Oleic acid_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.367855
IGFBP3 insulin-like growth factor binding protein 3 0.146193
PDIA4 protein disulfide isomerase family A, member 4 0.11412
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0753334
EGR1 early growth response 1 0.0720776
VCL vinculin 0.0690233
EEF2 eukaryotic translation elongation factor 2 0.0640694
FMN1 formin 1 0.0631672
MYH9 myosin, heavy chain 9, non-muscle 0.0537245
MACF1 microtubule-actin crosslinking factor 1 0.0517247
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0515748
WWTR1 WW domain containing transcription regulator 1 0.0513389
SETBP1 SET binding protein 1 0.0505168
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0504234
ACTN1 actinin, alpha 1 0.0489798
PLEC plectin 0.0482527
PDLIM5 PDZ and LIM domain 5 0.0481471
LOC112694756 uncharaterized LOC112694756 0.0475438
ASPH aspartate beta-hydroxylase 0.0465368
CUX1 cut-like homeobox 1 0.0461542
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0453364
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0447787
NAV1 neuron navigator 1 0.044326
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0443026
MYO1E myosin IE 0.0438606
APLP2 amyloid beta (A4) precursor-like protein 2 0.043565
TLE4 transducin-like enhancer of split 4 0.0421034
FTH1 ferritin, heavy polypeptide 1 0.040652
ZSWIM6 zinc finger, SWIM-type containing 6 0.0403498
AHNAK AHNAK nucleoprotein 0.0388577
MCL1 myeloid cell leukemia 1 0.03879
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.0382789
CEMIP2 cell migration inducing hyaluronidase 2 0.0374343
TIMP3 TIMP metallopeptidase inhibitor 3 0.0370355
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0369621
NPAS2 neuronal PAS domain protein 2 0.0356028
CLIC4 chloride intracellular channel 4 0.0355256
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.0343257
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0341199
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0336651
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0335241
SHISA5 shisa family member 5 0.0333993
SFTPA2 surfactant protein A2 0.0332297
SEPTIN9 septin 9 0.0328964
CABIN1 calcineurin binding protein 1 0.0328166
EXOC4 exocyst complex component 4 0.03227
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0321891
COPA coatomer protein complex, subunit alpha 0.0319933
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0317357
PAX3 paired box 3 0.0311695
BRD2 bromodomain containing 2 0.0307905
CYTH3 cytohesin 3 0.0305532
INTS6 integrator complex subunit 6 0.0303787
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0302558
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0299494
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.029703
GOLGB1 golgin B1 0.0292115
TRRAP transformation/transcription domain-associated protein 0.0290575
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0287051
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0285128
BPTF bromodomain PHD finger transcription factor 0.0282721
TMEM178B transmembrane protein 178B 0.0282083
MSN moesin 0.0280537
LPP LIM domain containing preferred translocation partner in lipoma 0.027534
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0274872
FLNA filamin A, alpha 0.0273252
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0267473
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0265201
VMP1 vacuole membrane protein 1 0.0264595
CALR calreticulin 0.0262511
UBASH3B ubiquitin associated and SH3 domain containing B 0.0259914
COL19A1 collagen, type XIX, alpha 1 0.0258974
GLS2 glutaminase 2 (liver, mitochondrial) 0.0258082
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0258073
JUN jun proto-oncogene 0.0257205
AKAP12 A kinase (PRKA) anchor protein 12 0.0255139
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.025491
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.025463
EFR3B EFR3 homolog B (S. cerevisiae) 0.0251079
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.024693
CPED1 cadherin-like and PC-esterase domain containing 1 0.0240088
WNK1 WNK lysine deficient protein kinase 1 0.0238049
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0235354
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0235318
FLNB filamin B, beta 0.0229938
APP amyloid beta (A4) precursor protein 0.0228774
OSBPL8 oxysterol binding protein-like 8 0.0227658
LIMA1 LIM domain and actin binding 1 0.0225435
EMP1 epithelial membrane protein 1 0.0224971
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0224047
SVIL supervillin 0.0222865
SHROOM4 shroom family member 4 0.0222023
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0221854
STAU2 staufen double-stranded RNA binding protein 2 0.0220959
LRRC23 leucine rich repeat containing 23 0.0220402
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 0.0218097
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0217523
FERMT2 fermitin family member 2 0.0215929
SPRED2 sprouty-related, EVH1 domain containing 2 0.0215062
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0214775

