Oleic acid_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.132658
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.124513
AKAP12 A kinase (PRKA) anchor protein 12 0.0896922
FMN1 formin 1 0.0811393
ANTXR1 anthrax toxin receptor 1 0.0741495
EXT1 exostosin glycosyltransferase 1 0.0655905
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0655413
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0614547
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0605917
MEIS2 Meis homeobox 2 0.0598848
SPTBN1 spectrin, beta, non-erythrocytic 1 0.058611
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0567752
FAM13A family with sequence similarity 13, member A 0.0566841
THBS1 thrombospondin 1 0.0564652
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0556523
FNDC3B fibronectin type III domain containing 3B 0.0556293
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0549643
VMP1 vacuole membrane protein 1 0.0535105
TRIO trio Rho guanine nucleotide exchange factor 0.0530348
CENPF centromere protein F, 350/400kDa 0.0530115
FAM107B family with sequence similarity 107, member B 0.0528835
FNBP1 formin binding protein 1 0.0520996
TLE4 transducin-like enhancer of split 4 0.0501815
NDRG1 N-myc downstream regulated 1 0.0479324
ITGA1 integrin, alpha 1 0.0474614
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0468462
SIK3 SIK family kinase 3 0.0452217
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0452184
MYH9 myosin, heavy chain 9, non-muscle 0.0447003
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0444478
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0442783
GPBP1 GC-rich promoter binding protein 1 0.0432077
MCL1 myeloid cell leukemia 1 0.0419524
H1-0 H1.0 linker histone 0.0411432
NPAS2 neuronal PAS domain protein 2 0.0406937
CEMIP cell migration inducing protein, hyaluronan binding 0.0405128
APLP2 amyloid beta (A4) precursor-like protein 2 0.0397611
PLAT plasminogen activator, tissue 0.0396285
MED13 mediator complex subunit 13 0.0396238
FLT1 fms-related tyrosine kinase 1 0.0376468
SMAD3 SMAD family member 3 0.0368072
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0367535
MAP1B microtubule-associated protein 1B 0.0366849
CCNL1 cyclin L1 0.0360465
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0342875
SEPTIN9 septin 9 0.0342755
TNIP1 TNFAIP3 interacting protein 1 0.0336409
DST dystonin 0.0333028
TPST1 tyrosylprotein sulfotransferase 1 0.0331122
PCNX1 pecanex 1 0.0327
EPAS1 endothelial PAS domain protein 1 0.032669
BIRC6 baculoviral IAP repeat containing 6 0.0324698
GOLGA4 golgin A4 0.0323229
ARHGAP9 Rho GTPase activating protein 9 0.0322124
ZNF292 zinc finger protein 292 0.0320877
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0318835
COPA coatomer protein complex, subunit alpha 0.0317176
STC1 stanniocalcin 1 0.0317046
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0315174
ATXN1 ataxin 1 0.0313398
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0312143
FTH1 ferritin, heavy polypeptide 1 0.0310887
PTPRK protein tyrosine phosphatase, receptor type, K 0.030481
HPCAL1 hippocalcin-like 1 0.0303539
PCBP3 poly(rC) binding protein 3 0.030263
HOMER1 homer scaffolding protein 1 0.0296068
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0288057
ADGRG6 adhesion G protein-coupled receptor G6 0.0285371
PRRC2C proline-rich coiled-coil 2C 0.0283769
FLNB filamin B, beta 0.0281889
KMT2E lysine (K)-specific methyltransferase 2E 0.0280521
EIF4B eukaryotic translation initiation factor 4B 0.0279711
WNK1 WNK lysine deficient protein kinase 1 0.0276418
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0275296
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.027519
USP9X ubiquitin specific peptidase 9, X-linked 0.0273934
PHIP pleckstrin homology domain interacting protein 0.0273834
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0272332
BRD2 bromodomain containing 2 0.0270479
COL4A2 collagen, type IV, alpha 2 0.0269903
GPATCH2L G patch domain containing 2-like 0.0269548
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0268963
ITGAV integrin, alpha V 0.0268681
SOS1 son of sevenless homolog 1 (Drosophila) 0.0268247
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.0268127
LOC112694756 uncharaterized LOC112694756 0.0267401
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0267237
RAD23B RAD23 homolog B (S. cerevisiae) 0.0267119
COL4A1 collagen, type IV, alpha 1 0.026452
FBXO11 F-box protein 11 0.026423
CHD4 chromodomain helicase DNA binding protein 4 0.0264008
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0261914
TRA2A transformer 2 alpha homolog (Drosophila) 0.0260654
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0260551
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0259772
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.0259707
SFTPA2 surfactant protein A2 0.0258098
