Oleic acid_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in HOP62 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLEC plectin 0.205208
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.194073
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.145318
CD44 CD44 molecule (Indian blood group) 0.133672
COL6A1 collagen, type VI, alpha 1 0.124342
SEPTIN9 septin 9 0.118806
MYH9 myosin, heavy chain 9, non-muscle 0.117049
EEF2 eukaryotic translation elongation factor 2 0.109724
FN1 fibronectin 1 0.0946512
FNDC3B fibronectin type III domain containing 3B 0.0890934
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0873089
AHNAK AHNAK nucleoprotein 0.0799528
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0798995
FLNA filamin A, alpha 0.0797743
DST dystonin 0.0796196
FTH1 ferritin, heavy polypeptide 1 0.0785575
ASPH aspartate beta-hydroxylase 0.0774194
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0755988
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0753983
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0673866
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0653347
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0647521
VEGFA vascular endothelial growth factor A 0.063893
MAP1B microtubule-associated protein 1B 0.0635701
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.062089
NDRG1 N-myc downstream regulated 1 0.0612483
TAC4 tachykinin 4 (hemokinin) 0.0603263
STC1 stanniocalcin 1 0.0600962
SFTPA2 surfactant protein A2 0.0596627
MSN moesin 0.0593324
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0587663
COL6A3 collagen, type VI, alpha 3 0.0587578
NAV1 neuron navigator 1 0.0554219
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0554012
COL5A1 collagen, type V, alpha 1 0.0553522
PDIA4 protein disulfide isomerase family A, member 4 0.0538884
CXCL8 chemokine (C-X-C motif) ligand 8 0.0528882
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0515222
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0513199
RRM2 ribonucleotide reductase M2 0.0510594
PTPRM protein tyrosine phosphatase, receptor type, M 0.0508811
MCL1 myeloid cell leukemia 1 0.0505493
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.049901
FAM13A family with sequence similarity 13, member A 0.0497781
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0487602
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0483068
COL6A2 collagen, type VI, alpha 2 0.0481946
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0476354
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0474789
ENO1 enolase 1, (alpha) 0.0458667
ERRFI1 ERBB receptor feedback inhibitor 1 0.0457767
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0450878
LOC112694756 uncharaterized LOC112694756 0.0447598
TNS1 tensin 1 0.0444751
CALR calreticulin 0.0443051
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0433526
SMAD3 SMAD family member 3 0.0433001
CAPRIN2 caprin family member 2 0.042944
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0425705
PDIA6 protein disulfide isomerase family A, member 6 0.0421798
FLNB filamin B, beta 0.0421106
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0408543
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.038948
ATXN1 ataxin 1 0.0389228
HSPA8 heat shock 70kDa protein 8 0.0385855
ZBTB38 zinc finger and BTB domain containing 38 0.0383883
INTS6 integrator complex subunit 6 0.0382293
TNIP1 TNFAIP3 interacting protein 1 0.0378051
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0374882
MPRIP myosin phosphatase Rho interacting protein 0.0365506
UBA6 ubiquitin-like modifier activating enzyme 6 0.0358712
PABPC1 poly(A) binding protein, cytoplasmic 1 0.035629
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0351286
YBX1 Y box binding protein 1 0.0350433
LDHA lactate dehydrogenase A 0.0343719
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0340732
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0340639
RCOR1 REST corepressor 1 0.033864
RUNX1 runt-related transcription factor 1 0.0336696
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0334186
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0332772
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0331706
GOLGB1 golgin B1 0.0331687
ANXA2 annexin A2 0.0331292
TGFB1 transforming growth factor, beta 1 0.0328128
EMP1 epithelial membrane protein 1 0.0322932
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0322792
NAV2 neuron navigator 2 0.0318243
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0310218
DSTN destrin (actin depolymerizing factor) 0.0307543
PKM pyruvate kinase, muscle 0.0304365
PRKCA protein kinase C, alpha 0.0302329
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0302015
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.030091
TPM3 tropomyosin 3 0.0300572
HOOK2 hook microtubule-tethering protein 2 0.0298341
WWOX WW domain containing oxidoreductase 0.0296172
RPS6 ribosomal protein S6 0.0293527
