Oleic acid_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.119814
EXT1 exostosin glycosyltransferase 1 0.0624097
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0623436
AHNAK AHNAK nucleoprotein 0.0571449
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0543104
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0532817
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.052565
TRIO trio Rho guanine nucleotide exchange factor 0.0493087
MYH9 myosin, heavy chain 9, non-muscle 0.0472495
LOC112694756 uncharaterized LOC112694756 0.0470547
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0464772
SAMD4A sterile alpha motif domain containing 4A 0.0458509
PLEC plectin 0.0451729
FLNA filamin A, alpha 0.0443047
RUNX1 runt-related transcription factor 1 0.0412411
KDM3A lysine (K)-specific demethylase 3A 0.0394781
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0385263
EFNA5 ephrin-A5 0.0369728
DST dystonin 0.0366026
DTNA dystrobrevin, alpha 0.0359048
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.035658
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0356148
MARCHF4 membrane associated ring-CH-type finger 4 0.0351117
ASPH aspartate beta-hydroxylase 0.0340538
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.03366
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0321441
APP amyloid beta (A4) precursor protein 0.0316942
HSPA8 heat shock 70kDa protein 8 0.031371
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0311904
MCTP1 multiple C2 domains, transmembrane 1 0.0309441
PRKCE protein kinase C, epsilon 0.0302217
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0300313
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0299734
CALD1 caldesmon 1 0.0282852
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0278855
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0276678
MYO10 myosin X 0.027442
HOOK2 hook microtubule-tethering protein 2 0.0263032
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0258411
CFAP251 cilia and flagella associated protein 251 0.0243613
ANO6 anoctamin 6 0.0242872
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0241168
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0239056
GPHN gephyrin 0.0238873
YAP1 Yes-associated protein 1 0.0238081
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.023717
TLE4 transducin-like enhancer of split 4 0.0237116
INTS6 integrator complex subunit 6 0.0228533
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.022397
EIF4B eukaryotic translation initiation factor 4B 0.0222758
EIF4A2 eukaryotic translation initiation factor 4A2 0.0222177
USP34 ubiquitin specific peptidase 34 0.0215865
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0215062
NCKAP1 NCK-associated protein 1 0.0214069
NUP58 nucleoporin 58 0.0212834
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.02121
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0209276
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0206845
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0206272
GLS2 glutaminase 2 (liver, mitochondrial) 0.0204548
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0203945
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0198857
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0197741
CORO1C coronin, actin binding protein, 1C 0.0197651
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0194905
OSBPL8 oxysterol binding protein-like 8 0.0194298
KMT2C lysine (K)-specific methyltransferase 2C 0.0194206
ZSWIM6 zinc finger, SWIM-type containing 6 0.0187738
APLP2 amyloid beta (A4) precursor-like protein 2 0.01874
WNK1 WNK lysine deficient protein kinase 1 0.0185073
PEAK1 pseudopodium-enriched atypical kinase 1 0.0183864
LIMA1 LIM domain and actin binding 1 0.0183489
ZFAND3 zinc finger, AN1-type domain 3 0.0183344
MACF1 microtubule-actin crosslinking factor 1 0.018156
STC1 stanniocalcin 1 0.0180477
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0180037
LPP LIM domain containing preferred translocation partner in lipoma 0.0176605
KTN1 kinectin 1 (kinesin receptor) 0.0176546
SPAG9 sperm associated antigen 9 0.0175938
TPM3 tropomyosin 3 0.0175863
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0175263
PAPOLA poly(A) polymerase alpha 0.0174848
CD44 CD44 molecule (Indian blood group) 0.0174063
TRIP12 thyroid hormone receptor interactor 12 0.0171211
BIRC6 baculoviral IAP repeat containing 6 0.0169936
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0169719
JMJD1C jumonji domain containing 1C 0.0166291
BRD2 bromodomain containing 2 0.0164359
RPS18 ribosomal protein S18 0.0163958
TLN1 talin 1 0.016378
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) 0.0162972
ZNF638 zinc finger protein 638 0.0161217
ZNF292 zinc finger protein 292 0.0160764
TAC4 tachykinin 4 (hemokinin) 0.0160678