decreased expression

Symbol Name Standardized Value
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.22105
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.18598
NAMPT nicotinamide phosphoribosyltransferase -0.155128
VIM vimentin -0.111944
TMSB10 thymosin beta 10 -0.0970597
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -0.0823582
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0797203
IFI16 interferon, gamma-inducible protein 16 -0.0790146
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0750865
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0722952
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0675528
CHSY1 chondroitin sulfate synthase 1 -0.0666947
HLA-B major histocompatibility complex, class I, B -0.0658922
HILPDA hypoxia inducible lipid droplet-associated -0.0635902
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0614453
DCT dopachrome tautomerase -0.0589188
PGK1 phosphoglycerate kinase 1 -0.0567631
WSB1 WD repeat and SOCS box containing 1 -0.0522221
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0516345
NLGN1 neuroligin 1 -0.0506256
MT2A metallothionein 2A -0.0460713
MT1X metallothionein 1X -0.0453523
GDF15 growth differentiation factor 15 -0.0446232
VGF VGF nerve growth factor inducible -0.044191
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0439513
ZMYND8 zinc finger, MYND-type containing 8 -0.0430844
S100A6 S100 calcium binding protein A6 -0.0424584
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0423429
WDR45B WD repeat domain 45B -0.0422501
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0412341
GNAS GNAS complex locus -0.0412098
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0411819
NAV3 neuron navigator 3 -0.0408244
MACROD2 MACRO domain containing 2 -0.0407925
PDE10A phosphodiesterase 10A -0.039139
ZNF292 zinc finger protein 292 -0.0382503
RPL35A ribosomal protein L35a -0.0380733
GPC6 glypican 6 -0.0378492
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0364731
CDC73 cell division cycle 73 -0.0355089
KMT2C lysine (K)-specific methyltransferase 2C -0.034935
PKM pyruvate kinase, muscle -0.0344368
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0340101
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.03363
TMEM123 transmembrane protein 123 -0.0331733
CD63 CD63 molecule -0.0324083
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0320448
S100A9 S100 calcium binding protein A9 -0.0315929
VDAC1 voltage-dependent anion channel 1 -0.0313518
CPEB2 cytoplasmic polyadenylation element binding protein 2 -0.0312463
TPT1 tumor protein, translationally-controlled 1 -0.0309335
NPR2 natriuretic peptide receptor 2 -0.0299738
PTPRD protein tyrosine phosphatase, receptor type, D -0.0292824
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0282957
OGA O-GlcNAcase -0.0281309
TAGLN2 transgelin 2 -0.0281242
INSIG1 insulin induced gene 1 -0.0280448
TPI1 triosephosphate isomerase 1 -0.0280403
FYN FYN proto-oncogene, Src family tyrosine kinase -0.028011
RPLP1 ribosomal protein, large, P1 -0.0276989
NDRG1 N-myc downstream regulated 1 -0.0276854
FOXJ3 forkhead box J3 -0.0276827
USP3 ubiquitin specific peptidase 3 -0.0274602
NPEPPS aminopeptidase puromycin sensitive -0.0274148
KMT2E lysine (K)-specific methyltransferase 2E -0.0271853
FTL ferritin, light polypeptide -0.0270348
GSN gelsolin -0.0270039
HMCN1 hemicentin 1 -0.0269401
RNF24 ring finger protein 24 -0.0266967
FAM162A family with sequence similarity 162, member A -0.0264462
COL1A2 collagen, type I, alpha 2 -0.0255516
PTMA prothymosin, alpha -0.0253739
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0250658
RPS19 ribosomal protein S19 -0.0249922
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.02477
RAD21 RAD21 homolog (S. pombe) -0.0244342
TNNC1 troponin C type 1 (slow) -0.0243022
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0241786
PHF21A PHD finger protein 21A -0.0241482
SPRED1 sprouty-related, EVH1 domain containing 1 -0.0239856
ENO1 enolase 1, (alpha) -0.0237538
LMNA lamin A/C -0.0234496
C1ORF21 chromosome 1 open reading frame 21 -0.0233629
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0231407
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0230145
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.022482
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD) -0.0218903
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0216928
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0216652
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.0215225
A2M alpha-2-macroglobulin -0.0214165
CENPF centromere protein F, 350/400kDa -0.0213117
IGF1R insulin-like growth factor 1 receptor -0.0213088
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0212697
ANXA5 annexin A5 -0.0212563
IFITM3 interferon induced transmembrane protein 3 -0.0211919
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) -0.0210958
FBXL7 F-box and leucine-rich repeat protein 7 -0.0208899
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0207896
B2M beta-2-microglobulin -0.0207155