Oleic acid_HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in HT-29 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.242334
FTH1 ferritin, heavy polypeptide 1 0.218369
KRT18 keratin 18, type I 0.186193
MYH14 myosin, heavy chain 14, non-muscle 0.139519
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.126141
KRT20 keratin 20, type I 0.109993
EZR ezrin 0.109302
KRT8 keratin 8, type II 0.103947
EXT1 exostosin glycosyltransferase 1 0.101345
LOC112694756 uncharaterized LOC112694756 0.0906513
SMAD3 SMAD family member 3 0.0882662
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0874035
EMP1 epithelial membrane protein 1 0.0873382
AHNAK AHNAK nucleoprotein 0.0830348
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0819508
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0808619
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0781873
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0769715
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0728418
EEF2 eukaryotic translation elongation factor 2 0.0702538
FAT1 FAT atypical cadherin 1 0.0697202
PLEC plectin 0.0672059
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0630323
SGMS2 sphingomyelin synthase 2 0.0611888
AFF1 AF4/FMR2 family, member 1 0.0608518
MYO1E myosin IE 0.0586914
BAIAP2L1 BAI1-associated protein 2-like 1 0.0586482
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0572305
TJP1 tight junction protein 1 0.0570197
EXPH5 exophilin 5 0.0557533
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.05514
SLC45A4 solute carrier family 45, member 4 0.0531687
LAMA4 laminin, alpha 4 0.0517855
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.049463
ANXA2 annexin A2 0.0484096
PELI1 pellino E3 ubiquitin protein ligase 1 0.0483575
ARHGAP42 Rho GTPase activating protein 42 0.0483078
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0482332
SEPTIN9 septin 9 0.0479853
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0464582
TRIB1 tribbles pseudokinase 1 0.0457521
MYO5B myosin VB 0.0455582
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.045483
NTN4 netrin 4 0.0453567
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0434597
EREG epiregulin 0.0433938
MYADM myeloid-associated differentiation marker 0.0428966
ARHGAP32 Rho GTPase activating protein 32 0.0428059
PDLIM5 PDZ and LIM domain 5 0.0426742
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0425527
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0425184
CTBP2 C-terminal binding protein 2 0.0424884
ZSWIM6 zinc finger, SWIM-type containing 6 0.0417732
PTPRK protein tyrosine phosphatase, receptor type, K 0.0416251
SIK3 SIK family kinase 3 0.0414076
SAMD12 sterile alpha motif domain containing 12 0.0405413
NCEH1 neutral cholesterol ester hydrolase 1 0.0404275
SHROOM3 shroom family member 3 0.0400906
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0395039
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0394045
FNDC3B fibronectin type III domain containing 3B 0.0389805
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.038573
PLA2R1 phospholipase A2 receptor 1, 180kDa 0.0368631
ESYT2 extended synaptotagmin-like protein 2 0.0368033
NEBL nebulette 0.0361136
RNF213 ring finger protein 213 0.035852
GNA14 guanine nucleotide binding protein (G protein), alpha 14 0.0356682
FOXP1 forkhead box P1 0.0356139
MAML3 mastermind-like 3 (Drosophila) 0.0350498
AKAP13 A kinase (PRKA) anchor protein 13 0.0349941
FOXO1 forkhead box O1 0.0348858
PDE4D phosphodiesterase 4D, cAMP-specific 0.0342108
UTRN utrophin 0.0341589
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0339067
ASPH aspartate beta-hydroxylase 0.033624
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0334425
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0328898
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.03254
PRKN parkin RBR E3 ubiquitin protein ligase 0.0321141
ETV6 ets variant 6 0.0320459
KLF5 Kruppel-like factor 5 (intestinal) 0.0320261
TMEM65 transmembrane protein 65 0.031972
CYSTM1 cysteine-rich transmembrane module containing 1 0.0319605
ATXN1 ataxin 1 0.0319512
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0317929
MYH9 myosin, heavy chain 9, non-muscle 0.0317796
TRAPPC9 trafficking protein particle complex 9 0.0317458
BCL2L1 BCL2-like 1 0.0316572
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0315971
PLK2 polo-like kinase 2 0.0315775
KLF3 Kruppel-like factor 3 (basic) 0.0311878
CD2AP CD2-associated protein 0.0305648
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0305559
KRT19 keratin 19, type I 0.0303482
PPARD peroxisome proliferator-activated receptor delta 0.0302704
CLMN calmin (calponin-like, transmembrane) 0.0297546
SPDYA speedy/RINGO cell cycle regulator family member A 0.0294428
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0291544
