Oleic acid_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.21155
AKAP12 A kinase (PRKA) anchor protein 12 0.210017
IGF2 insulin-like growth factor 2 0.20865
ERRFI1 ERBB receptor feedback inhibitor 1 0.188487
DSPP dentin sialophosphoprotein 0.137692
SPTBN1 spectrin, beta, non-erythrocytic 1 0.129408
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.119148
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.118187
SVIL supervillin 0.116013
SAMD4A sterile alpha motif domain containing 4A 0.107437
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.094624
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0765338
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0733849
EEF2 eukaryotic translation elongation factor 2 0.0720941
FAM107B family with sequence similarity 107, member B 0.0715573
ENO1 enolase 1, (alpha) 0.0711969
EXT1 exostosin glycosyltransferase 1 0.0696896
ASPH aspartate beta-hydroxylase 0.0692265
LOC112694756 uncharaterized LOC112694756 0.0647473
EHBP1 EH domain binding protein 1 0.0626382
ATXN1 ataxin 1 0.0623608
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0618375
DST dystonin 0.0612209
FRMD5 FERM domain containing 5 0.0569426
PDLIM5 PDZ and LIM domain 5 0.0552728
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0540451
MACF1 microtubule-actin crosslinking factor 1 0.0539043
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0536442
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0521264
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0519854
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.048712
PEG3 paternally expressed 3 0.048264
TRIO trio Rho guanine nucleotide exchange factor 0.0480842
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0475313
MBNL2 muscleblind-like splicing regulator 2 0.0463925
H1-0 H1.0 linker histone 0.0454764
FAT1 FAT atypical cadherin 1 0.0452782
FNDC3B fibronectin type III domain containing 3B 0.0441171
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0435653
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0431861
GPC6 glypican 6 0.0425898
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0409394
AFF1 AF4/FMR2 family, member 1 0.040603
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0401316
EPAS1 endothelial PAS domain protein 1 0.0397944
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0396943
MYH9 myosin, heavy chain 9, non-muscle 0.0389715
DSCAM Down syndrome cell adhesion molecule 0.0367255
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.03656
SDC4 syndecan 4 0.036237
LPP LIM domain containing preferred translocation partner in lipoma 0.0354159
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.03512
PAWR PRKC, apoptosis, WT1, regulator 0.0348992
RUNX1 runt-related transcription factor 1 0.0345572
KYNU kynureninase 0.0344201
TXNRD1 thioredoxin reductase 1 0.034236
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0341848
ELL2 elongation factor, RNA polymerase II, 2 0.0336592
CEMIP2 cell migration inducing hyaluronidase 2 0.0330412
PHF3 PHD finger protein 3 0.0321216
FOXP1 forkhead box P1 0.0319951
PLEC plectin 0.0314286
MBNL1 muscleblind-like splicing regulator 1 0.0311406
C3 complement component 3 0.030867
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0308565
GRB10 growth factor receptor-bound protein 10 0.0305013
RAI14 retinoic acid induced 14 0.0304562
NFE2L2 nuclear factor, erythroid 2-like 2 0.0300397
NDRG1 N-myc downstream regulated 1 0.0300211
VCL vinculin 0.0296049
DTNA dystrobrevin, alpha 0.0295261
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0290738
DSTN destrin (actin depolymerizing factor) 0.0285037
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0280228
KIAA1217 KIAA1217 0.0280158
SPATS2L spermatogenesis associated, serine-rich 2-like 0.027851
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0277913
TBC1D22A TBC1 domain family, member 22A 0.027711
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0276724
PLIN2 perilipin 2 0.0275753
GOLGA4 golgin A4 0.0274246
MYO1E myosin IE 0.0271411
ANO6 anoctamin 6 0.0269243
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0268347
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0266803
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0265525
FMNL2 formin-like 2 0.0262768
GCLC glutamate-cysteine ligase, catalytic subunit 0.0261277
SFTPA2 surfactant protein A2 0.026095
STK17A serine/threonine kinase 17a 0.0260227
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0259987
UBC ubiquitin C 0.0258909
ESYT2 extended synaptotagmin-like protein 2 0.025828
MALRD1 MAM and LDL receptor class A domain containing 1 0.0257864
KIF21A kinesin family member 21A 0.0257777
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0257729
KDM3A lysine (K)-specific demethylase 3A 0.0255158
CRY1 cryptochrome circadian clock 1 0.0254275