RPL7 ribosomal protein L7 0.0258089
STK38L serine/threonine kinase 38 like 0.025794
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0257528

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.134288
LSAMP limbic system-associated membrane protein -0.116931
NRG1 neuregulin 1 -0.101153
TPT1 tumor protein, translationally-controlled 1 -0.0888499
PTMA prothymosin, alpha -0.0868084
COL1A1 collagen, type I, alpha 1 -0.0776405
RPL31 ribosomal protein L31 -0.075533
RPS24 ribosomal protein S24 -0.0749072
PTPRD protein tyrosine phosphatase, receptor type, D -0.0626393
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0595324
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0574281
ACTG1 actin gamma 1 -0.0514868
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0499027
RPS6 ribosomal protein S6 -0.0489203
RPL38 ribosomal protein L38 -0.0472517
RPL35A ribosomal protein L35a -0.0453157
RPLP1 ribosomal protein, large, P1 -0.0448568
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0430837
AHR aryl hydrocarbon receptor -0.0428838
CRH corticotropin releasing hormone -0.04214
TMSB10 thymosin beta 10 -0.038819
SYT1 synaptotagmin I -0.0388112
CADM2 cell adhesion molecule 2 -0.0384299
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0371144
BCAS3 breast carcinoma amplified sequence 3 -0.0366815
DLC1 DLC1 Rho GTPase activating protein -0.035632
RPS3 ribosomal protein S3 -0.0347351
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0342527
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0341777
NREP neuronal regeneration related protein -0.0333971
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0330513
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0327105
RNF213 ring finger protein 213 -0.0325665
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0318908
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0314988
AUTS2 autism susceptibility candidate 2 -0.0304472
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0300096
RPS29 ribosomal protein S29 -0.0295422
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0295164
CANX calnexin -0.0291791
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0290957
TBL1X transducin (beta)-like 1X-linked -0.02892
RPL34 ribosomal protein L34 -0.028306
LMNA lamin A/C -0.0281915
RPS14 ribosomal protein S14 -0.0276547
IFI16 interferon, gamma-inducible protein 16 -0.0275853
RPL23 ribosomal protein L23 -0.0274985
GPC5 glypican 5 -0.0272173
COL4A5 collagen, type IV, alpha 5 -0.0269635
ATRNL1 attractin-like 1 -0.0261979
GNAS GNAS complex locus -0.025991
DCAF7 DDB1 and CUL4 associated factor 7 -0.0255896
DTNA dystrobrevin, alpha -0.0253459
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0251531
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 -0.0248522
PNISR PNN-interacting serine/arginine-rich protein -0.0245894
NVL nuclear VCP-like -0.0245564
RPS11 ribosomal protein S11 -0.0243097
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.0243036
RPL37A ribosomal protein L37a -0.024227
RAI14 retinoic acid induced 14 -0.0241959
RPL7A ribosomal protein L7a -0.023846
LARP1 La ribonucleoprotein domain family, member 1 -0.0237249
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0236183
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0235783
RPS21 ribosomal protein S21 -0.0235758
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0234669
CCT8 chaperonin containing TCP1, subunit 8 (theta) -0.0233816
CCDC47 coiled-coil domain containing 47 -0.0232668
RPL36A ribosomal protein L36a -0.0231984
SLC38A2 solute carrier family 38, member 2 -0.0230905
RPS17 ribosomal protein S17 -0.0230639
CDH13 cadherin 13 -0.0228193
RPL19 ribosomal protein L19 -0.0228138
VIM vimentin -0.02263
RPLP0 ribosomal protein, large, P0 -0.0225725
RPS27A ribosomal protein S27a -0.0224689
DKK2 dickkopf WNT signaling pathway inhibitor 2 -0.0221861
RPS27 ribosomal protein S27 -0.02213
RPL28 ribosomal protein L28 -0.022101
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0220124
PTPRS protein tyrosine phosphatase, receptor type, S -0.0219068
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0218923
NBEA neurobeachin -0.0217067
KPNB1 karyopherin (importin) beta 1 -0.0214949
RPLP2 ribosomal protein, large, P2 -0.021305
RIGI RNA sensor RIG-I -0.0213023
RPS10 ribosomal protein S10 -0.0213005
AEBP2 AE binding protein 2 -0.0212351
RANBP17 RAN binding protein 17 -0.0211291
PDE4D phosphodiesterase 4D, cAMP-specific -0.0211192
ANGPT1 angiopoietin 1 -0.0209982
RPS8 ribosomal protein S8 -0.0209132
MTPN myotrophin -0.0208116
SPOP speckle-type POZ protein -0.0205551
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0205045
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0204509
RPS19 ribosomal protein S19 -0.0203739
FRMPD4 FERM and PDZ domain containing 4 -0.0203034
BICD1 bicaudal D homolog 1 (Drosophila) -0.0202764