EPS8L1 EPS8-like 1 0.0291506
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0290532

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.16646
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.103507
PTMA prothymosin, alpha -0.0856046
PDIA3 protein disulfide isomerase family A, member 3 -0.059508
GOLGA4 golgin A4 -0.0588651
NDRG1 N-myc downstream regulated 1 -0.0512195
TPT1 tumor protein, translationally-controlled 1 -0.0509794
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0452459
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0428599
RAD21 RAD21 homolog (S. pombe) -0.0427007
RBM39 RNA binding motif protein 39 -0.0414912
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0412354
VCL vinculin -0.040662
GARS1 glycyl-tRNA synthetase 1 -0.0398231
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0395979
ANKRD12 ankyrin repeat domain 12 -0.0385168
RPS6 ribosomal protein S6 -0.037849
RPS24 ribosomal protein S24 -0.0374524
KMT2C lysine (K)-specific methyltransferase 2C -0.0373658
CANX calnexin -0.0360707
ZMYM2 zinc finger, MYM-type 2 -0.0354414
RPS19 ribosomal protein S19 -0.0337111
RPLP2 ribosomal protein, large, P2 -0.0335772
OGA O-GlcNAcase -0.0331006
RPL35A ribosomal protein L35a -0.031796
TXNRD1 thioredoxin reductase 1 -0.0313011
RTN3 reticulon 3 -0.0310491
KDM3A lysine (K)-specific demethylase 3A -0.0308569
IARS1 isoleucyl-tRNA synthetase 1 -0.030159
RPLP1 ribosomal protein, large, P1 -0.0300847
COG5 component of oligomeric golgi complex 5 -0.0298251
EIF1 eukaryotic translation initiation factor 1 -0.0295856
RPS13 ribosomal protein S13 -0.0284285
RPS3 ribosomal protein S3 -0.028304
ZNF292 zinc finger protein 292 -0.0279739
INTS6 integrator complex subunit 6 -0.0276414
RPS25 ribosomal protein S25 -0.0273869
HM13 histocompatibility (minor) 13 -0.026691
AGR2 anterior gradient 2 -0.0266437
RPS12 ribosomal protein S12 -0.0263568
UBE2B ubiquitin-conjugating enzyme E2B -0.0262774
FAM135A family with sequence similarity 135, member A -0.0261776
NAMPT nicotinamide phosphoribosyltransferase -0.0260085
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0257701
PHF20L1 PHD finger protein 20-like 1 -0.0249549
ZFAND3 zinc finger, AN1-type domain 3 -0.0248528
RPL9 ribosomal protein L9 -0.0243471
TMSB10 thymosin beta 10 -0.024225
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0237255
RSF1 remodeling and spacing factor 1 -0.0236454
RPS2 ribosomal protein S2 -0.0236341
TES testin LIM domain protein -0.022774
RAB1A RAB1A, member RAS oncogene family -0.0227372
MORF4L2 mortality factor 4 like 2 -0.0225301
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0224865
PSPC1 paraspeckle component 1 -0.0224785
RPS16 ribosomal protein S16 -0.0224641
PNISR PNN-interacting serine/arginine-rich protein -0.0218751
RPS23 ribosomal protein S23 -0.0218624
MAP4 microtubule-associated protein 4 -0.0218044
RPS5 ribosomal protein S5 -0.0218027
KDM6A lysine (K)-specific demethylase 6A -0.0216859
RPL23 ribosomal protein L23 -0.0215512
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0214782
HELZ helicase with zinc finger -0.0212155
PTEN phosphatase and tensin homolog -0.0208784
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0206784
RPL5 ribosomal protein L5 -0.0204349
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.0203184
TOP1 topoisomerase (DNA) I -0.0203117
TUFT1 tuftelin 1 -0.0202904
RPL26 ribosomal protein L26 -0.0200821
MTDH metadherin -0.019983
BTBD9 BTB (POZ) domain containing 9 -0.0199479
RPS11 ribosomal protein S11 -0.0196902
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.0196001
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0195918
RPL12 ribosomal protein L12 -0.0195736
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0195427
COPB1 coatomer protein complex, subunit beta 1 -0.0195245
CCDC186 coiled-coil domain containing 186 -0.0195084
CDK8 cyclin-dependent kinase 8 -0.0195081
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.01938
LCORL ligand dependent nuclear receptor corepressor-like -0.0192967
TRAM1 translocation associated membrane protein 1 -0.0192842
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0192481
FGD4 FYVE, RhoGEF and PH domain containing 4 -0.0189601
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0189193
RB1CC1 RB1-inducible coiled-coil 1 -0.0188268
CALR calreticulin -0.0188181
RPL37A ribosomal protein L37a -0.0185017
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0184687
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0183692
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.018358
CALU calumenin -0.0183531
RPS21 ribosomal protein S21 -0.0182313
FAM91A1 family with sequence similarity 91, member A1 -0.0182248
RPL7 ribosomal protein L7 -0.0181528
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0179985
UFM1 ubiquitin-fold modifier 1 -0.0179952