APLP2 amyloid beta (A4) precursor-like protein 2 0.0254119
DOCK4 dedicator of cytokinesis 4 0.0251885

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.104647
APOA2 apolipoprotein A-II -0.0860771
RPS12 ribosomal protein S12 -0.0615471
RPL37A ribosomal protein L37a -0.056088
TPT1 tumor protein, translationally-controlled 1 -0.0416381
RPS29 ribosomal protein S29 -0.0402217
RPS6 ribosomal protein S6 -0.0355333
TMSB10 thymosin beta 10 -0.0346513
RPLP2 ribosomal protein, large, P2 -0.0340737
RPL35A ribosomal protein L35a -0.0339591
EML4 echinoderm microtubule associated protein like 4 -0.031907
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0302035
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0293113
RPL36 ribosomal protein L36 -0.0286791
RPL38 ribosomal protein L38 -0.0280873
APOB apolipoprotein B -0.0275357
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0258306
RPS3 ribosomal protein S3 -0.0250214
RPS23 ribosomal protein S23 -0.0246618
RPS19 ribosomal protein S19 -0.0244076
RPS25 ribosomal protein S25 -0.0236061
RPL31 ribosomal protein L31 -0.022669
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.0224871
IFI6 interferon, alpha-inducible protein 6 -0.0222526
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.022186
RPL9 ribosomal protein L9 -0.0206148
RPL28 ribosomal protein L28 -0.0203143
PTMA prothymosin, alpha -0.0200106
RPS15 ribosomal protein S15 -0.0196564
RPL36A ribosomal protein L36a -0.0196115
RPS17 ribosomal protein S17 -0.0190085
RPS27A ribosomal protein S27a -0.0181628
A2M alpha-2-macroglobulin -0.0181512
RPL7A ribosomal protein L7a -0.0178428
IER3 immediate early response 3 -0.0178375
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0176501
APOA1 apolipoprotein A-I -0.017459
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0171678
FTL ferritin, light polypeptide -0.0168116
ISG15 ISG15 ubiquitin-like modifier -0.0167515
RPL19 ribosomal protein L19 -0.0164886
AMBP alpha-1-microglobulin/bikunin precursor -0.0162508
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.0161029
RPS24 ribosomal protein S24 -0.0159048
ARID3A AT rich interactive domain 3A (BRIGHT-like) -0.015856
RPS8 ribosomal protein S8 -0.0155167
RPL26 ribosomal protein L26 -0.015489
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0154009
RPL30 ribosomal protein L30 -0.0153172
APOC1 apolipoprotein C-I -0.0147331
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0146421
COL27A1 collagen, type XXVII, alpha 1 -0.0138228
APOH apolipoprotein H (beta-2-glycoprotein I) -0.0136174
IL32 interleukin 32 -0.0135826
RPS13 ribosomal protein S13 -0.0134997
RPL23 ribosomal protein L23 -0.013451
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0132859
RPS21 ribosomal protein S21 -0.0132271
CCNL1 cyclin L1 -0.0131512
RPL32 ribosomal protein L32 -0.0131112
HLA-B major histocompatibility complex, class I, B -0.0130273
LYZ lysozyme -0.012799
CST3 cystatin C -0.0126213
TMEM51 transmembrane protein 51 -0.0122338
S100A9 S100 calcium binding protein A9 -0.012001
RPL37 ribosomal protein L37 -0.0119993
APOC2 apolipoprotein C-II -0.011925
FABP1 fatty acid binding protein 1, liver -0.0118602
CELF1 CUGBP, Elav-like family member 1 -0.0115756
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0114917
CRLS1 cardiolipin synthase 1 -0.0114031
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0113629
VDAC1 voltage-dependent anion channel 1 -0.0113455
PDLIM7 PDZ and LIM domain 7 (enigma) -0.0111758
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0111061
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0111054
TRIM26 tripartite motif containing 26 -0.0110982
WSB1 WD repeat and SOCS box containing 1 -0.0110755
RPS10 ribosomal protein S10 -0.0109817
CFB complement factor B -0.0107903
TRA2B transformer 2 beta homolog (Drosophila) -0.0106954
ACSS3 acyl-CoA synthetase short-chain family member 3 -0.0105219
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0104838
PEG10 paternally expressed 10 -0.0104831
SCN1A sodium channel, voltage gated, type I alpha subunit -0.0104071
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0103516
LCN2 lipocalin 2 -0.010317
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0102471
OSMR oncostatin M receptor -0.0100549
CFI complement factor I -0.0100184
FGL1 fibrinogen-like 1 -0.0100099
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.00999091
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -0.00983596
IFITM3 interferon induced transmembrane protein 3 -0.00983153
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.00975812
RPL22 ribosomal protein L22 -0.00974953
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.00972347
APOE apolipoprotein E -0.00965936
PELI1 pellino E3 ubiquitin protein ligase 1 -0.00960494
SOX6 SRY (sex determining region Y)-box 6 -0.0094466