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0158911
KDM2A lysine (K)-specific demethylase 2A 0.0155545
TXNRD1 thioredoxin reductase 1 0.0155405
AGO2 argonaute RISC catalytic component 2 0.0155132
MED13L mediator complex subunit 13-like 0.0154167
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0154046

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.281252
TMSB10 thymosin beta 10 -0.202344
PTMA prothymosin, alpha -0.0764242
TPT1 tumor protein, translationally-controlled 1 -0.0723863
AKAP12 A kinase (PRKA) anchor protein 12 -0.0723698
RPS6 ribosomal protein S6 -0.0714155
RPL35A ribosomal protein L35a -0.0671213
MT2A metallothionein 2A -0.0586882
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0568628
MMP12 matrix metallopeptidase 12 -0.0550413
RPL23 ribosomal protein L23 -0.0530071
EGR1 early growth response 1 -0.0523607
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0514115
RPS19 ribosomal protein S19 -0.0483264
RPS3 ribosomal protein S3 -0.0450125
RPL37A ribosomal protein L37a -0.0434291
GPC6 glypican 6 -0.0412106
CDH13 cadherin 13 -0.0410981
RPLP2 ribosomal protein, large, P2 -0.0401732
RPS8 ribosomal protein S8 -0.0394786
LSAMP limbic system-associated membrane protein -0.0393608
PHACTR1 phosphatase and actin regulator 1 -0.0383802
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0334787
RPS13 ribosomal protein S13 -0.0330663
RPS25 ribosomal protein S25 -0.0328362
HMGA1 high mobility group AT-hook 1 -0.0322914
RPS21 ribosomal protein S21 -0.0316312
RPL26 ribosomal protein L26 -0.0315499
IFI16 interferon, gamma-inducible protein 16 -0.0302038
RPS24 ribosomal protein S24 -0.0296883
RPL31 ribosomal protein L31 -0.028835
TNNC1 troponin C type 1 (slow) -0.0283558
RPLP1 ribosomal protein, large, P1 -0.0277303
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0269649
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0265484
KIAA1217 KIAA1217 -0.0265401
NALF1 NALCN channel auxiliary factor 1 -0.0265023
PFN1 profilin 1 -0.0262361
HAS2 hyaluronan synthase 2 -0.0253782
C2CD2 C2 calcium-dependent domain containing 2 -0.025052
RPL9 ribosomal protein L9 -0.0248856
FN1 fibronectin 1 -0.0246136
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0243013
RPS12 ribosomal protein S12 -0.0238649
RPL36A ribosomal protein L36a -0.0235775
RPLP0 ribosomal protein, large, P0 -0.0232268
CSTB cystatin B (stefin B) -0.0231009
TPM4 tropomyosin 4 -0.022808
RPL19 ribosomal protein L19 -0.0226577
RPL5 ribosomal protein L5 -0.0225956
RPS27A ribosomal protein S27a -0.0219089
RPS29 ribosomal protein S29 -0.0215761
RPL34 ribosomal protein L34 -0.0215418
RPL38 ribosomal protein L38 -0.0213317
RPS23 ribosomal protein S23 -0.0211618
RPS16 ribosomal protein S16 -0.0210189
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0208428
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0207077
PTCHD4 patched domain containing 4 -0.0201452
RPL8 ribosomal protein L8 -0.0198381
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0198161
RTN4 reticulon 4 -0.0197214
RPL30 ribosomal protein L30 -0.0197051
RPL36 ribosomal protein L36 -0.019418
RPL37 ribosomal protein L37 -0.0193146
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0192657
RPS14 ribosomal protein S14 -0.0191615
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0189491
KIAA1549L KIAA1549-like -0.0189202
RPL28 ribosomal protein L28 -0.0185695
ENO2 enolase 2 (gamma, neuronal) -0.01846
RPL12 ribosomal protein L12 -0.0181251
BTG1 B-cell translocation gene 1, anti-proliferative -0.0177424
PRSS23 protease, serine, 23 -0.017415
HMGB1 high mobility group box 1 -0.0169682
RIGI RNA sensor RIG-I -0.0166538
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0164879
PDE4D phosphodiesterase 4D, cAMP-specific -0.0163381
ALCAM activated leukocyte cell adhesion molecule -0.0162978
RPL7A ribosomal protein L7a -0.0160553
TPI1 triosephosphate isomerase 1 -0.0158673
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0156684
POTEF POTE ankyrin domain family, member F -0.0155403
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0153548
PCBP2 poly(rC) binding protein 2 -0.0152985
RPL27A ribosomal protein L27a -0.0151123
CAVIN1 caveolae associated protein 1 -0.0148704
RPS5 ribosomal protein S5 -0.0148687
RPS10 ribosomal protein S10 -0.0146292
VDAC1 voltage-dependent anion channel 1 -0.0144301
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0144211
NAV1 neuron navigator 1 -0.0144107
WSB1 WD repeat and SOCS box containing 1 -0.0143315
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0142911
RPS27 ribosomal protein S27 -0.0142414
RPL27 ribosomal protein L27 -0.0142226
ATP5F1B ATP synthase F1 subunit beta -0.0140924
RPS11 ribosomal protein S11 -0.0140603
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0139484
BNC2 basonuclin 2 -0.0139172