Oleic acid_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KRT18 keratin 18, type I 0.223611
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.206112
FTH1 ferritin, heavy polypeptide 1 0.169376
LMO7 LIM domain 7 0.165487
FAT1 FAT atypical cadherin 1 0.165331
SPTBN1 spectrin, beta, non-erythrocytic 1 0.136238
EEF2 eukaryotic translation elongation factor 2 0.115839
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.114528
DSPP dentin sialophosphoprotein 0.10895
H1-0 H1.0 linker histone 0.107062
KRT8 keratin 8, type II 0.106282
AHNAK AHNAK nucleoprotein 0.105376
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0873517
EZR ezrin 0.0846415
ASPH aspartate beta-hydroxylase 0.0841666
EXT1 exostosin glycosyltransferase 1 0.0787429
ITGA6 integrin, alpha 6 0.0700421
LOC112694756 uncharaterized LOC112694756 0.0697232
AFF1 AF4/FMR2 family, member 1 0.0677044
PLEC plectin 0.0676937
MYO1E myosin IE 0.0674608
ALCAM activated leukocyte cell adhesion molecule 0.0647918
PDIA4 protein disulfide isomerase family A, member 4 0.0594968
DSG2 desmoglein 2 0.0563804
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.054297
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0541005
EMP1 epithelial membrane protein 1 0.0511994
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0479512
IQGAP1 IQ motif containing GTPase activating protein 1 0.0473828
CLCN3 chloride channel, voltage-sensitive 3 0.0470305
EREG epiregulin 0.0467627
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0459666
AKAP13 A kinase (PRKA) anchor protein 13 0.0445814
TGFBR3 transforming growth factor, beta receptor III 0.0441779
UBE2H ubiquitin-conjugating enzyme E2H 0.0440117
PDE4D phosphodiesterase 4D, cAMP-specific 0.0426974
ARHGAP21 Rho GTPase activating protein 21 0.0422457
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0419161
APP amyloid beta (A4) precursor protein 0.0417125
MACF1 microtubule-actin crosslinking factor 1 0.0413547
ANXA2 annexin A2 0.0413132
HSPA8 heat shock 70kDa protein 8 0.0412298
KLF5 Kruppel-like factor 5 (intestinal) 0.0410743
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0409851
MYO5B myosin VB 0.0405198
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0405091
EHF ets homologous factor 0.0403321
PDZD8 PDZ domain containing 8 0.0401583
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0391153
CD44 CD44 molecule (Indian blood group) 0.0389777
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0389006
SHROOM3 shroom family member 3 0.0384534
JMJD1C jumonji domain containing 1C 0.038335
USP6NL USP6 N-terminal like 0.0369178
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0363044
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0361949
BZW1 basic leucine zipper and W2 domains 1 0.0357539
PSD3 pleckstrin and Sec7 domain containing 3 0.0352302
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0350629
PARD3B par-3 family cell polarity regulator beta 0.0345281
EGFR epidermal growth factor receptor 0.0344178
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0341034
MED13 mediator complex subunit 13 0.0339212
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0338836
SOX9 SRY (sex determining region Y)-box 9 0.0337936
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0336986
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0332711
SVIL supervillin 0.0329886
ABLIM1 actin binding LIM protein 1 0.0323348
SIK3 SIK family kinase 3 0.0322819
CADPS Ca++-dependent secretion activator 0.0322497
MARCHF3 membrane associated ring-CH-type finger 3 0.0322247
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0321704
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0320195
SERINC5 serine incorporator 5 0.0315753
HDLBP high density lipoprotein binding protein 0.030953
PELI1 pellino E3 ubiquitin protein ligase 1 0.0309406
FLNB filamin B, beta 0.0309339
ARHGAP42 Rho GTPase activating protein 42 0.0309296
MYH9 myosin, heavy chain 9, non-muscle 0.0302854
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0301912
PGK1 phosphoglycerate kinase 1 0.030144
CLIP2 CAP-GLY domain containing linker protein 2 0.0298142
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0297453
EPS8 epidermal growth factor receptor pathway substrate 8 0.0296615
SEPTIN9 septin 9 0.029655
ABHD2 abhydrolase domain containing 2 0.0296448
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0291496
CRY1 cryptochrome circadian clock 1 0.0283718
SFTPA2 surfactant protein A2 0.0282779
LPP LIM domain containing preferred translocation partner in lipoma 0.0282141
FOXO1 forkhead box O1 0.0277881
TPM3 tropomyosin 3 0.0277733
UNC13B unc-13 homolog B (C. elegans) 0.0275044
LDHA lactate dehydrogenase A 0.0274366
TRPS1 trichorhinophalangeal syndrome I 0.0270988
TMSB4X thymosin beta 4, X-linked 0.0268829
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 0.0266747
TXNRD1 thioredoxin reductase 1 0.0263069
