIPK2 homeodomain interacting protein kinase 2 0.0205779
SEPTIN9 septin 9 0.0202409
EFNA5 ephrin-A5 0.020159
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.0201362
SLFN5 schlafen family member 5 0.0198009
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0196094
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0196006
ATXN1 ataxin 1 0.0195467
ARID4B AT rich interactive domain 4B (RBP1-like) 0.019457
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.019328
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0192546
ENAH enabled homolog (Drosophila) 0.01913
KIAA1217 KIAA1217 0.0183985
FAM168A family with sequence similarity 168, member A 0.0182952
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.018187
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0181385
RIMS2 regulating synaptic membrane exocytosis 2 0.0180836
MSI2 musashi RNA-binding protein 2 0.0178422
ANKRD11 ankyrin repeat domain 11 0.0177349
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0176621
YAP1 Yes-associated protein 1 0.0176299
CLIP1 CAP-GLY domain containing linker protein 1 0.0175816
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0174002
UNC13B unc-13 homolog B (C. elegans) 0.0173216
RNF213 ring finger protein 213 0.0171235
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0171102
VCL vinculin 0.0169965
PMP22 peripheral myelin protein 22 0.0167887
AGO2 argonaute RISC catalytic component 2 0.0167458
NRIP1 nuclear receptor interacting protein 1 0.0166751
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0163236
ANKRD17 ankyrin repeat domain 17 0.0162704
CUX1 cut-like homeobox 1 0.0162687
ALCAM activated leukocyte cell adhesion molecule 0.0161546
ANKHD1 ankyrin repeat and KH domain containing 1 0.0160865
DTNA dystrobrevin, alpha 0.0160219
GMDS GDP-mannose 4,6-dehydratase 0.0159868
STXBP4 syntaxin binding protein 4 0.0159338
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0158281
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0157602
PLSCR2 phospholipid scramblase 2 0.0157191
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 0.0156377
TAS2R14 taste receptor, type 2, member 14 0.0156339
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0156111
HLA-C major histocompatibility complex, class I, C 0.0155121
MX1 MX dynamin-like GTPase 1 0.0154058
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0153297
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0153173
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0152426
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 0.0151584
ADIPOR2 adiponectin receptor 2 0.0150425
MAP7 microtubule-associated protein 7 0.0150301
RBM47 RNA binding motif protein 47 0.0150243
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0149505
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0148155
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0147055
MYH9 myosin, heavy chain 9, non-muscle 0.0145823
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 0.014525
DSPP dentin sialophosphoprotein 0.014436
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.0144235
MIPOL1 mirror-image polydactyly 1 0.0143846
TRPS1 trichorhinophalangeal syndrome I 0.0143292
ARHGAP32 Rho GTPase activating protein 32 0.0142747

decreased expression

Symbol Name Standardized Value
RPL23 ribosomal protein L23 -0.218113
RPL19 ribosomal protein L19 -0.0693104
PTMA prothymosin, alpha -0.0678211
UBC ubiquitin C -0.0545718
MT2A metallothionein 2A -0.0542089
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.053963
TMSB10 thymosin beta 10 -0.0537197
RPS3 ribosomal protein S3 -0.04655
SLC38A1 solute carrier family 38, member 1 -0.0359317
IGFBP5 insulin-like growth factor binding protein 5 -0.0335408
S100A9 S100 calcium binding protein A9 -0.0321003
WSB1 WD repeat and SOCS box containing 1 -0.0310791
S100A8 S100 calcium binding protein A8 -0.0307619
TPT1 tumor protein, translationally-controlled 1 -0.0289891
VMP1 vacuole membrane protein 1 -0.0284705
RPS27A ribosomal protein S27a -0.0284604
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0281686
RPL35A ribosomal protein L35a -0.0248147
RPL12 ribosomal protein L12 -0.024189
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0236007
RPL31 ribosomal protein L31 -0.0234326
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.02258
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0225458
NAMPT nicotinamide phosphoribosyltransferase -0.0223638
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0219741
RPS12 ribosomal protein S12 -0.02175
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0213273
GRB7 growth factor receptor-bound protein 7 -0.0213201
RPS19 ribosomal protein S19 -0.0207703
RPL34 ribosomal protein L34 -0.019754
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0195094
PKM pyruvate kinase, muscle -0.0189279
AREG amphiregulin -0.0188658
ELL2 elongation factor, RNA polymerase II, 2 -0.0187884
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0186366
RPS29 ribosomal protein S29 -0.0185705
MIEN1 migration and invasion enhancer 1 -0.0184057
RPS8 ribosomal protein S8 -0.018231
MYL12B myosin, light chain 12B, regulatory -0.0181759
S100A6 S100 calcium binding protein A6 -0.0181561
AHNAK AHNAK nucleoprotein -0.0179055
CCNI cyclin I -0.0176514
FTL ferritin, light polypeptide -0.017609
POTEF POTE ankyrin domain family, member F -0.0174336
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 -0.0173435
RPL9 ribosomal protein L9 -0.0173211
JUN jun proto-oncogene -0.0171487
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 -0.0170019
PCBP2 poly(rC) binding protein 2 -0.0169438
RPL37A ribosomal protein L37a -0.016832
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0167285
S100A14 S100 calcium binding protein A14 -0.016317
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0158236
ZMYND8 zinc finger, MYND-type containing 8 -0.0157828
ACTG1 actin gamma 1 -0.0156586
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0154865
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0154656
RPS13 ribosomal protein S13 -0.0153715
RPL26 ribosomal protein L26 -0.0151986
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0151193
RPS27 ribosomal protein S27 -0.0150932
SDC4 syndecan 4 -0.0150495
RPS24 ribosomal protein S24 -0.0149028
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0143928
RPLP1 ribosomal protein, large, P1 -0.0143852
RPL28 ribosomal protein L28 -0.014274
LDHA lactate dehydrogenase A -0.0141441
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0139464
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0139214
S100A7 S100 calcium binding protein A7 -0.0139167
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0138782
EIF1 eukaryotic translation initiation factor 1 -0.0138602
RPLP2 ribosomal protein, large, P2 -0.0137003
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0134463
RPS6 ribosomal protein S6 -0.013357
B2M beta-2-microglobulin -0.0133243
ASPH aspartate beta-hydroxylase -0.0131736
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0131456
RPS15 ribosomal protein S15 -0.0131142
ENO1 enolase 1, (alpha) -0.0130966
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0128261
RPL36 ribosomal protein L36 -0.0125083
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0123351
SPTSSA serine palmitoyltransferase, small subunit A -0.0123133
RPL7A ribosomal protein L7a -0.0121938
TMEM165 transmembrane protein 165 -0.0120902
RPL8 ribosomal protein L8 -0.0120646
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0120101
PDIA3 protein disulfide isomerase family A, member 3 -0.0119875
RPL5 ribosomal protein L5 -0.0117313
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0115786
RPS16 ribosomal protein S16 -0.0114634
MLPH melanophilin -0.0113749
RACK1 receptor for activated C kinase 1 -0.0112466
DUSP6 dual specificity phosphatase 6 -0.0111841
RPL36A ribosomal protein L36a -0.0111509
SERF2 small EDRK-rich factor 2 -0.0111464
MT1X metallothionein 1X -0.0111018
MDK midkine (neurite growth-promoting factor 2) -0.0110096
S100A10 S100 calcium binding protein A10 -0.0109097