Oleic acid_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.129961
EEF2 eukaryotic translation elongation factor 2 0.103035
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0936761
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0864872
LOC112694756 uncharaterized LOC112694756 0.0624858
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0488443
GOLGA4 golgin A4 0.0479491
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0414158
INTS6 integrator complex subunit 6 0.0393184
PDIA4 protein disulfide isomerase family A, member 4 0.0391905
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0378516
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0371854
DSCAM Down syndrome cell adhesion molecule 0.0355808
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0351274
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0350507
APLP2 amyloid beta (A4) precursor-like protein 2 0.0348789
PLEC plectin 0.0341882
MYH9 myosin, heavy chain 9, non-muscle 0.0337116
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0329653
TTC3 tetratricopeptide repeat domain 3 0.0324188
ZSWIM6 zinc finger, SWIM-type containing 6 0.0318092
BRD2 bromodomain containing 2 0.0302842
MCL1 myeloid cell leukemia 1 0.0302673
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0301095
CANX calnexin 0.029564
GOLGB1 golgin B1 0.0294286
HELZ helicase with zinc finger 0.0290168
AKAP9 A kinase (PRKA) anchor protein 9 0.0288066
SEC31A SEC31 homolog A (S. cerevisiae) 0.0284984
FTH1 ferritin, heavy polypeptide 1 0.0283243
COPB1 coatomer protein complex, subunit beta 1 0.0279949
LRRC23 leucine rich repeat containing 23 0.0275651
HDLBP high density lipoprotein binding protein 0.0268489
COG6 component of oligomeric golgi complex 6 0.026674
TMF1 TATA element modulatory factor 1 0.0263653
SEC24D SEC24 family member D 0.0262704
COPA coatomer protein complex, subunit alpha 0.0253365
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0250936
RUNX1 runt-related transcription factor 1 0.0244947
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0240729
SFTPA2 surfactant protein A2 0.0229643
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0224372
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0222739
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0221343
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0217338
FOXO3 forkhead box O3 0.0211039
FNDC3B fibronectin type III domain containing 3B 0.0210629
OGA O-GlcNAcase 0.0205789
FLNA filamin A, alpha 0.0205465
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0203707
PHF3 PHD finger protein 3 0.0202975
UBA6 ubiquitin-like modifier activating enzyme 6 0.0199535
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.019672
SRP54 signal recognition particle 54kDa 0.0196327
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.019539
KRT18 keratin 18, type I 0.0195064
PGM3 phosphoglucomutase 3 0.0193652
TMED2 transmembrane emp24 domain trafficking protein 2 0.0192583
KIAA1217 KIAA1217 0.0190275
SUCO SUN domain containing ossification factor 0.0189115
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0187744
WDR26 WD repeat domain 26 0.0186318
NBAS neuroblastoma amplified sequence 0.0185829
ZNF638 zinc finger protein 638 0.0185376
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0185293
SPAG9 sperm associated antigen 9 0.0184936
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0183076
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0181589
SEC24A SEC24 family member A 0.0181269
SQSTM1 sequestosome 1 0.0180829
HYOU1 hypoxia up-regulated 1 0.0180463
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0178821
YEATS2 YEATS domain containing 2 0.017761
PRELID2 PRELI domain containing 2 0.0177548
RIOK3 RIO kinase 3 0.0174877
KDM4C lysine (K)-specific demethylase 4C 0.0172355
RAB1A RAB1A, member RAS oncogene family 0.0167631
RNF24 ring finger protein 24 0.0167434
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0166464
MON2 MON2 homolog (S. cerevisiae) 0.0165684
EIF4A2 eukaryotic translation initiation factor 4A2 0.0165191
CALR calreticulin 0.0164024
ZNF292 zinc finger protein 292 0.0163828
SCFD1 sec1 family domain containing 1 0.0162332
ARFGEF3 ARFGEF family member 3 0.0161029
CEMIP2 cell migration inducing hyaluronidase 2 0.0158983
CCDC186 coiled-coil domain containing 186 0.015882
RPL3 ribosomal protein L3 0.0158539
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0157677
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0156259
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0155772
NEBL nebulette 0.0154809
PAPOLA poly(A) polymerase alpha 0.0154032
RNMT RNA (guanine-7-) methyltransferase 0.015387
ATXN1 ataxin 1 0.0151883
EXT1 exostosin glycosyltransferase 1 0.0150426