IGFBP3 insulin-like growth factor binding protein 3 0.0293432
CDCP1 CUB domain containing protein 1 0.0293213

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.219666
TMSB10 thymosin beta 10 -0.157918
IGF2 insulin-like growth factor 2 -0.0774066
CDH13 cadherin 13 -0.0612179
TPT1 tumor protein, translationally-controlled 1 -0.0606557
LAMB3 laminin, beta 3 -0.0532736
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0520885
MT2A metallothionein 2A -0.0508487
TENM2 teneurin transmembrane protein 2 -0.0503168
CAVIN1 caveolae associated protein 1 -0.0484936
EGR1 early growth response 1 -0.0476601
ACTG1 actin gamma 1 -0.0458166
PTMA prothymosin, alpha -0.0454316
COL1A1 collagen, type I, alpha 1 -0.0441928
RPL35A ribosomal protein L35a -0.0423061
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.042147
RAI14 retinoic acid induced 14 -0.0386292
ZMYND8 zinc finger, MYND-type containing 8 -0.0383294
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.037941
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0372577
RTN4 reticulon 4 -0.0350104
RRBP1 ribosome binding protein 1 -0.0342639
GNAS GNAS complex locus -0.03246
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0323626
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0310573
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0302421
CLMP CXADR-like membrane protein -0.0294582
WSB1 WD repeat and SOCS box containing 1 -0.0292836
BTG1 B-cell translocation gene 1, anti-proliferative -0.0284066
MT1X metallothionein 1X -0.0281952
PRSS23 protease, serine, 23 -0.0273057
MYL12B myosin, light chain 12B, regulatory -0.0258316
KPNB1 karyopherin (importin) beta 1 -0.0257314
RPLP1 ribosomal protein, large, P1 -0.0257125
RPS19 ribosomal protein S19 -0.0253627
INHBA inhibin, beta A -0.0253057
RAB7A RAB7A, member RAS oncogene family -0.0248877
FTL ferritin, light polypeptide -0.0244516
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0238619
FMN1 formin 1 -0.0236142
RBM25 RNA binding motif protein 25 -0.0236105
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0235509
EIF1 eukaryotic translation initiation factor 1 -0.0234304
RPS24 ribosomal protein S24 -0.0231071
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0228975
VASP vasodilator-stimulated phosphoprotein -0.0228678
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0227096
WDFY2 WD repeat and FYVE domain containing 2 -0.0226442
SAMD3 sterile alpha motif domain containing 3 -0.0226106
PLAUR plasminogen activator, urokinase receptor -0.022384
SPRY4 sprouty homolog 4 (Drosophila) -0.0222806
TMEM165 transmembrane protein 165 -0.0216908
IGFBP4 insulin-like growth factor binding protein 4 -0.0201233
RPLP2 ribosomal protein, large, P2 -0.0198791
NAMPT nicotinamide phosphoribosyltransferase -0.0197356
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0194964
RPL38 ribosomal protein L38 -0.0190987
RAD21 RAD21 homolog (S. pombe) -0.0187933
MON2 MON2 homolog (S. cerevisiae) -0.0187291
RASA3 RAS p21 protein activator 3 -0.018665
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.0186251
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.018585
BASP1 brain abundant, membrane attached signal protein 1 -0.0183983
THBS2 thrombospondin 2 -0.0181229
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0178455
LOX lysyl oxidase -0.0177761
TUBB6 tubulin, beta 6 class V -0.0177543
TMEM87A transmembrane protein 87A -0.0176139
ANTXR2 anthrax toxin receptor 2 -0.0174631
TPM1 tropomyosin 1 (alpha) -0.0174553
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0173582
RIN2 Ras and Rab interactor 2 -0.0172672
CCDC91 coiled-coil domain containing 91 -0.0172563
TNNC1 troponin C type 1 (slow) -0.0172191
RPL30 ribosomal protein L30 -0.0171785
OSMR oncostatin M receptor -0.0170491
RPL34 ribosomal protein L34 -0.016892
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0167333
RPS13 ribosomal protein S13 -0.016692
RPS21 ribosomal protein S21 -0.0166789
PTPN1 protein tyrosine phosphatase, non-receptor type 1 -0.0165768
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0164746
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0162059
ZBTB20 zinc finger and BTB domain containing 20 -0.0161922
DNER delta/notch-like EGF repeat containing -0.0160917
URI1 URI1, prefoldin-like chaperone -0.0157749
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0157348
KIF18B kinesin family member 18B -0.0155133
TM9SF3 transmembrane 9 superfamily member 3 -0.0154014
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 -0.0151534
RPL23 ribosomal protein L23 -0.0150631
SEC63 SEC63 homolog (S. cerevisiae) -0.0148166
NAV3 neuron navigator 3 -0.0147931
TRPS1 trichorhinophalangeal syndrome I -0.0147725
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0147495
TMEM263 transmembrane protein 263 -0.0145814
RPS29 ribosomal protein S29 -0.0143692
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0143503
TPM4 tropomyosin 4 -0.0143137
TCF25 transcription factor 25 (basic helix-loop-helix) -0.0142706