Oleic acid_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.195403
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.152982
IGFBP3 insulin-like growth factor binding protein 3 0.151867
FNDC3B fibronectin type III domain containing 3B 0.109876
TGM2 transglutaminase 2 0.105915
KRT19 keratin 19, type I 0.105533
APOL1 apolipoprotein L, 1 0.0917838
LAMA4 laminin, alpha 4 0.0916009
EFNA5 ephrin-A5 0.0772585
IFI27 interferon, alpha-inducible protein 27 0.0641007
H1-0 H1.0 linker histone 0.0640944
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0617963
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0599828
PLEC plectin 0.0597976
MMP7 matrix metallopeptidase 7 0.0552029
LOC112694756 uncharaterized LOC112694756 0.0532886
SP100 SP100 nuclear antigen 0.0522123
MX1 MX dynamin-like GTPase 1 0.050373
RNF213 ring finger protein 213 0.0493312
EXT1 exostosin glycosyltransferase 1 0.0489835
ZSWIM6 zinc finger, SWIM-type containing 6 0.0472553
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0467375
MX2 MX dynamin-like GTPase 2 0.0459464
LCN2 lipocalin 2 0.0457557
SGMS2 sphingomyelin synthase 2 0.0450966
HLA-A major histocompatibility complex, class I, A 0.0434365
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0432791
MYO1E myosin IE 0.0417771
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0412611
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.039869
FTL ferritin, light polypeptide 0.038853
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0383303
B2M beta-2-microglobulin 0.0379414
KYNU kynureninase 0.0377857
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0374269
NRG3 neuregulin 3 0.0371978
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0368784
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0361432
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0357623
SFTPA2 surfactant protein A2 0.0354939
RAD51B RAD51 paralog B 0.0347757
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.0330883
GRB10 growth factor receptor-bound protein 10 0.0323383
FAM107B family with sequence similarity 107, member B 0.0320433
ARHGAP26 Rho GTPase activating protein 26 0.0319534
EPAS1 endothelial PAS domain protein 1 0.0312278
TSC22D2 TSC22 domain family, member 2 0.0301371
SMAD3 SMAD family member 3 0.0293401
CP ceruloplasmin (ferroxidase) 0.0292328
HLA-C major histocompatibility complex, class I, C 0.0277356
ATXN1 ataxin 1 0.0275877
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0269393
VEGFA vascular endothelial growth factor A 0.0269371
BZW1 basic leucine zipper and W2 domains 1 0.0268489
RIGI RNA sensor RIG-I 0.0266409
RSAD2 radical S-adenosyl methionine domain containing 2 0.0265797
ECE1 endothelin converting enzyme 1 0.0262608
SEPTIN9 septin 9 0.0261825
KIAA1217 KIAA1217 0.0259744
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.0258288
PPARD peroxisome proliferator-activated receptor delta 0.0257287
STC1 stanniocalcin 1 0.0256584
STAT1 signal transducer and activator of transcription 1, 91kDa 0.025301
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0244115
KRT18 keratin 18, type I 0.0243624
ZMIZ1 zinc finger, MIZ-type containing 1 0.0242812
SH3KBP1 SH3-domain kinase binding protein 1 0.024096
F11R F11 receptor 0.0240017
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0237612
NFE2L2 nuclear factor, erythroid 2-like 2 0.0237161
DSG2 desmoglein 2 0.0230229
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.022973
LOC102724023 ES1 protein homolog, mitochondrial 0.0219484
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0218938
BCL2L1 BCL2-like 1 0.0214699
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0213146
ZC3H12C zinc finger CCCH-type containing 12C 0.0211236
MAML2 mastermind-like 2 (Drosophila) 0.0209506
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0207458
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0206644
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0203101
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0202374
SAMD9 sterile alpha motif domain containing 9 0.0200478
LAMC2 laminin, gamma 2 0.0198634
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0197404
CMIP c-Maf inducing protein 0.019467
IFI6 interferon, alpha-inducible protein 6 0.0192614
TMC5 transmembrane channel-like 5 0.0190699
PMP22 peripheral myelin protein 22 0.0190639
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0188317
BIRC3 baculoviral IAP repeat containing 3 0.0186099
ATF3 activating transcription factor 3 0.0186012
CATSPERB catsper channel auxiliary subunit beta 0.0185791
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0184646
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0184473
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0184217
TNIP1 TNFAIP3 interacting protein 1 0.0183516
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.018213
HILPDA hypoxia inducible lipid droplet-associated 0.0180247
INTS6 integrator complex subunit 6 0.0180157

decreased expression

