Oleic acid_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Oleic acid perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Oleic acid_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.135109
FTH1 ferritin, heavy polypeptide 1 0.125401
SLTM SAFB-like, transcription modulator 0.10157
CES1 carboxylesterase 1 0.101363
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.085358
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0655247
GRAMD1B GRAM domain containing 1B 0.0628048
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0531584
LOC112694756 uncharaterized LOC112694756 0.0528639
PLEC plectin 0.0496754
SOD2 superoxide dismutase 2, mitochondrial 0.0455518
H1-0 H1.0 linker histone 0.0394713
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0389188
FAM13A family with sequence similarity 13, member A 0.0388226
THSD4 thrombospondin, type I, domain containing 4 0.0387087
MYOF myoferlin 0.0385333
DOCK5 dedicator of cytokinesis 5 0.0382127
MYH9 myosin, heavy chain 9, non-muscle 0.0380445
ELL2 elongation factor, RNA polymerase II, 2 0.0369026
TXNRD1 thioredoxin reductase 1 0.03661
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0365752
GCLC glutamate-cysteine ligase, catalytic subunit 0.03576
BCAR3 breast cancer anti-estrogen resistance 3 0.0357034
SPAG9 sperm associated antigen 9 0.0352397
LMO7 LIM domain 7 0.0338038
SMAD3 SMAD family member 3 0.0333707
KRT18 keratin 18, type I 0.0331613
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0330673
TBC1D22A TBC1 domain family, member 22A 0.0324189
RUNX1 runt-related transcription factor 1 0.0322544
LAMA4 laminin, alpha 4 0.0315698
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0312146
LAMC2 laminin, gamma 2 0.0305172
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0302564
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0289999
GSK3B glycogen synthase kinase 3 beta 0.0277304
CEMIP cell migration inducing protein, hyaluronan binding 0.0272478
JMJD1C jumonji domain containing 1C 0.0269225
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0267223
AGO2 argonaute RISC catalytic component 2 0.0264847
ERRFI1 ERBB receptor feedback inhibitor 1 0.0252655
CXCL8 chemokine (C-X-C motif) ligand 8 0.0244408
RICTOR RPTOR independent companion of MTOR, complex 2 0.0242716
EEF2 eukaryotic translation elongation factor 2 0.0242628
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0240645
DSCAM Down syndrome cell adhesion molecule 0.0240304
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0238031
TES testin LIM domain protein 0.0237502
ANO6 anoctamin 6 0.0236804
TSC22D2 TSC22 domain family, member 2 0.0235495
MACF1 microtubule-actin crosslinking factor 1 0.0233709
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0232802
DSPP dentin sialophosphoprotein 0.0231719
OSMR oncostatin M receptor 0.0231009
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0227969
MSN moesin 0.0225262
ZC3H11A zinc finger CCCH-type containing 11A 0.0223374
ADAM9 ADAM metallopeptidase domain 9 0.0214987
SAMD4A sterile alpha motif domain containing 4A 0.0213569
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.02112
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0208883
PAPOLA poly(A) polymerase alpha 0.0206251
SON SON DNA binding protein 0.020514
TPM3 tropomyosin 3 0.0200941
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0199639
HSPA8 heat shock 70kDa protein 8 0.0193487
SMYD3 SET and MYND domain containing 3 0.0190381
VEGFC vascular endothelial growth factor C 0.0188977
CDCP1 CUB domain containing protein 1 0.0187567
TRIP12 thyroid hormone receptor interactor 12 0.018729
KDM2A lysine (K)-specific demethylase 2A 0.0187066
PDLIM5 PDZ and LIM domain 5 0.0186221
LRP12 low density lipoprotein receptor-related protein 12 0.0185554
CUL4A cullin 4A 0.0184869
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0183634
BZW1 basic leucine zipper and W2 domains 1 0.0183338
TNIP1 TNFAIP3 interacting protein 1 0.0182429
HDLBP high density lipoprotein binding protein 0.0182119
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0180767
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0179783
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0179551
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0179137
TOP1 topoisomerase (DNA) I 0.0178516
OGA O-GlcNAcase 0.0176697
EIF4A2 eukaryotic translation initiation factor 4A2 0.0176251
MKI67 marker of proliferation Ki-67 0.0175615
UBA6 ubiquitin-like modifier activating enzyme 6 0.0174663
AHNAK AHNAK nucleoprotein 0.017357
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0172074
NPAS2 neuronal PAS domain protein 2 0.0171309
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0169626
ZNF638 zinc finger protein 638 0.0167916
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0167091
NCKAP1 NCK-associated protein 1 0.01666
CPE carboxypeptidase E 0.016447