MYOF myoferlin 0.0261682

decreased expression

Symbol Name Standardized Value
MUC6 mucin 6, oligomeric mucus/gel-forming -0.142102
TMSB10 thymosin beta 10 -0.127826
NPSR1 neuropeptide S receptor 1 -0.119065
RPL35A ribosomal protein L35a -0.0800141
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0684036
VCL vinculin -0.067398
RPL9 ribosomal protein L9 -0.0538474
GPHN gephyrin -0.0504084
TPT1 tumor protein, translationally-controlled 1 -0.0503469
NDRG1 N-myc downstream regulated 1 -0.0478927
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0404747
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0380684
S100P S100 calcium binding protein P -0.0375763
RPLP2 ribosomal protein, large, P2 -0.0356846
TNS4 tensin 4 -0.0336142
GOLGA4 golgin A4 -0.0324796
RPL31 ribosomal protein L31 -0.0317999
FAM13A family with sequence similarity 13, member A -0.0312888
EGR1 early growth response 1 -0.0308292
RPL23 ribosomal protein L23 -0.0307129
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0297525
PTMA prothymosin, alpha -0.029578
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0290936
RPS23 ribosomal protein S23 -0.0287342
RPS19 ribosomal protein S19 -0.0285742
RPL37A ribosomal protein L37a -0.0284011
RPS29 ribosomal protein S29 -0.0283825
IARS1 isoleucyl-tRNA synthetase 1 -0.0283593
PNISR PNN-interacting serine/arginine-rich protein -0.0269436
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0269356
HMGA1 high mobility group AT-hook 1 -0.0260936
FTL ferritin, light polypeptide -0.0256435
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.024783
INSIG1 insulin induced gene 1 -0.0246167
RPL5 ribosomal protein L5 -0.024537
ANTXR2 anthrax toxin receptor 2 -0.0245034
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0240096
RPL34 ribosomal protein L34 -0.0235028
RPL36 ribosomal protein L36 -0.0234956
CALB1 calbindin 1, 28kDa -0.0231585
RPS24 ribosomal protein S24 -0.0231141
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0214361
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0212012
NUPR1 nuclear protein, transcriptional regulator, 1 -0.021101
PRELID2 PRELI domain containing 2 -0.0209089
DENND1A DENN/MADD domain containing 1A -0.0208781
RAB6A RAB6A, member RAS oncogene family -0.0207408
RPLP1 ribosomal protein, large, P1 -0.0206389
ATP5F1B ATP synthase F1 subunit beta -0.0201236
TFF1 trefoil factor 1 -0.0200232
RPS6 ribosomal protein S6 -0.0197826
RBM39 RNA binding motif protein 39 -0.0196249
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0191101
RNF43 ring finger protein 43 -0.0190123
RPS13 ribosomal protein S13 -0.0189177
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0188181
RPL28 ribosomal protein L28 -0.0187774
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0185677
TFF3 trefoil factor 3 (intestinal) -0.0184827
MON2 MON2 homolog (S. cerevisiae) -0.018458
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0183598
SETD5 SET domain containing 5 -0.0183235
ANKRD10 ankyrin repeat domain 10 -0.0182528
BACE2 beta-site APP-cleaving enzyme 2 -0.0181889
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma -0.0181854
FOSL1 FOS-like antigen 1 -0.0180721
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0179925
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0179774
RPS3 ribosomal protein S3 -0.017943
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0177932
EIF1 eukaryotic translation initiation factor 1 -0.0170835
ATF4 activating transcription factor 4 -0.01705
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0170176
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0169762
RPS8 ribosomal protein S8 -0.0169442
HM13 histocompatibility (minor) 13 -0.0167227
PABPN1 poly(A) binding protein, nuclear 1 -0.0167131
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0166517
FERMT1 fermitin family member 1 -0.0166347
ESRP1 epithelial splicing regulatory protein 1 -0.0165855
PFN1 profilin 1 -0.0165373
RPL26 ribosomal protein L26 -0.0165356
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0164975
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0164728
FDPS farnesyl diphosphate synthase -0.0163895
RPL11 ribosomal protein L11 -0.0162104
GRB10 growth factor receptor-bound protein 10 -0.0161298
RPS25 ribosomal protein S25 -0.0160688
ISG15 ISG15 ubiquitin-like modifier -0.0160196
WSB1 WD repeat and SOCS box containing 1 -0.0158826
MAML2 mastermind-like 2 (Drosophila) -0.015882
RBM25 RNA binding motif protein 25 -0.0158304
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0156334
ANXA3 annexin A3 -0.0152256
HILPDA hypoxia inducible lipid droplet-associated -0.0151434
AGR2 anterior gradient 2 -0.0150624
RPS21 ribosomal protein S21 -0.0150579
CD46 CD46 molecule, complement regulatory protein -0.0150026
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0149801
PDXK pyridoxal (pyridoxine, vitamin B6) kinase -0.0147395