Symbol Name Standardized Value
UBC ubiquitin C -0.217441
PTMA prothymosin, alpha -0.158253
TMSB10 thymosin beta 10 -0.135297
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0796843
RPS27A ribosomal protein S27a -0.0759137
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0738115
NAMPT nicotinamide phosphoribosyltransferase -0.0659519
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0639846
LAMB3 laminin, beta 3 -0.0637544
FLNB filamin B, beta -0.0626162
OGA O-GlcNAcase -0.0620294
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0607428
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0584616
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0581367
TMSB4X thymosin beta 4, X-linked -0.0573632
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0572998
ACTG1 actin gamma 1 -0.0572634
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0557321
PCBP2 poly(rC) binding protein 2 -0.0544743
EIF1 eukaryotic translation initiation factor 1 -0.0526712
RBM39 RNA binding motif protein 39 -0.0525964
RPL23 ribosomal protein L23 -0.0519971
SPAG9 sperm associated antigen 9 -0.0507824
PICALM phosphatidylinositol binding clathrin assembly protein -0.0498845
STRN3 striatin, calmodulin binding protein 3 -0.0488114
AKAP13 A kinase (PRKA) anchor protein 13 -0.0485395
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0478636
ASPH aspartate beta-hydroxylase -0.0475624
ADAM9 ADAM metallopeptidase domain 9 -0.0473914
PGK1 phosphoglycerate kinase 1 -0.0464144
WIPF2 WAS/WASL interacting protein family, member 2 -0.0458768
POTEF POTE ankyrin domain family, member F -0.0452059
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0447936
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0445913
RTN4 reticulon 4 -0.0433795
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0432698
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.042839
TRIO trio Rho guanine nucleotide exchange factor -0.0424502
RAB6A RAB6A, member RAS oncogene family -0.0409339
PRRC2C proline-rich coiled-coil 2C -0.0405446
TOP1 topoisomerase (DNA) I -0.0402981
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0402857
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0397589
RPS3 ribosomal protein S3 -0.0385614
KDM3A lysine (K)-specific demethylase 3A -0.0374962
RASA2 RAS p21 protein activator 2 -0.0374634
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0372918
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0372429
MT1X metallothionein 1X -0.0371389
NPEPPS aminopeptidase puromycin sensitive -0.0369306
KMT2C lysine (K)-specific methyltransferase 2C -0.0364402
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.036391
SPDYA speedy/RINGO cell cycle regulator family member A -0.0363737
CCNL1 cyclin L1 -0.0360186
JUN jun proto-oncogene -0.0352804
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0351825
VMP1 vacuole membrane protein 1 -0.0351725
VIM vimentin -0.0350752
ACTN4 actinin, alpha 4 -0.0339727
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0335276
DTNA dystrobrevin, alpha -0.0333766
CANX calnexin -0.0332759
F3 coagulation factor III (thromboplastin, tissue factor) -0.0331468
FRYL FRY-like -0.0331414
WSB1 WD repeat and SOCS box containing 1 -0.0327789
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0327478
ENO1 enolase 1, (alpha) -0.0325021
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0324111
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0323379
CD47 CD47 molecule -0.0320746
CD46 CD46 molecule, complement regulatory protein -0.0319899
USP53 ubiquitin specific peptidase 53 -0.0317238
CLIP4 CAP-GLY domain containing linker protein family, member 4 -0.0316289
YTHDC1 YTH domain containing 1 -0.031535
CD2AP CD2-associated protein -0.0312875
ITPRID2 ITPR interacting domain containing 2 -0.0312383
COG5 component of oligomeric golgi complex 5 -0.0311047
JMJD1C jumonji domain containing 1C -0.0309015
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0308176
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa -0.0307134
FOXO3 forkhead box O3 -0.0301383
TM9SF3 transmembrane 9 superfamily member 3 -0.0301183
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0300814
TMEM165 transmembrane protein 165 -0.0298007
CCNY cyclin Y -0.0297848
CALR calreticulin -0.0297102
KLF6 Kruppel-like factor 6 -0.0293937
NIPBL Nipped-B homolog (Drosophila) -0.0291715
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0291372
PLAUR plasminogen activator, urokinase receptor -0.0290634
RPL9 ribosomal protein L9 -0.0287227
GCC2 GRIP and coiled-coil domain containing 2 -0.0286656
PDIA6 protein disulfide isomerase family A, member 6 -0.0285795
TFG TRK-fused gene -0.0284387
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0283835
MYO6 myosin VI -0.0282193
ACBD3 acyl-CoA binding domain containing 3 -0.028213
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0282077
FNIP1 folliculin interacting protein 1 -0.0280482
RAP1B RAP1B, member of RAS oncogene family -0.0279989