GLS2 glutaminase 2 (liver, mitochondrial) 0.0164434
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.016278
ATP13A3 ATPase type 13A3 0.0160545
EP300 E1A binding protein p300 0.0158993
BMP6 bone morphogenetic protein 6 0.0158711

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.179801
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.169657
PTMA prothymosin, alpha -0.102723
TPT1 tumor protein, translationally-controlled 1 -0.092814
ACTG1 actin gamma 1 -0.0782871
RPL35A ribosomal protein L35a -0.0747841
FTL ferritin, light polypeptide -0.0593892
S100A10 S100 calcium binding protein A10 -0.0578063
RPLP1 ribosomal protein, large, P1 -0.0520205
CST3 cystatin C -0.0494217
RPS24 ribosomal protein S24 -0.0488619
RPS25 ribosomal protein S25 -0.0463527
SEC61G Sec61 gamma subunit -0.0463197
EGR1 early growth response 1 -0.0460785
RPL34 ribosomal protein L34 -0.0434595
RPL37A ribosomal protein L37a -0.0425988
SLC38A1 solute carrier family 38, member 1 -0.0422183
RPL31 ribosomal protein L31 -0.042179
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0380161
IFI6 interferon, alpha-inducible protein 6 -0.0356913
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0356473
RPS29 ribosomal protein S29 -0.035325
RPS27A ribosomal protein S27a -0.0350348
HLA-B major histocompatibility complex, class I, B -0.0345473
B2M beta-2-microglobulin -0.0329983
RPS3 ribosomal protein S3 -0.0326683
MT2A metallothionein 2A -0.0324902
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0323691
RPS8 ribosomal protein S8 -0.0313575
RPL11 ribosomal protein L11 -0.0306685
S100P S100 calcium binding protein P -0.0306056
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0300517
RPS23 ribosomal protein S23 -0.0299862
RPS6 ribosomal protein S6 -0.0293579
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.028955
ZMYND8 zinc finger, MYND-type containing 8 -0.0288349
WSB1 WD repeat and SOCS box containing 1 -0.0280117
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0277335
S100A11 S100 calcium binding protein A11 -0.0275598
RPL37 ribosomal protein L37 -0.0271474
RPLP2 ribosomal protein, large, P2 -0.0271002
RPL23 ribosomal protein L23 -0.0268305
EIF1 eukaryotic translation initiation factor 1 -0.0261394
RPS27 ribosomal protein S27 -0.0258091
S100A9 S100 calcium binding protein A9 -0.0249926
RPS19 ribosomal protein S19 -0.0245521
IER3 immediate early response 3 -0.024549
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0244347
KRT7 keratin 7, type II -0.024048
RPS21 ribosomal protein S21 -0.0233827
KPNB1 karyopherin (importin) beta 1 -0.0233517
RPL38 ribosomal protein L38 -0.0228668
RPS13 ribosomal protein S13 -0.0222227
AGR2 anterior gradient 2 -0.0218168
RPL36 ribosomal protein L36 -0.0217757
RPS14 ribosomal protein S14 -0.0215772
RPL9 ribosomal protein L9 -0.0212936
FUS FUS RNA binding protein -0.0209735
RPL26 ribosomal protein L26 -0.0206791
BTG1 B-cell translocation gene 1, anti-proliferative -0.0205659
AKR1C1 aldo-keto reductase family 1, member C1 -0.0203146
C15ORF48 chromosome 15 open reading frame 48 -0.0202105
INTS6 integrator complex subunit 6 -0.0200432
RPL19 ribosomal protein L19 -0.0197764
LRP1B low density lipoprotein receptor-related protein 1B -0.0192717
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.0191158
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0190867
RPS12 ribosomal protein S12 -0.0185278
NDRG1 N-myc downstream regulated 1 -0.0182768
RPL12 ribosomal protein L12 -0.018227
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0181792
TRIM56 tripartite motif containing 56 -0.0179243
S100A6 S100 calcium binding protein A6 -0.0176655
PTPRM protein tyrosine phosphatase, receptor type, M -0.017598
RPL28 ribosomal protein L28 -0.0173725
RPS17 ribosomal protein S17 -0.0173349
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0173102
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0171596
PKM pyruvate kinase, muscle -0.0170938
RPL30 ribosomal protein L30 -0.0169873
RPL5 ribosomal protein L5 -0.0169772
RPL36A ribosomal protein L36a -0.0169492
AREG amphiregulin -0.0166143
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0164896
RACK1 receptor for activated C kinase 1 -0.0161937
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0161589
CIB1 calcium and integrin binding 1 (calmyrin) -0.0161489
CTSL cathepsin L -0.0157614
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0154188
ENO2 enolase 2 (gamma, neuronal) -0.0153568
HMGA1 high mobility group AT-hook 1 -0.0153204
RPL8 ribosomal protein L8 -0.0150557
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0147859
CP ceruloplasmin (ferroxidase) -0.0146302
KRT19 keratin 19, type I -0.014491
RPL7A ribosomal protein L7a -0.0143347
RPS10 ribosomal protein S10 -0.0142624
GM2A GM2 ganglioside activator -0.0140688
RPS16 ribosomal protein S16 -0.0140572
ISG15 ISG15 ubiquitin-like modifier -0.013685