Oleic acid_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PSD3 pleckstrin and Sec7 domain containing 3 0.184666
DST dystonin 0.175153
TP63 tumor protein p63 0.172615
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.12008
FTH1 ferritin, heavy polypeptide 1 0.106218
HLA-B major histocompatibility complex, class I, B 0.10043
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0984284
CAPRIN2 caprin family member 2 0.0966321
CD44 CD44 molecule (Indian blood group) 0.0930489
ZDHHC14 zinc finger, DHHC-type containing 14 0.0836302
CADM2 cell adhesion molecule 2 0.0718431
SP100 SP100 nuclear antigen 0.0643506
NPAS2 neuronal PAS domain protein 2 0.0567134
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0563922
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0556436
TSC22D1 TSC22 domain family, member 1 0.0548628
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0548262
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0546366
PDE10A phosphodiesterase 10A 0.0537085
DPYD dihydropyrimidine dehydrogenase 0.0532589
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0532244
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0530104
RNF213 ring finger protein 213 0.0521177
TNS3 tensin 3 0.050085
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0495554
PRELID2 PRELI domain containing 2 0.0493242
BCAR3 breast cancer anti-estrogen resistance 3 0.0488126
TGM2 transglutaminase 2 0.0485787
RUNX1 runt-related transcription factor 1 0.0472732
HDAC9 histone deacetylase 9 0.0457426
MACF1 microtubule-actin crosslinking factor 1 0.0424991
RAD51B RAD51 paralog B 0.0420591
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0399718
WWTR1 WW domain containing transcription regulator 1 0.0388618
FMNL2 formin-like 2 0.0385643
SOD2 superoxide dismutase 2, mitochondrial 0.0385468
PLEC plectin 0.0381264
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0373335
RIGI RNA sensor RIG-I 0.0369651
WARS1 tryptophanyl-tRNA synthetase 1 0.0360496
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0359566
VCL vinculin 0.0359384
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0358535
EHBP1 EH domain binding protein 1 0.035203
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0351399
LPP LIM domain containing preferred translocation partner in lipoma 0.0350466
ZSWIM6 zinc finger, SWIM-type containing 6 0.0349235
CSMD3 CUB and Sushi multiple domains 3 0.0346662
EPHA4 EPH receptor A4 0.0345728
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0340566
HLA-E major histocompatibility complex, class I, E 0.0335162
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0330466
RPS12 ribosomal protein S12 0.032635
EFNA5 ephrin-A5 0.0323589
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0319875
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0315937
CFLAR CASP8 and FADD-like apoptosis regulator 0.0315478
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0314315
ZBTB38 zinc finger and BTB domain containing 38 0.0312544
INTS6 integrator complex subunit 6 0.0308542
DPH6 diphthamine biosynthesis 6 0.0308337
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0300332
BICD1 bicaudal D homolog 1 (Drosophila) 0.0297003
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0295949
IFI6 interferon, alpha-inducible protein 6 0.0294067
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.029325
DNER delta/notch-like EGF repeat containing 0.0291944
NEK10 NIMA-related kinase 10 0.0290431
AEBP2 AE binding protein 2 0.0289164
TMSB4X thymosin beta 4, X-linked 0.0285736
EEF2 eukaryotic translation elongation factor 2 0.0285251
B2M beta-2-microglobulin 0.0283952
PLSCR1 phospholipid scramblase 1 0.0283513
EXOC4 exocyst complex component 4 0.0283391
KRT18 keratin 18, type I 0.0278437
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0275949
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0274666
HOMER1 homer scaffolding protein 1 0.0269315
SDK1 sidekick cell adhesion molecule 1 0.0260726
H1-0 H1.0 linker histone 0.0259587
RPS6 ribosomal protein S6 0.0259243
PMP22 peripheral myelin protein 22 0.0256434
DOCK1 dedicator of cytokinesis 1 0.0255986
SMYD3 SET and MYND domain containing 3 0.0253449
EGFR epidermal growth factor receptor 0.0251102
PRKCE protein kinase C, epsilon 0.0250918
BIRC3 baculoviral IAP repeat containing 3 0.0247641
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0246461
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0246123
IFIH1 interferon induced with helicase C domain 1 0.0244263
HLA-A major histocompatibility complex, class I, A 0.0243739
HLA-C major histocompatibility complex, class I, C 0.0239626
SFTPA2 surfactant protein A2 0.0239412
SQSTM1 sequestosome 1 0.0238492
SVIL supervillin 0.0235616
PTK2 protein tyrosine kinase 2 0.0232826
CMIP c-Maf inducing protein 0.0232766
RPL12 ribosomal protein L12 0.0231031
HELZ2 helicase with zinc finger 2, transcriptional coactivator 0.0229208
