Oleic acid_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.305001
IGFBP3 insulin-like growth factor binding protein 3 0.282241
COL6A3 collagen, type VI, alpha 3 0.182626
STC1 stanniocalcin 1 0.143191
CXCL8 chemokine (C-X-C motif) ligand 8 0.140503
AKAP12 A kinase (PRKA) anchor protein 12 0.136406
KYNU kynureninase 0.130274
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.125719
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.116013
CD44 CD44 molecule (Indian blood group) 0.115683
FNDC3B fibronectin type III domain containing 3B 0.106361
EXT1 exostosin glycosyltransferase 1 0.0938373
AHNAK AHNAK nucleoprotein 0.0875267
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0837651
TPM4 tropomyosin 4 0.0819659
EEF2 eukaryotic translation elongation factor 2 0.0812861
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0715333
ASPH aspartate beta-hydroxylase 0.0700997
MKI67 marker of proliferation Ki-67 0.0690745
LOC112694756 uncharaterized LOC112694756 0.0681249
VIM vimentin 0.0678545
B2M beta-2-microglobulin 0.0673124
CALD1 caldesmon 1 0.0658467
PLEC plectin 0.0612647
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0610899
PDIA3 protein disulfide isomerase family A, member 3 0.0610556
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.060505
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0603806
SMAD3 SMAD family member 3 0.0603449
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0590054
CALU calumenin 0.0585645
MYH9 myosin, heavy chain 9, non-muscle 0.0553313
CENPF centromere protein F, 350/400kDa 0.0551876
HIPK2 homeodomain interacting protein kinase 2 0.0539925
CANX calnexin 0.053892
PDIA4 protein disulfide isomerase family A, member 4 0.0538834
APP amyloid beta (A4) precursor protein 0.0535738
TIMP3 TIMP metallopeptidase inhibitor 3 0.0524966
ERRFI1 ERBB receptor feedback inhibitor 1 0.0513898
NALF1 NALCN channel auxiliary factor 1 0.051389
LMAN1 lectin, mannose-binding, 1 0.0512219
MYO10 myosin X 0.0508121
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0494332
PKM pyruvate kinase, muscle 0.0492344
ENO1 enolase 1, (alpha) 0.0492298
MAP1B microtubule-associated protein 1B 0.0491613
LOX lysyl oxidase 0.0484651
TGFBI transforming growth factor, beta-induced, 68kDa 0.0483692
DGKD diacylglycerol kinase, delta 130kDa 0.047645
MYLK myosin light chain kinase 0.0474285
OSMR oncostatin M receptor 0.0473524
EGR1 early growth response 1 0.0467035
NDRG1 N-myc downstream regulated 1 0.0458615
NLGN1 neuroligin 1 0.0457592
ATXN1 ataxin 1 0.0454724
TXNRD1 thioredoxin reductase 1 0.0448445
SFTPA2 surfactant protein A2 0.0447832
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0445442
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0443099
ANTXR2 anthrax toxin receptor 2 0.0417752
FTL ferritin, light polypeptide 0.0412385
FLNA filamin A, alpha 0.0410288
TPI1 triosephosphate isomerase 1 0.0400778
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0397917
FTH1 ferritin, heavy polypeptide 1 0.0397897
NFE2L2 nuclear factor, erythroid 2-like 2 0.0397882
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0397095
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0396002
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0393209
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0391201
WWTR1 WW domain containing transcription regulator 1 0.03836
KTN1 kinectin 1 (kinesin receptor) 0.0383313
IL6ST interleukin 6 signal transducer 0.0381259
LAMB1 laminin, beta 1 0.0378688
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0377891
PGK1 phosphoglycerate kinase 1 0.0377634
ELL2 elongation factor, RNA polymerase II, 2 0.0376705
GOLGB1 golgin B1 0.0371636
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.03688
VEGFA vascular endothelial growth factor A 0.0360476
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0356224
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) 0.0355601
INHBA inhibin, beta A 0.0354371
TNIP1 TNFAIP3 interacting protein 1 0.035419
ANXA2 annexin A2 0.0353152
PTK2 protein tyrosine kinase 2 0.03501
TXNIP thioredoxin interacting protein 0.0349658
SH3KBP1 SH3-domain kinase binding protein 1 0.0349652
MAST4 microtubule associated serine/threonine kinase family member 4 0.0348667
FAM13A family with sequence similarity 13, member A 0.0345601
C1S complement component 1, s subcomponent 0.0342271
LIMS1 LIM and senescent cell antigen-like domains 1 0.034157
HLA-C major histocompatibility complex, class I, C 0.0326432
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.032361
NAMPT nicotinamide phosphoribosyltransferase 0.0322612
IQGAP1 IQ motif containing GTPase activating protein 1 0.0322559
JARID2 jumonji, AT rich interactive domain 2 0.0318895
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0318446
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0315306
NAV1 neuron navigator 1 0.0314878

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.0764154
GRB10 growth factor receptor-bound protein 10 -0.0543718
SDK1 sidekick cell adhesion molecule 1 -0.0496873