CALU calumenin 0.0149747
HM13 histocompatibility (minor) 13 0.0149357
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.0146702
FNIP1 folliculin interacting protein 1 0.0146067

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.264679
FAT1 FAT atypical cadherin 1 -0.253703
TMSB10 thymosin beta 10 -0.167161
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0957465
MKI67 marker of proliferation Ki-67 -0.0794191
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0667583
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0664595
TPT1 tumor protein, translationally-controlled 1 -0.0600845
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0579992
RPL35A ribosomal protein L35a -0.0561343
MT2A metallothionein 2A -0.0508565
PKM pyruvate kinase, muscle -0.0496741
TPM4 tropomyosin 4 -0.0486859
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0449036
RPS6 ribosomal protein S6 -0.0444108
KPNB1 karyopherin (importin) beta 1 -0.0442664
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0441048
SERINC5 serine incorporator 5 -0.0439806
AHNAK AHNAK nucleoprotein -0.0426839
S100A9 S100 calcium binding protein A9 -0.0425945
RPLP2 ribosomal protein, large, P2 -0.041158
MSI2 musashi RNA-binding protein 2 -0.0411539
ACTG1 actin gamma 1 -0.0403021
DLG1 discs, large homolog 1 (Drosophila) -0.0398171
RPS8 ribosomal protein S8 -0.0392466
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0388702
TUBA1B tubulin, alpha 1b -0.0388229
HMGB2 high mobility group box 2 -0.0369928
CENPF centromere protein F, 350/400kDa -0.0364371
RPLP1 ribosomal protein, large, P1 -0.036239
TUBB tubulin, beta class I -0.0355919
CADPS Ca++-dependent secretion activator -0.0355872
DIAPH3 diaphanous-related formin 3 -0.0351269
S100A6 S100 calcium binding protein A6 -0.0344032
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0338463
HMGA2 high mobility group AT-hook 2 -0.0336568
RPS3 ribosomal protein S3 -0.0334594
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0332659
S100A10 S100 calcium binding protein A10 -0.0327397
RPS19 ribosomal protein S19 -0.0323985
RAD51B RAD51 paralog B -0.031589
CCND1 cyclin D1 -0.0311088
ZNRF3 zinc and ring finger 3 -0.0305015
PFN1 profilin 1 -0.0304107
HMGB1 high mobility group box 1 -0.02991
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0298186
ENO1 enolase 1, (alpha) -0.0296546
POTEF POTE ankyrin domain family, member F -0.0295858
EPCAM epithelial cell adhesion molecule -0.0295362
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0292358
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0291642
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0291296
SMC4 structural maintenance of chromosomes 4 -0.0291124
SLC38A2 solute carrier family 38, member 2 -0.0285243
MED13L mediator complex subunit 13-like -0.0282799
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.028072
RPS21 ribosomal protein S21 -0.0278594
CBX3 chromobox homolog 3 -0.0275984
RPL26 ribosomal protein L26 -0.027376
RPS25 ribosomal protein S25 -0.0272093
RPS24 ribosomal protein S24 -0.027065
RPL34 ribosomal protein L34 -0.0267843
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0266032
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0265303
LDHA lactate dehydrogenase A -0.0263611
TUBB4B tubulin, beta 4B class IVb -0.0262058
TPI1 triosephosphate isomerase 1 -0.0260722
RPL23 ribosomal protein L23 -0.0257892
RBM25 RNA binding motif protein 25 -0.0257504
RPL37A ribosomal protein L37a -0.0256261
FHIT fragile histidine triad -0.0254731
RPL36 ribosomal protein L36 -0.0253713
RPL5 ribosomal protein L5 -0.0249511
RPS27A ribosomal protein S27a -0.0244381
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0243059
FRMD5 FERM domain containing 5 -0.0238704
RPL38 ribosomal protein L38 -0.0237716
RNF43 ring finger protein 43 -0.0236154
RPL8 ribosomal protein L8 -0.0235269
CUX1 cut-like homeobox 1 -0.0231473
RPS29 ribosomal protein S29 -0.0230246
FAF1 Fas (TNFRSF6) associated factor 1 -0.0227664
RPL19 ribosomal protein L19 -0.0223831
TCF12 transcription factor 12 -0.0222852
RAD21 RAD21 homolog (S. pombe) -0.0219956
HELLS helicase, lymphoid-specific -0.0219268
OLA1 Obg-like ATPase 1 -0.0217626
DEK DEK proto-oncogene -0.0216575
DIAPH2 diaphanous-related formin 2 -0.021625
PSIP1 PC4 and SFRS1 interacting protein 1 -0.021618
RPS15 ribosomal protein S15 -0.0215583
ACACA acetyl-CoA carboxylase alpha -0.0214871
WWOX WW domain containing oxidoreductase -0.0213807
EREG epiregulin -0.0212678
RPS23 ribosomal protein S23 -0.0210754
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.02104
ACTN4 actinin, alpha 4 -0.0209948
IGFBP4 insulin-like growth factor binding protein 4 -0.0208476
SH3BP4 SH3-domain binding protein 4 -0.0207546
LMNA lamin A/C -0.0206459