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0228219

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.144681
TXNRD1 thioredoxin reductase 1 -0.12378
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.120998
TMSB10 thymosin beta 10 -0.0817417
RAI1 retinoic acid induced 1 -0.067954
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0650981
TM4SF1 transmembrane 4 L six family member 1 -0.0545501
VIM vimentin -0.0532416
UBC ubiquitin C -0.0527986
PTMA prothymosin, alpha -0.0496047
RTN4 reticulon 4 -0.0487898
GARS1 glycyl-tRNA synthetase 1 -0.0481467
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0406717
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0396566
TMEM41B transmembrane protein 41B -0.0373392
EZR ezrin -0.0356806
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0355942
CENPF centromere protein F, 350/400kDa -0.0348683
SLC38A2 solute carrier family 38, member 2 -0.0346493
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0345712
CANX calnexin -0.0345514
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0330065
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0318111
NAMPT nicotinamide phosphoribosyltransferase -0.0311451
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0306324
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0286282
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0280495
MT1X metallothionein 1X -0.0278074
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0275113
EIF1 eukaryotic translation initiation factor 1 -0.0272472
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0272264
TOP1 topoisomerase (DNA) I -0.0270641
JUN jun proto-oncogene -0.0256974
ADAM17 ADAM metallopeptidase domain 17 -0.0255202
RBM25 RNA binding motif protein 25 -0.025352
ANXA1 annexin A1 -0.025262
MATR3 matrin 3 -0.0249518
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0248618
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0248106
SMC4 structural maintenance of chromosomes 4 -0.0246808
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.02461
KDM3A lysine (K)-specific demethylase 3A -0.0245873
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0245196
ECT2 epithelial cell transforming 2 -0.0240912
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.023692
MKI67 marker of proliferation Ki-67 -0.0234325
USP34 ubiquitin specific peptidase 34 -0.0233261
RBM39 RNA binding motif protein 39 -0.0232568
ACTG1 actin gamma 1 -0.0228791
NUP58 nucleoporin 58 -0.0227718
WSB1 WD repeat and SOCS box containing 1 -0.0221699
BRWD1 bromodomain and WD repeat domain containing 1 -0.021751
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.021682
YBX3 Y box binding protein 3 -0.0216048
SEPTIN7 septin 7 -0.021154
UPP1 uridine phosphorylase 1 -0.0205927
RAD21 RAD21 homolog (S. pombe) -0.0204823
WDR45B WD repeat domain 45B -0.0203558
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0199584
TNPO1 transportin 1 -0.01992
ZFAND3 zinc finger, AN1-type domain 3 -0.0198966
MIS18BP1 MIS18 binding protein 1 -0.0198888
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.0197658
ZMYND8 zinc finger, MYND-type containing 8 -0.0194329
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0193451
RPS27A ribosomal protein S27a -0.0192675
AHNAK AHNAK nucleoprotein -0.0191446
PRRC2C proline-rich coiled-coil 2C -0.018945
PUM2 pumilio RNA-binding family member 2 -0.0187667
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0186866
CKAP5 cytoskeleton associated protein 5 -0.0184741
PCBP2 poly(rC) binding protein 2 -0.0184078
HMGB2 high mobility group box 2 -0.0182942
ARHGAP29 Rho GTPase activating protein 29 -0.0182783
PDIA3 protein disulfide isomerase family A, member 3 -0.0181199
LDHA lactate dehydrogenase A -0.0179639
TM9SF3 transmembrane 9 superfamily member 3 -0.0179324
XPO1 exportin 1 -0.0179081
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0177749
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0177148
ANLN anillin, actin binding protein -0.0175773
ZFR zinc finger RNA binding protein -0.0174647
POM121 POM121 transmembrane nucleoporin -0.0173288
ANKRD28 ankyrin repeat domain 28 -0.0172733
MORF4L2 mortality factor 4 like 2 -0.0171028
SPRY4 sprouty homolog 4 (Drosophila) -0.0170827
MARCHF6 membrane associated ring-CH-type finger 6 -0.017041
CALU calumenin -0.0170169
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0169817
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.016907
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0169055
DIAPH3 diaphanous-related formin 3 -0.0168034
PUM1 pumilio RNA-binding family member 1 -0.0167746
GOLGA4 golgin A4 -0.0166899
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0166735
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0165705
CEP170 centrosomal protein 170kDa -0.0163926
TPX2 TPX2, microtubule-associated -0.016136
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0160821
RBM27 RNA binding motif protein 27 -0.0160616