ZNF804A zinc finger protein 804A -0.0382863
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0358725
RPL37A ribosomal protein L37a -0.0348638
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0346975
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0340541
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0338196
RPL31 ribosomal protein L31 -0.0315123
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0304956
WSB1 WD repeat and SOCS box containing 1 -0.0297033
RPLP2 ribosomal protein, large, P2 -0.0290731
PDE4D phosphodiesterase 4D, cAMP-specific -0.0274958
TPT1 tumor protein, translationally-controlled 1 -0.025377
RPL28 ribosomal protein L28 -0.0248404
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0236318
RPS27A ribosomal protein S27a -0.0229961
ANKUB1 ankyrin repeat and ubiquitin domain containing 1 -0.0222382
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0219106
RPL38 ribosomal protein L38 -0.0218416
RPS12 ribosomal protein S12 -0.0209364
RPL7A ribosomal protein L7a -0.020471
RPS3 ribosomal protein S3 -0.0204512
RPL36A ribosomal protein L36a -0.0192593
PSD3 pleckstrin and Sec7 domain containing 3 -0.019107
KDM4B lysine (K)-specific demethylase 4B -0.0187419
RPS23 ribosomal protein S23 -0.0178002
TENT5A terminal nucleotidyltransferase 5A -0.0174212
TCF25 transcription factor 25 (basic helix-loop-helix) -0.0174093
RPL36 ribosomal protein L36 -0.0172426
SPMIP6 sperm microtubule inner protein 6 -0.0171968
NABP1 nucleic acid binding protein 1 -0.0170261
RPS29 ribosomal protein S29 -0.0168675
CHD6 chromodomain helicase DNA binding protein 6 -0.0168355
EIF5B eukaryotic translation initiation factor 5B -0.0163173
IGF2 insulin-like growth factor 2 -0.0160669
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0159227
RPL9 ribosomal protein L9 -0.015695
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase -0.0156848
FUS FUS RNA binding protein -0.0156753
KCTD16 potassium channel tetramerization domain containing 16 -0.0156426
SOX5 SRY (sex determining region Y)-box 5 -0.0155757
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0153155
GPC6 glypican 6 -0.0152324
RPS21 ribosomal protein S21 -0.0148234
PHEX phosphate regulating endopeptidase homolog, X-linked -0.0147435
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.014707
SLC38A2 solute carrier family 38, member 2 -0.0146858
ZMYND8 zinc finger, MYND-type containing 8 -0.0146593
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0146357
DENND1A DENN/MADD domain containing 1A -0.0144761
APOL2 apolipoprotein L, 2 -0.0143724
MAML3 mastermind-like 3 (Drosophila) -0.0141472
ACTN4 actinin, alpha 4 -0.0140637
DMTF1 cyclin D binding myb-like transcription factor 1 -0.01403
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 -0.013678
FBXO11 F-box protein 11 -0.0136294
RPS16 ribosomal protein S16 -0.013551
FGFR1 fibroblast growth factor receptor 1 -0.0133641
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0133125
USP9Y ubiquitin specific peptidase 9, Y-linked -0.0131677
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -0.0131081
CHD9 chromodomain helicase DNA binding protein 9 -0.0129259
LRRC23 leucine rich repeat containing 23 -0.0129239
VDAC1 voltage-dependent anion channel 1 -0.0128821
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 -0.0128192
ENO2 enolase 2 (gamma, neuronal) -0.012739
PRELID2 PRELI domain containing 2 -0.0126937
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa -0.0124699
JAZF1 JAZF zinc finger 1 -0.0124481
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0121567
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0121419
NREP neuronal regeneration related protein -0.0120587
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0120564
ADGRB3 adhesion G protein-coupled receptor B3 -0.0119572
RPS24 ribosomal protein S24 -0.0119542
SEM1 SEM1 26S proteasome subunit -0.0119272
PTCHD4 patched domain containing 4 -0.0118996
ZNF207 zinc finger protein 207 -0.0118776
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase) -0.0118399
PARP8 poly (ADP-ribose) polymerase family, member 8 -0.0117817
CDH12 cadherin 12, type 2 (N-cadherin 2) -0.0116674
RPLP1 ribosomal protein, large, P1 -0.011667
ENKUR enkurin, TRPC channel interacting protein -0.0116426
NCK1 NCK adaptor protein 1 -0.0116209
OFD1 oral-facial-digital syndrome 1 -0.011554
WDR49 WD repeat domain 49 -0.0115287
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.011367
SRSF11 serine/arginine-rich splicing factor 11 -0.0113395
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.011254
LYPD6B LY6/PLAUR domain containing 6B -0.0112117
ISG15 ISG15 ubiquitin-like modifier -0.0111441
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0110654
INTS6 integrator complex subunit 6 -0.0109261
PTPRD protein tyrosine phosphatase, receptor type, D -0.0109166
ADAM17 ADAM metallopeptidase domain 17 -0.0108157
KANSL1L KAT8 regulatory NSL complex subunit 1-like -0.0107518
CD81 CD81 molecule -0.010708
ADAM32 ADAM metallopeptidase domain 32 -0.0106592